Stereoselective amino acid synthesis by synergistic photoredox-pyridoxal radical biocatalysis

Cited by (253)

Items 101–200 of 253

1. Enantioselective [2π+2σ] Cycloaddition to Bicyclo[2.1.1]hexanes Enabled by an Artificial Photoenzyme
   Jinsi Li, Ping Du, Tai-Ping Zhou, Wenhao Hu, Hui Li, Binju Wang, Hui‐Jie Pan · 2026 · Journal of the American Chemical Society
2. Photocatalytic regeneration of nicotinamide cofactor biomimetics drives biocatalytic reduction by Old Yellow enzymes
   Feifan Luo, Xiangyuan Gu, Yichun Zhu, Jieyu Zhou, Guochao Xu, Ye Ni · 2024 · Bioorganic Chemistry
3. A One‐Pot Biocatalytic Cascade to Access Diverse l ‐Phenylalanine Derivatives from Aldehydes or Carboxylic Acids
   Shelby R. Anderson, Madan R. Gopal, Abigail P. Spangler, Michaela A. Jones, D’Jana R. Wyllis, Aditya M. Kunjapur · 2024 · ChemCatChem
4. Enantioselective Radical Hydrocyanoalkylation of Alkenes via Photoenzymatic Catalysis
   Dongshan Wu, Zeying Sun, Sanshan Wang, Jun Yang, Jingyuan He, Xiaoguang Lei · 2025 · JACS Au
5. Kinetic Hydrolysis of Sulfinamides toward S(IV) Chirality Enabled by Visible-Light-Excited Ene-Reductases
   Zihan Zhang, Qiaoyu Zhang, Tianhang Wang, Beibei Zhao, Bin Chen, Xiaoyu Wang, Jianlin Chun, Tianying Zhang, Binju Wang, Xiaoqiang Huang · 2025 · ACS Catalysis
6. Classification of GBA1 variants and their impact on Parkinson’s disease: an in silico score analysis
   Aymeric Lanore, Christelle Tesson, Aymeric Basset, François‐Xavier Lejeune, Guillaume Cogan, Graziella Mangone, Sara Sambin, Nathalie Bertille, Mathieu Anheim, Isabelle Arnulf et al. · 2025 · npj Parkinson s Disease
7. Directed Evolution of Threonine Aldolases for the Photobiocatalytic Synthesis of β-Branched-α-Tetrasubstituted and Other Noncanonical Amino Acids
   Tian-Ci Wang, Xiangyu Zhang, Zheng Zhang, G Gangadhareswar Rao, Zhiyu Bo, Pei‐Pei Xie, Jiedong Li, Qiang Yang, Xiaoyong Li, R. David Britt et al. · 2026 · Journal of the American Chemical Society
8. Merging High‐Pressure Syngas Metal Catalysis and Biocatalysis in Tandem One‐Pot Processes for the Synthesis of Nonchiral and Chiral Alcohols from Alkenes in Water
   Hannah Bork, Kim E. Naße, Andreas J. Vorholt, Harald Gröger · 2024 · Angewandte Chemie International Edition
9. Recent Advancements and Future Prospects of Asymmetrically Coordinated Single-Atom Nanozymes with High Enzymatic-like Activity for Biotherapy and Diagnosis: A Review
   Changli Chen, Gangzhi Qin, Xinyue Geng, Hongxiang Wang, Bingchao Wang, Minggang Liu, Yingshu Guo · 2025 · ACS Applied Nano Materials
10. Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine
    Andrew Michael Glazer, Daniel R. Tabet, Victoria Nicole Parikh, Brett M. Kroncke, Atina G. Coté, Yuta Yamamoto, Qianru Wang, Ayesha Muhammad, Megan Cummins Lancaster, Matthew J. O’Neill et al. · 2025 · Nature Reviews Cardiology
11. Engineering non-haem enzymes for nickel-catalysed C(sp2)‒S coupling via ligand-to-metal charge transfer photocatalysis
    Xiuze Wang, Xianhai Tian, Xiahe Chen, Guoxiong Xu, Jared C. Paris, Yuqi Song, Yuxuan Su, James G. Zhang, Xin Hong, Marc Garcia‐Borràs et al. · 2026 · Nature Synthesis
12. Enantioselective C(sp3)–C(sp3) bond formation by synergistic thiamine-dependent radical biocatalysis and photoredox catalysis
    Jianlin Chun, Yuyan Bao, Qiaoyu Zhang, Xueli Hou, Zhouping Wu, Hailong Sun, Zhongqiu Xing, Bin Chen, Zihan Zhang, Yue Chun Zhao et al. · 2026 · Nature Catalysis
13. Mechanistic investigation of repurposed photoenzymes with new-to-nature reactivity
    Zhengyi Zhang, Mao‐Lin Li, Huimin Zhao · 2025 · Current Opinion in Green and Sustainable Chemistry
14. Hybrid Catalytic Systems: Integrating Biocatalysis in the Chemical Space
    David Lim, Francesca Paradisi · 2025 · ACS Catalysis
15. Copper‐Catalyzed Phosphorus Radical Transformations for the Assembly of P‐Stereogenic Architectures
    Yujin Zi, Boxuan Yang, Ziqi Ye, Yu‐Mei Lin, Qianyi Zhao, Binju Wang, Lei Gong · 2025 · Angewandte Chemie International Edition
16. In vivo mitochondrial base editing restores genotype and visual function in a mouse model of LHON
    Sanghun Kim, Jieun Kim, Seongkwang Cha, Sungjin Ju, Chae Jin Lim, Seongho Hong, Jiyoung Bae, Yeji Oh, Sungmo Jung, Sol Pin Kim et al. · 2025 · Nature Communications
17. Mechanism-Guided Computational Design Drives meso-Diaminopimelate Dehydrogenase to Efficient Synthesis of Aromatic d -amino Acids
    Tianfu Wu, Yihan Chen, Wanqing Wei, Wei Song, Jing Wu, Jian Wen, Guipeng Hu, Xiaomin Li, Cong Gao, Xiulai Chen et al. · 2024 · ACS Synthetic Biology
18. Asymmetric Radical Alkylation Enabled by Synergistic Photoredox Enamine Biocatalysis
    Qiaoqiao Li, Rui Zhang, Yuqiu Lan, Yulian Li, Chun-Ping Tang, Chang‐Qiang Ke, Yang Ye, Cangsong Liao · 2025 · ChemCatChem
19. A Multi-level Perspective on the Evolution of Orthologs and Their Functions
    Felix Langschied, Ruben Iruegas, Mateusz Sikora, Roberto Covino, Ingo Ebersberger · 2025 · Journal of Molecular Evolution
20. Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations
    John P. McElderry, Tongwu Zhang, Zhao Wei, Phuc H. Hoang, Samuel Anyaso-Samuel, Jian Sang, Azhar Khandekar, Caleb Hartman, Frank J. Colón-Matos, Mona Miraftab et al. · 2025 · Nature Communications
21. A Convergent, One-Step Biocatalytic Cascade for the Synthesis of Structurally Diverse Noncanonical Amino Acids
    John A. McIntosh, Susan L. Zultanski, Jackson K. B. Cahn, Zhongxue Dai, Luan Zhengjiao, Fan Haiyang, Mengmeng Bian, Deeptak Verma, Chey M. Jones, Michael Hartmann et al. · 2026 · ACS Catalysis
22. Thiamine-based photobiocatalysis for the enantioselective construction of all-carbon quaternary stereocentres with two minimally different alkyl groups
    Jintong Bai, Yan Xu, Ruobin Sun, Fuhua Che, 尚国辉, Guangtao Zhang, Xiaoqiang Huang, Chunshuai Huang · 2026 · Nature Synthesis
23. Universal Chiral Nanopaint for Metal Oxide Biomaterials
    Wookjin Jung, Dongkyu Lee, Hohyeon Kim, Boyoung Son, Seung‐Jun Oh, Jeong Eun Gong, Daehong Kim, Jungwon Yoon, Jihyeon Yeom · 2025 · ACS Nano
24. One-pot chemoenzymatic syntheses of non-canonical amino acids
    Tsung-Han Chao, Xiangyu Wu, Hans Renata · 2024 · Journal of Industrial Microbiology & Biotechnology
25. Light-Driven Reactions Catalyzed by Radical S-Adenosylmethionine Enzymes
    He Li, Wei Ding, Fen‐Er Chen, Qi Zhang · 2025 · ACS Catalysis
26. Photoenzymatic Aliphatic C─Br Activation for Enantioselective Synthesis of γ‐Stereogenic Nitriles from Alkenes
    Yiwei Liu, Zhiping Yin, Marion B. Ansorge‐Schumacher, Changzhu Wu · 2025 · Angewandte Chemie International Edition
27. Enzymatic Mannich Reaction for the Synthesis of γ-Chiral Amino-Substituted α-Amino Acids
    Lu Wang, Duo Zhang, Kangni Yin, Guojing Wu, Xinyu Duan, Chunlei Yang, Lishuang Ma, Xiaoyang Chen, Jian Feng Xu · 2026 · ACS Catalysis
28. Harnessing thia-Rh-carbenes for the enantioselective synthesis of chiral α,α-diheteroatomic carboxylic acids
    Yajie Xing, Yuqi Fang, Yicheng Zhao, Jiean Chen, Yong Huang · 2026 · Nature Catalysis
29. Metallic Ag-BiAg Heterostructured Dendrites Accelerate Carbon–Nitrogen Coupling for Air Plasma-Derived Amino Acid Electrosynthesis
    Kun Chen, X Zheng, Lin Luo, Dan Liú, Han Cheng, Pengzuo Chen, Yun Tong, Changzheng Wu · 2026 · Journal of the American Chemical Society
30. Biocatalytic Amino Acid Functionalisation
    Mark R. Petchey, Pascal Schneider, Lucy A. Harwood · 2024 · ChemMedChem
31. Prediction of pathogenic mutations in human transmembrane proteins and their associated diseases via utilizing pre-trained Bio-LLMs
    Lexin Cao, Lijun Quan, Qiufeng Chen, B. X. Zhang, Zhijun Zhang, Liangchen Peng, Junkai Wang, Yelu Jiang, Liangpeng Nie, Geng Li et al. · 2025 · Communications Biology
32. Cooperative Photometallobiocatalysis: Nonheme Fe Enzyme‐Catalyzed Enantioconvergent Radical Decarboxylative Azidation, Thiocyanation, and Isocyanation of Redox‐Active Esters
    Liu‐Peng Zhao, Ken Lin, Pei‐Pei Xie, Huichong Liu, Hengye Xiang, Xin Zhe Liu, Yunlong Zhao, Peng Liu, Yang Yang · 2025 · Angewandte Chemie
33. Enantiodivergent Radical Alkylation by Synergistic Lewis‐Acid‐Enzyme and Photoredox Catalysis
    Jiawei Zhang, Qiaoyu Zhang, Ran Ge, Aokun Liu, Bin Chen, Zihan Zhang, Beibei Zhao, Jinhai Yu, Yue Zhao, Lu Yu et al. · 2025 · Angewandte Chemie
34. CdS-enzyme composite promotes photobiocatalytic conversion of plastic-derived lactate to chiral chemicals
    Willy W. L. See, Phuc T.T. Nguyen, Heng Yih Tan, Jie Fu Jeff Zhou, Sie Shing Wong, Kang Zhou, Ning Yan · 2025 · Green Energy & Environment
35. Electrocatalytic C–N coupling of carbon dioxide and nitrogen-containing small molecules for synthesizing organic nitrogenous compounds
    Youyu Long, Yingchun He, Wenbo Wei, Hua Lin, Qi‐Long Zhu · 2026 · Journal of Energy Chemistry
36. Chemoenzymatic Catalysts Immobilized on Metal–Organic Layers for the Asymmetric Reduction of Unreactive Stereoisomers of Alkenes
    Wei Wang, Lihong Chen, Yintao Li, Jun Huang, Bing‐Feng Shi, Wenbin Lin, Pengfei Ji · 2024 · Chemistry of Materials
37. Update: Enzymatische Synthese für industrielle Anwendungen
    Thomas Bayer, Shuke Wu, Radka Šnajdrová, Kai Baldenius, Uwe T. Bornscheuer · 2025 · Angewandte Chemie
38. α-Hydrazino Acids Inhibit Pyridoxal Phosphate-Dependent Decarboxylases via “Catalytically Correct” Ketoenamine Tautomers: A Special Motif for Chemical Biology and Drug Discovery?
    Jonathan M. Baine, Yoan Duhoo, Tzanko I. Doukov, Ambroise Desfosses, Giovanni Bisello, Matthew L. Beio, Olivia Bauer, Massimiliano Perduca, Maria Bacia‐Verloop, Mariarita Bertoldi et al. · 2025 · ACS Catalysis
39. The neuropathy-linked protein TECPR2 is a Rab5 effector that regulates cargo recycling from early endosomes
    Sankalita Paul, Rajat Pant, Poonam Sharma, Kshitiz Walia, Suhasi Gupta, Adhil Aseem, Kamlesh Kumari Bajwa, Ruben George, Yudish Varma, Tripta Bhatia et al. · 2025 · Nature Communications
40. Computational Study on the Catalytic Mechanism of UstD Catalyzing the Synthesis of γ-Hydroxy-α-Amino Acids
    Binbin Chen, Jiahui Huang, Yingchun Liu, Lirong Yang, Qi Wang, Haoran Yu · 2025 · Journal of Chemical Information and Modeling
41. Designing Enzymatic Reactivity with an Expanded Palette
    Reuben B. Leveson‐Gower · 2025 · ChemBioChem
42. Synthesis of L‐Tryptophan Analogs by Ancestral L‐Tryptophan Synthase β‐Subunit with High Organic Solvent Tolerance
    Misaki Ohata, Shoryu Fujita, Kana Uchida, Seina Kobayashi, Taichi Chisuga, Shogo Nakano · 2025 · ChemCatChem
43. Mechanistic and Structural Analyses of Non-Heme Iron Enzyme TqaM for α-Tertiary Amino Acid Synthesis
    Huibin Wang, Angela Yao, Masahiro Kanaida, Takahiro Mori, Shilin Liu, Eliott Le Du, Yu‐Cong Zheng, Takayoshi Awakawa, Hans Renata, Wei‐chen Chang et al. · 2025 · Journal of the American Chemical Society
44. Structure and Mechanism of the Pyridoxal 5′-Phosphate-Dependent Amino Acid γ-Substitution Enzyme in 6-Alkyl-Pipecolate Biosynthesis
    Yuxiang Gao, Binju Wang, Jiahai Zhou, Yang Gu · 2025 · ACS Catalysis
45. The genetic architecture of Parkinson’s disease on the Island of Crete
    Iro Boura, Shaimaa Sait, Nikolaos M. Marinakis, Arvind Kumar, Ruth Chia, Anindita Ray, Giannis Vatsellas, Theodoros Loupis, Vasiliki Pavlaki, Periklis Makrythanasis et al. · 2025 · npj Parkinson s Disease
46. Engineered Flavin-Dependent Halogenases Catalyze C–C Bond Formation via Enantioselective Semipinacol Rearrangement
    Xuzhong Shen, Paras Gupta, Pratibha Gandhi, IanGustavo Ramirez, Dibyendu Mondal, Jared C. Lewis · 2026 · Journal of the American Chemical Society
47. De novo variants in the splicing factor gene SF3B1 are associated with neurodevelopmental disorders
    Kévin Uguen, Tiffany Bergot, Marie‐Pier Scott‐Boyer, Solène Chapalain, Camille Desdouets, Séverine Commet, Changlian Zhu, Yiran Xu, Yangong Wang, Tony Roscioli et al. · 2026 · Nature Communications
48. Photoenzymatic Cascade Catalysis with an Artificial CDCase for Stereoselective Cross-Dehydrogenative Coupling
    Yong Fu Tang, Yongqi Zeng, Chunyu Wang, Chuang Du, Fengxi Li, Lei Wang · 2026 · ACS Catalysis
49. Establishing the Fatty Acid Photodecarboxylase Cv FAP as a Platform for Photobiocatalytic Radical Transformations
    Florian Weißensteiner, Cristina Berga, Emilia Iglesias-Moncayo, Sara Salehi, Isabel Oroz‐Guinea, Klaus Zangger, Ferran Feixas, Marc Garcia‐Borràs, Wolfgang Kroutil, Christoph K. Winkler · 2026 · ACS Catalysis
50. Stereoselective photometallobiocatalytic cross-coupling of organoboron reagents and diazo compounds via an outer-sphere mechanism
    Huanan Wang, Binh Khanh Mai, Chongtao Li, Xiao‐Wang Chen, Rachel Weiss, Bryan J. Kudisch, Peng Liu, Yang Yang · 2026 · Nature Catalysis
51. Catalytically Promiscuous PLP-Dependent Aminotransferases Are Biocatalysts for C–C Bond Formation
    Alexander T. Kim, James R. Howard, Andrés G. Cuba Caceres, Kyle I. Chong, William A. Aye, Matthew S. Sigman, Alison R. H. Narayan · 2026 · ACS Central Science
52. Engineering a Thiamine-Dependent Benzoylformate Decarboxylase for Stereodivergent Radical C(sp 3 )–C(sp 3 ) Bond Formation
    Zhouping Wu, Yuyan Bao, Jianlin Chun, Ruobin Sun, Ming Yang, Zihao Guo, Zhongqiu Xing, Yue Chun Zhao, Xiaoqiang Huang · 2026 · Journal of the American Chemical Society
53. Evaluation of Organic Hydride/Acid Pairs as a Type of Thermodynamic-Potential-Regulated Multisite Proton-Coupled Electron Transfer Reagents
    Guang‐Bin Shen, Guang-Ze Luo, Bao‐Chen Qian, Xiao‐Qing Zhu · 2024 · The Journal of Organic Chemistry
54. Advances in Photoenzyme-Catalyzed Asymmetric Radical Addition Reactions
    Chenyang Jiang, Yanli Yin, Zhiyong Jiang · 2025 · Chinese Journal of Organic Chemistry
55. Structure and mechanism of the RalGAP tumor suppressor complex
    René Rasche, Björn Udo Klink, Lisa Helene Apken, Esther Michalke, Minghao Chen, Andrea Oeckinghaus, Christos Gatsogiannis, Daniel Kümmel · 2025 · Nature Communications
56. Expanding biocatalytic reactivity landscapes by physical fields and chemical strategies for green manufacturing
    Renjie Li, Hanbing Feng, Miao Shi, Aodi Zhang, Jing Su · 2025 · Biotechnology Advances
57. Computational Investigation of the PazB-Catalyzed Cyclopropanation Reaction: Role of Active-Site Water in SN2 Mechanism
    Shenggan Luo, Yike Zou · 2025 · ACS Catalysis
58. Characterization of prevalent genetic variants in the Estonian Biobank body-mass index GWAS
    Abner, Erik, Batool, Kanwal, Taba, Nele, Nikopensius, Tiit, Läll, Kristi, Alekseienko, Anastasiia, Eriksson, Anders, Rämö, Joel, Haapaniemi, Hele, Kariis, Hanna Maria et al. · 2025 · Nature Communications
59. Biocatalytic kinetic resolution for efficient and enantioselective synthesis of δ-haloalcohols and tetrahydrofurans
    Yuanfei Wang, Xia Hua, Zhang-Yang Wang, Xiao Ling Jin, Hui‐Hui Wang, Yong‐Zheng Chen, Nan‐Wei Wan · 2025 · Communications Chemistry
60. Copper‐Catalyzed Phosphorus Radical Transformations for the Assembly of P‐Stereogenic Architectures
    Yujin Zi, Boxuan Yang, Ziqi Ye, Yu‐Mei Lin, Qianyi Zhao, Binju Wang, Lei Gong · 2025 · Angewandte Chemie
61. Cascade biocatalysis for pyridoxal 5′-phosphate synthesis with ATP autonomy via polyphosphate kinase
    Jinnian Wang, Haoming Zhao, Shijun Tong, Xingjian Zhang, Shuyu Ding, Han Zhang, Zhong-Hua Yang · 2026 · Bioorganic Chemistry
62. Mannich Reaction With Pyridoxal 5′‐Phosphate Dependent Decarboxylative Aldolase for Synthesis of Noncanonical α ‐Amino Acids
    Yuqiu Lan, Lingrui Zhang, Keying Yu, Rui Zhang, Cangsong Liao · 2026 · ChemistryEurope
63. PCA‐Based Database Mining Enables the Discovery of Bacterial Carbene Transferases for Stereodivergent Cyclopropanation
    Shunsuke Kato, Koki Takeuchi, Kohei Umeda, Hisashi Kudo, Tomohisa Hasunuma, Takashi Hayashi · 2026 · Angewandte Chemie International Edition
64. Reprogramming Imine Reductases for Enantioselective Reduction of Electron-Rich Enamides
    Xiao-Qi Liu, Ru Li, Jun-Liang Chen, Ye Li, L Wei, Hongli Wu, Li Li, Ben-Hong Chen, Ying Wu, Si-Jia Liu et al. · 2026 · JACS Au
65. New insights into neurodevelopmental disorders by whole genome sequencing of 100 families from Italy
    Giovanni Spirito, Sara Trova, Gaia Treves, Khudayar Farmanli, Mariacristina Franzese Canonico, Agata Fant, Stefano Marangoni, Federica Furia, Debora Charrance, Nicola Locci et al. · 2026 · npj Genomic Medicine
66. Evaluation of non-canonical p53 functions in DNA replication and recombination for variant classification
    Rebecca Jansche, Benedikt Heitmeir, Ulrike Faust, Helmut Pospiech, Christian Sutter, Christian Albig, Finja Hennig, Wolfgang Janni, Rita Schmutzler, Jan Hauke et al. · 2026 · Cell Death and Disease
67. Machine learning/molecular mechanics enzymology for the next generation of computational enzymatic catalysis
    Xujian Wang, Junmei Wang, Wan-Lu Li · 2026 · Chem Catalysis
68. Massively parallel quantification of mutational impact on IAPP amyloid formation
    Marta Badia, Cristina Batlle, Benedetta Bolognesi · 2026 · Nature Communications
69. Pathogenic variants in the cohesin loader subunit MAU2 underlie a distinct Cornelia de Lange Syndrome subtype
    Ilaria Parenti, Alina Hesters, Marta Gil‐Salvador, Laura Duffy, Deniz Kanber, Jasmin Beygo, Jennifer Kerkhof, Laura Steenpaß, Elsa Leitão, Julia Woestefeld et al. · 2026 · Nature Communications
70. Asymmetric Synthesis of α-Aryl α-Amino Acids via NHC-Catalyzed Dynamic Kinetic Resolution
    Huai-Gui Li, Lu Jiang, Jun-Li Li, Xinyue Wang, Xiyike Deng, Can‐Ming Zhu, Cao‐Bo Li, Hao-Yuan Li, Jian‐Ji Zhong, Song Ye et al. · 2026 · Organic Letters
71. Plasma-assisted nitrogen circular economy: from fixation to valorization
    Jieping Fan, Jing Sun, Junhui Wang, Z ZHANG, Yongqin Fan, Tianyu Li, Rusen Zhou, D X Liu, Dorna Esrafilzadeh, Rouhollah Jalili et al. · 2026 · Green Chemistry
72. Pyridoxal photoenzymes for asymmetric radical–radical cross-couplings
    Cole C. Sorensen, Suhao Wang, Yao Ouyang, Saim Waheed, Claire G. Page, Greg Mann, Simon Allmendinger, Todd K. Hyster · 2026 · Nature
73. Asymmetric Chemoenzymatic One-Pot Synthesis: Process Concepts & Recent Progress in Combining Chemo- & Biocatalytic Reactions for the Formation of Chiral Molecules
    Harald Gröger, Kateryna Zelenska · 2024 · Elsevier eBooks
74. Biocatalytic Steroidal 9α‐Hydroxylation and Fragmentation Enable the Concise Chemoenzymatic Synthesis of 9,10‐Secosteroids
    Hanxin Song, Zeliang Zhang, Chunyang Cao, Zhijun Tang, Jinghan Gui, Wen Liu · 2024 · Angewandte Chemie
75. Genetic Incorporation of a Thioxanthone‐Containing Amino Acid for the Design of Artificial Photoenzymes
    Kai‐Yue Chen, Hui Ming, Hexiang Wang, Hua-Qi Wang, Zheng Xiang · 2024 · Angewandte Chemie
76. SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity
    Garrett W. Cooper, Benjamin P. Lee, Won Jun Kim, Yongdong Su, Victor Z. Chen, Eliseo Salas, Xiaoping Yang, Robert E. Lintner, Federica Piccioni, Andrew O. Giacomelli et al. · 2026 · Nature Communications
77. Repurposing Visible‐Light‐Excited Ene‐Reductases for Diastereo‐ and Enantioselective Lactones Synthesis
    Jinhai Yu, Qiaoyu Zhang, Beibei Zhao, Tianhang Wang, Yu Zheng, Binju Wang, Yan Zhang, Xiaoqiang Huang · 2024 · Angewandte Chemie
78. Single‐Electron Oxidation Triggered by Visible‐Light‐Excited Enzymes for Asymmetric Biocatalysis
    Jinhai Yu, Bin Chen, Xiaoqiang Huang · 2024 · Angewandte Chemie
79. Semirational Protein Engineering of a Decarboxylative Aldolase for the Regiodivergent and Stereodivergent Synthesis of Cyclic Imino Acids
    Yuqiu Lan, Chenghua Zhang, Chunping Tang, Ye Yang, Rui Zhang, Xiang Sheng, Cangsong Liao · 2025 · Angewandte Chemie
80. Kinetic resolution of amino acids by phosphine oxide catalyzed enantioselective esterification
    Ji‐Wei Ren, Jing-Hui Sun, Ke-Hang Li, Mu-Ran Lin, Jin-Lan Zeng, Xiao-Mei Ai · 2026 · Nature Communications
81. Direct nitrile electrosynthesis from amino acids on nickel oxyhydroxide
    Xudong Liu, Zhe Chen, Tao Jiang, Wei Du, Can Lei, Xueting Cao, Shuangshuang Cha, Mengxin Qu, Xinchi Zhou, Ming Gong · 2025 · Green Chemistry
82. Photoinduced Ene‐Reductase Catalysis via Electron Donor–Acceptor Complexes
    Shuang Liu, Runmiao Yang, Jian Feng Xu · 2025 · ChemBioChem
83. Expanding the understanding of DDX3X-related neurodevelopmental disorder in males
    Silvia De Rubeis · 2025 · European Journal of Human Genetics
84. Single-molecule fluorescence microscopy reveals regulatory mechanisms of MYO7A-driven cargo transport in stereocilia of live inner ear hair cells
    Miyoshi, Takushi, Vishwasrao, Harshad D., Belyantseva, Inna A., Miyoshi, Junko, Sajeevadathan, Mrudhula, Ishibashi, Yasuko, Adadey, Samuel M., Harada, Narinobu, Shroff, Hari, Friedman, Thomas B. · 2025 · Nature Communications
85. Threonine aldolase-catalyzed stereoselective radical α-alkylation of amino acids
    Tim Ke, Yang Yang · 2025 · Methods in enzymology on CD-ROM/Methods in enzymology
86. Aromatic compound production by Corynebacterium glutamicum: unified strategies at the core and diversity by extension
    Nora Junker, Sara-Sophie Poethe, Volker F. Wendisch · 2025 · Current Opinion in Biotechnology
87. Directed Evolution of a Nonheme Iron Enzyme to Access Chiral α‐Amino Acid Derivatives by 1,3‐Migratory Nitrene C(sp 3 )─H Insertion
    Minghui Cheng, Tao Li, Yamei Gan, Wentao Zhang, Chen Xu, Qun Zhao · 2025 · Angewandte Chemie
88. Construction of dual-cofactor artificial metalloenzymes for synergistic and enantiodivergent catalysis of Michael addition reactions
    Weijin Wang, Xinjian Ji, Pol Gorrea-Acín, Kelvin Lau, Florence Pojer, Thomas R. Ward, Xile Hu · 2025 · Nature Synthesis
89. Photoenzymatic Aliphatic C─Br Activation for Enantioselective Synthesis of γ‐Stereogenic Nitriles from Alkenes
    Yiwei Liu, Zhiping Yin, Marion B. Ansorge‐Schumacher, Changzhu Wu · 2025 · Angewandte Chemie
90. Site-saturation functional screens identify PALB2 missense variants associated with increased breast cancer risk
    Rick A.C.M. Boonen, Sabine Knaup, Roberta Menafra, Merel E. Braspenning, Magdalena B. Rother, Petra Kleiblová, Markéta Janatová, Dina Ruano, Chunling Hu, Huaizhi Huang et al. · 2026 · Nature Communications
91. Functional signatures of de novo GABBR1 and GABBR2 variants associated with neurodevelopmental disorders
    Michał Stawarski, Noa Bielopolski, Ilana Roitman, Karen Fridman, Shane Wald-Altman, Megan M. Eitel, Benedict Hui, Anneke Vulto‐van Silfhout, Alexander P.A. Stegmann, Adela Chiriță-Emandi et al. · 2026 · npj Genomic Medicine
92. Structural and Mechanistic Insights into Fgm3-Catalyzed Cβ−Cγ Bond Cleavage of an Amino Acid
    Huiru Zhang, Mingyu Xia, Xia Mu, Pengfei Fang, Zhijun Tang, Wen Liu · 2026 · ACS Catalysis
93. Low-penetrance TP53 variants are mainly hypomorphic: an underestimated issue with high clinical significance
    Léa Rodriguez, Bernard Leroy, Franck Toledo, Julianne S. Funk, Thorsten Stiewe, Panagiotis Baliakas, François Delhommeau, Thierry Soussi · 2026 · npj Genomic Medicine
94. Revisiting LSDMCA: male lethality escape and genotype-phenotype correlations
    Alfonso Manuel D’Alessio, Alessia Indrieri, Giuseppina Vitiello, Manuela Morleo, Susan L. Schelley, Gregory M. Enns, Chiara Passarelli, Roberta Tammaro, Valeria Tiranti, Camille Peron et al. · 2026 · European Journal of Human Genetics
95. Engineering Enantiocomplementary Protoglobins for Stereoconvergent Construction of N -Alkylated α-Aminoketones
    Ziyang Qin, Zi‐Qi Li, Chi Zhang, Jan L Heise, Runze Mao, Sophia J. Wu, Kendall N. Houk, William A. Goddard III, Frances H. Arnold · 2026 · Journal of the American Chemical Society
96. Promiscuity‐Guided Enzyme Evolution via Substrate Multiplexed Screening
    Holly A Weilbaker, Meghan E. Campbell, Peyton M. Higgins, Andrew R. Buller · 2026 · Angewandte Chemie International Edition
97. Decoding variants of uncertain significance in systemic autoinflammatory diseases
    Guilaine Boursier, Alessandra Carbone, Sinisa Savic, Thomas Henry · 2026 · Nature Reviews Rheumatology
98. Radical hydroazidation of alkene enabled by synergistic photobiocatalysis combining ene-reductase with an organophotocatalyst
    Jinhai Yu, Yingdi Hao, Yingzhi Ren, Beibei Zhao, Ge Ma, Zihao Guo, Yan Zhang, Xiaoqiang Huang · 2026 · CHINESE JOURNAL OF CATALYSIS (CHINESE VERSION)
99. Implications of monogenic bicuspid aortic valve (BAV) forms among sporadic BAV patients
    Christopher M H Bruenger, Frank Oeffner, Laura L. Koebbe, Sebastian Zimmer, Verena Veulemans, Matti Adam, Jessica Bigge, Stefanie Heilmann‐Heimbach, Malte Kelm, Stephan E. Baldus et al. · 2025 · European Journal of Human Genetics
100. Combined biosynthesis and site-specific incorporation of phenylalanine derivatives from aryl aldehydes or carboxylic acids in engineered bacteria
     Shelby R. Anderson, Abigail P. Spangler, Michaela A. Jones, Roman M. Dickey, Aditya M. Kunjapur · 2024 · bioRxiv (Cold Spring Harbor Laboratory)