The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
APOBEC3 deaminase editing in mpox virus as evidence for sustained human transmission since at least 2016
Open accessAbstract
Historically, mpox has been characterized as an endemic zoonotic disease that transmits through contact with the reservoir rodent host in West and Central Africa. However, in May 2022, human cases of mpox were detected spreading internationally beyond countries with known endemic reservoirs. When the first cases from 2022 were sequenced, they shared 42 nucleotide differences from the closest mpox virus (MPXV) previously sampled. Nearly all these mutations are characteristic of the action of APOBEC3 deaminases, host enzymes with antiviral function. Assuming APOBEC3 editing is characteristic of human MPXV infection, we developed a dual-process phylogenetic molecular clock that—inferring a rate of ~6 APOBEC3 mutations per year—estimates that MPXV has been circulating in humans since 2016. These observations of sustained MPXV transmission present a fundamental shift to the perceived paradigm of MPXV epidemiology as a zoonosis and highlight the need for revising public health messaging around MPXV as well as outbreak management and control.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kimura, M. (1980) · Journal of Molecular Evolution · doi:10.1007/bf01731581 · Cited by 29,778
Minimap2: Pairwise alignment for nucleotide sequences
Li, H. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty191 · Cited by 14,807
Dating of the human–ape splitting by a molecular clock of mitochondrial DNA.
Hasegawa, M., Kishino, H., & Yano, T.-A. (1985) · Journal of Molecular Evolution · doi:10.1007/bf02101694 · Cited by 8,687
Statistical Rethinking: A Bayesian Course with Examples in R and Stan
McElreath, R. (2020) · doi:10.1201/9780429029608 · Cited by 1,959
Cited by
Sustained human outbreak of a new MPXV clade I lineage in eastern Democratic Republic of the Congo
Vakaniaki, E. H., Kacita, C., Kinganda-Lusamaki, E., O’Toole, Á., Wawina-Bokalanga, T., Mukadi-Bamuleka, D., Amuri-Aziza, A., Malyamungu-Bubala, N., Mweshi-Kumbana, F., Mutimbwa-Mambo, L., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03130-3 · Cited by 404
Self-citation(2024) · doi:10.7554/elife.100545 · Cited by 16
Metadata
- Authors
- O’Toole, Á., Neher, R. A., Ndodo, N., Borges, V., Gannon, B., Gomes, J. P., Groves, N., King, D. J., Maloney, D., Lemey, P., Lewandowski, K., Loman, N., Myers, R., Omah, I. F., Suchard, M. A., Worobey, M., Chand, M., Ihekweazu, C., Ulaeto, D., Adetifa, I., & Rambaut, A.
- Venue
- Science
- Published
- 2023-11-03
- Volume
- 382
- Issue
- 6670
- Pages
- 595-600
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4388215071
- Cited by
- 208
- References
- 4
- FWCI
- 24.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: APOBEC3 deaminase editing in mpox virus as evidence for sustained human transmission since at least 2016. https://app.cochat.ai/papers/10.1126/science.adg8116
- The paper
- O’Toole, Á., Neher, R. A., Ndodo, N., Borges, V., Gannon, B., Gomes, J. P., Groves, N., King, D. J., Maloney, D., Lemey, P., Lewandowski, K., Loman, N., Myers, R., Omah, I. F., Suchard, M. A., Worobey, M., Chand, M., Ihekweazu, C., Ulaeto, D., . . . Rambaut, A. (2023). APOBEC3 deaminase editing in mpox virus as evidence for sustained human transmission since at least 2016. Science. https://doi.org/10.1126/science.adg8116
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
