Epigenomics of human CD8 T cell differentiation and aging
Moskowitz, David M., Zhang, David W., Hu, Bin, Le Saux, Sabine, Yanes, Rolando E., Ye, Zhongde, Buenrostro, Jason D., Weyand, Cornelia M. +2 more·2017·Science Immunology
Cited by (253)
Items 201–253 of 253
- The Genomic Loci of Specific Human tRNA Genes Exhibit Ageing-Related DNA HypermethylationRichard Acton, Wei Yuan, Fei Gao, Yudong Xia, Emma Bourne, Eva L. Woźniak, Jordana T. Bell, Karen A. Lillycrop, Jun Wang, Elaine Margaret Dennison et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Single cell analysis of blood mononuclear cells stimulated through CD3 and CD28 shows collateral activation of B and NK cells and demise of monocytesNathan T Lawlor, Djamel Nehar-Belaid, Jessica D. S. Grassmann, Marlon Stoeckius, Peter Smibert, Michael L. Stitzel, Virginia Pascual, Jacques Banchereau, Adam Williams, Duygu Ucar · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Mucosal vaccination for SARS-CoV-2 elicits superior systemic T central memory function and cross-neutralizing antibodies against variants of concernAled O’Neill, Monica Palanichamy Kala, Chee Wah Tan, Wilfried A. A. Saron, Chinmay Kumar Mantri, Abhay P. S. Rathore, Lin‐Fa Wang, Ashley L. St. John · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Distinct Heterogeneity in the Naive T cell Compartments of Children and AdultsClaire E. Gustafson, Zachary Thomson, Ziyuan He, Elliott G. Swanson, Katherine Henderson, Mark-Phillip Pebworth, Lauren Y. Okada, Alexander T. Heubeck, Charles R. Roll, Veronica Hernandez et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Comprehensive single cell aging atlas of mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancerBrittany Lynn Angarola, Siddhartha M. Sharma, Neerja Katiyar, Hyeon Gu Kang, Djamel Nehar-Belaid, Sung‐Hee Park, Rachel Gott, Giray Naim Eryilmaz, Mark A. LaBarge, Karolina Palucka et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Utilizing blood single-cell transcriptomics to integrate intrinsic and systemic immune agingAlan Tomusiak, Sierra Lore, Morten Scheibye‐Knudsen, Eric M. Verdin · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activationMatthew C. Pahl, Prabhat Kumar Sharma, Rajan M. Thomas, Zachary Thompson, Zachary Mount, James A. Pippin, Peter A. Morawski, Peng Sun, Chun Su, Daniel Campbell et al. · 2024 · eLife
- Ever-evolving insights into the cellular and molecular drivers of lymphoid cell developmentVu L. Tran, Myriam Luydmila Rachelle Haltalli, Jingjing Li, Dawn S. Y. Lin, Masayuki Yamashita, Shalin H. Naik, Ellen V. Rothenberg · 2024 · Experimental Hematology
- Mitochondrial Bioenergetic Profiling in T Cell Subsets Associates With Functional Health in Older Adults: A Cross-sectional Analysis From the INSPIRE-T CohortNabila Jabrane‐Ferrat, Jérémy Raffin, Jordi Gouilly, Souad Najib, Anne-Laure Iscache, Catherine Marques, Julien Hall, Nathan Jolivet, Guillaume Combes, Nathalie Viguerie et al. · 2025 · The Journals of Gerontology Series A
- Continuous β− particle exposure: A study of DNA damage in ex vivo peripheral blood mononuclear cells irradiation with RadioiodineLaura Mazzitelli-Fuentes, Lara Negrin, Virginia Venier, Hadar Romano, Lucia Pereira, Jerónimo Leberle, Maria Soledad Ausas, Ananya Choudhury, Luisa Vanesa Biolatti · 2025 · Clinical and Translational Radiation Oncology
- Correlation Between the Proportion of Senescence-Associated β-Galactosidase-Stained CD8+ T Cells and Age: A Cross-Sectional Study in JapanMasaya Tsubokawa, Yoshiki Shimizu, Misato Yazaki, Shieri Shimodan, Masayuki Noguchi, Arisa Yamazaki, Tomomichi Watanabe, Makoto Ocho, Tsuyoshi Sakurada, Yoshie Hirose et al. · 2025 · International Journal of Molecular Sciences
- Modulation of the immunological and neuroinflammatory microenvironment in older people with multiple sclerosisCelia Oreja‐Guevara, Sven Guenther Meuth, Nikos Grigoriadis, Patrick Vermersch, Hans Peter Hartung, Per Soelberg Sørensen, Letizia Leocani, Klaus Schmierer, Ralf Gold, O Fernandez · 2026 · Frontiers in Immunology
- Regulation of T Cell Senescence in Health and DiseasesSewon Mun, S Choi, Jae‐Joong Kim, Jihyun Kim, Yeonseok Chung · 2026 · Immune Network
- Distribution and function of human long-lasting T cells in aging and non-small cell lung cancerJia Xuan Tan, Hua Run Yu, Yong Gu, Hai Hong · 2026 · Frontiers in Immunology
- Aging microenvironment induces CD8+ T cell exhaustion by suppressing hepatic β-hydroxybutyrylate synthesisYifeng Xiao, Yanling Zhang, Zihao Zhao, Zijian Zhang, Xiaohui Zhang, Pengju Chen, Jin Gu, Haichuan Zhu, Peng Jiang, Jie Cheng · 2026 · Cell Metabolism
- Lymph node contraction links sex-biased naive CD8+ T cell decline to compromised antigen recognition during middle ageLutz Menzel, Maria Zschummel, Meghan J. O’Melia, Mårten Sandstedt, Hengbo Zhou, Pin-Ji Lei, Lingshan Liu, Hang Lee, Debattama R. Sen, Lance L. Munn et al. · 2026 · Nature Aging
- Immunological ChangesTamàs Fülöp, Anis Larbi, Abdelouahed Khalil, Katsuiku Hirokawa, Alan Arthur Cohen, Jacek Maciej Witkowski · 2022 · Lessons from the ICU
- EPIGENETIC ALTERATIONS IN GENE EXPRESSION IN THE AGING IMMUNE SYSTEMDimitrina Miteva, Tsvetelina Veselinova Velikova · 2023 · Anti-Aging Eastern Europe
- Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elementsMatthew C. Pahl, Prabhat Kumar Sharma, Rajan M. Thomas, Zachary Thompson, Zachary Mount, James A. Pippin, Peter A. Morawski, Chun Su, Daniel Campbell, Struan F.A. Grant et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activationMatthew C. Pahl, Prabhat Kumar Sharma, Rajan M. Thomas, Zachary Thompson, Zachary Mount, James A. Pippin, Peter A. Morawski, Peng Sun, Chun Su, Daniel Campbell et al. · 2024 · eLife
- Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activationMatthew C. Pahl, Prabhat Kumar Sharma, Rajan M. Thomas, Zachary Thompson, Zachary Mount, James A. Pippin, Peter A. Morawski, Peng Sun, Chun Su, Daniel Campbell et al. · 2024 · eLife
- IMMClock reveals immune aging and T cell function at single-cell resolutionYael Gurevich, Di Wu, Sanna Madan, Sanju Sinha, Sahil Sahni, Vishaka Gopalan, Binbin Wang, Saugato Rahman Dhruba, Alejandro A. Schäffer, Nan‐ping Weng et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Basic-Leucine-Zipper Transcription Factors Regulate Selective Molecular Phenotypes in Regulatory T Cells During IL-2-Induced ActivationJoyce Ka Yu Tse, Xuan Liu, Ittai E. Eres, Tracy Yamawaki, Matt Kanke, Marisela Lua Killian, Junedh Amrute, Ashutosh Chaudhry, Anupama Sahoo, Wenjun Liu et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- The Immunosenescence of �? & ?� T cells in human blood and skinWeili Xu · 2019
- Identification of age and ethnicity specific gene expression biomarkers for immune agingYang Hu, Yudai Xu, Lipeng Mao, Lei Wen, Jian Xiang, Guodong Zhu, Yutian Hu, Haitao Niu, Feng Gao, Lijuan Gao et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Estudio celular de la inmunosenescencia en adultos mayores vacunados y en pacientes con cáncer de mamaRodríguez Rodríguez, Ivon Johanna · 2021
- AP-1 complex activation is a conserved signature of immune system aging and a potential regulator of inflammaging in human and miceEmin Onur Karakaslar, Muneer G. Hasham, Neerja Katiyar, Ahrim Youn, Siddhartha M. Sharma, Cheng‐Han Chung, Radu Marcheş, Ron Korstanje, Jacques Banchereau, Duygu Ucar · 2021 · Research Square
- Faculty Opinions recommendation of Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality.Michael McDermott, Marveh Rahmati · 2021 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Reduced polymerase pausing compensates for increased chromatin accessibility in the aging liverMihaela Bozukova, Dora Grbavac, Chrysa Nikopoulou, Peter Tessarz · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Faculty Opinions recommendation of Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells.Rémy Bosselut · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Epigenetic aging and its reversalCristina de la Parte, Diana Guallar · 2022 · Elsevier eBooks
- Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elementsAndrew D. Wells, Matthew C. Pahl, Prabhat Kumar Sharma, Rajan M. Thomas, Zachary Thompson, Zachary Mount, James A. Pippin, Peter A. Morawski, Daniel Campbell, Struan F.A. Grant et al. · 2023 · Research Square
- Single-Cell Transcriptional Survey of Murine Intestinal Graft-Versus-Host DiseaseFei Gao, Hengwei Wu, Xin Jin, Zhuoyue Shi, Limengmeng Wang, Shanshan Pei, He Huang, Yanmin Zhao · 2024 · SSRN Electronic Journal
- Reviewer #3 (Public Review): Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation2024 · eLife
- Reviewer #1 (Public Review): Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation2024 · eLife
- Author response: Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activationMatthew C. Pahl, Prabhat Kumar Sharma, Rajan M. Thomas, Zachary Thompson, Zachary Mount, James A. Pippin, Peter A. Morawski, Peng Sun, Chun Su, Daniel Campbell et al. · 2024 · eLife
- Reviewer #2 (Public Review): Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation2024 · eLife
- eLife Assessment: Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activationNicholas E. Banovich · 2024 · eLife
- Adaptive immune responses against common viruses are sustained and functional in end-of-life patientsAnna Olofsson, Marion Humbert, Rokeya Sultana Rekha, Maria Helde Frankling, Fridtjof Lund‐Johansen, Peter Bergman, Linda Björkhem‐Bergman, Annika C. Karlsson · 2025 · iScience
- Inmunosenescencia y autoinmunidad: mecanismos e implicaciones patológicasAdriana Simoneta Pimienta Ibarra, Juan Criado-Villamizar, Marco Niebles-Navas, Gabriel Rojas-Castro, Diana M. Monsalve, Yeny Acosta‐Ampudia, Carolina Ramı́rez-Santana · 2024 · Medicina
- Advances in dietary bioactives: Unlocking chromatin accessibilityWenqi Huang, Shiye Lin, Yi Yuan, Mohamed Ali Farag, Hui Wang, Jianbo Xiao · 2025 · Phytochemistry Reviews
- Development of αβ and γδ T Cells in the Thymus and Methods of AnalysisБулыгин Алексей Сергеевич, Elena Golikova, Sergey Vitalievich Sennikov · 2025 · International Journal of Molecular Sciences
- Targeting BATF: A new strategy for cancer immunotherapyLinyang Li, Xuwen Lin, Qun Wang, Sanhong Liu · 2026 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Efficacité et évolution de la réponse lymphocytaire T CD8 au cours de l'infection par VIH-1Eoghann White · 2022 · theses.fr (ABES)
- Etude de l'accessibilité chromatinienne des néoplasies lymphoïdes T matures : amélioration de la précision diagnostique et classification par cellule d'origineEdith Julia · 2023
- miRNA delivery via nanowires restores functional responses in aged T cellsZhonghao Dai, Shaylyn Grier, Zhe Zhong, Ameya Dravid, Joscelyn C. Mejías, Jean Louise Koff, Andrés J. Garcı́a, Ankur K. Singh · 2026 · Cell Biomaterials
- Nuclear morphology and chromatin compaction modulate T cell cytoskeletal remodeling and immune synapse formationIvan Rey‐Suarez, Aashli Pathni, F. Fazekas, Matthew Connell, Arpita Upadhyaya · 2026 · Molecular Biology of the Cell
- Molecular and epigenetic landscapes of immunosenescence in biological aging: A narrative reviewRahul Mittal, Danay Saavedra, Mannat Mittal, Camilo Jaramillo, Khemraj Hirani · 2026 · Aging advances.
- Senescence of the immune system in SLE: Pathogenic mechanisms and therapeutic implicationsXiaojing Jiang, Ziqian Liang, Chaoran Zhao, Fang Li, Qinyi Su, Yan Wang, Shengxiao Zhang, Ting Cheng · 2026 · Autoimmunity Reviews
- Male and female mice achieve equivalent protection against heterologous SARS-CoV-2 infection through divergent immune mechanismsDevin Kenney, 真央 松尾, Andrea Pantelias, Joseph Leger, Ava Kaplan, Faith Cerbo, D. W. Chen, Scott Adams, Giulia Unali, Douglas Wallace et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Coordinated transcriptional and epigenetic regulation of type 2 CD8+ T cells in asthmaMichaela Schedel, Sonia M. Leach, Laura D. Harmacek, Thomas Danhorn, Jia Yi, V Meyboom, Fangkun Ning, Katsuyuki Takeda, Sven Michel, Brian P. O’Connor et al. · 2026 · Frontiers in Immunology
- Immunosenescence in colorectal cancer: Interplay of microbiota, inflammaging, and metabolic reprogrammingDongjie Wu, Pengfei Zhang, Changchun Zeng · 2026 · Cytokine & Growth Factor Reviews
- Parameter for convolutional neural networks predicting log-transformed counts of ATAC-seq peaks from Calderon et al. 2019Alexander Sasse · 2024 · Zenodo (CERN European Organization for Nuclear Research)
