SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responses
Agerer, Benedikt, Koblischke, Maximilian, Gudipati, Venugopal, Montaño-Gutierrez, Luis Fernando, Smyth, Mark, Popa, Alexandra, Genger, Jakob-Wendelin, Endler, Lukas +35 more·2021·Science Immunology
Cited by (172)
Items 101–172 of 172
- Immune Evasion by the Highly Mutated SARS-CoV-2 Omicron VariantHylemariam Mihiretie Mengist, Arnaud John Kombe Kombe, Tengchuan Jin · 2022 · Infection and Drug Resistance
- HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2Ludmila N. Bubnova, Irina E. Pavlova, Maria Terentieva, Glazanova Tv, Elena Belyaeva, Sergei Sidorkevich, N. S. Bashketova, Irina Chkhingeria, Malvina A. Kozhemyakina, Азаров Даниил Валерьевич et al. · 2022 · International Journal of Environmental Research and Public Health
- A multifaceted approach for identification, validation, and immunogenicity of naturally processed and in silico-predicted highly conserved SARS-CoV-2 peptidesTamar Ratishvili, Huy Quang Quach, Iana H. Haralambieva, Yogesh R. Suryawanshi, Inna G. Ovsyannikova, Richard B. Kennedy, Gregory A. Poland · 2023 · Vaccine
- Lower T cell response against SARS-CoV-2 variants of concern after mRNA vaccine and risk of breakthrough infections in people with HIVJosé L. Casado, Pilar Vizcarra, Sara Martín-Colmenarejo, Judith del Pino, Sandra Gómez-Maldonado, Adrián Martín-Hondarza, Alejandro Vallejo · 2023 · AIDS
- Decoding long COVID-associated cardiovascular dysfunction: Mechanisms, models, and new approach methodologiesDilip Thomas, Phillip Chung-Ming Yang, Joseph C. Wu, Nazish Sayed · 2025 · Journal of Molecular and Cellular Cardiology
- T Cell Peptide Prediction, Immune Response, and Host–Pathogen Relationship in Vaccinated and Recovered from Mild COVID-19 SubjectsIole Macchia, Valentina La Sorsa, Alessandra Ciervo, Irene Ruspantini, Donatella R. M. Negri, Martina Borghi, Maria Laura De Angelis, Francesca Luciani, Antonio Martina, Silvia Taglieri et al. · 2024 · Biomolecules
- The molecular mechanisms of CD8+ T cell responses to SARS-CoV-2 infection mediated by TCR-pMHC interactionsShasha Deng, Zhihao Xu, Jing Hu, Yunru Yang, Fang Zhu, Zhuan Liu, Hongliang Zhang, Songquan Wu, Tengchuan Jin · 2024 · Frontiers in Immunology
- A high-throughput immunopeptidome platform for MHC II alleles to characterize antigen-specific CD4+ T cellsJing Chen, Xu Zhu, Jun Huo, Shang Wu, Ting Zhou, Chunyu Cheng, Hao Dong, Yan Li, Xianchi Dong, Yuxin Chen · 2025 · Biomedical Technology
- The protective immunity induced by SARS-CoV-2 infection and vaccination: a critical appraisalEduardo Tosta · 2021 · Exploration of Immunology
- COVID-19 Pandemic: Escape of Pathogenic Variants and MHC EvolutionPierre Pontarotti, Julien Paganini · 2022 · International Journal of Molecular Sciences
- Immunology and controlling of coronaviruses; the current enemy for humanity: A reviewSarah I. Othman, Mohamed A. Nayel, Maha Abdulla Alwaele, Haifa E. Alfassam, Gasem Mohammad Abu-Taweel, Naif Ghazi Altoom, Ahmed M. Almalki, Ahmed A. Allam, Asma M. Alturki, Rehan M. El-Shabasy · 2021 · International Journal of Biological Macromolecules
- Mutations of SARS-CoV-2 variants of concern escaping Spike-specific T cellsNina Le Bert, Anthony Tanoto Tan, Kamini Kunasegaran, Adeline Chia, Nicole Tan, Qi Chen, Shou Kit Hang, Martin Qui, Bianca Su-Wan Chan, Jenny Guek Hong Low et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Resistance potential of the HLA-A2-restricted immunodominant SARS-CoV-2-specific CD8+ T cell receptor repertoire to antigenic driftMichael J. Malone, Chao Ming Huang, Yong Zhang, Yijun Qi, Lea Williams, Laura F. Su, Jizhong Lou, Ning Jenny Jiang · 2025 · Nature Communications
- CoV2-TCR: A web server for screening TCR CDR3 from TCR immune repertoire of COVID-19 patients and their recognized SARS-CoV-2 epitopesXingxing Jian, Yu Long Zhang, Jingjing Zhao, Zhuoming Zhao, Manman Lu, Lu Xie · 2023 · Computational and Structural Biotechnology Journal
- Rise of the SARS-CoV-2 Variants: can proteomics be the silver bullet?Arup Acharjee, Joshua Stephen Kingsly, Madhura Kamat, Vishakha Kurlawala, Aparajita Chakraborty, Priyanka A. Vyas, Radhika A. Vaishnav, Sanjeeva Srivastava · 2022 · Espert Review of Proteomics
- Viral immunogenic footprints conferring T cell cross-protection to SARS-CoV-2 and its variantsEduardo Cheuiche Antonio, Mariana Rost Meireles, Marcelo Alves de Souza Bragatte, Gustavo Fioravanti Vieira · 2022 · Frontiers in Immunology
- Highly Networked SARS-CoV-2 Peptides Elicit T Cell Responses with Enhanced SpecificityGabriel Duette, Eunok Lee, Gabriela Martins Costa Gomes, Katie Tungatt, Chloe M. Doyle, Vicki V Stylianou, Ashley Lee, Susan Maddocks, Janette Taylor, Rajiv Khanna et al. · 2023 · ImmunoHorizons
- Differences in Presentation of SARS-CoV-2 Omicron Strain Variant BA.1–BA.5 Peptides by HLA MoleculesStepan A. Nersisyan, M. Yu. Shkurnikov, Anton Zhiyanov, Victor Novosad, Alexander Tonevitsky · 2022 · Doklady Biochemistry and Biophysics
- Immunogenic SARS-CoV2 Epitopes Defined by Mass SpectrometryKe Pan, Yulun Chiu, Eric L. Huang, Michelle M. Chen, Junmei Wang, Ivy P. Lai, Shailbala Singh, Rebecca Shaw, Michael J. MacCoss, Cassian Yee · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Features of Highly Homologous T-Cell Receptor Repertoire in the Immune Response to Mutations in Immunogenic EpitopesKsenia V. Zornikova, Dmitry Vladimirovich Dianov, N. O. Ivanova, Vassa D Davydova, Tatiana A. Nenasheva, Ekaterina I. Fefelova, Боголюбова Аполлинария Васильевна · 2024 · International Journal of Molecular Sciences
- Enhanced and long-lasting SARS-CoV-2 immune memory in individuals with common cold coronavirus cross-reactive T cell immunityDavid M. Florian, Michael W Bauer, Amelie Popovitsch, Ingrid Faé, David Niklas Springer, Marianne Graninger, Marianna Theresia Traugott, Lukas Weseslindtner, Stephan Walter Aberle, Gottfried Fischer et al. · 2025 · Frontiers in Immunology
- Comprehensive Analysis of the Immune Response to SARS-CoV-2 Epitopes: Unveiling Potential Targets for Vaccine DevelopmentHuixiong Deng, Yanlei Li, Gefei Wang, Rui Li · 2025 · Biology
- CHARM: COVID-19 Health Action Response for Marines–Association of antigen-specific interferon-gamma and IL2 responses with asymptomatic and symptomatic infections after a positive qPCR SARS-CoV-2 testMartha Sedegah, Chad K. Porter, Michael R. Hollingdale, Harini D. Ganeshan, Jun Huang, Carl W. Goforth, María Belmonte, Arnel D. Belmonte, Dawn L. Weir, Rhonda A. Lizewski et al. · 2022 · PLoS ONE
- Peptidome Surveillance Across Evolving SARS-CoV-2 Lineages Reveals HLA Binding Conservation in Nucleocapsid Among Variants With Most Potential for T-Cell Epitope Loss in SpikeKamil Wnuk, Jeremi Sudol, Patricia Spilman, Patrick Soon‐Shiong · 2022 · Frontiers in Immunology
- Unsuppressed HIV infection impairs T cell responses to SARS-CoV-2 infection and abrogates T cell cross-recognitionThandeka Nkosi, Caroline Chasara, Anele Mbatha, Mza Nsimbi, Andrea Olga Papadopoulos, Tiza L Nguni, Farina Karim, Mohomed Yunus S Moosa, Inbal Gazy, Kondwani Jambo et al. · 2022 · medRxiv
- SABRE: Self-Attention Based model for predicting T-cell Receptor Epitope SpecificityZicheng Wang, Yufeng Shen · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Methodological approach to identify immunogenic epitopes candidates for vaccines against emerging pathogens tailored to defined HLA populationsNicolás Lalinde-Ruiz, Laura Camila Martínez-Enriquez, Daniel Alzate Gutierrez, Holman Hernandez Nieto, Luís Fernando Niño, Carlos Parra-López · 2025 · Computational Biology and Chemistry
- The Impact of Vaccination Frequency on COVID-19 Public Health Outcomes: A Model-Based AnalysisLin Yuan, Madison Stoddard, Sharanya Sarkar, Debra Van Egeren, Shruthi Mangalaganesh, Ryan P. Nolan, Michael S. Rogers, Greg Hather, Laura Forsberg White, Arijit Chakravarty · 2025 · Vaccines
- Characterization of human CMV-specific CD8+ T cells using multi-layer single-cell omicsIoanna D. Gemünd, Lorenzo Bonaguro, Matthias Becker, Sophie Merit Müller, Clemens Joos, Elena De Domenico, Anna C. Aschenbrenner, Joachim Ludwig Schultze, Andreas Moosmann, Marc Beyer · 2025 · Cell Reports Methods
- In Silico Analysis of Post-COVID-19 Condition (PCC) Associated SNP rs9367106 Predicts the Molecular Basis of Abnormalities in the Lungs and Brain FunctionsAmit K. Maiti · 2025 · International Journal of Molecular Sciences
- Computational Design of Next‐Generation Universal Nanovaccine for COVID ‐19: A Self‐Assembling Coiled‐Coil Platform ApproachPuja Jaishwal, Satarudra Prakash Singh · 2026 · Peptide Science
- De novo design of anti-variant COVID-19 vaccineGoswami, Arpita, Kumar, Madan, Ullah, Samee, Gore, Milind M · 2023 · Biology Methods and Protocols
- In-silico evaluation of the T-cell based immune response against SARS-CoV-2 omicron variantsShivangi Sharma, Diya Roy, Sarah Cherian · 2024 · Scientific Reports
- Extensive cross-reactive T cell epitopes across SARS-CoV-2 Omicron variant spikes with finite immune evasion mutationsMengze Gan, Jinge Cao, Qi Ouyang, Xinyue Xu, Xingxing Wang, Peihang Dan, Yinlong Yao, Hui Fu, Xuanyu Yao, Xiaosong Lin et al. · 2025 · Journal of Translational Medicine
- Characterization of CD8 T Cell-Mediated Mutations in the Immunodominant Epitope GP33-41 of Lymphocytic Choriomeningitis VirusMark Smyth, Kseniya Khamina, Alexandra Popa, Venugopal Gudipati, Benedikt Agerer, Alexander Lercher, Lindsay Kosack, Lukas Endler, Hatoon Baazim, Csilla Viczenczová et al. · 2021 · Frontiers in Immunology
- Beyond Spike: Identification of nine highly prevalent SARS-CoV-2-specific CD8 T-cell epitopes in a large Norwegian cohortSaskia Meyer, Isaac Blaas, Ravi Chand Bollineni, Marina Delić-Šarac, Trung The Tran, Cathrine F. Knetter, Ke‐Zheng Dai, Torfinn Støve Madssen, John Torgils Vaage, Alice Gustavsen et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Impact of mutations in immunodominant regions of SARS-CoV-2 variants on recognition by CD8+ T cell: An in silico analysisGreice Carolina Santos da Silva, Victoria Cruz Paraná, Filipe Ferreira de Almeida Rego, Manuel Portela, Mariana Barros Queiroz, Raimundo Coutinho, Carlos Gustavo Régis da Silva, Luana Leandro Gois, Maria Fernanda Rios Grassi · 2025 · Journal of Infection and Public Health
- C > U mutations generate immunogenic peptides in SARS-CoV-2Gergő Mihály Balogh, Balázs Koncz, Leó Asztalos, Eszter EA Ari, Nikolett Gémes, Gábor J. Szebeni, Benjamin Tamás Papp, Flóra Tóth, Balázs Papp, Csaba Pál et al. · 2025 · Nature Communications
- Preferential boosting of SARS-CoV-2 Omicron lineage-specific immune responses by monovalent XBB.1.5 vaccinationDaryl Geers, Muriel Aguilar-Bretones, Luca M. Zaeck, Paul A. Gill, Cristina Gonzalez‐Lopez, Kim Handrejk, Ngoc H. Tan, Yvette den Hartog, Lennert Gommers, Susanne Bogers et al. · 2026 · Journal of Infection
- Preclinical evaluation of DENV1 mRNA vaccines in mice: Toward improved neutralizing antibody and T cell responsesChirayus Khawsang, Eakachai Prompetchara, Supichcha Saithong, Kittipan Tharakhet, Papatsara Kaewpang, Nongnaphat Yostrerat, Pachara Wangsoontorn, Patrawadee Pitakpolrat, Supranee Buranapraditkun, Chunya Puttikhunt et al. · 2026 · Biomedicine & Pharmacotherapy
- SARS-CoV-2 Infection and Vaccination, Immune Dysregulation, and CancerDace Pjanova, Aysha Rafeeque · 2026 · Vaccines
- HLA class I escape drives the evolution of SARS-CoV-2 in human populationsEkaterina D. Riumina, Evgeniia I. Alekseeva, Galya V. Klink, Stepan E Feigin, Iaroslava Vinogradova, Natalia Ivanova, Dmitry Dianov, Ksenia V. Zornikova, Vassa D Davydova, Боголюбова Аполлинария Васильевна et al. · 2026 · Proceedings of the National Academy of Sciences
- Adoptive T-cell therapies to overcome T cell-dependent immune dysregulations in COVID-19Sevgi Kalkanlı Taş, Merve Saide Uzunoğlu, Aylin Seher Uzunoğlu, Duygu Kırkık, Derya Altunkanat, Nevin Kalkanli · 2022 · TURKISH JOURNAL OF BIOLOGY
- Preclinical Development of a Novel Epitope-based DNA Vaccine Candidate against SARS-CoV-2 and Evaluation of Immunogenicity in BALB/c MiceKanwal Khalid, Hui Xuan Lim, Ayaz Anwar, Soon Hao Tan, Jung Shan Hwang, Seng‐Kai Ong, Chit Laa Poh · 2024 · AAPS PharmSciTech
- A nonadjuvanted HLA-restricted peptide vaccine induced both T and B cell immunity against SARS-CoV-2 spike proteinYi-Ru Lee, Chiung-Wen Liou, I‐Hua Liu, Jia-Ming Chang · 2024 · Scientific Reports
- Omicron Variant Could Be an Antigenic Shift of SARS-CoV-2Anju Kaushal · 2025 · COVID
- Adenosine-related small molecules show utility of recall antigen assay to screen compounds for off-target effects on memory T cellsEden Kleiman, Gloria Sierra, Binchen Mao, Dennie Magcase, Marybeth George, Pirouz M. Daftarian · 2021 · Scientific Reports
- SARS-CoV-2 vaccination in androgen sensitive phenotypes – A study on associated factors for SARS-CoV-2 vaccination and its adverse effects among androgenetic alopecia and benign prostate hyperplasia patientsZhihua Fan, Shixin Duan, Fangfen Liu, Wei Shi, Ziye Yang, Ruiyang Bai, Tao Li, Jingxian Chen, Hongfu Xie, Ji Li et al. · 2022 · Frontiers in Immunology
- In Silico Defined SARS-CoV2 Epitopes May Not Predict Immunogenicity to COVID19Ke Pan, Yulun Chiu, Michelle M. Chen, Junmei Wang, Ivy P. Lai, Shailbala Singh, Rebecca Shaw, Cassian Yee · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Adoptive T-cell therapies to overcome T cell-dependent immune dysregulations in COVID-19Sevgi Kalkanlı Taş, Merve Saide Uzunoğlu, Aylin Seher Uzunoğlu, Duygu Kırkık, Derya Altunkanat, Nevin Kalkanli · 2021 · TURKISH JOURNAL OF BIOLOGY
- Clonal diversity determines persistence of SARS-CoV-2 epitope-specific T cell responseKsenia V. Zornikova, Alexandra A. Khmelevskaya, Savely A. Sheetikov, Dmitry Olegovych Kiryukhin, Olga V. Shcherbakova, Aleksei Titov, Ivan V. Zvyagin, Grigory Aleksandrovich Efimov · 2022 · medRxiv
- T cell immunity of the nonadjuvanted HLA-restricted peptide COVID-19 vaccineYi-Ru Lee, Chiung-Wen Liou, I‐Hua Liu, Jia-Ming Chang · 2023 · Research Square
- The Omicron Strain of the SARS-CoV-2 Coronavirus and Its VariantsS. G. Sсherbak, D. A. Vologzhanin, A. Golota, A. Sarana, S. Makarenko · 2023 · Journal of Clinical Practice
- Understanding SARS-CoV-2 spike glycoprotein clusters and their impact on immunity of the population from Rio Grande do Norte, BrazilDiego Gomes Teixeira, João Firmino Rodrigues-Neto, Dayse Caroline Severiano da Cunha, Selma M. B. Jerônimo · 2024 · Infection Genetics and Evolution
- Evolution of SARS-COV-2Manuela Sironi, Fernando Gónzález‐Candelas · 2024 · Elsevier eBooks
- Virus-specific T cell response in SARS-CoV-2 infection and vaccinationsAntonio Bertoletti, Martin Qui, Joey Ming Er Lim · 2025 · Elsevier eBooks
- Introducing immunology: Types of immunity, immune responses, deficiencies, and disordersZainab N. Rahman, Faheem Shehjar, Reetika Mahajan · 2025 · Elsevier eBooks
- Severe Acute Respiratory Syndrome Coronavirus 2 Immunology and Coronavirus Disease 2019 Clinical OutcomesAljawharah Alrubayyi, Hsinyen Huang, Gaurav D. Gaiha · 2025 · Infectious Disease Clinics of North America
- Population-level toggling of T cell immune escape at human leukocyte antigen anchor residues in SARS-CoV-2 Spike proteins, in an ethnically diverse population regionN. Ngandu, B. Fielding, P. van Heusden, Kuhle Mcinga, Kriheska Francis, G. Harkins · 2025 · PLoS Comput. Biol.
- Effects of aging and inflammation on antigen-specific CD8+ T-cell responses that protect against severe disease following SARS-CoV-2 infectionTakuto Nogimori, Takuya Yamamoto · 2025 · Uirusu
- TinyHLAnet : A Light‐Weight 3D Structure‐Aware Architecture for Rapid and Explainable Identification of CD8 + T‐Cell AntigensNaren Chandran Sakthivel, Sumanta Mukherjee, Nagasuma R Chandra · 2025 · HLA
- Preferential boosting of SARS-CoV-2 Omicron lineage-specific immune responses by monovalent XBB.1.5 vaccinationDaryl Geers, Muriel Aguilar-Bretones, Luca M. Zaeck, Paul A. Gill, Cristina Gonzalez‐Lopez, Kim Handrejk, Ngoc H. Tan, Yvette den Hartog, Lennert Gommers, Susanne Bogers et al. · 2025 · medRxiv
- Impaired and restored CD8+ T cell responses to a sequentially mutated spike epitope in Omicron variantsEun Joo Chung, Soyoung Park, Su‐Hwan Kim, Ju‐Yeon Choi, Hye-Sook Jeong, Jae‐Hoon Ko, Joon Young Song, Young Jae Lee · 2025 · Frontiers in Immunology
- HLA-C–derived peptide MH-1 as an early-stage intervention against SARS-CoV-2 infectionTing-Yan Jian, S. T. Huang, Chia-Yu Chang, Chih-Heng Huang, Lik Voon Kiew, Yu-Ling Lin, Y. -H. Liu, Yen-Chin Liu, Yen-Chen Chen, Yi-Xuan Huang et al. · 2026 · Molecular Medicine
- Structural Design of T-Cell Epitope-Based mRNA Vaccine Constructs Determines the Quality of T-Cell Immunity and Protective Efficacy Against SARS-CoV-2 in MiceVladimir A. Gushchin, Andrei E. Siniavin, Andrei A. Pochtovyi, Alina Sh. Dzharullaeva, Д. Н. Щербинин, Anastasiya S. Ungur, Тухватулин Амир Ильдарович, Inna V. Shuliakova, Denis A. Kleymenov, Elena P. Mazunina et al. · 2026 · Vaccines
- T cell decision-making decodes the dynamic antigenic landscapeInbal Eizenberg-Magar, Lior Dayan, Benny Chain, Yaron E. Antebi · 2026 · Frontiers in Immunology
- Host-pathogen interplay of Orientia tsutsugamushi: pathomolecular epidemiology and phylo-immuno profiling in naturally infected rodents and shrewsAkash Balasaheb Mote, Himani Dhanze, Asok Kumar Mariappan, Prasad Thomas, Princee Verma, Vibha Singh, Rahul Singh, Ishita Gupta, Murthy Suman Kumar, Rajeev Singh et al. · 2026 · Microbial Pathogenesis
- Antigenic Variation and Immune Recognition Inference From the COVID‐19 Pandemic: An In Silico Comparative Analysis of Spike T Cell Epitopes From the SARS‐CoV‐2 Variants of ConcernKatherine Li, Sandstrom Pv, Hezhao Ji · 2026 · Influenza and Other Respiratory Viruses
- Functional Pairing of TCR-peptide-MHC Interactomes by Single-cell Clonal ExpansionLiu Daisy Liu, Seung Won Shin, Kevin M. Joslin, Chunyu Wang, James Pai, Rong Ma, Xinyu Xiang, Iain C. Clark, K. Christopher García · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Understanding HLA risk in immune-mediated inflammatory diseases requires antigen discoveryHesham ElAbd, Aya K.H. Mahdy, André Franke · 2026 · Trends in Immunology
- Smallpox vaccine elicits CD8 + T cell immunity persisting over four decades with cross-recognition of monkeypox virusYujuan Du, zongmian yang, Yinying Xiao, Huajun Duan, Hong Kong, Chanchan Xiao, Jun Su · 2026 · Aging Research
- Host Genetic Determinants of SARS-CoV-2 Susceptibility in Transplant Recipients and Donor Candidates: A Multicohort Analysis of HLA VariationMakbule Nihan Somuncu, Mahmut Selman Yıldırım, Ayşe Gül Zamanı, Zahide Aleyna Yılık, Sümeyye Sultan Var · 2026 · Biomedicines