SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responses
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SARS-CoV-2 mutations in MHC-I epitopes identified by deep viral sequencing evade CTL responses through decreased peptide-MHC-I binding.
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A study that followed a sequencing-based approach identified mutations in CD8+ T cell epitopes after sequencing 747 SARS-CoV-2 isolates and showed that tetramer-sorted CD8+ T cell clones responded to mutant peptides in a transcriptionally different manner.
“A study that followed a sequencing-based approach identified mutations in CD8+ T cell epitopes after sequencing 747 SARS-CoV-2 isolates and showed that tetramer-sorted CD8+ T cell clones responded to mutant peptides in a transcriptionally different manner (70).”
From SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients (2021) · cites this paper as [70]
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- Authors
- Agerer, B., Koblischke, M., Gudipati, V., Montaño-Gutierrez, L. F., Smyth, M., Popa, A., Genger, J.-W., Endler, L., Florian, D. M., Mühlgrabner, V., Graninger, M., Aberle, S. W., Husa, A.-M., Shaw, L. E., Lercher, A., Gattinger, P., Torralba-Gombau, R., Trapin, D., Penz, T., Barreca, D., Fae, I., Wenda, S., Traugott, M., Walder, G., Pickl, W. F., Thiel, V., Allerberger, F., Stockinger, H., Puchhammer-Stöckl, E., Weninger, W., Fischer, G., Hoepler, W., Pawelka, E., Zoufaly, A., Valenta, R., Bock, C., Paster, W., Geyeregger, R., Farlik, M., Halbritter, F., Huppa, J. B., Aberle, J. H., & Bergthaler, A.
- Affiliations
- Austrian Academy of Sciences (AT)
- Medical University of Vienna (AT)
- St. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria.
- St. Anna Children's Cancer Research Institute (AT)
- Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
- Department of Medicine 4, Clinic Favoriten, Vienna, Austria.
- Innsbruck Medical University (AT)
- Karl Landsteiner University of Health Sciences (AT)
- University of Bern (CH)
- Austrian Agency for Health and Food Safety (AT)
- Center for Virology, Medical University of Vienna, Vienna, Austria.
- Sechenov University (RU)
- Corresponding author
- Agerer, Benedikt
- Koblischke, Maximilian
- Gudipati, Venugopal
- Huppa, Johannes B.
- Aberle, Judith H.
- Bergthaler, Andreas
- ORCID
- Agerer, Benedikt
- Koblischke, Maximilian
- Gudipati, Venugopal
- Montaño-Gutierrez, Luis Fernando
- Smyth, Mark
- Popa, Alexandra
- Genger, Jakob-Wendelin
- Endler, Lukas
- Florian, David M.
- Mühlgrabner, Vanessa
- Graninger, Marianne
- Husa, Anna-Maria
- Shaw, Lisa Ellen
- Lercher, Alexander
- Gattinger, Pia
- Torralba-Gombau, Ricard
- Barreca, Daniele
- Fae, Ingrid
- Wenda, Sabine
- Traugott, Marianna
- Walder, Gernot
- Pickl, Winfried F.
- Thiel, Volker
- Allerberger, Franz
- Stockinger, Hannes
- Weninger, Wolfgang
- Fischer, Gottfried
- Hoepler, Wolfgang
- Pawelka, Erich
- Zoufaly, Alexander
- Valenta, Rudolf
- Bock, Christoph
- Paster, Wolfgang
- Geyeregger, René
- Farlik, Matthias
- Halbritter, Florian
- Huppa, Johannes B.
- Aberle, Judith H.
- Bergthaler, Andreas
- Venue
- Science Immunology
- Published
- 2021-03-04
- Volume
- 6
- Issue
- 57
- ISSN
- 2470-9468 (ISSN-L)
- PMC
- PMC8224398
- OpenAlex
- W3134643257
- Cited by
- 172
- References
- 70
- Citations by year
- 2026: 14 · 2025: 24 · 2024: 16 · 2023: 32 · 2022: 52 · 2021: 34
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Science Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- H2020 European Research Council (677006, 679146)
- European Research Council (679146, 677006)
- Vienna Science and Technology Fund (COVID-19 Rapid Response Funding 2020, LS14-031, COVID-19 Rapid Response Funding 2020 COV20-009)
- Austrian Science Fund (DK W1212, WWTF COVID-19 R)
- Austrian Academy of Sciences (24813, 24158, 24955)
- Scientific Fund of the Mayor of the federal capital Vienna (COVID003, COVID006)
- Medical-Scientific Fund of the Mayor of Vienna
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- SARS-CoV-2, viral mutations, MHC class I epitopes, CD8+ T cells, cytotoxic T lymphocytes, peptide-MHC binding, immune evasion, epitope loss
- MeSH terms
- COVID-19, SARS-CoV-2, Humans, Immunity, Cellular, Interferon-gamma, Mutation, Peptides, HLA-A Antigens, CD8-Positive T-Lymphocytes, Epitopes, T-Lymphocyte, Cell Proliferation, High-Throughput Nucleotide Sequencing
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