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Cited by 610

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Open access
Bastard, Paul, Gervais, Adrian, Le Voyer, Tom, Rosain, Jérémie, Philippot, Quentin, Manry, Jérémy, Michailidis, Eleftherios, Hoffmann, Hans-Heinrich, Eto, Shohei, Garcia-Prat, Marina, Bizien, Lucy, Parra-Martínez, Alba, Yang, Rui, Haljasmägi, Liis, Migaud, Mélanie, Särekannu, Karita, Maslovskaja, Julia, de Prost, Nicolas, Tandjaoui-Lambiotte, Yacine, Luyt, Charles-Edouard, Amador-Borrero, Blanca, Gaudet, Alexandre, Poissy, Julien, Morel, Pascal, Richard, Pascale, Cognasse, Fabrice, Troya, Jesus, Trouillet-Assant, Sophie, Belot, Alexandre, Saker, Kahina, Garçon, Pierre, Rivière, Jacques G., Lagier, Jean-Christophe, Gentile, Stéphanie, Rosen, Lindsey B., Shaw, Elana, Morio, Tomohiro, Tanaka, Junko, Dalmau, David, Tharaux, Pierre-Louis, Sene, Damien, Stepanian, Alain, Megarbane, Bruno, Triantafyllia, Vasiliki, Fekkar, Arnaud, Heath, James R., Franco, José Luis, Anaya, Juan-Manuel, Solé-Violán, Jordi, Imberti, Luisa, Biondi, Andrea, Bonfanti, Paolo, Castagnoli, Riccardo, Delmonte, Ottavia M., Zhang, Yu, Snow, Andrew L., Holland, Steven M., Biggs, Catherine M., Moncada-Vélez, Marcela, Arias, Andrés Augusto, Lorenzo, Lazaro, Boucherit, Soraya, Coulibaly, Boubacar, Anglicheau, Dany, Planas, Anna M., Haerynck, Filomeen, Duvlis, Sotirija, Nussbaum, Robert L., Ozcelik, Tayfun, Keles, Sevgi, Bousfiha, Ahmed A., El Bakkouri, Jalila, Ramirez-Santana, Carolina, Paul, Stéphane, Pan-Hammarström, Qiang, Hammarström, Lennart, Dupont, Annabelle, Kurolap, Alina, Metz, Christine N., Aiuti, Alessandro, Casari, Giorgio, Lampasona, Vito, Ciceri, Fabio, Barreiros, Lucila A., Dominguez-Garrido, Elena, Vidigal, Mateus, Zatz, Mayana, van de Beek, Diederik, Sahanic, Sabina, Tancevski, Ivan, Stepanovskyy, Yurii, Boyarchuk, Oksana, Nukui, Yoko, Tsumura, Miyuki, Vidaur, Loreto, Tangye, Stuart G., Burrel, Sonia, Duffy, Darragh, Quintana-Murci, Lluis, Klocperk, Adam, Kann, Nelli Y., Shcherbina, Anna, Lau, Yu-Lung, Leung, Daniel, Coulongeat, Matthieu, Marlet, Julien, Koning, Rutger, Reyes, Luis Felipe, Chauvineau-Grenier, Angélique, Venet, Fabienne, Monneret, Guillaume, Nussenzweig, Michel C., Arrestier, Romain, Boudhabhay, Idris, Baris-Feldman, Hagit, Hagin, David, Wauters, Joost, Meyts, Isabelle, Dyer, Adam H., Kennelly, Sean P., Bourke, Nollaig M., Halwani, Rabih, Sharif-Askari, Narjes Saheb, Dorgham, Karim, Sallette, Jérome, Mehlal Sedkaoui, Souad, AlKhater, Suzan, Rigo-Bonnin, Raúl, Morandeira, Francisco, Roussel, Lucie, Vinh, Donald C., Ostrowski, Sisse Rye, Condino-Neto, Antonio, Prando, Carolina, Bondarenko, Anastasiia, Spaan, András N., Gilardin, Laurent, Fellay, Jacques, Lyonnet, Stanislas, Bilguvar, Kaya, Lifton, Richard P., Mane, Shrikant, HGID Lab, COVID Clinicians, COVID-STORM Clinicians, NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish CHGE, Danish Blood Donor Study, St. James’s Hospital SARS CoV2 Interest group, French COVID Cohort Study Group, Imagine COVID-Group, The Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank Investigators, COVID Human Genetic Effort, CONSTANCES cohort, 3C-Dijon Study, Cerba HealthCare, Etablissement du Sang study group, Anderson, Mark S., Boisson, Bertrand, Béziat, Vivien, Zhang, Shen-Ying, Andreakos, Evangelos, Hermine, Olivier, Pujol, Aurora, Peterson, Pärt, Mogensen, Trine H., Rowen, Lee, Mond, James, Debette, Stéphanie, de Lamballerie, Xavier, Duval, Xavier, Mentré, France, Zins, Marie, Soler-Palacin, Pere, Colobran, Roger, Gorochov, Guy, Solanich, Xavier, Susen, Sophie, Martinez-Picado, Javier, Raoult, Didier, Vasse, Marc, Gregersen, Peter K., Piemonti, Lorenzo, Rodríguez-Gallego, Carlos, Notarangelo, Luigi D., Su, Helen C., Kisand, Kai, Okada, Satoshi, Puel, Anne, Jouanguy, Emmanuelle, Rice, Charles M., Tiberghien, Pierre, Zhang, Qian, Cobat, Aurélie, Abel, Laurent, Casanova, Jean-Laurent·2021·Science Immunology
DOI 10.1126/sciimmunol.abl4340
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Abstract

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or IFN-ω (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or IFN-ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases.

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Authors
Bastard, P., Gervais, A., Le Voyer, T., Rosain, J., Philippot, Q., Manry, J., Michailidis, E., Hoffmann, H.-H., Eto, S., Garcia-Prat, M., Bizien, L., Parra-Martínez, A., Yang, R., Haljasmägi, L., Migaud, M., Särekannu, K., Maslovskaja, J., de Prost, N., Tandjaoui-Lambiotte, Y., Luyt, C.-E., Amador-Borrero, B., Gaudet, A., Poissy, J., Morel, P., Richard, P., Cognasse, F., Troya, J., Trouillet-Assant, S., Belot, A., Saker, K., Garçon, P., Rivière, J. G., Lagier, J.-C., Gentile, S., Rosen, L. B., Shaw, E., Morio, T., Tanaka, J., Dalmau, D., Tharaux, P.-L., Sene, D., Stepanian, A., Megarbane, B., Triantafyllia, V., Fekkar, A., Heath, J. R., Franco, J. L., Anaya, J.-M., Solé-Violán, J., Imberti, L., Biondi, A., Bonfanti, P., Castagnoli, R., Delmonte, O. M., Zhang, Y., Snow, A. L., Holland, S. M., Biggs, C. M., Moncada-Vélez, M., Arias, A. A., Lorenzo, L., Boucherit, S., Coulibaly, B., Anglicheau, D., Planas, A. M., Haerynck, F., Duvlis, S., Nussbaum, R. L., Ozcelik, T., Keles, S., Bousfiha, A. A., El Bakkouri, J., Ramirez-Santana, C., Paul, S., Pan-Hammarström, Q., Hammarström, L., Dupont, A., Kurolap, A., Metz, C. N., Aiuti, A., Casari, G., Lampasona, V., Ciceri, F., Barreiros, L. A., Dominguez-Garrido, E., Vidigal, M., Zatz, M., van de Beek, D., Sahanic, S., Tancevski, I., Stepanovskyy, Y., Boyarchuk, O., Nukui, Y., Tsumura, M., Vidaur, L., Tangye, S. G., Burrel, S., Duffy, D., Quintana-Murci, L., Klocperk, A., Kann, N. Y., Shcherbina, A., Lau, Y.-L., Leung, D., Coulongeat, M., Marlet, J., Koning, R., Reyes, L. F., Chauvineau-Grenier, A., Venet, F., Monneret, G., Nussenzweig, M. C., Arrestier, R., Boudhabhay, I., Baris-Feldman, H., Hagin, D., Wauters, J., Meyts, I., Dyer, A. H., Kennelly, S. P., Bourke, N. M., Halwani, R., Sharif-Askari, N. S., Dorgham, K., Sallette, J., Mehlal Sedkaoui, S., AlKhater, S., Rigo-Bonnin, R., Morandeira, F., Roussel, L., Vinh, D. C., Ostrowski, S. R., Condino-Neto, A., Prando, C., Bondarenko, A., Spaan, A. N., Gilardin, L., Fellay, J., Lyonnet, S., Bilguvar, K., Lifton, R. P., Mane, S., Lab, H., Clinicians, C., Clinicians, C.-S., NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish, C. H. G. E., Study, D. B. D., St. James’s Hospital SARS CoV2 Interest group, French COVID Cohort Study Group, Imagine COVID-Group, The Milieu Intérieur Consortium, Cohort, C.-C., Amsterdam UMC Covid-19 Biobank Investigators, Effort, C. H. G., cohort, C., Study, 3.-D., HealthCare, C., Etablissement du Sang study group, Anderson, M. S., Boisson, B., Béziat, V., Zhang, S.-Y., Andreakos, E., Hermine, O., Pujol, A., Peterson, P., Mogensen, T. H., Rowen, L., Mond, J., Debette, S., de Lamballerie, X., Duval, X., Mentré, F., Zins, M., Soler-Palacin, P., Colobran, R., Gorochov, G., Solanich, X., Susen, S., Martinez-Picado, J., Raoult, D., Vasse, M., Gregersen, P. K., Piemonti, L., Rodríguez-Gallego, C., Notarangelo, L. D., Su, H. C., Kisand, K., Okada, S., Puel, A., Jouanguy, E., Rice, C. M., Tiberghien, P., Zhang, Q., Cobat, A., Abel, L., & Casanova, J.-L.
Venue
Science Immunology
Publisher
American Association for the Advancement of Science (AAAS)
Published
2021-08-10
Volume
6
Issue
62
ISSN
2470-9468 (ISSN-L)
DOI
10.1126/sciimmunol.abl4340
OpenAlex
W3195130348
Cited by
610
References
11
FWCI
36.82
Type
journal article
Language
en
Open access
hybrid

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