Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19
Open accessPublished version of a preprint
Abstract
Pediatric Coronavirus Disease 2019 (pCOVID-19) is rarely severe; however, a minority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might develop multisystem inflammatory syndrome in children (MIS-C), with substantial morbidity. In this longitudinal multi-institutional study, we applied multi-omics (analysis of soluble biomarkers, proteomics, single-cell gene expression and immune repertoire analysis) to profile children with COVID-19 (n = 110) and MIS-C (n = 76), along with pediatric healthy controls (pHCs; n = 76). pCOVID-19 was characterized by robust type I interferon (IFN) responses, whereas prominent type II IFN-dependent and NF-κB-dependent signatures, matrisome activation and increased levels of circulating spike protein were detected in MIS-C, with no correlation with SARS-CoV-2 PCR status around the time of admission. Transient expansion of TRBV11-2 T cell clonotypes in MIS-C was associated with signatures of inflammation and T cell activation. The association of MIS-C with the combination of HLA A*02, B*35 and C*04 alleles suggests genetic susceptibility. MIS-C B cells showed higher mutation load than pCOVID-19 and pHC. These results identify distinct immunopathological signatures in pCOVID-19 and MIS-C that might help better define the pathophysiology of these disorders and guide therapy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SASP-typical cytokines, extracellular matrix-active proteases, and SASP-related pro-coagulant and complement-activating factors are strongly elevated in the serum of COVID-19 patients compared with healthy controls.
“were also strongly elevated in the serum of patients with COVID-19 compared to healthy controls28,52,67–70.”
From COVID-19 and cellular senescence (2023) · cites this paper as [69]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
Complex heatmaps reveal patterns and correlations in multidimensional genomic data
Gu, Z., Eils, R., & Schlesner, M. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw313 · Cited by 10,122 · see citing works
Factors associated with COVID-19-related death using OpenSAFELY
Williamson, E. J., Walker, A. J., Bhaskaran, K., Bacon, S., Bates, C., Morton, C. E., Curtis, H. J., Mehrkar, A., Evans, D., Inglesby, P., et al. (2020) · Nature · doi:10.1038/s41586-020-2521-4 · Cited by 6,674 · see citing works
voom: precision weights unlock linear model analysis tools for RNA-seq read counts
Law, C. W., Chen, Y., Shi, W., & Smyth, G. K. (2014) · Genome Biology · doi:10.1186/gb-2014-15-2-r29 · Cited by 6,155 · see citing works
McCarthy, D. J., Chen, Y., & Smyth, G. K. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks042 · Cited by 5,195 · see citing works
Simultaneous epitope and transcriptome measurement in single cells
Stoeckius, M., Hafemeister, C., Stephenson, W., Houck-Loomis, B., Chattopadhyay, P. K., Swerdlow, H., Satija, R., & Smibert, P. (2017) · Nature Methods · doi:10.1038/nmeth.4380 · Cited by 3,098 · see citing works
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
Hadjadj, J., Yatim, N., Barnabei, L., Corneau, A., Boussier, J., Smith, N., Péré, H., Charbit, B., Bondet, V., Chenevier-Gobeaux, C., et al. (2020) · Science · doi:10.1126/science.abc6027 · Cited by 2,984 · see citing works
Hyperinflammatory shock in children during COVID-19 pandemic
Riphagen, S. D., Gomez, X., González-Martínez, C., Wilkinson, N. M., & Theocharis, P. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31094-1 · Cited by 2,492 · see citing works
Verdoni, L., Mazza, A., Gervasoni, A., Martelli, L., Ruggeri, M., Ciuffreda, M., Bonanomi, E., & D’Antiga, L. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31103-x · Cited by 2,379 · see citing works
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Zhang, Q., Bastard, P., Liu, Z., Le Pen, J., Moncada-Velez, M., Chen, J., Ogishi, M., Sabli, I. K. D., Hodeib, S., Korol, C., et al. (2020) · Science · doi:10.1126/science.abd4570 · Cited by 2,229 · see citing works
Self-citationInferring Regulatory Networks from Expression Data Using Tree-Based Methods
Huynh-Thu, V. A., Irrthum, A., Wehenkel, L., & Geurts, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012776 · Cited by 2,131 · see citing works
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment
Schulte-Schrepping, J., Reusch, N., Paclik, D., Baßler, K., Schlickeiser, S., Zhang, B., Krämer, B., Krammer, T., Brumhard, S., Bonaguro, L., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.001 · Cited by 1,461 · see citing works
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
Querec, T. D., Akondy, R. S., Lee, E. K., Cao, W., Nakaya, H. I., Teuwen, D. E., Pirani, A. M., Gernert, K. M., Deng, J., Marzolf, B., et al. (2008) · Nature Immunology · doi:10.1038/ni.1688 · Cited by 1,123 · see citing works
Castagnoli, R., Votto, M., Licari, A., Brambilla, I., Bruno, R., Perlini, S., Rovida, F., Baldanti, F., & Marseglia, G. L. (2020) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2020.1467 · Cited by 1,085 · see citing works
Self-citationThe extracellular matrix: tools and insights for the "omics" era
Naba, A., Clauser, K. R., Ding, H., Whittaker, C. A., Carr, S. A., & Hynes, R. O. (2016) · Matrix Biology · doi:10.1016/j.matbio.2015.06.003 · Cited by 1,037 · see citing works
Shekerdemian, L. S., Mahmood, N., Wolfe, K. K., Riggs, B. J., Ross, C. E., McKiernan, C. A., Heidemann, S. M., Kleinman, L. C., Sen, A. I., Hall, M. W., et al. (2020) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2020.1948 · Cited by 985 · see citing works
Expanding roles for CD4+ T cells in immunity to viruses
Swain, S. L., McKinstry, K. K., & Strutt, T. M. (2012) · Nature reviews. Immunology · doi:10.1038/nri3152 · Cited by 960 · see citing works
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19
Consiglio, C. R., Cotugno, N., Sardh, F., Pou, C., Amodio, D., Rodriguez, L., Tan, Z., Zicari, S., Ruggiero, A., Pascucci, G. R., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.016 · Cited by 919 · see citing works
SAMBLASTER : fast duplicate marking and structural variant read extraction
Faust, G. G., & Hall, I. M. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu314 · Cited by 880 · see citing works
Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data
Gupta, N. T., Heiden, J. A. V., Uduman, M., Gadala-Maria, D., Yaari, G., & Kleinstein, S. H. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv359 · Cited by 869 · see citing works
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19
Woodruff, M. C., Ramonell, R. P., Nguyen, D. C., Cashman, K. S., Saini, A. S., Haddad, N. S., Ley, A. M., Kyu, S., Howell, J. C., Ozturk, T., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-00814-z · Cited by 791 · see citing works
Bastard, P., Gervais, A., Voyer, T. L., Rosain, J., Philippot, Q., Manry, J., Michailidis, E., Hoffmann, H.-H., Eto, S., García-Prat, M., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abl4340 · Cited by 605 · see citing works
Self-citationGruber, C. N., Patel, R. S., Trachtman, R., Lepow, L., Amanat, F., Krammer, F., Wilson, K. M., Onel, K., Geanon, D., Tuballes, K., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.034 · Cited by 551 · see citing works
Burbelo, P. D., Riedo, F. X., Morishima, C., Rawlings, S. A., Smith, D. M., Das, S., Strich, J. R., Chertow, D. S., Davey, R. T., & Cohen, J. I. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa273 · Cited by 466 · see citing works
Self-citationSystematic identification of type I and type II interferon-induced antiviral factors
Liu, S.-Y., Sanchez, D. J., Aliyari, R., Sun, L., & Cheng, G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114981109 · Cited by 446 · see citing works
CCR4 and its ligands: from bench to bedside
Yoshie, O., & Matsushima, K. (2014) · International Immunology · doi:10.1093/intimm/dxu079 · Cited by 427 · see citing works
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19
Asano, T., Boisson, B., Onodi, F., Matuozzo, D., Moncada‐Vélez, M., Renkilaraj, M. R. L. M., Zhang, P., Meertens, L., Bolze, A., Materna, M., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abl4348 · Cited by 406 · see citing works
Self-citationGlucocorticoids in T cell apoptosis and function
Herold, M. J., McPherson, K., & Reichardt, H. M. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5390-y · Cited by 400 · see citing works
Assessment of Variability in the SOMAscan Assay
Candia, J., Cheung, F., Kotliarov, Y., Fantoni, G., Sellers, B. A., Griesman, T., Huang, J., Stuccio, S., Zingone, A., Ryan, B. M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-14755-5 · Cited by 399 · see citing works
Self-citationCheng, M. H., Zhang, S., Porritt, R. A., Rivas, M. N., Paschold, L., Willscher, E., Binder, M., Arditi, M., & Bahar, İ. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2010722117 · Cited by 390 · see citing works
Local and systemic responses to SARS-CoV-2 infection in children and adults
Yoshida, M., Worlock, K. B., Huang, N., Lindeboom, R. G. H., Butler, C. R., Kumasaka, N., Dominguez Conde, C., Mamanova, L., Bolt, L., Richardson, L., et al. (2022) · Nature · doi:10.1038/s41586-021-04345-x · Cited by 365 · see citing works
Self-citationTreatment of Multisystem Inflammatory Syndrome in Children
McArdle, A. J., Vito, O., Patel, H., Seaby, E. G., Shah, P., Wilson, C., Broderick, C. M., Nijman, R., Tremoulet, A. H., Munblit, D., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2102968 · Cited by 352 · see citing works
Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients
Pierce, C. A., Preston‐Hurlburt, P., Dai, Y., Aschner, C. B., Cheshenko, N., Galen, B. T., Garforth, S., Herrera, N. G., Jangra, R. K., Morano, N. C., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abd5487 · Cited by 351 · see citing works
Loske, J., Roehmel, J. F., Lukassen, S., Stricker, S., Magalhães, V. G., Liebig, J., Chua, R. L., Thürmann, L., Messingschlager, M., Seegebarth, A., et al. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-01037-9 · Cited by 351 · see citing works
An immune-based biomarker signature is associated with mortality in COVID-19 patients
Abers, M. S., Delmonte, O. M., Ricotta, E., Fintzi, J., Fink, D. L., de Jesus, A. A., Zarember, K. A., Alehashemi, S., Oikonomou, V., Desai, J. V., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.144455 · Cited by 335 · see citing works
Self-citationCross-reactive CD4 + T cells enhance SARS-CoV-2 immune responses upon infection and vaccination
Loyal, L., Braun, J., Henze, L., Kruse, B., Dingeldey, M., Reimer, U., Kern, F., Schwarz, T., Mangold, M., Unger, C., et al. (2021) · Science · doi:10.1126/science.abh1823 · Cited by 283 · see citing works
Ramaswamy, A., Brodsky, N. N., Sumida, T. S., Comi, M., Asashima, H., Hoehn, K. B., Li, N., Liu, Y., Shah, A. S., Ravindra, N. G., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.04.003 · Cited by 270 · see citing works
Self-citationRapp, M., Wintergerst, M. W. M., Kunz, W. G., Vetter, V. K., Knott, M. M. L., Lisowski, D., Haubner, S., Moder, S., Thaler, R., Eiber, S., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20170277 · Cited by 268 · see citing works
Type I IFN immunoprofiling in COVID-19 patients
Trouillet‐Assant, S., Viel, S., Gaymard, A., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.04.029 · Cited by 268 · see citing works
Yonker, L. M., Gilboa, T., Ogata, A. F., Senussi, Y., Lazarovits, R., Boribong, B. P., Bartsch, Y. C., Loiselle, M., Rivas, M. N., Porritt, R. A., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci149633 · Cited by 246 · see citing works
Snyder, T. M., Gittelman, R. M., Klinger, M., et al. (2020) · medRxiv · doi:10.1101/2020.07.31.20165647 · Cited by 234 · see citing works
Self-citationInterferon induction and function at the mucosal surface
Durbin, R. K., Kotenko, S. V., & Durbin, J. E. (2013) · Immunological Reviews · doi:10.1111/imr.12101 · Cited by 221 · see citing works
Vella, L. A., Giles, J. R., Baxter, A. E., Oldridge, D. A., Diorio, C. J., Kuri-Cervantes, L., Alanio, C., Pampena, M. B., Wu, J. E., Chen, Z., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abf7570 · Cited by 219 · see citing works
Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19
Liu, C., Martins, A. J., Lau, W. W., Rachmaninoff, N., Chen, J., Imberti, L., Mostaghimi, D., Fink, D. L., Burbelo, P. D., Dobbs, K., et al. (2021) · Cell · doi:10.1016/j.cell.2021.02.018 · Cited by 209 · see citing works
Self-citationNormalizing and denoising protein expression data from droplet-based single cell profiling
Mulè, M. P., Martins, A. J., & Tsang, J. S. (2022) · Nature Communications · doi:10.1038/s41467-022-29356-8 · Cited by 197 · see citing works
Self-citationDowell, A. C., Butler, M., Jinks, E., Tut, G., Lancaster, T., Sylla, P., Begum, J., Bruton, R. K., Pearce, H., Verma, K., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-01089-8 · Cited by 195 · see citing works
Development of a Validated Interferon Score Using NanoString Technology
Kim, H., de Jesus, A. A., Brooks, S. R., Liu, Y., Huang, Y., VanTries, R., Sanchez, G. A. M., Rotman, Y., Gadina, M., & Goldbach‐Mansky, R. T. (2018) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2017.0127 · Cited by 192 · see citing works
Self-citationGadala-Maria, D., Yaari, G., Uduman, M., & Kleinstein, S. H. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417683112 · Cited by 188 · see citing works
Porritt, R. A., Paschold, L., Rivas, M. N., Cheng, M. H., Yonker, L. M., Chandnani, H. K., Lopez, M., Simnica, D., Schultheiß, C., Santiskulvong, C., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci146614 · Cited by 186 · see citing works
Woods, C. W., McClain, M. T., Chen, M., Zaas, A. K., Nicholson, B. P., Varkey, J. B., Veldman, T., Kingsmore, S. F., Huang, Y., Lambkin‐Williams, R., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0052198 · Cited by 185 · see citing works
IL-33 in T Cell Differentiation, Function, and Immune Homeostasis
Peine, C., Marek, R. M., & Löhning, M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.03.007 · Cited by 180 · see citing works
Respiratory Syncytial Virus Disease Is Mediated by Age-Variable IL-33
Saravia, J., You, D., Shrestha, B., Jaligama, S., Siefker, D. T., Lee, G. I., Harding, J. N., Jones, T. L., Rovnaghi, C. R., Bagga, B., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005217 · Cited by 170 · see citing works
The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children
Porritt, R. A., Binek, A., Paschold, L., Rivas, M. N., McArdle, A., Yonker, L. M., Alter, G., Chandnani, H. K., Lopez, M., Fasano, A., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci151520 · Cited by 155 · see citing works
HLA*LA—HLA typing from linearly projected graph alignments
Dilthey, A., Mentzer, A. J., Carapito, R., Cutland, C., Cereb, N., Madhi, S. A., Rhie, A., Koren, S., Bahram, S., McVean, G., et al. (2019) · Bioinformatics · doi:10.1093/bioinformatics/btz235 · Cited by 151 · see citing works
Nolan, S., Vignali, M., Klinger, M., Dines, J. N., Kaplan, I. M., Svejnoha, E., Craft, T., Boland, K., Pesesky, M., Gittelman, R., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-51964/v1 · Cited by 151 · see citing works
Self-citationMoreews, M., Gouge, K. L., Khaldi-Plassart, S., Pescarmona, R., Mathieu, A., Malcus, C., Djebali, S., Bellomo, A., Dauwalder, O., Perret, M., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abh1516 · Cited by 149 · see citing works
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19Preprint
Consiglio, C. R., Cotugno, N., Sardh, F., et al. (2020) · medRxiv · doi:10.1101/2020.07.08.20148353 · Cited by 138 · see citing works
Regulation of Macrophage-Derived Chemokine (MDC/ CCL22) Production
Yamashita, U., & Kuroda, E. (2002) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v22.i2.10 · Cited by 137 · see citing works
Esteve‐Solé, A., Antón, J., Pino-Ramirez, R. M., Sánchez-Manubens, J., Fumadó, V., Fortuny, C., Ríos-Barnés, M., Sánchez-de-Toledo, J., Girona‐Alarcón, M., Mosquera, J. M., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144554 · Cited by 131 · see citing works
Spontaneous and glucocorticoid-induced apoptosis in human mature T lymphocytes
Brunetti, M., Martelli, N., Colasante, A., et al. (1995) · Blood · doi:10.1182/blood.v86.11.4199.bloodjournal86114199 · Cited by 125 · see citing works
Mitochondrial Glucocorticoid Receptors and Their Actions
Kokkinopoulou, I., & Moutsatsou, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116054 · Cited by 120 · see citing works
Mathew, N. R., Jayanthan, J. K., Smirnov, I. V., Robinson, J. L., Axelsson, H., Nakka, S. S., Emmanouilidi, A., Czarnewski, P., Yewdell, W. T., Schön, K., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109286 · Cited by 115 · see citing works
Prednisone increases apoptosis in in vitro activated human peripheral blood T lymphocytes
Lanza, L., SCUDELETTI, M., Puppo, F., Bosco, O., Peirano, L., Filaci, G., Fecarotta, E., Vidali, G., & Indiveri, F. (1996) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1996.tb08306.x · Cited by 109 · see citing works
Reyes, M., Filbin, M. R., Bhattacharyya, R. P., Sonny, A., Mehta, A., Billman, K., Kays, K. R., Pinilla-Vera, M., Benson, M. E., MGH COVID-19 Collection & Processing Team, et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe9599 · Cited by 108 · see citing works
Gruber, C. N., Patel, R. S., Trachman, R., et al. (2020) · medRxiv · doi:10.1101/2020.07.04.20142752 · Cited by 104 · see citing works
TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C
Hoste, L., Roels, L., Naesens, L., Bosteels, V., Vanhee, S., Dupont, S., Bosteels, C., Browaeys, R., Vandamme, N., Verstaen, K., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20211381 · Cited by 87 · see citing works
Environmental allergens trigger type 2 inflammation through ripoptosome activation
Brusilovsky, M., Rochman, M., Rochman, Y., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-01011-2 · Cited by 78 · see citing works
Abdel‐Haq, N., Asmar, B. I., Leon, M. D., McGrath, E. J., Arora, H. S., Cashen, K., Tilford, B., Eddine, A. C., Sethuraman, U., & Ang, J. Y. (2021) · European Journal of Pediatrics · doi:10.1007/s00431-021-03935-1 · Cited by 74 · see citing works
Regulation of CD4+ T‐cell contraction during pathogen challenge
McKinstry, K. K., Strutt, T. M., & Swain, S. L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00921.x · Cited by 70 · see citing works
Determination of Human Anticytokine Autoantibody Profiles Using a Particle-Based Approach
Ding, L., Mo, A., Jutivorakool, K., et al. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-011-9621-8 · Cited by 67 · see citing works
Zhang, Y., Liu, H., Wang, L., Yang, F., Hu, Y., Ren, X., Li, G., Yu, Y., Sun, S., Li, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067430 · Cited by 59 · see citing works
Self-citationEndothelial injury and repair in systemic vasculitis of the young
Clarke, L. A., Hong, Y., Eleftheriou, D., et al. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27418 · Cited by 58 · see citing works
Vella, L. A., Giles, J. R., Baxter, A. E., et al. (2020) · medRxiv · doi:10.1101/2020.09.25.20201863 · Cited by 57 · see citing works
Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells
Fong, J. J., Tsai, C., Saha, S., Nizet, V., Varki, A. P., & Bui, J. D. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1804108115 · Cited by 45 · see citing works
IFN-γ Directly Controls IL-33 Protein Level through a STAT1- and LMP2-dependent Mechanism
Kopach, P., Lockatell, V., Pickering, E. M., Haskell, R. E., Anderson, R. D., Hasday, J. D., Todd, N. W., Luzina, I. G., & Atamas, S. P. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.534396 · Cited by 41 · see citing works
Molecular adjuvant IL-33 enhances the potency of a DNA vaccine in a lethal challenge model
Villarreal, D. O., Svoronos, N., Wise, M. C., Shedlock, D. J., Morrow, M. P., Conejo-Garcia, J. R., & Weiner, D. B. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.03.086 · Cited by 31 · see citing works
Immunotherapy for MIS-C — IVIG, Glucocorticoids, and Biologics
DeBiasi, R. L. (2021) · New England Journal of Medicine · doi:10.1056/nejme2108276 · Cited by 29 · see citing works
Assessment of kinship detection using RNA-seq data
Blay, N., Casas, E., Galván‐Femenía, I., Graffelman, J., de Cid, R., & Vavouri, T. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz776 · Cited by 16 · see citing works
Serum Cytokines and FeNO in School-Aged Children with Mycoplasma pneumoniae Pneumonia
Jin, H., Zhan, L., Mei, S.-F., et al. (2020) · Medical Science Monitor · doi:10.12659/msm.923449 · Cited by 13 · see citing works
Increased serum levels of IL‐33 and soluble ST2 in neonates with human cytomegalovirus infection
Chen, Y., & Qian, J. (2018) · Journal of Medical Virology · doi:10.1002/jmv.25187 · Cited by 7 · see citing works
Autoantibodies Detected in MIS-C Patients due to Administration of Intravenous ImmunoglobulinPreprint
Burbelo, P. D., Castagnoli, R., Shimizu, C., et al. (2021) · medRxiv · doi:10.1101/2021.11.03.21265769 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [63]COVID-19 Treatment Guidelines Panel. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. National Institutes of Health. Available at https://www.covid19treatmentguidelines.nih.gov/. Accessed 28 June 2021. 34003615
Cited by
Sorted by citations
COVID-19 and cellular senescence
Schmitt, C. A., Tchkonia, T., Niedernhofer, L. J., Robbins, P. D., Kirkland, J. L., & Lee, S. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-022-00785-2 · Cited by 153 · see citing works
- Authors
- Sacco, K., Castagnoli, R., Vakkilainen, S., Liu, C., Delmonte, O. M., Oguz, C., Kaplan, I. M., Alehashemi, S., Burbelo, P. D., Bhuyan, F., de Jesus, A. A., Dobbs, K., Rosen, L. B., Cheng, A., Shaw, E., Vakkilainen, M. S., Pala, F., Lack, J., Zhang, Y., Fink, D. L., Oikonomou, V., Snow, A. L., Dalgard, C. L., Chen, J., Sellers, B. A., Montealegre Sanchez, G. A., Barron, K., Rey-Jurado, E., Vial, C., Poli, M. C., Licari, A., Montagna, D., Marseglia, G. L., Licciardi, F., Ramenghi, U., Discepolo, V., Lo Vecchio, A., Guarino, A., Eisenstein, E. M., Imberti, L., Sottini, A., Biondi, A., Mató, S., Gerstbacher, D., Truong, M., Stack, M. A., Magliocco, M., Bosticardo, M., Kawai, T., Danielson, J. J., Hulett, T., Askenazi, M., Hu, S., NIAID Immune Response to COVID Group, Barnett, J., Cheng, X., Kaladi, K., Kuram, V., Mackey, J., Bansal, N. M., Martins, A. J., Palterer, B., Matthews, H., Mudunuri, U., Nambiar, M., Oler, A. J., Rastegar, A., Samuel, S., Shyu, C., Waingankar, V., Weber, S., Xirasagar, S., Chile MIS-C Group, Espinosa, Y., Astudillo, C., Piñera, C., González, R., Pavia Pediatric COVID-19 Group, De Filippo, M., Votto, M., Montagna, L., Cohen, J. I., Su, H. C., Kuhns, D. B., Lionakis, M. S., Snyder, T. M., Holland, S. M., Goldbach-Mansky, R., Tsang, J. S., & Notarangelo, L. D.
- Affiliations
- National Institutes of Health (US)
- Adaptive Biotechnologies (United States) (US)
- Aalto University (FI)
- Frederick National Laboratory for Cancer Research (US)
- Uniformed Services University of the Health Sciences (US)
- Clínica Alemana (CL)
- University of Pavia (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- University of Naples Federico II (IT)
- Hadassah Medical Center (IL)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Legacy Emanuel Medical Center (US)
- Stanford Medicine (US)
- National Institute of Allergy and Infectious Diseases (US)
- Hospital Roberto del Rio (CL)
- Corresponding author
- Notarangelo, Luigi D.
- ORCID
- Sacco, Keith
- Castagnoli, Riccardo
- Vakkilainen, Svetlana
- Liu, Can
- Delmonte, Ottavia M.
- Oguz, Cihan
- Kaplan, Ian M.
- Alehashemi, Sara
- Burbelo, Peter D.
- Bhuyan, Farzana
- Dobbs, Kerry
- Rosen, Lindsey B.
- Cheng, Aristine
- Shaw, Elana
- Vakkilainen, Mikko S.
- Pala, Francesca
- Lack, Justin
- Zhang, Yu
- Fink, Danielle L.
- Oikonomou, Vasileios
- Snow, Andrew L.
- Dalgard, Clifton L.
- Chen, Jinguo
- Sellers, Brian A.
- Barron, Karyl
- Rey-Jurado, Emma
- Vial, Cecilia
- Poli, Maria Cecilia
- Licari, Amelia
- Montagna, Daniela
- Marseglia, Gian Luigi
- Licciardi, Francesco
- Ramenghi, Ugo
- Discepolo, Valentina
- Guarino, Alfredo
- Eisenstein, Eli M.
- Imberti, Luisa
- Sottini, Alessandra
- Biondi, Andrea
- Gerstbacher, Dana
- Stack, Michael A.
- Bosticardo, Marita
- Kawai, Tomoki
- Danielson, Jeffrey J.
- Hulett, Tyler
- Askenazi, Manor
- Hu, Shaohui
- Cheng, Xi
- Martins, Andrew J.
- Palterer, Boaz
- Oler, Andrew J.
- Rastegar, Andre
- Astudillo, Camila
- González, Ricardo
- Votto, Martina
- Cohen, Jeffrey I.
- Su, Helen C.
- Kuhns, Douglas B.
- Lionakis, Michail S.
- Snyder, Thomas M.
- Holland, Steven M.
- Tsang, John S.
- Notarangelo, Luigi D.
- Venue
- Nature Medicine
- Published
- 2022-02-17
- Volume
- 28
- Issue
- 5
- Pages
- 1050-1062
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC9119950
- OpenAlex
- W4213211303
- Cited by
- 247
- References
- 84
- Citations by year
- 2026: 17 · 2025: 35 · 2024: 56 · 2023: 78 · 2022: 60 · 2021: 1
- FWCI
- 54.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature Medicine (publishedVersion)
- medRxiv (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Aaltodoc (Aalto University) (submittedVersion, other-oa)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Funders
- U.S. Department of Defense
- U.S. Department of Health and Human Services (75N91019D00024)
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases (75N91019D00024)
- Università degli Studi di Napoli Federico II
- Suomen Lääketieteen Säätiö
- Università degli Studi di Pavia
- Orionin Tutkimussäätiö
- Regione Lombardia
- Agencia Nacional de Investigación y Desarrollo (1201240, 11181222)
- National Institutes of Health (75N91019D00024, COVID-19)
- Uniformed Services University of the Health Sciences
- National Cancer Institute (75N91019D00024)
- National Institute of Allergy and Infectious Diseases (AI001270, COVID-19, 75N91019D00024, ZIAAI001265, ZIAAI001270)
- National Institute of Dental and Craniofacial Research
- NHLBI Division of Intramural Research
- Topics
- Health Sciences › Medicine › Surgery › Kawasaki Disease and Coronary Complications
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- multisystem inflammatory syndrome in children, pediatric COVID-19, SARS-CoV-2, immunopathology, type I interferon response, interferon-gamma, NF-κB signaling, T cell activation, immune repertoire, proteomics, transcriptomics, single-cell gene expression
- MeSH terms
- COVID-19, SARS-CoV-2, Child, Humans, T-Lymphocytes, Systemic Inflammatory Response Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
