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Cited by 19Microtubule and mitosis dynamicsCellular Mechanics and InteractionsWnt/β-catenin signaling in development and cancer

FAM123A Binds to Microtubules and Inhibits the Guanine Nucleotide Exchange Factor ARHGEF2 to Decrease Actomyosin Contractility

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Siesser, Priscila F., Motolese, Marta, Walker, Matthew P., Goldfarb, Dennis, Gewain, Kelly, Yan, Feng, Kulikauskas, Rima M., Chien, Andy J. +2 more·2012·Science Signaling
DOI 10.1126/scisignal.2002871PMC PMC3733483
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Abstract

Unlike related proteins, FAM123A interacts with microtubule-associated proteins and alters microtubule dynamics.

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Crossref · 10.1126/scisignal.2002871

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  • The mechanism by which microtubules bind and regulate GEFH1, and consequently RhoA-mediated signaling, remains elusive.

    “The mechanism by which microtubules bind and regulate the activity of GEFH1, and consequently RhoA-mediated signaling, remains elusive.”

    From Structural basis of microtubule-mediated signal transduction (2026) · cites this paper as [23]

    The Discussion (page unavailable) says that the precise mechanism by which FAM123A inhibits GEF-H1 remains to be established and that more work is needed to understand how FAM123A’s effect on microtubule dynamics reaches the actomyosin network through GEF-H1. It also links GEF-H1 to RhoA signaling. It does not specifically say that the mechanism by which microtubules bind and regulate GEF-H1 remains elusive; its stated uncertainty concerns FAM123A. (LLM, conf=0.78)

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Cited by

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Authors
Siesser, P. F., Motolese, M., Walker, M. P., Goldfarb, D., Gewain, K., Yan, F., Kulikauskas, R. M., Chien, A. J., Wordeman, L., & Major, M. B.
Affiliations
  • University of North Carolina at Chapel Hill (US)
  • Howard Hughes Medical Institute (US)
  • University of Washington (US)
Corresponding author
  • Siesser, Priscila F.
  • Motolese, Marta
  • Major, Michael B.
ORCID
Venue
Science Signaling
Publisher
American Association for the Advancement of Science (AAAS)
Published
2012-09-04
Volume
5
Issue
240
Pages
ra64-ra64
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
DOI
10.1126/scisignal.2002871
PMC
PMC3733483
OpenAlex
W1971332116
Cited by
19
References
3
Citations by year
2025: 3 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1
FWCI
0.56
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • Howard Hughes Medical Institute
  • National Institutes of Health (1dp2od007149-01)
  • National Cancer Institute (P30CA016086)
  • National Institute of General Medical Sciences (R01GM069429, GM69429)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Keywords
WTX, microtubule dynamics, actomyosin contractility, ARHGEF2, RhoA, EB1, EB3, focal adhesions, cell migration, protein-protein interaction network, tumor suppressor
MeSH terms
Actomyosin, Chromatography, Affinity, Humans, Microtubule-Associated Proteins, Microtubules, Mass Spectrometry, Guanine Nucleotide Exchange Factors, Amino Acid Motifs, Focal Adhesions, Tumor Suppressor Proteins, Protein Interaction Mapping, Adaptor Proteins, Signal Transducing, Rho Guanine Nucleotide Exchange Factors

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