Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations
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Cancer-associated mutations in the catalytically inactive receptor HER3 enhance its ability to activate other members of the human epidermal growth factor receptor family.
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HER3 features very low catalytic activity but engages in oncogenic signaling by acting as a scaffold to enable receptor heterodimerization.
“HER3 features very low catalytic activity but engages in oncogenic signaling by acting as a scaffold to enable receptor heterodimerization.8−10”
From Advancing Targeted Protein Degradation via Multiomics Profiling and Artificial Intelligence (2023) · cites this paper as [10]
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Advancing Targeted Protein Degradation via Multiomics Profiling and Artificial Intelligence
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HER3 Alterations in Cancer and Potential Clinical Implications
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- Authors
- Littlefield, P., Liu, L., Mysore, V., Shan, Y., Shaw, D. E., & Jura, N.
- Affiliations
- University of California, San Francisco (US)
- D. E. Shaw Research (US)
- Corresponding author
- Jura, Natalia
- Venue
- Science Signaling
- Published
- 2014-12-02
- Volume
- 7
- Issue
- 354
- Pages
- ra114-ra114
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC4492339
- OpenAlex
- W2157884341
- Cited by
- 126
- References
- 69
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 6 · 2023: 12 · 2022: 12 · 2021: 15 · 2020: 13 · 2019: 14 · 2018: 13 · 2017: 10 · 2016: 9 · 2015: 6 · 2014: 2
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Update notices
- correction (2015-09-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Public Health Service (R01 RGM109176A)
- National Institute of General Medical Sciences (R01GM109176)
- Topics
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- HER3, EGFR, heterodimerization, allosteric activation, kinase domain crystal structure, cancer-associated mutations, dimer interface, HER2, receptor tyrosine kinase signaling
- MeSH terms
- Cloning, Molecular, Crystallization, Humans, Models, Molecular, Mutation, Signal Transduction, Mutagenesis, Site-Directed, Protein Structure, Tertiary, Dimerization, Receptor, ErbB-3, Molecular Dynamics Simulation, ErbB Receptors
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