The DOI matches its Crossref record; 324 of the 324 references it cites were found in a registry or an index.
Stress-activated cap’n’collar transcription factors in aging and human disease
Open accessAbstract
The oxidative stress response is an attractive target for treating human diseases and extending the healthy life span.
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“Progressive and irreversible oxidative damage accumulates with age and diminishes critical aspects of cell physiology [57,201,202].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [57]
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5 retracted
Malhotra, D., Thimmulappa, R. K., Navas‐Acién, A., Sandford, A. J., Elliott, M., Singh, A., Chen, L., Zhuang, X., Hogg, J. C., Paré, P. D., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200803-380oc · Cited by 358
RetractedNuclear Import and Export Signals in Control of Nrf2
Jain, A. K., Bloom, D. A., & Jaiswal, A. K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502083200 · Cited by 195
RetractedPhosphorylation of Tyrosine 568 Controls Nuclear Export of Nrf2
Jain, A. K., & Jaiswal, A. K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511198200 · Cited by 171
RetractedProthymosin-α Mediates Nuclear Import of the INrf2/Cul3·Rbx1 Complex to Degrade Nuclear Nrf2
Niture, S. K., & Jaiswal, A. K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808084200 · Cited by 66
RetractedPhosphorylation and Dephosphorylation of Tyrosine 141 Regulate Stability and Degradation of INrf2
Jain, A. K., Mahajan, S., & Jaiswal, A. K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709854200 · Cited by 49
RetractedStaging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Oxidative stress: oxidants and antioxidants
Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577
Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634
Research works printed but not linked: 1
- 10.1172/JCI200421146 · DOI
Cited by
Sorted by citations
Łoboda, A., Damulewicz, M., Pyza, E., Józkowicz, A., & Dulak, J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2223-0 · Cited by 2,709
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
Hayes, J. D., & Dinkova‐Kostova, A. T. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.002 · Cited by 2,210
Selective autophagy mediated by autophagic adapter proteins
Johansen, T., & Lamark, T. (2011) · Autophagy · doi:10.4161/auto.7.3.14487 · Cited by 1,788
The Biology of Proteostasis in Aging and Disease
Labbadia, J., & Morimoto, R. I. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-033955 · Cited by 1,472
The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
Lei, G., Zhang, Y., Koppula, P., Liu, X., Zhang, J., Lin, S. H., Ajani, J. A., Xiao, Q., Liao, Z., Wang, H., et al. (2020) · Cell Research · doi:10.1038/s41422-019-0263-3 · Cited by 1,318
Metadata
- Authors
- Sykiotis, G. P., & Bohmann, D.
- Affiliations
- Harvard University (US)
- University of Rochester Medicine (US)
- Corresponding author
- Sykiotis, Gerasimos P.
- Venue
- Science Signaling
- Published
- 2010-03-09
- Volume
- 3
- Issue
- 112
- Pages
- re3-re3
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC2991085
- OpenAlex
- W2163292409
- Cited by
- 776
- References
- 324
- Citations by year
- 2026: 26 · 2025: 20 · 2024: 37 · 2023: 45 · 2022: 58 · 2021: 58 · 2020: 45 · 2019: 61 · 2018: 65 · 2017: 68 · 2016: 49 · 2015: 47 · 2014: 53 · 2013: 57 · 2012: 39
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R03CA123591)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- Nrf2, NRF1, Nrf3, SKN-1, CncC, oxidative stress response, aging, age-related diseases, neurodegeneration, respiratory diseases, cancer, longevity
- MeSH terms
- Aging, Animals, Humans, Polymorphism, Genetic, Repressor Proteins, Transcription Factors, Oxidative Stress, Drosophila Proteins
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