Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population
Abstract
Dysfunctional genotype combinations of polymorphic adenosine 5′-triphosphate–binding cassette transporter gene ABCG2/BCRP , which encodes a high-capacity urate secretion transporter in human gut and kidney, are major causes of gout.
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ABCG2 expressed on the apical side of proximal tubular cells in human kidney plays a pivotal role in renal excretion of serum uric acid.
“Since ABCG2, expressed on the apical side of the proximal tubular cells in human kidney, plays a pivotal role in renal excretion of serum uric acid [68]”
Cites
Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line
Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V., & Deeley, R. G. (1992) · Science · doi:10.1126/science.1360704 · Cited by 3,037 · see citing works
Nejentsev, S., Walker, N., Riches, D., Egholm, M., & Todd, J. A. (2009) · Science · doi:10.1126/science.1167728 · Cited by 958 · see citing works
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Ishikawa, T., Takahashi, K., Ikeda, N., Kajimoto, Y., Hagiya, Y., Ogura, S.-I., Miyatake, S.-I., & Kuroiwa, T. (2011) · Pharmaceutics · doi:10.3390/pharmaceutics3030615 · Cited by 34 · see citing works
- Authors
- Matsuo, H., Takada, T., Ichida, K., Nakamura, T., Nakayama, A., Ikebuchi, Y., Ito, K., Kusanagi, Y., Chiba, T., Tadokoro, S., Takada, Y., Oikawa, Y., Inoue, H., Suzuki, K., Okada, R., Nishiyama, J., Domoto, H., Watanabe, S., Fujita, M., Morimoto, Y., Naito, M., Nishio, K., Hishida, A., Wakai, K., Asai, Y., Niwa, K., Kamakura, K., Nonoyama, S., Sakurai, Y., Hosoya, T., Kanai, Y., Suzuki, H., Hamajima, N., & Shinomiya, N.
- Affiliations
- National Defense Medical College (JP)
- University of Tokyo Hospital (JP)
- Jikei University School of Medicine (JP)
- RIKEN (JP)
- Japan Air Self-Defense Force (JP)
- National Defense Medical College Hospital (JP)
- Toho University (JP)
- Fujita Health University (JP)
- Nagoya University (JP)
- Japan Self-Defense Forces Hospital Yokosuka (JP)
- Self-Defense Forces Kure Hospital (JP)
- Seirei Social Welfare Community (JP)
- The University of Osaka (JP)
- Corresponding author
- Matsuo, Hirotaka
- ORCID
- Matsuo, Hirotaka
- Takada, Tappei
- Ichida, Kimiyoshi
- Nakamura, Takahiro
- Nakayama, Akiyoshi
- Ito, Kousei
- Chiba, Toshinori
- Tadokoro, Shin
- Takada, Yuzo
- Suzuki, Koji
- Okada, Rieko
- Nishiyama, Junichiro
- Domoto, Hideharu
- Watanabe, Satoru
- Fujita, Masanori
- Morimoto, Yuji
- Naito, Mariko
- Hishida, Asahi
- Wakai, Kenji
- Niwa, Kazuki
- Nonoyama, Shigeaki
- Sakurai, Yutaka
- Kanai, Yoshikatsu
- Hamajima, Nobuyuki
- Shinomiya, Nariyoshi
- Venue
- Science Translational Medicine
- Published
- 2009-11-04
- Volume
- 1
- Issue
- 5
- Pages
- 5ra11-5ra11
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2159295592
- Cited by
- 437
- References
- 2
- Citations by year
- 2026: 23 · 2025: 18 · 2024: 31 · 2023: 24 · 2022: 24 · 2021: 31 · 2020: 42 · 2019: 32 · 2018: 24 · 2017: 32 · 2016: 23 · 2015: 15 · 2014: 37 · 2013: 29 · 2012: 22
- FWCI
- 11.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- ABCG2, gout, hyperuricemia, urate transport, urate secretion, serum uric acid, genetic susceptibility, haplotypes, uric acid excretion, Japanese population
- MeSH terms
- ATP Binding Cassette Transporter, Subfamily G, Member 2, Amino Acid Sequence, Genetics, Population, Genotype, Gout, Humans, Japan, Molecular Sequence Data, Mutation, Neoplasm Proteins, ATP-Binding Cassette Transporters
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