The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Traversing the Valley of Death: A Guide to Assessing Prospects for Translational Success
Open accessAbstract
On the basis of our experience in drug and device development, we have identified six broad categories of issues that profoundly affect the probability for successful translation of basic scientific discoveries into effective therapies. Within each category, we propose a series of questions that form the beginnings of a self-guided global risk assessment tool. Although this preliminary tool will require validation and adjustment, we offer it to stimulate a discussion about more rigorous methods for selecting and conducting translational projects.
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“The decreasing efficiency of this approach has been attributed to the so-called”
From Cytokine Response Is Determined by Duration of Receptor and Signal Transducers and Activators of Transcription 3 (STAT3) Activation (2013) · cites this paper as [28]
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Citations
Cites
Translation of highly promising basic science research into clinical applications
Contopoulos-Ioannidis, D. G., Ntzani, E. E., & Ioannidis, J. P. A. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(03)00013-5 · Cited by 323
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- Califf R. M., Berglund L., Linking scientific discovery and better health for the nation: The maturation of clinical and translational research in the United States. Acad. Med., in press.
- 10.1172/JCI119470 · DOI
- 10.1056/NEJMsb055203 · DOI
- 10.1038/453840a · DOI · Paper page
- 10.1126/science.1160622 · DOI · Paper page
- 10.1016/j.amjmed.2003.09.006 · DOI
- 10.1097/ACM.0b013e31819a817f · DOI
- 10.1067/mhj.2001.119375 · DOI
- 10.1016/S0002-9343(03)00119-0 · DOI
- 10.1067/mhj.2001.119375 · DOI
- 10.1016/j.bcp.2007.12.005 · DOI
- 10.1161/CIRCULATIONAHA.108.824177 · DOI
- 10.1371/journal.pmed.0030136 · DOI
- 10.1186/1750-1172-3-33 · DOI
- 10.1001/jama.2009.940 · DOI
- S. A. Merrill R. C. Levin M. B. Myers A Patent System for the 21st Century (National Academies Press Washington DC 2004).
- 10.1001/jama.294.16.2075 · DOI
- 10.1038/sj.clpt.6100393 · DOI
- 10.1038/449174a · DOI
- 10.1177/0272989X05282640 · DOI
- M. R. Gold J. E. Siegel L. B. Russell M. C. Weinstein Eds. Cost-Effectiveness in Health and Medicine (Oxford Univ. Press New York 1996). · DOI · Paper page
- 10.1182/blood-2008-06-077891 · DOI
- 10.1161/CIRCULATIONAHA.109.881979 · DOI
- 10.1161/01.CIR.0000023218.39412.32 · DOI
- 10.1111/j.1747-0285.2007.00522.x · DOI
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Braun, D. A., Fribourg, M., & Sealfon, S. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.386573 · Cited by 168
“The decreasing efficiency of this approach has been attributed to the so-called “valley of death,” the difficulty of bringing target modulators into clinical trials (27, 28).”
Background
Metadata
- Authors
- Coller, B. S., & Califf, R. M.
- Affiliations
- Rockefeller University (US)
- Duke Medical Center (US)
- Venue
- Science Translational Medicine
- Published
- 2009-12-09
- Volume
- 1
- Issue
- 10
- Pages
- 10cm9-10cm9
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC2879158
- OpenAlex
- W2132798272
- Cited by
- 99
- References
- 1
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 4 · 2019: 5 · 2018: 8 · 2017: 5 · 2016: 6 · 2015: 11 · 2014: 10 · 2013: 9 · 2012: 3
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL019278)
- National Center for Research Resources (UL1RR024153, UL1RR024143)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health and Medical Research Impacts
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Science, Research, and Medicine
- Keywords
- translational research, risk assessment, drug development, medical device development
- MeSH terms
- National Institutes of Health (U.S.), Medical Laboratory Science, United States, Drug Design
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