Translational research: crossing the valley of death
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The decreasing efficiency of the target-based drug discovery approach has been attributed to the so-called valley of death, the difficulty of bringing target modulators into clinical trials.
“The decreasing efficiency of this approach has been attributed to the so-called”
From Cytokine Response Is Determined by Duration of Receptor and Signal Transducers and Activators of Transcription 3 (STAT3) Activation (2013) · cites this paper as [27]
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“The decreasing efficiency of this approach has been attributed to the so-called “valley of death,” the difficulty of bringing target modulators into clinical trials (27, 28).”
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- Authors
- Butler, D.
- Corresponding author
- Butler, Declan
- Venue
- Nature
- Published
- 2008-06
- Volume
- 453
- Issue
- 7197
- Pages
- 840-842
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2075432689
- Cited by
- 712
- References
- 0
- Citations by year
- 2026: 29 · 2025: 44 · 2024: 34 · 2023: 36 · 2022: 60 · 2021: 65 · 2020: 46 · 2019: 49 · 2018: 41 · 2017: 45 · 2016: 42 · 2015: 32 · 2014: 29 · 2013: 41 · 2012: 36
- Type
- other
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health and Medical Research Impacts
- Health Sciences › Medicine › Reproductive Medicine › Science, Research, and Medicine
- Social Sciences › Decision Sciences › Information Systems and Management › Interdisciplinary Research and Collaboration
- Keywords
- translational research, research-practice gap, National Institutes of Health, biomedical research, patient involvement, research funding
- MeSH terms
- Animals, Humans, Medicine, National Institutes of Health (U.S.), Research Personnel, Research Support as Topic, United States, Universities, Technology Transfer, Biomedical Research
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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