The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Cardiac AAV9-S100A1 Gene Therapy Rescues Post-Ischemic Heart Failure in a Preclinical Large Animal Model
Open accessAbstract
A protein that regulates cellular calcium, delivered percutaneously to the heart by gene therapy, improves cardiac function in pigs with heart failure and may also be effective in humans.
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“Successful cardiac transduction in large species requires surgical and catheter-based approaches that can preferentially target the heart”
From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Pleger, et al., 2011
In the citing paper
“Heart failure can be induced in swine by a variety of methods such as rapid pacing (Lacroix, et al., 2002) and myocardial infarction (Pleger, et al., 2011).”
From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Pleger, et al., 2011
In the citing paper
“Myocardial gene deliveries have been performed with the aid of AAVs with methods that deliver the vectors preferentially to the myocardium such as myocardial injections (H. Su, et al., 2008), direct intracoronary (Kaspar, et al., 2005), and selective retroinfusion coupled with coronary artery occlusion (Pleger, et al., 2011; Raake, et al., 2008).”
From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Pleger, et al., 2011
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Cites
Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association
Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J., Berry, J. D., Brown, T. M., Carnethon, M. R., Dai, S., de Simone, G., Ford, E. S., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182009701 · Cited by 6,149
Cardiac excitation–contraction coupling
Bers, D., & Despa, S. (2002) · Nature · doi:10.1038/415198a · Cited by 4,927
The epidemiology of heart failure: The Framingham Study
Ho, K. K. L., Pinsky, J. L., Kannel, W. B., & Levy, D. A. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90455-a · Cited by 2,246
Flather, M. D., Yusuf, S., Køber, L., Pfeffer, M. A., Hall, A. S., Murray, G. D., Torp-Pedersen, C. T., Ball, S. G., Pogue, J. M., Moyé, L. A., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02212-1 · Cited by 1,585
Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure.
Gwathmey, J. K., Copelas, L., MacKinnon, R., Schöen, F. J., Feldman, M. D., Grossman, W., & Morgan, J. P. (1987) · Circulation Research · doi:10.1161/01.res.61.1.70 · Cited by 924
Energy metabolism in heart failure
Ventura‐Clapier, R., Garnier, A., & Veksler, V. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.055095 · Cited by 514
Haghighi, K., Kolokathis, F., Pater, L., Lynch, R. A., Asahi, M., Gramolini, A. O., Fan, G.-C., Tsiapras, D., Hahn, H. S., Adamopoulos, S., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17892 · Cited by 478
Greenberg, B., Quiñones, M. A., Koilpillai, C. J., Limacher, M. C., Shindler, D. M., Benedict, C. R., & Shelton, B. J. (1995) · Circulation · doi:10.1161/01.cir.91.10.2573 · Cited by 473
McMurray, J. J. V. (2010) · New England Journal of Medicine · doi:10.1056/nejmcp0909392 · Cited by 464
Müller, O. J., Kaul, F., Weitzman, M. D., Pasqualini, R., Arap, W., Kleinschmidt, J. A., & Trepel, M. (2003) · Nature Biotechnology · doi:10.1038/nbt856 · Cited by 411
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Modulation of Cardiac Contractility by the Phopholamban/SERCA2a Regulatome
Kranias, E. G., & Hajjar, R. J. (2012) · Circulation Research · doi:10.1161/circresaha.111.259754 · Cited by 533
Small and large animal models in cardiac contraction research: advantages and disadvantages
Milani-Nejad, N., & Janssen, P. M. L. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.007 · Cited by 484
The AAV Vector Toolkit: Poised at the Clinical Crossroads
Asokan, A., Schaffer, D. V., & Samulski, R. J. (2012) · Molecular Therapy · doi:10.1038/mt.2011.287 · Cited by 480
Viral Vectors for Gene Therapy: Translational and Clinical Outlook
Kotterman, M. A., Chalberg, T. W., & Schaffer, D. V. (2015) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-104938 · Cited by 424
S100 Proteins As an Important Regulator of Macrophage Inflammation
Xia, C. Q., Braunstein, Z., Toomey, A. C., Zhong, J., & Rao, X. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01908 · Cited by 432
Metadata
- Authors
- Pleger, S. T., Shan, C., Ksienzyk, J., Bekeredjian, R., Boekstegers, P., Hinkel, R., Schinkel, S., Leuchs, B., Ludwig, J., Qiu, G., Weber, C., Raake, P., Koch, W. J., Katus, H. A., Müller, O. J., & Most, P.
- Affiliations
- Heidelberg University (DE)
- LMU Klinikum (DE)
- German Cancer Research Center (DE)
- Thomas Jefferson University (US)
- Corresponding author
- Müller, Oliver J.
- Most, Patrick
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2011-07-20
- Volume
- 3
- Issue
- 92
- Pages
- 92ra64-92ra64
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4095769
- OpenAlex
- W2110557028
- Cited by
- 234
- References
- 49
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 10 · 2023: 10 · 2022: 14 · 2021: 15 · 2020: 17 · 2019: 16 · 2018: 14 · 2017: 16 · 2016: 19 · 2015: 22 · 2014: 15 · 2013: 22 · 2012: 24
- FWCI
- 12.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01 HL 56205, R01HL061690, R01HL92130-02S1, R01HL056205, R01 HL92130, R01HL092130, P01HL075443)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- S100A1, AAV9 gene therapy, cardiac gene therapy, heart failure, myocardial infarction, coronary artery occlusion, sarcoplasmic reticulum calcium handling, cardiac contractility, left ventricular remodeling, energy homeostasis, domestic pigs
- MeSH terms
- Dependovirus, Animals, Calcium, Disease Models, Animal, Energy Metabolism, Heart Failure, Heart Function Tests, Homeostasis, Humans, Myocardial Infarction, Myocardium, S100 Proteins, Organ Specificity, Sarcoplasmic Reticulum, Genetic Therapy, Biomarkers, Myocardial Ischemia, Gene Transfer Techniques, Myocytes, Cardiac, Sus scrofa
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