Evaluating Preclinical Efficacy
Abstract
Recent disappointing results of clinical trials seeking type 1 diabetes (T1D) reversal suggest the need for a reevaluation of our translational efforts. This Commentary explores the need for standards in evaluating therapeutic efficacy in preclinical models of T1D.
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Therapeutic interventions have clearly benefited from studies in animal models of type 1 diabetes, particularly the NOD mouse.
“Finally, although controversial, therapeutic interventions have clearly benefited from studies in animal models of type 1 diabetes, particularly the NOD mouse.127”
From Type 1 diabetes (2014) · cites this paper as [127]
Cites
The NOD mouse model of type 1 diabetes: As good as it gets?
Atkinson, M. A., & Leiter, E. H. (1999) · Nature Medicine · doi:10.1038/9442 · Cited by 588 · see citing works
Self-citation
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Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60591-7 · Cited by 2,713 · see citing works
Self-citation
- Authors
- Atkinson, M. A.
- Affiliations
- University of Florida (US)
- Corresponding author
- Atkinson, Mark A.
- ORCID
- Atkinson, Mark A.
- Venue
- Science Translational Medicine
- Published
- 2011-08-17
- Volume
- 3
- Issue
- 96
- Pages
- 96cm22-96cm22
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W1977505683
- Cited by
- 39
- References
- 1
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 5 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- type 1 diabetes, translational research, preclinical animal models, clinical trial failure, diabetes reversal
- MeSH terms
- Animals, Clinical Trials as Topic, Diabetes Mellitus, Type 1, Disease Models, Animal, Drug Evaluation, Preclinical, Humans
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