The NOD mouse model of type 1 diabetes: As good as it gets?

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

Delovitch, T. L., & Singh, B. (1997) · Immunity · doi:10.1016/s1074-7613(00)80392-1 · Cited by 676 · see citing works

An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus

Rabinovitch, A. (1998) · Diabetes/Metabolism Reviews · doi:10.1002/(sici)1099-0895(199806)14:2 · Cited by 456 · see citing works

Impaired Yield, Phenotype, and Function of Monocyte-Derived Dendritic Cells in Humans at Risk for Insulin-Dependent Diabetes

Takahashi, K., Honeyman, M. C., & Harrison, L. C. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.5.2629 · Cited by 136 · see citing works

Kilham Rat Virus Triggers T-Cell–Dependent Autoimmune Diabetes in Multiple Strains of Rat

Ellerman, K. E., Richards, C. A., Guberski, D. L., Shek, W. R., & LIKE, A. A. (1996) · Diabetes · doi:10.2337/diab.45.5.557 · Cited by 89 · see citing works

Establishment of Two Substrains, Diabetes-Prone and Non-Diabetic, from Long-Evans Tokushima Lean(LETL) Rats.

Komeda, K., Noda, M., Terao, K., Kuzuya, N., Kanazawa, M., & Kanazawa, Y. (1998) · Endocrine Journal · doi:10.1507/endocrj.45.737 · Cited by 57 · see citing works

Noncalcemic Actions of Vitamin D Receptor Ligands

Nagpal, S., Na, S., & Rathnachalam, R. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0002 · Cited by 960 · see citing works

THE NOD MOUSE: A Model of Immune Dysregulation

Anderson, M. S., & Bluestone, J. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115643 · Cited by 1,113 · see citing works

Mouse Models of Diabetic Nephropathy

Brosius, F. C., Alpers, C. E., Böttinger, E. P., Breyer, M. D., Coffman, T. M., Gurley, S. B., Harris, R. C., Kakoki, M., Kretzler, M., Leiter, E. H., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009070721 · Cited by 898 · see citing works

Animal models of diabetes mellitus

Rees, A., & Alcolado, J. C. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01499.x · Cited by 735 · see citing works

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

Liang, S. C., Latchman, Y. E., Buhlmann, J. E., Tomczak, M. F., Horwitz, B. H., Freeman, G. J., & Sharpe, A. H. (2003) · European Journal of Immunology · doi:10.1002/eji.200324228 · Cited by 635 · see citing works

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

Delong, T., Wiles, T. A., Baker, R. L., Bradley, B., Barbour, G., Reisdorph, R. M., Armstrong, M., Powell, R. L., Reisdorph, N. A., Kumar, N., et al. (2016) · Science · doi:10.1126/science.aad2791 · Cited by 507 · see citing works

C-Peptide Is the Appropriate Outcome Measure for Type 1 Diabetes Clinical Trials to Preserve β-Cell Function

Palmer, J. P., Fleming, G. A., Greenbaum, C. J., Herold, K. C., Jansa, L. D., Kolb, H., Lachin, J. M., Polonsky, K. S., Pozzilli, P., Skyler, J. S., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.1.250 · Cited by 491 · see citing works

A 1α,25-Dihydroxyvitamin D3 Analog Enhances Regulatory T-Cells and Arrests Autoimmune Diabetes in NOD Mice

Gregori, S., Giarratana, N., Smiroldo, S., Uskoković, M. R., & Adorini, L. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1367 · Cited by 482 · see citing works

Mouse Models of Diabetic Nephropathy

Breyer, M. D., Böttinger, E. P., Brosius, F. C., Coffman, T. M., Harris, R. C., Heilig, C. W., & Sharma, K. (2004) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004080648 · Cited by 468 · see citing works

Tolerance and Autoimmunity

Kamradt, T., & Mitchison, N. A. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103013440907 · Cited by 462 · see citing works

European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes

Gale, E. A. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15786-3 · Cited by 534 · see citing works

The role of T-cells in the pathogenesis of Type 1 diabetes: From cause to cure

Roep, B. O. (2003) · Diabetologia · doi:10.1007/s00125-003-1089-5 · Cited by 427 · see citing works

Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study

Stene, L. C., & Joner, G. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.6.1128 · Cited by 425 · see citing works

Human T Regulatory Cell Therapy: Take a Billion or So and Call Me in the Morning

Riley, J. L., June, C. H., & Blazar, B. R. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.006 · Cited by 412 · see citing works

Genetics of type 1 diabetes mellitus

Pociot, F., & McDermott, M. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363875 · Cited by 356 · see citing works

Type 1 diabetes: recent developments

Devendra, D., Liu, E., & Eisenbarth, G. S. (2004) · BMJ · doi:10.1136/bmj.328.7442.750 · Cited by 352 · see citing works

Remodeling of networks of interstitial cells of Cajal in a murine model of diabetic gastroparesis.

Ördög, T., Takayama, I., Cheung, W. K., Ward, S. M., & Sanders, K. M. (2000) · Diabetes · doi:10.2337/diabetes.49.10.1731 · Cited by 335 · see citing works

The immunological functions of the vitamin D endocrine system.

Hayes, C. E., Nashold, F. E., Spach, K. M., & Pedersen, L. B. (2003) · PubMed · Cited by 331 · see citing works

Effect of maternal diabetes on the embryo, fetus, and children: Congenital anomalies, genetic and epigenetic changes and developmental outcomes

Ornoy, A., Reece, E. A., Pavlínková, G., Kappen, C., & Miller, R. K. (2015) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21090 · Cited by 317 · see citing works

Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development

Guay, C., Kruit, J. K., Rome, S., Menoud, V., Mulder, N. L., Jurdzinski, A., Mancarella, F., Sebastiani, G., Donda, A., González, B. J., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.011 · Cited by 280 · see citing works

Extreme genetic risk for type 1A diabetes

Aly, T. A., Ide, A., Jahromi, M. M., Barker, J. M., Fernando, M. S., Babu, S. R., Yu, L., Miao, D., Erlich, H. A., Fain, P. R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606349103 · Cited by 256 · see citing works

Network resilience

Liu, X., Li, D., Ma, M., Szymanski, B. K., Stanley, E., & Gao, J. (2022) · Physics Reports · doi:10.1016/j.physrep.2022.04.002 · Cited by 262 · see citing works

No Alterations in the Frequency of FOXP3+ Regulatory T-Cells in Type 1 Diabetes

Brusko, T. M., Wasserfall, C. H., MCGRAIL, K. M., Schatz, R., Viener, H. L., Schatz, D., Haller, M. J., Rockell, J., Gottlieb, P. A., Clare-Salzler, M. J., et al. (2007) · Diabetes · doi:10.2337/db06-1248 · Cited by 253 · see citing works

The use of animal models in the study of diabetes mellitus.

Chatzigeorgiou, A., Halapas, A., Kalafatakis, K., & Kamper, E. F. (2009) · PubMed · Cited by 252 · see citing works

Heme Oxygenase-1 Protects Interstitial Cells of Cajal From Oxidative Stress and Reverses Diabetic Gastroparesis

Choi, K. M., Gibbons, S. J., Nguyen, T. V., Stoltz, G. J., Lurken, M. S., Ordog, T., Szurszewski, J. H., & Farrugia, G. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.09.003 · Cited by 239 · see citing works

Dynamics of Pathogenic and Suppressor T Cells in Autoimmune Diabetes Development

Gregori, S., Giarratana, N., Smiroldo, S., & Adorini, L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.8.4040 · Cited by 236 · see citing works

Viral infections as potential triggers of type 1 diabetes

van der Werf, N., Kroese, F., Rozing, J., & Hillebrands, J. (2007) · Diabetes/Metabolism Research Reviews · doi:10.1002/dmrr.695 · Cited by 247 · see citing works

Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood

Trudeau, J. D., Kelly-Smith, C., Verchere, C. B., Elliott, J. F., Dutz, J. P., Finegood, D. T., Santamaría, P., & Tan, R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200316409 · Cited by 232 · see citing works

Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases

Adorini, L., Penna, G., Giarratana, N., & Uskoković, M. R. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10340 · Cited by 229 · see citing works

B Lymphocyte Depletion by CD20 Monoclonal Antibody Prevents Diabetes in Nonobese Diabetic Mice despite Isotype-Specific Differences in FcγR Effector Functions

Xiu, Y., Wong, C. P., Bouaziz, J., Hamaguchi, Y., Wang, Y., Pop, S. M., Tisch, R., & Tedder, T. F. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.2863 · Cited by 225 · see citing works

Cytokines and β-Cell Biology: from Concept to Clinical Translation

Donath, M. Y., Størling, J., Berchtold, L. A., Billestrup, N., & Mandrup-Poulsen, T. R. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0033 · Cited by 219 · see citing works

Rat Models of Type 1 Diabetes: Genetics, Environment, and Autoimmunity

Mordes, J. P., Bortell, R., Blankenhorn, E. P., Rossini, A. A., & Greiner, D. L. (2004) · ILAR Journal · doi:10.1093/ilar.45.3.278 · Cited by 218 · see citing works

Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes

Roep, B. O., Atkinson, M. A., & von Herrath, M. (2004) · Nature reviews. Immunology · doi:10.1038/nri1502 · Cited by 211 · see citing works

Modelling diabetic nephropathy in mice

Azushima, K., Gurley, S. B., & Coffman, T. M. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.142 · Cited by 208 · see citing works

A Defect in Tryptophan Catabolism Impairs Tolerance in Nonobese Diabetic Mice

Grohmann, U., Fallarino, F., Bianchi, R., Orabona, C., Vacca, C., Fioretti, M. C., & Puccetti, P. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030633 · Cited by 209 · see citing works

Towards a medically approved technology for alginate-based microcapsules allowing long-term immunoisolated transplantation

Zimmermann, H., Zimmermann, D., REUSS, R., Feilen, P. J., Manz, B., Katsen‐Globa, A., Weber, M., Ihmig, F. R., Ehrhart, F., Geßner, P., et al. (2005) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-005-0523-2 · Cited by 204 · see citing works

Autoimmune islet destruction in spontaneous type 1 diabetes is not β-cell exclusive

Winer, S., Tsui, H., Lau, A. K., Song, A., Li, X., Cheung, R. K., Sampson, A., Afifiyan, F. N., Elford, A. R., Jackowski, G., et al. (2003) · Nature Medicine · doi:10.1038/nm818 · Cited by 200 · see citing works

Redirection of Human Autoreactive T-Cells Upon Interaction With Dendritic Cells Modulated by TX527, an Analog of 1,25 Dihydroxyvitamin D3

van Halteren, A. G. S., van Etten, E., de Jong, E. C., Bouillon, R., Roep, B. O., & Mathieu, C. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2119 · Cited by 196 · see citing works

Intervention in autoimmunity: The potential of vitamin D receptor agonists

Adorini, L. (2005) · Cellular Immunology · doi:10.1016/j.cellimm.2005.04.013 · Cited by 195 · see citing works

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes

Xiao, X., Guo, P., Shiota, C., Zhang, T., Coudriet, G. M., Fischbach, S., Prasadan, K. L., Fusco, J. C., Ramachandran, S., Witkowski, P., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2017.11.020 · Cited by 197 · see citing works

Immunomodulatory molecules of Fasciola hepatica: Candidates for both vaccine and immunotherapeutic development

Dalton, J. P., Robinson, M. W., Mulcahy, G. M., O’Neill, S. M., & Donnelly, S. (2013) · Veterinary Parasitology · doi:10.1016/j.vetpar.2013.04.008 · Cited by 194 · see citing works

The bile acid sensor FXR regulates insulin transcription and secretion

Renga, B., Mencarelli, A., Vavassori, P., Brancaleone, V., & Fiorucci, S. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.01.002 · Cited by 189 · see citing works

A Vitamin D Analog Down-Regulates Proinflammatory Chemokine Production by Pancreatic Islets Inhibiting T Cell Recruitment and Type 1 Diabetes Development

Giarratana, N., Penna, G., Amuchastegui, S., Mariani, R., Daniel, K. C., & Adorini, L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2280 · Cited by 174 · see citing works

Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse

Shi, F., Flodström‐Tullberg, M., Balasa, B., Kim, S. H., Gunst, K. V., Strominger, J. L., Wilson, S. B., & Sarvetnick, N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121169698 · Cited by 176 · see citing works

Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era

Akil, A. A., Yassin, E., Al-Maraghi, A., ALIYEV, E. E., Al-Malki, K., & Fakhro, K. A. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02778-6 · Cited by 184 · see citing works

The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis

Dedrick, S., Sundaresh, B., Huang, Q., Brady, C., Yoo, T., Cronin, C. T., Rudnicki, C., Flood, M., Momeni, B., Ludvigsson, J., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00078 · Cited by 163 · see citing works

The challenge of modulating β-cell autoimmunity in type 1 diabetes

Atkinson, M. A., Roep, B. O., Posgai, A. L., Wheeler, D. C. S., & Peakman, M. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30112-8 · Cited by 163 · see citing works

Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice

Seung, E., Iwakoshi, N. N., Woda, B. A., Markees, T. G., Mordes, J. P., Rossini, A. A., & Greiner, D. L. (2000) · Blood · doi:10.1182/blood.v95.6.2175 · Cited by 160 · see citing works

Toward Testing the Hypothesis that Group B Coxsackieviruses (CVB) Trigger Insulin-Dependent Diabetes: Inoculating Nonobese Diabetic Mice with CVB Markedly Lowers Diabetes Incidence

Tracy, S., Drescher, K. M., Chapman, N. M., Kim, K., Carson, S. D., Pirruccello, S. J., Lane, P. H., Romero, J. R., & Leser, J. S. (2002) · Journal of Virology · doi:10.1128/jvi.76.23.12097-12111.2002 · Cited by 158 · see citing works

Extract of Moringa oleifera leaves ameliorates streptozotocin-induced Diabetes mellitus in adult rats

Yassa, H. D., & Tohamy, A. F. (2014) · Acta Histochemica · doi:10.1016/j.acthis.2014.02.002 · Cited by 157 · see citing works

Vitamin D and autoimmune diabetes

Zella, J. B., & DeLuca, H. F. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10347 · Cited by 155 · see citing works

Therapeutic vaccination using CD4 + CD25 + antigen-specific regulatory T cells

Bluestone, J. A., & Tang, Q. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405234101 · Cited by 154 · see citing works

Oral delivery of human biopharmaceuticals, autoantigens and vaccine antigens bioencapsulated in plant cells

Kwon, K., Verma, D., Singh, N. D., Herzog, R. W., & Daniell, H. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.005 · Cited by 150 · see citing works

Immunomodulatory effects of vitamin D receptor ligands in autoimmune diseases

Adorini, L. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(02)00049-8 · Cited by 149 · see citing works

Cannabidiol arrests onset of autoimmune diabetes in NOD mice

Weiss, L., Zeira, M., Reich, S., Slavin, S., Raz, I., Mechoulam, R., & Gallily, R. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.06.029 · Cited by 143 · see citing works

Vaccination with Empty Plasmid DNA or CpG Oligonucleotide Inhibits Diabetes in Nonobese Diabetic Mice: Modulation of Spontaneous 60-kDa Heat Shock Protein Autoimmunity1

Quintana, F., Rotem, A., Carmi, P., & Cohen, I. (2000) · Journal of Immunology · doi:10.4049/jimmunol.165.11.6148 · Cited by 170 · see citing works

Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes

Fiorina, P., Vergani, A., Dada, S., Jurewicz, M., Wong, M., Law, K., Wu, E., Tian, Z., Abdi, R., Guleria, I., et al. (2008) · Diabetes · doi:10.2337/db08-0420 · Cited by 149 · see citing works

Immunologic and Genetic Factors in Type 1 Diabetes

Notkins, A. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r200012200 · Cited by 140 · see citing works

Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice

Goudy, K., Song, S., Wasserfall, C. H., Zhang, Y. C., Kapturczak, M., MUIR, A. B., Powers, M. A., Scott-Jorgensen, M., Campbell‐Thompson, M., Crawford, J. M., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251532298 · Cited by 141 · see citing works

IV. Genetic and animal models of GI motility disorders caused by loss of interstitial cells of Cajal

Sanders, K. M., Ördög, T., & Ward, S. M. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00362.2001 · Cited by 140 · see citing works

Selective delivery of β cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8 + T cells in NOD mice

Mukhopadhaya, A., Hanafusa, T., Jarchum, I., Chen, Y.-G., Iwai, Y., SERREZE, D. V., Steinman, R. M., Tarbell, K. V., & DiLorenzo, T. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802644105 · Cited by 139 · see citing works

Cannabinoids and autoimmune diseases: A systematic review

Katchan, V., David, P., & Shoenfeld, Y. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.02.008 · Cited by 143 · see citing works

Diabetes Mellitus as a Modulating Factor of Endodontic Infections

FOUAD, A. F. (2003) · Journal of Dental Education · doi:10.1002/j.0022-0337.2003.67.4.tb03647.x · Cited by 137 · see citing works

Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: insulitis determines susceptibility of pancreatic islets to virus infection

Drescher, K. M., Kono, K., Bopegamage, S., Carson, S. D., & Tracy, S. (2004) · Virology · doi:10.1016/j.virol.2004.06.049 · Cited by 137 · see citing works

Immunotherapy of Type 1 Diabetes: Where Are We and Where Should We Be Going?

Luo, X., Herold, K. C., & Miller, S. D. (2010) · Immunity · doi:10.1016/j.immuni.2010.04.002 · Cited by 136 · see citing works

Fetal cardiac effects of maternal hyperglycemia during pregnancy

Corrigan, N., Brazil, D. P., & McAuliffe, F. M. (2009) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20567 · Cited by 135 · see citing works

Autologous umbilical cord blood infusion for type 1 diabetes

Haller, M. J., Viener, H. L., Wasserfall, C. H., Brusko, T. M., Atkinson, M. A., & Schatz, D. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.01.009 · Cited by 133 · see citing works

Amelioration of diabetes by imatinib mesylate (Gleevec®): role of ‐cell NF‐KB activation and anti‐apoptotic preconditioning

Hägerkvist, R., Sandler, S., Mokhtari, D., & Welsh, N. (2006) · The FASEB Journal · doi:10.1096/fj.06-6910com · Cited by 132 · see citing works

Systemic Overexpression of IL-10 Induces CD4+CD25+ Cell Populations In Vivo and Ameliorates Type 1 Diabetes in Nonobese Diabetic Mice in a Dose-Dependent Fashion

Goudy, K., Burkhardt, B. R., Wasserfall, C. H., Song, S., Campbell‐Thompson, M., Brusko, T. M., Powers, M. A., Clare-Salzler, M. J., Sobel, E. S., Ellis, T. M., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.5.2270 · Cited by 131 · see citing works

TLR Activation Synergizes with Kilham Rat Virus Infection to Induce Diabetes in BBDR Rats

Zipris, D., Lien, E., Xie, J. X., Greiner, D. L., Mordes, J. P., & Rossini, A. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.1.131 · Cited by 129 · see citing works

NOD Mice Are Defective in Proteasome Production and Activation of NF-κB

Hayashi, T., & Faustman, D. L. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8646 · Cited by 127 · see citing works

The stages of type 1A diabetes: 2005

Gianani, R., & Eisenbarth, G. S. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00248.x · Cited by 127 · see citing works

Engineering immunomodulatory biomaterials for type 1 diabetes

Stabler, C. L., Li, Y., Stewart, J. M., & Keselowsky, B. G. (2019) · Nature Reviews Materials · doi:10.1038/s41578-019-0112-5 · Cited by 126 · see citing works

Reversal of Spontaneous Autoimmune Insulitis in Nonobese Diabetic Mice by Soluble Lymphotoxin Receptor

Wu, Q., Salomon, B. L., Chen, M., Wang, Y., Hoffman, L. M., Bluestone, J. A., & Fu, Y. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.11.1327 · Cited by 121 · see citing works

Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice

Niki, S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26971 · Cited by 119 · see citing works

Insulin‐like growth factor‐1 stimulates regulatory T cells and suppresses autoimmune disease

Bilbao, D., Luciani, L., Jóhannesson, B., Piszczek, A., & Rosenthal, N. A. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201303376 · Cited by 120 · see citing works

CTLA-4–Ig Activates Forkhead Transcription Factors and Protects Dendritic Cells from Oxidative Stress in Nonobese Diabetic Mice

Fallarino, F., Bianchi, R., Orabona, C., Vacca, C., Belladonna, M. L., Fioretti, M. C., SERREZE, D. V., Grohmann, U., & Puccetti, P. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040942 · Cited by 120 · see citing works

Understanding type 1 diabetes: etiology and models

Acharjee, S., Ghosh, B., Al-Dhubiab, B. E., & Nair, A. B. (2013) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2013.05.001 · Cited by 117 · see citing works

Genes and Cellular Requirements for Autoimmune Diabetes Susceptibility in Nonobese Diabetic Mice

SERREZE, D. V., & Leiter, E. H. (2001) · KARGER eBooks · doi:10.1159/000060527 · Cited by 117 · see citing works

Understanding autoimmune diabetes: insights from mouse models

Adorini, L., Gregori, S., & Harrison, L. C. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02193-1 · Cited by 116 · see citing works

Prevention of Autoimmune Diabetes by Ectopic Pancreatic β-Cell Expression of Interleukin-35

Bettini, M., Castellaw, A. H., Lennon, G. P., Burton, A. R., & Vignali, D. A. A. (2012) · Diabetes · doi:10.2337/db11-0784 · Cited by 115 · see citing works

International Workshop on Lessons From Animal Models for Human Type 1 Diabetes

Bonifacio, E. E., Atkinson, M. A., Eisenbarth, G. S., SERREZE, D. V., Kay, T. W. H., Lee‐Chan, E., & Singh, B. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2451 · Cited by 115 · see citing works

Cannabinoids and Endocannabinoids in Metabolic Disorders with Focus on Diabetes

Marzo, V. D., Piscitelli, F., & Mechoulam, R. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-17214-4_4 · Cited by 114 · see citing works

Endogenous Pancreatic β Cell Regeneration: A Potential Strategy for the Recovery of β Cell Deficiency in Diabetes

Zhong, F., & Jiang, Y. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00101 · Cited by 110 · see citing works

Thirty Years of Investigating the Autoimmune Basis for Type 1 Diabetes

Atkinson, M. A. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1253 · Cited by 109 · see citing works

Study design of the Trial to Reduce IDDM in the Genetically at Risk (TRIGR)

The TRIGR Study Group* (2007) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2007.00239.x · Cited by 107 · see citing works

Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice

Oldenborg, P. (2002) · Blood · doi:10.1182/blood.v99.10.3500 · Cited by 108 · see citing works

Mechanism of regulation of autoimmunity by iNKT cells

Novák, J., & Lehuen, A. (2010) · Cytokine · doi:10.1016/j.cyto.2010.11.001 · Cited by 107 · see citing works

Functional Plasticity of Dendritic Cell Subsets as Mediated by CD40 Versus B7 Activation

Grohmann, U., Bianchi, R., Orabona, C., Fallarino, F., Vacca, C., Micheletti, A., Fioretti, M. C., & Puccetti, P. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.5.2581 · Cited by 106 · see citing works

Prevention of Diabetes in Nonobese Diabetic Mice Mediated by CD1d-Restricted Nonclassical NKT Cells

Duarte, N., Stenström, M., Campino, S. G., Bergman, M., Lundholm, M., Holmberg, D., & Cardell, S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.3112 · Cited by 105 · see citing works

Tryptophan degradation in autoimmune diseases

Opitz, C. A., Wick, W., Steinman, L., & Platten, M. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7140-9 · Cited by 100 · see citing works

Gene and Cell-Replacement Therapy in the Treatment of Type 1 Diabetes

Halban, P. A., Kahn, S. E., Lernmark, Å., & Rhodes, C. J. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2181 · Cited by 103 · see citing works

Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone

Fallarino, F., Luca, G., Calvitti, M., Mancuso, F., Nastruzzi, C., Fioretti, M. C., Grohmann, U., Becchetti, E., Burgevin, A., Kratzer, R., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090134 · Cited by 102 · see citing works

Combining Mouse Congenic Strains and Microarray Gene Expression Analyses to Study a Complex Trait: The NOD Model of Type 1 DiabetesPreprint

Eaves, I. A., Wicker, L. S., Ghandour, G., Lyons, P., Peterson, L. B., Todd, J. A., & Glynne, R. J. (2002) · Genome Research · doi:10.1101/gr.214102 · Cited by 102 · see citing works

Detecting early-warning signals of type 1 diabetes and its leading biomolecular networks by dynamical network biomarkers

Liu, X., Liu, R., Zhao, X.-M., & Chen, L. (2013) · BMC Medical Genomics · doi:10.1186/1755-8794-6-s2-s8 · Cited by 101 · see citing works

Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice

Song, S., Goudy, K., Campbell‐Thompson, M., Wasserfall, C. H., Scott-Jorgensen, M., Wang, J., Tang, Q., Crawford, J., Ellis, T., Atkinson, M. A., et al. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302156 · Cited by 100 · see citing works

Differentiation and Transplantation of Functional Pancreatic Beta Cells Generated from Induced Pluripotent Stem Cells Derived from a Type 1 Diabetes Mouse Model

Jeon, K., Lim, H., Kim, J.-H., Nguyen, T., Park, S.-H., Lim, Y., Choi, H., Lee, E.-R., Kim, J.-H., Lee, M.-S., et al. (2012) · Stem Cells and Development · doi:10.1089/scd.2011.0665 · Cited by 111 · see citing works

Adeno-Associated Virus-Mediated IL-10 Gene Therapy Inhibits Diabetes Recurrence in Syngeneic Islet Cell Transplantation of NOD Mice

Zhang, Y. C., Pileggi, A., Agarwal, A., Molano, R. D., Powers, M. A., Brusko, T. M., Wasserfall, C. H., Goudy, K., Zahr, E., Poggioli, R., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.3.708 · Cited by 97 · see citing works

On the Pathogenicity of Autoantigen-Specific T-Cell Receptors

Burton, A. R., Vincent, E., Arnold, P. Y., Lennon, G. P., Smeltzer, M. P., Li, C., HASKINS, K. M., Hutton, J. C., Tisch, R., Sercarz, E. E., et al. (2008) · Diabetes · doi:10.2337/db07-1129 · Cited by 95 · see citing works

Nonobese Diabetic (NOD) Mice Congenic for a Targeted Deletion of 12/15-Lipoxygenase Are Protected From Autoimmune Diabetes

MCDUFFIE, M. J., Maybee, N. A., Keller, S. R., Stevens, B. K., Garmey, J. C., MORRIS, M. A., Kropf, E., Rival, C. M., Ma, K., Carter, J. D., et al. (2007) · Diabetes · doi:10.2337/db07-0830 · Cited by 93 · see citing works

Is the NOD mouse a good model for type 1 diabetes?

Wong, F. S., Pearson, J. A., & Li, W. (2025) · Diabetologia · doi:10.1007/s00125-025-06579-0 · Cited by 8 · see citing works

Lessons from the NOD mouse for the pathogenesis and immunotherapy of human Type 1 (insulin-dependent) diabetes mellitus

Lampeter, E. F., Signore, A., Gale, E. A. M., & Pozzilli, P. (1989) · Diabetologia · doi:10.1007/bf00274528 · Cited by 79 · see citing works

Thinking bedside at the bench: the NOD mouse model of T1DM

Reed, J. C., & Herold, K. C. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.236 · Cited by 87 · see citing works

Are Insights Gained from NOD Mice Sufficient to Guide Clinical Translation?

Roep, B. O. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1394.018 · Cited by 66 · see citing works

Use of Nonobese Diabetic Mice to Understand Human Type 1 Diabetes

Thayer, T. C., Wilson, S. B., & Mathews, C. E. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2010.05.001 · Cited by 80 · see citing works