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Human Cartilage Repair with a Photoreactive Adhesive-Hydrogel Composite
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A photoactive hydrogel is used in combination with microfracture to heal cartilage defects in patients.
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“the superficial and deep cartilage layers interact to maintain homeostasis and increase new tissue production when needed25”
From Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment (2017) · cites this paper as [25]
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Metadata
- Authors
- Sharma, B., Fermanian, S., Gibson, M., Unterman, S., Herzka, D. A., Cascio, B., Coburn, J., Hui, A. Y., Marcus, N., Gold, G. E., & Elisseeff, J. H.
- Affiliations
- Johns Hopkins University (US)
- Department of Orthopedics, Lake Charles Memorial Hospital, Lake Charles, LA 70601, USA.
- Private Practice Orthopedic Surgery, Springfield, VA 22151, USA.
- Stanford Medicine (US)
- Corresponding author
- Gold, Garry E.
- Elisseeff, Jennifer H.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2013-01-09
- Volume
- 5
- Issue
- 167
- Pages
- 167ra6-167ra6
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3972413
- OpenAlex
- W2106782312
- Cited by
- 342
- References
- 37
- Citations by year
- 2026: 11 · 2025: 26 · 2024: 25 · 2023: 20 · 2022: 32 · 2021: 32 · 2020: 34 · 2019: 27 · 2018: 23 · 2017: 27 · 2016: 28 · 2015: 18 · 2014: 30 · 2013: 8
- FWCI
- 22.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (1P01159992-01)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR054005, K24AR062068)
- National Institute of Biomedical Imaging and Bioengineering (R01EB005517, R01EB002524)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- cartilage repair, articular cartilage defects, composite hydrogels, poly(ethylene glycol) diacrylate hydrogel, mesenchymal stem cells, extracellular matrix deposition, knee osteoarthritis, cartilage resurfacing, IKDC score
- MeSH terms
- Animals, Biocompatible Materials, Cartilage, Goats, Humans, Magnetic Resonance Imaging, Tissue Adhesives, Hydrogels, Tissue Engineering
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