Cited by 342Osteoarthritis Treatment and MechanismsHydrogels: synthesis, properties, applicationsTissue Engineering and Regenerative Medicine

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Human Cartilage Repair with a Photoreactive Adhesive-Hydrogel Composite

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Sharma, Blanka, Fermanian, Sara, Gibson, Matthew, Unterman, Shimon, Herzka, Daniel A., Cascio, Brett, Coburn, Jeannine, Hui, Alexander Y., Marcus, Norman, Gold, Garry E., Elisseeff, Jennifer H.·2013·Science Translational Medicine

DOI 10.1126/scitranslmed.3004838PMC PMC3972413

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Abstract

A photoactive hydrogel is used in combination with microfracture to heal cartilage defects in patients.

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THE MICROFRACTURE TECHNIQUE FOR THE TREATMENT OF ARTICULAR CARTILAGE LESIONS IN THE KNEE
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Authors: Sharma, B., Fermanian, S., Gibson, M., Unterman, S., Herzka, D. A., Cascio, B., Coburn, J., Hui, A. Y., Marcus, N., Gold, G. E., & Elisseeff, J. H.
Affiliations: Johns Hopkins University (US)
Department of Orthopedics, Lake Charles Memorial Hospital, Lake Charles, LA 70601, USA.
Private Practice Orthopedic Surgery, Springfield, VA 22151, USA.
Stanford Medicine (US)
Corresponding author: Gold, Garry E.
Elisseeff, Jennifer H.
ORCID: Sharma, Blanka
Unterman, Shimon
Herzka, Daniel A.
Coburn, Jeannine
Gold, Garry E.
Elisseeff, Jennifer H.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2013-01-09
Volume: 5
Issue: 167
Pages: 167ra6-167ra6
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3004838
PMC: PMC3972413
OpenAlex: W2106782312
Cited by: 342
References: 37
Citations by year: 2026: 11 · 2025: 26 · 2024: 25 · 2023: 20 · 2022: 32 · 2021: 32 · 2020: 34 · 2019: 27 · 2018: 23 · 2017: 27 · 2016: 28 · 2015: 18 · 2014: 30 · 2013: 8
FWCI: 22.97
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Public Health Service (1P01159992-01)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR054005, K24AR062068)
National Institute of Biomedical Imaging and Bioengineering (R01EB005517, R01EB002524)
Topics: Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords: cartilage repair, articular cartilage defects, composite hydrogels, poly(ethylene glycol) diacrylate hydrogel, mesenchymal stem cells, extracellular matrix deposition, knee osteoarthritis, cartilage resurfacing, IKDC score
MeSH terms: Animals, Biocompatible Materials, Cartilage, Goats, Humans, Magnetic Resonance Imaging, Tissue Adhesives, Hydrogels, Tissue Engineering

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Human Cartilage Repair with a Photoreactive Adhesive-Hydrogel Composite

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