TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF- Mutant Melanoma

Corcoran, Ryan B.; Rothenberg, Stephen Michael; Hata, Aaron N.; Faber, Anthony C.; Piris, Adriano; Nazarian, Rosalynn M.; Brown, Ronald D.; Godfrey, Jason T.; Winokur, Daniel; Walsh, John; Mino-Kenudson, Mari; Maheswaran, Shyamala; Settleman, Jeffrey; Wargo, Jennifer A.; Flaherty, Keith T.; Haber, Daniel A.; Engelman, Jeffrey A.

doi:10.1126/scitranslmed.3005753

TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF- Mutant Melanoma

Suppression of TORC1 activity after treatment with RAF or MEK inhibitors predicts drug sensitivity in BRAF -mutant melanoma and can be monitored in patients.