Epidermal EGFR Controls Cutaneous Host Defense and Prevents Inflammation
Abstract
Epidermal EGFR regulates skin inflammation and contributes to skin barrier function and host defense.
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Epidermal inactivation of EGFR in mice showed that skin rashes were a direct consequence of epidermal EGFR, which was attributed to chemokine-driven inflammation.
“Epidermal inactivation of EGFR in mice showed that these rashes were a direct consequence of epidermal EGFR, which was attributed to chemokine-driven inflammation51–53.”
From E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning (2017) · cites this paper as [53]
Cites
Signalling pathways of the TNF superfamily: a double-edged sword
Aggarwal, B. B. (2003) · Nature Reviews Immunology · doi:10.1038/nri1184 · Cited by 2,793 · see citing works
The EGF Receptor Provides an Essential Survival Signal for SOS-Dependent Skin Tumor Development
Sibilia, M., Fleischmann, A., Behrens, A., Stingl, L., Carroll, J., Watt, F. M., Schlessinger, J., & Wagner, E. F. (2000) · Cell · doi:10.1016/s0092-8674(00)00026-x · Cited by 304 · see citing works
Self-citationFranzke, C.-W., Cobzaru, C., Triantafyllopoulou, A., Löffek, S., Horiuchi, K., Threadgill, D. W., Kurz, T., van Rooijen, N., Bruckner-Tuderman, L., & Blobel, C. P. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112258 · Cited by 186 · see citing works
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Rübsam, M., Mertz, A. F., Kubo, A., Marg, S., Jüngst, C., Goranci-Buzhala, G., Schauss, A. C., Horsley, V., Dufresne, E. R., Moser, M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01170-7 · Cited by 210 · see citing works
- Authors
- Lichtenberger, B. M., Gerber, P. A., Holcmann, M., Buhren, B. A., Amberg, N., Smolle, V., Schrumpf, H., Boelke, E., Ansari, P., Mackenzie, C., Wollenberg, A., Kislat, A., Fischer, J. W., Röck, K., Harder, J., Schröder, J. M., Homey, B., & Sibilia, M.
- Affiliations
- Comprehensive Cancer Center Vienna (AT)
- Heinrich Heine University Düsseldorf (DE)
- Ludwig-Maximilians-Universität München (DE)
- Institute of Pharmacology and Clinical Pharmacology, Heinrich-Heine-University Düsseldorf, 40225 Duesseldorf, Germany.
- University Hospital Schleswig-Holstein (DE)
- Corresponding author
- Lichtenberger, Beate M.
- Gerber, Peter A.
- Holcmann, Martin
- Homey, Bernhard
- Sibilia, Maria
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2013-08-21
- Volume
- 5
- Issue
- 199
- Pages
- 199ra111-199ra111
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2164613605
- Cited by
- 241
- References
- 3
- Citations by year
- 2026: 13 · 2025: 12 · 2024: 13 · 2023: 13 · 2022: 20 · 2021: 21 · 2020: 25 · 2019: 18 · 2018: 18 · 2017: 19 · 2016: 20 · 2015: 29 · 2014: 15 · 2013: 3
- FWCI
- 26.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Keywords
- epidermal growth factor receptor, EGFR inhibitors, skin inflammation, keratinocytes, chemokines, antimicrobial peptides, skin barrier function, host defense, Staphylococcus aureus, mast cells, T cell recruitment, Langerhans cells, innate immunity
- MeSH terms
- Erlotinib Hydrochloride, Animals, Antineoplastic Agents, Dermatitis, Exanthema, Humans, Interleukin-1, Langerhans Cells, Lymphocytes, Male, Mice, Inbred C57BL, Middle Aged, Neoplasms, Quinazolines, Skin, Keratinocytes, Cytokines, Mice, Knockout, Inflammation Mediators, Hair Follicle, Chemokines, Mice, Translational Research, Biomedical, Mice, 129 Strain, ErbB Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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