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Cited by 113Sleep and Wakefulness ResearchTraumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular Disturbances

Dietary Therapy Mitigates Persistent Wake Deficits Caused by Mild Traumatic Brain Injury

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Lim, Miranda M., Elkind, Jaclynn, Xiong, Guoxiang, Galante, Ray, Zhu, Jingxu, Zhang, Lin, Lian, Jie, Rodin, Julianna +3 more·2013·Science Translational Medicine
DOI 10.1126/scitranslmed.3007092PMC PMC3951738
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Abstract

Mild traumatic brain injury causes persistent deficits in wakefulness in mice, which are mitigated by a dietary therapy containing branched-chain amino acids.

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Crossref · 10.1126/scitranslmed.3007092

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  • Animal models recapitulate sleep phenotypes of disordered sleep in humans, especially excessive daytime sleepiness.

    “Animal models recapitulate sleep phenotypes of disordered sleep in humans, especially that of EDS.22,44,45,48,49,64–73”

    From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [67]

  • Some studies show no significant differences in orexin neurons between injured and sham-injured animals.

    “Some studies show no significant differences in orexin neurons between injured and sham-injured animals.44,67,69,71,74”

    From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [67]

  • Injured animals had a smaller percentage of orexin neurons stained with cFos, indicating less active orexin neurons after injury.

    “we found that injured animals had a smaller percentage of orexin neurons stained with cFos indicating less active orexin neurons after injury.”

    From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [67]

  • In the authors' previous study, animals with mild TBI had greater sleepiness in their waking period.

    “In one of our previous studies, we reported that the animals with mild TBI had greater sleepiness in their waking period.67”

    From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [67]

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Research works printed but not linked: 43

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Authors
Lim, M. M., Elkind, J., Xiong, G., Galante, R., Zhu, J., Zhang, L., Lian, J., Rodin, J., Kuzma, N. N., Pack, A. I., & Cohen, A. S.
Affiliations
  • University of Pennsylvania (US)
  • Children's Hospital of Philadelphia (US)
  • Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Corresponding author
  • Lim, Miranda M.
  • Pack, Allan I.
  • Cohen, Akiva S.
ORCID
Venue
Science Translational Medicine
Publisher
American Association for the Advancement of Science (AAAS)
Published
2013-12-11
Volume
5
Issue
215
Pages
215ra173-215ra173
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
DOI
10.1126/scitranslmed.3007092
PMC
PMC3951738
OpenAlex
W2152708103
Cited by
113
References
6
Citations by year
2026: 4 · 2025: 13 · 2024: 10 · 2023: 8 · 2022: 11 · 2021: 4 · 2020: 12 · 2019: 7 · 2018: 13 · 2017: 7 · 2016: 10 · 2015: 9 · 2014: 4 · 2013: 1
FWCI
4.37
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (T32HL007713, R01HL111725)
  • National Institute of Neurological Disorders and Stroke (R01NS069629)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD059288, R37HD059288)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
mild traumatic brain injury, sleep disorders, orexin neurons, branched-chain amino acids, dietary supplementation, cognitive rehabilitation, neurocognitive impairment
MeSH terms
Orexins, Amino Acids, Branched-Chain, Animals, Behavior, Animal, Brain Injuries, Cognition, Disease Models, Animal, Electroencephalography, Male, Mice, Inbred C57BL, Neurons, Neuropeptides, Wakefulness, Cognitive Behavioral Therapy, Glutamic Acid, Intracellular Signaling Peptides and Proteins, Mice

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