Local sleep in awake rats
Open accessAbstract
In an awake state, neurons in the cerebral cortex fire irregularly and electroencephalogram (EEG) recordings display low-amplitude, high-frequency fluctuations. During sleep, neurons oscillate between 'on' periods, when they fire as in an awake brain, and 'off' periods, when they stop firing altogether and the EEG displays high-amplitude slow waves. However, what happens to neuronal firing after a long period of being awake is not known. Here we show that in freely behaving rats after a long period in an awake state, cortical neurons can go briefly 'offline' as in sleep, accompanied by slow waves in the local EEG. Neurons often go offline in one cortical area but not in another, and during these periods of 'local sleep', the incidence of which increases with the duration of the awake state, rats are active and display an 'awake' EEG. However, they are progressively impaired in a sugar pellet reaching task. Thus, although both the EEG and behaviour indicate wakefulness, local populations of neurons in the cortex may be falling asleep, with negative consequences for performance.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
As distinct qualitative differences between <1 Hz slow oscillations and 1-4 Hz delta oscillations have not been confirmed, the decrease in SWA across sleep appears to be most parsimoniously explained by a decrease in the incidence of high-amplitude slow waves.
“However, as distinct qualitative differences between both frequency bands have not been confirmed, the decrease in SWA across sleep appears to be most parsimoniously explained by a decrease in the incidence of high-amplitude slow waves (1267).”
From About Sleep's Role in Memory (2013) · cites this paper as [1267]
Split into 2 atoms — 1 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredEncoding of information during waking enhances subsequent SWA in specific brain regions.
“in demonstrating that the encoding of information during waking enhances subsequent SWA in specific brain regions, these studies provide compelling evidence that SWA is regulated locally in addition to its global regulation by brain stem and diencephalic structures (672, 859, 975, 1267).”
From About Sleep's Role in Memory (2013) · cites this paper as [1267]
In “Wake OFF periods occur asynchronously in distant cortical regions” (page unavailable), the paper reports that manipulations affecting plasticity during wake are followed by local increases in sleep SWA. This supports the local SWA point, but the passage does not establish that encoding information during wake caused those increases. (LLM, conf=0.82)
Experimental — accuracy not yet measuredSWA is regulated locally in addition to its global regulation by brain stem and diencephalic structures.
“these studies provide compelling evidence that SWA is regulated locally in addition to its global regulation by brain stem and diencephalic structures (672, 859, 975, 1267).”
From About Sleep's Role in Memory (2013) · cites this paper as [1267]
The section “Wake OFF periods occur asynchronously in distant cortical regions” (page unavailable) says sleep can be regulated locally, citing local increases in SWA, and reports local slow waves in the rats’ recordings. Our copy does not attribute global regulation of SWA to brain stem or diencephalic structures, so it supports only the local-regulation part of the sentence. (LLM, conf=0.87)
Experimental — accuracy not yet measuredThe intensity of slow waves in the cortical field potential slowly increases over the active period, in direct relationship to more frequent and longer sleep bouts.
“Likewise, the intensity of slow waves in the cortical field potential slowly increases over the active period, in direct relationship to more frequent and longer sleep bouts”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Vyazovskiy et al., 2011
The degree of habituation to an experimental situation may change the prevalence of low-frequency rhythms in the cortex.
“In addition to the phenomena described above, the degree of habituation to an experimental situation may also change the prevalence of low frequency rhythms in the cortex”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Vyazovskiy et al., 2011
The ability of animals to perform a difficult pellet retrieval task was significantly impaired during the appearance of Off periods in cortical networks.
“In one recent study, the ability of animals to perform a difficult pellet retrieval task was significantly impaired during the appearance of Off periods in cortical networks, supporting the hypothesis that these sudden, but brief, cessations of cortical activity are detrimental to behaviorally relevant cortical operation (Vyazovskiy et al., 2011)”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Vyazovskiy et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760 · see citing works
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543 · see citing works
Van Dongen, H. P. A., Maislin, G., Mullington, J. M., & Dinges, D. F. (2003) · Sleep · doi:10.1093/sleep/26.2.117 · Cited by 3,173 · see citing works
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151 · see citing works
Self-citationHuber, R., Felice Ghilardi, M., Massimini, M., & Tononi, G. (2004) · Nature · doi:10.1038/nature02663 · Cited by 1,854 · see citing works
Self-citationSleep Homeostasis and Models of Sleep Regulation
Borb, A. A., & Achermann, P. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000894 · Cited by 1,503 · see citing works
Effects of sleep deprivation on cognition
Killgore, W. D. S. (2010) · Progress in Brain Research · doi:10.1016/b978-0-444-53702-7.00007-5 · Cited by 1,421 · see citing works
Natural waking and sleep states: a view from inside neocortical neurons
Steriade, M., Timofeev, I., & Grenier, F. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.5.1969 · Cited by 1,296 · see citing works
Learning-Induced LTP in Neocortex
Rioult-Pedotti, M.-S., Friedman, D. J., & Donoghue, J. P. (2000) · Science · doi:10.1126/science.290.5491.533 · Cited by 1,014 · see citing works
Regional Slow Waves and Spindles in Human Sleep
Nir, Y., Staba, R. J., Andrillon, T., Vyazovskiy, V. V., Cirelli, C., Fried, I., & Tononi, G. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.043 · Cited by 924 · see citing works
Self-citationSustained attention performance during sleep deprivation: evidence of state instability.
Doran, S. M., Dongen, H. P. A. V., & Dinges, D. F. (2001) · PubMed · Cited by 801 · see citing works
Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice
Poulet, J. F. A., & Petersen, C. C. H. (2008) · Nature · doi:10.1038/nature07150 · Cited by 796 · see citing works
Cortical firing and sleep homeostasis
Vyazovskiy, V. V., Olcese, U., Lazimy, Y. M., Faraguna, U., Esser, S. K., Williams, J. C., Cirelli, C., & Tononi, G. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.024 · Cited by 740 · see citing works
Self-citationCirelli, C., & Tononi, G. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060216 · Cited by 646 · see citing works
Self-citationCircadian and sleep/wake dependent aspects of subjective alertness and cognitive performance
Dijk, D., Duffy, J. F., & Czeisler, C. A. (1992) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1992.tb00021.x · Cited by 602 · see citing works
Sleep as a fundamental property of neuronal assemblies
Krueger, J. M., Rector, D. M., Roy, S., Van Dongen, H. P. A., Belenky, G., & Panksepp, J. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2521 · Cited by 596 · see citing works
Functional neuroimaging of normal human sleep by positron emission tomography
Maquet (2000) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2000.00214.x · Cited by 581 · see citing works
Functional neuroimaging of normal human sleep by positron emission tomography
Aquet, P. I. M. (2000) · Cited by 496 · see citing works
Why do we sleep?11Published on the World Wide Web on 7 November 2000.
Sejnowski, T. J., & Destexhe, A. (2000) · Brain Research · doi:10.1016/s0006-8993(00)03007-9 · Cited by 489 · see citing works
Finelli, L. A., Baumann, H., Borbély, A. A., & Achermann, P. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00409-7 · Cited by 447 · see citing works
Riedner, B. A., Vyazovskiy, V. V., Huber, R., Massimini, M., Esser, S., Murphy, M., & Tononi, G. (2007) · Sleep · doi:10.1093/sleep/30.12.1643 · Cited by 424 · see citing works
Self-citationModeling Sleep and Wakefulness in the Thalamocortical System
Hill, S., & Tononi, G. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00915.2004 · Cited by 417 · see citing works
Self-citationInsights from studying human sleep disorders
Mahowald, M. W., & Schenck, C. H. (2005) · Nature · doi:10.1038/nature04287 · Cited by 330 · see citing works
Esser, S. K., Hill, S. L., & Tononi, G. (2007) · Sleep · doi:10.1093/sleep/30.12.1617 · Cited by 315 · see citing works
Self-citationFunctional Neuroimaging Insights into the Physiology of Human Sleep.
Dang-Vu, T. T., Schabus, M., Desseilles, M., Sterpenich, V., Bonjean, M., & Maquet, P. (2010) · SLEEP · doi:10.1093/sleep/33.12.1589 · Cited by 284 · see citing works
Origin of Active States in Local Neocortical Networks during Slow Sleep Oscillation
Chauvette, S., Volgushev, M., & Timofeev, I. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq009 · Cited by 266 · see citing works
Terzaghi, M., Sartori, I., Tassi, L., Didato, G., Rustioni, V., LoRusso, G., Manni, R., & Nobili, L. (2009) · Sleep · doi:10.1093/sleep/32.3.409 · Cited by 222 · see citing works
Locus coeruleus neurons: cessation of activity during cataplexy
Wu, M.-F., Gulyani, S., Yau, E., Mignot, E. J.-M., Phan, B., & Siegel, J. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00600-9 · Cited by 220 · see citing works
Theta activity in the waking EEG is a marker of sleep propensity in the rat
Vyazovskiy, V. V., & Tobler, I. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.022 · Cited by 210 · see citing works
Self-citationSleep homeostasis in the rat is preserved during chronic sleep restriction
Leemburg, S., Vyazovskiy, V. V., Olcese, U., Bassetti, C. L., Tononi, G., & Cirelli, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002570107 · Cited by 154 · see citing works
Self-citationEffects of Skilled Training on Sleep Slow Wave Activity and Cortical Gene Expression in the Rat
Hanlon, E. C., Faraguna, U., Vyazovskiy, V. V., Tononi, G., & Cirelli, C. (2009) · Sleep · doi:10.1093/sleep/32.6.719 · Cited by 148 · see citing works
Self-citationVyazovskiy, V. V., Faraguna, U., Cirelli, C., & Tononi, G. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91157.2008 · Cited by 134 · see citing works
Self-citationEvidence for asynchronous development of sleep in cortical areas
Pigarev, I. N., Nothdurft, H., & Kästner, S. (1997) · Neuroreport · doi:10.1097/00001756-199707280-00027 · Cited by 125 · see citing works
Moruzzi, G. (1965) · Springer eBooks · doi:10.1007/978-3-642-49168-9_15 · Cited by 121 · see citing works
Sleep Homeostasis and Models of Sleep Regulation
Borbély, A. A., & Achermann, P. (2005) · Elsevier eBooks · doi:10.1016/b0-72-160797-7/50040-9 · Cited by 104 · see citing works
Unit activity of rat basal forebrain neurons: Relationship to cortical activity
Núñez, Á. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00582-x · Cited by 97 · see citing works
Handedness Leads to Interhemispheric EEG Asymmetry During Sleep in the Rat
Vyazovskiy, V. V., & Tobler, I. (2007) · Journal of Neurophysiology · doi:10.1152/jn.01154.2007 · Cited by 73 · see citing works
Self-citationFerrillo, F., Beelke, M., Carli, F. D., Cossu, M., Munari, C., Rosadini, G., & Nobili, L. (2000) · Clinical Neurophysiology · doi:10.1016/s1388-2457(00)00246-7 · Cited by 62 · see citing works
Laplante, F., Morin, Y., Quirion, R., & Vaucher, E. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.059 · Cited by 58 · see citing works
Marrocco, R. T., Lane, R., McClurkin, J. W., Blaha, C. D., & Alkire, M. T. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-09-02756.1987 · Cited by 46 · see citing works
Tirunahari, V. L., Zaidi, S. A., Sharma, R., Skurnick, J., & Ashtyani, H. (2003) · Sleep Medicine · doi:10.1016/s1389-9457(02)00250-2 · Cited by 46 · see citing works
Quantifying microsleep to help assess subjective sleepiness
Blaivas, A. J., Patel, R., Hom, D. L., Antigua, K., & Ashtyani, H. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.06.011 · Cited by 41 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [12]Sejnowski TJ Destexhe A Why do we sleep? Brain Res 886 1–2 208 223 2000 11119697
Cited by
Sorted by citations
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
Tononi, G., & Cirelli, C. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.025 · Cited by 2,356 · see citing works
Self-citationControl of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477 · see citing works
An opportunity cost model of subjective effort and task performance
Kurzban, R., Duckworth, A., Kable, J. W., & Myers, J. (2013) · Behavioral and Brain Sciences · doi:10.1017/s0140525x12003196 · Cited by 1,381 · see citing works
The sleep-deprived human brain
Krause, A. J., Simon, E. B., Mander, B. A., Greer, S. M., Saletin, J. M., Goldstein-Piekarski, A. N., & Walker, M. P. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.55 · Cited by 1,200 · see citing works
Neural Circuitry of Wakefulness and Sleep
Scammell, T. E., Arrigoni, E., & Lipton, J. O. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.014 · Cited by 966 · see citing works
Regional Slow Waves and Spindles in Human Sleep
Nir, Y., Staba, R. J., Andrillon, T., Vyazovskiy, V. V., Cirelli, C., Fried, I., & Tononi, G. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.043 · Cited by 924 · see citing works
Self-citationSleep, insomnia, and depression
Riemann, D. W., Krone, L. B., Wulff, K., & Nissen, C. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0411-y · Cited by 863 · see citing works
Waking state: rapid variations modulate neural and behavioral responses
McGinley, M. J., Vinck, M., Reimer, J., Batista-Brito, R., Zagha, E., Cadwell, C. R., Tolias, A. S., Cardin, J. A., & McCormick, D. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.012 · Cited by 801 · see citing works
“Likewise, the intensity of slow waves in the cortical field potential slowly increases over the active period, in direct relationship to more frequent and longer sleep bouts (Curie et al., 2013; Hasan et al., 2012; Vyazovskiy et al., 2011).”
InfluentialCortical membrane potential signature of optimal states for sensory signal detection
McGinley, M. J., David, S. V., & McCormick, D. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.038 · Cited by 728 · see citing works
Ultrastructural evidence for synaptic scaling across the wake/sleep cycle
de Vivo, L., Bellesi, M., Marshall, W., Bushong, E. A., Ellisman, M. H., Tononi, G., & Cirelli, C. (2017) · Science · doi:10.1126/science.aah5982 · Cited by 574 · see citing works
Self-citationRoh, J. H., Huang, Y., Bero, A. W., Kasten, T., Stewart, F. R., Bateman, R. J., & Holtzman, D. M. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004291 · Cited by 563 · see citing works
Brain mechanisms of insomnia: new perspectives on causes and consequences
Someren, E. J. W. V. (2020) · Physiological Reviews · doi:10.1152/physrev.00046.2019 · Cited by 558 · see citing works
An electrophysiological marker of arousal level in humans
Lendner, J. D., Helfrich, R. F., Mander, B. A., Romundstad, L. G., Lin, J. J., Walker, M. P., Larsson, P. G., & Knight, R. T. (2020) · eLife · doi:10.7554/elife.55092 · Cited by 403 · see citing works
Sleep deprivation, vigilant attention, and brain function: a review
Hudson, A. N., Dongen, H. P. A. V., & Honn, K. A. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0432-6 · Cited by 397 · see citing works
Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness
Lewis, L. D., Weiner, V. S., Mukamel, E. A., Donoghue, J., Eskandar, E. N., Madsen, J. R., Anderson, W. S., Hochberg, L. R., Cash, S. S., Brown, E. N., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210907109 · Cited by 387 · see citing works
Astrocytes regulate cortical state switching in vivo
Poskanzer, K. E., & Yuste, R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520759113 · Cited by 377 · see citing works
Sleep and the single neuron: the role of global slow oscillations in individual cell rest
Vyazovskiy, V. V., & Harris, K. D. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3494 · Cited by 362 · see citing works
Self-citationFunctions and Mechanisms of Sleep
Zielinski, M. R., McKenna, J. T., & McCarley, R. W. (2016) · AIMS neuroscience · doi:10.3934/neuroscience.2016.1.67 · Cited by 347 · see citing works
Evidence that birds sleep in mid-flight
Rattenborg, N. C., Voirin, B., Cruz, S. M., Tisdale, R. K., Dell’Omo, G., Lipp, H., Wikelski, M. C., & Vyssotski, A. L. (2016) · Nature Communications · doi:10.1038/ncomms12468 · Cited by 341 · see citing works
Forward-genetics analysis of sleep in randomly mutagenized mice
Funato, H., Miyoshi, C., Fujiyama, T., Kanda, T., Sato, M., Wang, Z., Ma, J., Nakane, S., Tomita, J., Ikkyu, A., et al. (2016) · Nature · doi:10.1038/nature20142 · Cited by 327 · see citing works
Sleep and waking modulate spine turnover in the adolescent mouse cortex
Maret, S., Faraguna, U., Nelson, A. B., Cirelli, C., & Tononi, G. (2011) · Nature Neuroscience · doi:10.1038/nn.2934 · Cited by 315 · see citing works
Self-citationSleep Neurophysiological Dynamics Through the Lens of Multitaper Spectral Analysis
Prerau, M. J., Brown, R. E., Bianchi, M. T., Ellenbogen, J. M., & Purdon, P. L. (2016) · Physiology · doi:10.1152/physiol.00062.2015 · Cited by 308 · see citing works
Neuromodulation of brain state and behavior
McCormick, D. A., Nestvogel, D. B., & He, B. J. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-100219-105424 · Cited by 303 · see citing works
Schmidt, M. H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.001 · Cited by 291 · see citing works
The Slow Oscillation in Cortical and Thalamic Networks: Mechanisms and Functions
Neske, G. T. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2015.00088 · Cited by 283 · see citing works
Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive
Eban-Rothschild, A., Appelbaum, L., & de Lecea, L. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.294 · Cited by 282 · see citing works
Oscillating circuitries in the sleeping brain
Adamantidis, A. R., Gutierrez Herrera, C., & Gent, T. C. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0223-4 · Cited by 281 · see citing works
Slow-wave sleep: From the cell to the clinic
Léger, D., Debellemanière, E., Rabat, A., Bayon, V., Benchenane, K., & Chennaoui, M. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.01.008 · Cited by 261 · see citing works
Adaptive Sleep Loss in Polygynous Pectoral Sandpipers
Lesku, J. A., Rattenborg, N. C., Vâlcu, M., Vyssotski, A. L., Kuhn, S., Kümmeth, F., Heidrich, W., & Kempenaers, B. (2012) · Science · doi:10.1126/science.1220939 · Cited by 260 · see citing works
Genzel, L., Kroes, M. C. W., Dresler, M., & Battaglia, F. P. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.10.002 · Cited by 259 · see citing works
Making Waves: Initiation and Propagation of Corticothalamic Ca2+ Waves In Vivo
Stroh, A., Adelsberger, H., Groh, A., Rühlmann, C., Fischer, S., Schierloh, A., Deisseroth, K. A., & Konnerth, A. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.031 · Cited by 249 · see citing works
Humans can learn new information during sleep
Arzi, A., Shedlesky, L., Ben-Shaul, M., Nasser, K., Oksenberg, A., Hairston, I. S., & Sobel, N. (2012) · Nature Neuroscience · doi:10.1038/nn.3193 · Cited by 240 · see citing works
Enhancement of sleep slow waves: underlying mechanisms and practical consequences
Bellesi, M., Riedner, B. A., Garcia-Molina, G. N., Cirelli, C., & Tononi, G. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00208 · Cited by 239 · see citing works
Self-citationImaging neural circuit dynamics with a voltage-sensitive fluorescent protein
Akemann, W., Mutoh, H., Perron, A., Park, Y. K., Iwamoto, Y., & Knöpfel, T. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00452.2012 · Cited by 237 · see citing works
Unraveling the evolutionary determinants of sleep
Joiner, W. J. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.068 · Cited by 232 · see citing works
Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease
Roh, J. H., Jiang, H., Finn, M. B., Stewart, F. R., Mahan, T. E., Cirrito, J. R., Heda, A., Snider, B. J., Li, M., Yanagisawa, M., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20141788 · Cited by 230 · see citing works
The Input-Output Relationship of the Cholinergic Basal Forebrain
Gielow, M. R., & Záborszky, L. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.060 · Cited by 230 · see citing works
The claustrum coordinates cortical slow-wave activity
Narikiyo, K., Mizuguchi, R., Ajima, A., Mitsui, S., Shiozaki, M., Hamanaka, H., Johansen, J. P., Mori, K., & Yoshihara, Y. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0625-7 · Cited by 228 · see citing works
Properties of Slow Oscillation during Slow-Wave Sleep and Anesthesia in Cats
Chauvette, S., Crochet, S., Volgushev, M., & Timofeev, I. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2339-11.2011 · Cited by 227 · see citing works
Circadian regulation of human cortical excitability
Ly, J. Q. M., Gaggioni, G., Chellappa, S. L., Papachilleos, S., Brzozowski, A., Borsu, C., Rosanova, M., Sarasso, S., Middleton, B., Luxen, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms11828 · Cited by 226 · see citing works
Local Experience-Dependent Changes in the Wake EEG after Prolonged Wakefulness
Hung, C., Sarasso, S., Ferrarelli, F., Riedner, B. A., Ghilardi, M. F., Cirelli, C., & Tononi, G. (2012) · SLEEP · doi:10.5665/sleep.2302 · Cited by 224 · see citing works
Self-citationEssential Thalamic Contribution to Slow Waves of Natural Sleep
David, F., Schmiedt, J. T., Taylor, H. L., Orbán, G., Giovanni, G. D., Uebele, V. N., Renger, J. J., Lambert, R. C., Leresche, N., & Crunelli, V. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3169-13.2013 · Cited by 223 · see citing works
Predicting lapses of attention with sleep-like slow waves
Andrillon, T., Burns, A. C., Mackay, T., Windt, J., & Tsuchiya, N. (2021) · Nature Communications · doi:10.1038/s41467-021-23890-7 · Cited by 218 · see citing works
Napping: a public health issue. From epidemiological to laboratory studies
Faraut, B., Andrillon, T., Vecchierini, M.-F., & Leger, D. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.09.002 · Cited by 217 · see citing works
Local aspects of sleep and wakefulness
Siclari, F., & Tononi, G. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.05.008 · Cited by 208 · see citing works
Self-citationThalamic reticular nucleus induces fast and local modulation of arousal state
Lewis, L. D., Voigts, J., Flores, F. J., Schmitt, L. I., Wilson, M. A., Halassa, M. M., & Brown, E. N. (2015) · eLife · doi:10.7554/elife.08760 · Cited by 204 · see citing works
Specific basal forebrain-cortical cholinergic circuits coordinate cognitive operations
Záborszky, L., Gombkoto, P., Varsanyi, P., Gielow, M. R., Poe, G., Role, L. W., Ananth, M., Rajebhosale, P., Talmage, D. A., Hasselmo, M. E., et al. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1676-18.2018 · Cited by 202 · see citing works
Hinard, V., Mikhail, C., Pradervand, S., Curie, T., Houtkooper, R. H., Auwerx, J. H., Franken, P., & Tafti, M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2306-12.2012 · Cited by 202 · see citing works
Consciousness among delta waves: a paradox?
Frohlich, J., Toker, D., & Monti, M. M. (2021) · Brain · doi:10.1093/brain/awab095 · Cited by 197 · see citing works
Selective neuronal lapses precede human cognitive lapses following sleep deprivation
Nir, Y., Andrillon, T., Marmelshtein, A., Suthana, N., Cirelli, C., Tononi, G., & Fried, I. (2017) · Nature Medicine · doi:10.1038/nm.4433 · Cited by 191 · see citing works
Self-citationBrain state dependent activity in the cortex and thalamus
McCormick, D. A., McGinley, M. J., & Salkoff, D. B. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.10.003 · Cited by 189 · see citing works
A global brain state underlies C. elegans sleep behavior
Nichols, A. L. A., Eichler, T., Latham, R., & Zimmer, M. (2017) · Science · doi:10.1126/science.aam6851 · Cited by 188 · see citing works
The consequences of sleep deprivation on cognitive performance
Khan, M., & Al-Jahdali, H. H. (2023) · Neurosciences · doi:10.17712/nsj.2023.2.20220108 · Cited by 188 · see citing works
Lag structure in resting-state fMRI
Mitra, A., Snyder, A. Z., Hacker, C. D., & Raichle, M. E. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00804.2013 · Cited by 185 · see citing works
Zagha, E., & McCormick, D. A. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.09.010 · Cited by 184 · see citing works
Breathing coordinates cortico-hippocampal dynamics in mice during offline states
Karalis, N., & Sirota, A. (2022) · Nature Communications · doi:10.1038/s41467-022-28090-5 · Cited by 179 · see citing works
Local Slow Waves in Superficial Layers of Primary Cortical Areas during REM Sleep
Funk, C. M., Honjoh, S., Rodriguez, A. V., Cirelli, C., & Tononi, G. (2016) · Current Biology · doi:10.1016/j.cub.2015.11.062 · Cited by 178 · see citing works
Self-citationThe Impact of Cortical Deafferentation on the Neocortical Slow Oscillation
Lemieux, M., Chen, J., Lonjers, P., Bazhenov, M., & Timofeev, I. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1156-13.2014 · Cited by 177 · see citing works
NREM and REM Sleep: Complementary Roles in Recovery after Wakefulness
Vyazovskiy, V. V., & Delogu, A. (2014) · The Neuroscientist · doi:10.1177/1073858413518152 · Cited by 169 · see citing works
Self-citationThalamocortical synchronization during induction and emergence from propofol-induced unconsciousness
Flores, F. J., Hartnack, K. E., Fath, A. B., Kim, S., Wilson, M. A., Brown, E. N., & Purdon, P. L. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1700148114 · Cited by 169 · see citing works
Sleep-wake control and the thalamus
Gent, T. C., Bassetti, C. L., & Adamantidis, A. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.08.002 · Cited by 165 · see citing works
The thalamocortical network as a single slow wave-generating unit
Crunelli, V., David, F., Lörincz, M. L., & Hughes, S. W. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.09.001 · Cited by 162 · see citing works
Schmitt, L. I., Sims, R. E., Dale, N., & Haydon, P. G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5689-11.2012 · Cited by 162 · see citing works
Deconstructing and reconstructing cognitive performance in sleep deprivation
Jackson, M. L., Glenn Gunzelmann, A., Whitney, P. J., Hinson, J. M., Belenky, G. L., Rabat, A., & Dongen, H. P. A. V. (2012) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.06.007 · Cited by 159 · see citing works
UP-DOWN cortical dynamics reflect state transitions in a bistable network
Jercog, D., Roxin, A., Barthó, P., Luczak, A., Compte, A., & de la Rocha, J. (2017) · eLife · doi:10.7554/elife.22425 · Cited by 159 · see citing works
Gating of Sensory Input by Spontaneous Cortical Activity
Luczak, A., Barthó, P., & Harris, K. D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2928-12.2013 · Cited by 157 · see citing works
Regional Delta Waves In Human Rapid Eye Movement Sleep
Bernardi, G., Betta, M., Ricciardi, E., Pietrini, P., Tononi, G., & Siclari, F. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.2298-18.2019 · Cited by 156 · see citing works
Self-citationTapping the Brakes: Cellular and Synaptic Mechanisms that Regulate Thalamic Oscillations
Fogerson, P. M., & Huguenard, J. R. (2016) · Neuron · doi:10.1016/j.neuron.2016.10.024 · Cited by 155 · see citing works
Bernardi, G., Siclari, F., Yu, X., Zennig, C., Bellesi, M., Ricciardi, E., Cirelli, C., Ghilardi, M. F., Pietrini, P., & Tononi, G. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4567-14.2015 · Cited by 153 · see citing works
Self-citationSleep recalibrates homeostatic and associative synaptic plasticity in the human cortex
Kuhn, M., Wolf, E., Maier, J. G., Mainberger, F., Feige, B., Schmid, H., Bürklin, J., Maywald, S., Mall, V., Jung, N. H., et al. (2016) · Nature Communications · doi:10.1038/ncomms12455 · Cited by 152 · see citing works
A role for the cortex in sleep–wake regulation
Krone, L. B., Yamagata, T., Blanco‐Duque, C., Guillaumin, M. C. C., Kahn, M. C., van der Vinne, V., McKillop, L. E., Tam, S. K. E., Peirson, S. N., Akerman, C. J., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00894-6 · Cited by 148 · see citing works
Self-citationA neuron–glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis
Haynes, P. R., Pyfrom, E. S., Li, Y., Stein, C., Cuddapah, V. A., Jacobs, J. A., Yue, Z., & Sehgal, A. (2024) · Nature Neuroscience · doi:10.1038/s41593-023-01568-1 · Cited by 146 · see citing works
Schmidt, M., Bakker, R., Shen, K., Bezgin, G., Diesmann, M., & van Albada, S. J. (2018) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006359 · Cited by 145 · see citing works
Amyloid-β diurnal pattern: possible role of sleep in Alzheimer's disease pathogenesis
Lucey, B. P., & Bateman, R. J. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.035 · Cited by 144 · see citing works
Central control of cardiovascular function during sleep
Silvani, A., & Dampney, R. A. L. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00554.2013 · Cited by 138 · see citing works
Krueger, J. M., Nguyen, J., Dykstra-Aiello, C., & Taishi, P. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.10.001 · Cited by 136 · see citing works
Resting state EEG correlates of memory consolidation
Brokaw, K., Tishler, W., Manceor, S., Hamilton, K., Gaulden, A. D., Parr, E., & Wamsley, E. J. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.01.008 · Cited by 135 · see citing works
Top-down cortical input during NREM sleep consolidates perceptual memory
Miyamoto, D., Hirai, D., Fung, C. C. A., Inutsuka, A., Odagawa, M., Suzuki, T., Boehringer, R., Adaikkan, C., Matsubara, C., Matsuki, N., et al. (2016) · Science · doi:10.1126/science.aaf0902 · Cited by 135 · see citing works
Meisel, C., Schulze‐Bonhage, A., Freestone, D. R., Cook, M. J., Achermann, P., & Plenz, D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1513716112 · Cited by 134 · see citing works
Riemann, D. W., Dressle, R. J., Benz, F., Spiegelhalder, K., Johann, A. F., Nissen, C., Hertenstein, E., Baglioni, C., Palagini, L., Krone, L. B., et al. (2024) · Journal of Sleep Research · doi:10.1111/jsr.14252 · Cited by 134 · see citing works
The vigilant sleeper: neural mechanisms of sensory (de)coupling during sleep
Andrillon, T., & Kouider, S. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.12.002 · Cited by 133 · see citing works
Nir, Y., Vyazovskiy, V. V., Cirelli, C., Banks, M. I., & Tononi, G. (2015) · Cerebral Cortex · doi:10.1093/cercor/bht328 · Cited by 132 · see citing works
Self-citationReal-time dialogue between experimenters and dreamers during REM sleep
Konkoly, K. R., Appel, K., Chabani, E., Mangiaruga, A., Gott, J., Mallett, R., Caughran, B., Witkowski, S., Whitmore, N. W., Mazurek, C. Y., et al. (2021) · Current Biology · doi:10.1016/j.cub.2021.01.026 · Cited by 131 · see citing works
Identification of Neurons with a Privileged Role in Sleep Homeostasis in Drosophila melanogaster
Seidner, G. A., Robinson, J. E., Wu, M., Worden, K., Masek, P., Roberts, S. W., Keene, A. C., & Joiner, W. J. (2015) · Current Biology · doi:10.1016/j.cub.2015.10.006 · Cited by 131 · see citing works
Brain energetics during the sleep-wake cycle
DiNuzzo, M., & Nedergaard, M. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.09.010 · Cited by 130 · see citing works
The interconnected causes and consequences of sleep in the brain
Lewis, L. D. (2021) · Science · doi:10.1126/science.abi8375 · Cited by 130 · see citing works
Cleaning the sleeping brain – the potential restorative function of the glymphatic system
Hauglund, N. L., Pavan, C., & Nedergaard, M. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.10.020 · Cited by 129 · see citing works
Local sleep-like cortical reactivity in the awake brain after focal injury
Sarasso, S., D’Ambrosio, S., Fecchio, M., Casarotto, S., Viganò, A., Landi, C., Mattavelli, G., Gosseries, O., Quarenghi, M., Laureys, S., et al. (2020) · Brain · doi:10.1093/brain/awaa338 · Cited by 128 · see citing works
Ongoing physiological processes in the cerebral cortex
Leopold, D. A., & Maier, A. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.059 · Cited by 127 · see citing works
Neurovascular coupling and bilateral connectivity during NREM and REM sleep
Turner, K. L., Gheres, K. W., Proctor, E. A., & Drew, P. J. (2020) · eLife · doi:10.7554/elife.62071 · Cited by 125 · see citing works
Andrillon, T., Windt, J., Silk, T. J., Drummond, S. P. A., Bellgrove, M. A., & Tsuchiya, N. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00949 · Cited by 124 · see citing works
Sleep-related epileptic behaviors and non-REM-related parasomnias: Insights from stereo-EEG
Gibbs, S. A., Proserpio, P., Terzaghi, M., Pigorini, A., Sarasso, S., Russo, G. L., Tassi, L., & Nobili, L. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.05.002 · Cited by 123 · see citing works
The Cortical States of Wakefulness
Poulet, J. F. A., & Crochet, S. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2018.00064 · Cited by 119 · see citing works
Spontaneous behaviors drive multidimensional, brain-wide activityPreprint
Stringer, C., Pachitariu, M., Steinmetz, N. A., Reddy, C. B., Carandini, M., & Harris, K. D. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/306019 · Cited by 119 · see citing works
Sleep slow oscillation and plasticity
Timofeev, I., & Chauvette, S. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.03.019 · Cited by 118 · see citing works
Gaskell, A. L., Hight, D., Winders, J., Tran, G., Defresne, A., Bonhomme, V. L., Raz, A., SLEIGH, J. W., & Sanders, R. D. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex170 · Cited by 118 · see citing works
How networks communicate: propagation patterns in spontaneous brain activity
Mitra, A., & Raichle, M. E. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0546 · Cited by 115 · see citing works
Tanabe, S., Mohanty, R., Lindroth, H. L., Casey, C., Ballweg, T., Farahbakhsh, Z. Z., Krause, B. M., Prabhakaran, V., Banks, M. I., & Sanders, R. D. (2020) · British Journal of Anaesthesia · doi:10.1016/j.bja.2020.02.027 · Cited by 115 · see citing works
Time to Be SHY? Some Comments on Sleep and Synaptic Homeostasis
Tononi, G., & Cirelli, C. (2012) · Neural Plasticity · doi:10.1155/2012/415250 · Cited by 114 · see citing works
Self-citation
- Authors
- Vyazovskiy, V. V., Olcese, U., Hanlon, E. C., Nir, Y., Cirelli, C., & Tononi, G.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Tononi, Giulio
- Venue
- Nature
- Published
- 2011-04
- Volume
- 472
- Issue
- 7344
- Pages
- 443-447
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3085007
- OpenAlex
- W2039029351
- Cited by
- 865
- References
- 42
- Citations by year
- 2026: 55 · 2025: 72 · 2024: 58 · 2023: 54 · 2022: 64 · 2021: 65 · 2020: 73 · 2019: 73 · 2018: 53 · 2017: 62 · 2016: 50 · 2015: 36 · 2014: 45 · 2013: 46 · 2012: 39
- FWCI
- 24.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Funders
- National Institutes of Health (5p20mh077967-04, DP1OD000579)
- National Institute of Mental Health (P20MH-077967)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- local sleep, cortical neuronal activity, slow waves, EEG, wakefulness, prolonged wakefulness, sleep-like state, cognitive impairment, rats, sleep-wake transition
- MeSH terms
- Action Potentials, Animals, Behavior, Animal, Cerebral Cortex, Electroencephalography, Male, Models, Neurological, Rats, Inbred WKY, Reward, Sleep, Sleep Deprivation, Wakefulness, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
