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Cortical GABAergic excitation contributes to epileptic activities around human glioma
Open accessAbstract
Epileptic discharges in the neocortex surrounding human gliomas are initiated by GABAergic interneurons through alterations of chloride homeostasis in pyramidal cells.
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“the remaining GABAergic neurons show a significantly reduced inhibitory potential.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [5]
Experimental — accuracy not yet measuredIn the citing paper
“The cellular and molecular changes underlying tumor-associated epilepsy collectively point to a decrease in GABAergic and increase in glutamatergic transmission as the major contributors3–6.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [5]
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“Seizures originate from the PTC, and previous studies3,5,6 show altered excitation−inhibition balance in the PTC due to changes in glutamatergic and GABAergic activity.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [5]
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Brain Tumor and Seizures: Pathophysiology and Its Implications for Treatment Revisited
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RetractedThe 2007 WHO Classification of Tumours of the Central Nervous System
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Metadata
- Authors
- Pallud, J., Le Van Quyen, M., Bielle, F., Pellegrino, C., Varlet, P., Labussiere, M., Cresto, N., Dieme, M.-J., Baulac, M., Duyckaerts, C., Kourdougli, N., Chazal, G., Devaux, B., Rivera, C., Miles, R., Capelle, L., & Huberfeld, G.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Sorbonne Universités, University Pierre and Marie Curie (UPMC) University of Paris 06, F-75005 Paris, France.
- Sorbonne Université (FR)
- Inserm (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- University of Helsinki (FI)
- Corresponding author
- Bielle, Franck
- Pellegrino, Christophe
- Huberfeld, Gilles
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2014-07-09
- Volume
- 6
- Issue
- 244
- Pages
- 244ra89-244ra89
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4409113
- OpenAlex
- W2157338202
- Cited by
- 300
- References
- 64
- Citations by year
- 2026: 15 · 2025: 24 · 2024: 32 · 2023: 35 · 2022: 34 · 2021: 25 · 2020: 18 · 2019: 28 · 2018: 26 · 2017: 22 · 2016: 23 · 2015: 14 · 2014: 4
- FWCI
- 16.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- glioma, epileptogenicity, chloride homeostasis, KCC2, NKCC1, interictal epileptiform discharges, pyramidal neurons, interneurons, excitatory-inhibitory imbalance
- MeSH terms
- Action Potentials, Brain Neoplasms, Chlorides, Epilepsy, gamma-Aminobutyric Acid, Glioma, Glutamates, Humans, Interneurons, Neocortex
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