The DOI matches its Crossref record; 63 of the 64 references it cites were found in a registry or an index.
Cortical GABAergic excitation contributes to epileptic activities around human glioma
Open accessAbstract
Epileptic discharges in the neocortex surrounding human gliomas are initiated by GABAergic interneurons through alterations of chloride homeostasis in pyramidal cells.
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In the citing paper
“the remaining GABAergic neurons show a significantly reduced inhibitory potential.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [5]
Experimental — accuracy not yet measuredIn the citing paper
“The cellular and molecular changes underlying tumor-associated epilepsy collectively point to a decrease in GABAergic and increase in glutamatergic transmission as the major contributors3–6.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [5]
In the citing paper
“Seizures originate from the PTC, and previous studies3,5,6 show altered excitation−inhibition balance in the PTC due to changes in glutamatergic and GABAergic activity.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [5]
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Citations
Cites
1 retracted
Brain Tumor and Seizures: Pathophysiology and Its Implications for Treatment Revisited
Schaller, B. J., & Rüegg, S. J. (2003) · Epilepsia · doi:10.1046/j.1528-1157.2003.05203.x · Cited by 129
RetractedThe 2007 WHO Classification of Tumours of the Central Nervous System
Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., Scheithauer, B. W., & Kleihues, P. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0243-4 · Cited by 15,675
Erratum to: The 2007 WHO classification of tumours of the central nervous system
Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., Scheithauer, B. W., & Kleihues, P. (2007) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-156115 · Cited by 4,435
The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
Rivera, C., Voipio, J., Payne, J. A., Ruusuvuori, E., Lahtinen, H., Lamsa, K., Pirvola, U., Saarma, M., & Kaila, K. (1999) · Nature · doi:10.1038/16697 · Cited by 2,152
Self-citationNKCC1 transporter facilitates seizures in the developing brain
Dzhala, V. I., Talos, D. M., Sdrulla, D., Brumback, A. C., Mathews, G. C., Benke, T. A., Delpire, E. J., Jensen, F. E., & Staley, K. J. (2005) · Nature Medicine · doi:10.1038/nm1301 · Cited by 1,004
On the Origin of Interictal Activity in Human Temporal Lobe Epilepsy in Vitro
Cohen, I., Navarro, V., Clémenceau, S., Baulac, M., & Miles, R. (2002) · Science · doi:10.1126/science.1076510 · Cited by 1,001
Self-citationEpilepsy in patients with brain tumours: epidemiology, mechanisms, and management
van Breemen, M. S. M., Wilms, E. B., & Vecht, C. J. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70103-5 · Cited by 913
Staba, R. J., Wilson, C. L., Bragin, A., Fried, I., & Engel, J. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.4.1743 · Cited by 666
Perturbed Chloride Homeostasis and GABAergic Signaling in Human Temporal Lobe Epilepsy
Huberfeld, G., Wittner, L., Clémenceau, S., Baulac, M., Kaila, K., Miles, R., & Rivera, C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2761-07.2007 · Cited by 634
Self-citationGlutamate release promotes growth of malignant gliomas
Takano, T., Lin, J. H.-C., Arcuino, G., Gao, Q., Yang, J., & Nedergaard, M. (2001) · Nature Medicine · doi:10.1038/nm0901-1010 · Cited by 610
Cited by
Sorted by citations
Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning
Buzsáki, G. (2015) · Hippocampus · doi:10.1002/hipo.22488 · Cited by 1,759
Neuron–glia interactions in the pathophysiology of epilepsy
Patel, D. C., Tewari, B. P., Chaunsali, L., & Sontheimer, H. W. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0126-4 · Cited by 478
NKCC1 Chloride Importer Antagonists Attenuate Many Neurological and Psychiatric Disorders
Ben‐Ari, Y. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.07.001 · Cited by 249
Lemonnier, E., Villeneuve, N., Sonie, S., Serret, S., Rosier, A., Roue, M., Brosset, P., Viellard, M., Bernoux, D., Rondeau, S., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.10 · Cited by 218
Tewari, B. P., Chaunsali, L., Campbell, S. L., Patel, D. C., Goode, A. E., & Sontheimer, H. (2018) · Nature Communications · doi:10.1038/s41467-018-07113-0 · Cited by 208
Metadata
- Authors
- Pallud, J., Le Van Quyen, M., Bielle, F., Pellegrino, C., Varlet, P., Labussiere, M., Cresto, N., Dieme, M.-J., Baulac, M., Duyckaerts, C., Kourdougli, N., Chazal, G., Devaux, B., Rivera, C., Miles, R., Capelle, L., & Huberfeld, G.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Sorbonne Universités, University Pierre and Marie Curie (UPMC) University of Paris 06, F-75005 Paris, France.
- Sorbonne Université (FR)
- Inserm (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- University of Helsinki (FI)
- Corresponding author
- Bielle, Franck
- Pellegrino, Christophe
- Huberfeld, Gilles
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2014-07-09
- Volume
- 6
- Issue
- 244
- Pages
- 244ra89-244ra89
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4409113
- OpenAlex
- W2157338202
- Cited by
- 300
- References
- 64
- Citations by year
- 2026: 15 · 2025: 24 · 2024: 32 · 2023: 35 · 2022: 34 · 2021: 25 · 2020: 18 · 2019: 28 · 2018: 26 · 2017: 22 · 2016: 23 · 2015: 14 · 2014: 4
- FWCI
- 16.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- glioma, epileptogenicity, chloride homeostasis, KCC2, NKCC1, interictal epileptiform discharges, pyramidal neurons, interneurons, excitatory-inhibitory imbalance
- MeSH terms
- Action Potentials, Brain Neoplasms, Chlorides, Epilepsy, gamma-Aminobutyric Acid, Glioma, Glutamates, Humans, Interneurons, Neocortex
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