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Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells
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Four different T cell populations with different functions and migration patterns protect human skin.
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“Both CD8+ and CD4+ Trm have been identified in the human skin, lung, intestines, salivary glands, bone marrow, brain, spleen, tonsils, and lymph nodes [241, 244, 246, 253-259].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [255]
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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“TCM, as first described, were thought to be a subset of T cells that recirculated between the blood and lymph nodes and lacked tissue tropism (20).”
BackgroundInfluentialWHO-EORTC classification for cutaneous lymphomas
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- Gaide O., Emerson R. O., Jiang X., Nizza S., Desmarais C., Robins H., Clark R. A., Kupper T. S., Naive T cells give rise equally to TCR-identical TRM and TCM after skin antigen exposure, which exist in separate anatomic compartments and have different roles in long term memory. Nat. Med., in press.
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Metadata
- Authors
- Watanabe, R., Gehad, A., Yang, C., Scott, L. L., Teague, J. E., Schlapbach, C., Elco, C. P., Huang, V., Matos, T. R., Kupper, T. S., & Clark, R. A.
- Affiliations
- Brigham and Women's Hospital (US)
- University of Bern (CH)
- Corresponding author
- Clark, Rachael A.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2015-03-18
- Volume
- 7
- Issue
- 279
- Pages
- 279ra39-279ra39
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4425193
- OpenAlex
- W2166321278
- Cited by
- 569
- References
- 34
- Citations by year
- 2026: 23 · 2025: 44 · 2024: 40 · 2023: 43 · 2022: 58 · 2021: 84 · 2020: 58 · 2019: 56 · 2018: 52 · 2017: 54 · 2016: 37 · 2015: 18
- FWCI
- 26.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- BORIS (University Library Bern) (submittedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Open Access CRIS of the University of Bern
- Funders
- National Institute of Allergy and Infectious Diseases (R01 AI097128)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (R01 AR063962)
- NIAMS (R01 AR056720)
- Damon Runyon Clinical Investigator Award
- Leukemia and Lymphoma Society
- Swiss National Science Foundation
- NIH/National Cancer Institute (P50 CA9368305)
- Fondation Rene Touraine
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- skin-resident memory T cells, central memory T cells, alemtuzumab, CD103, CD69, CCR7, L-selectin, cutaneous T-cell lymphoma, T cell migration, T cell effector function, human skin
- MeSH terms
- Alemtuzumab, CD69 Antigens, Animals, Antigens, Differentiation, T-Lymphocyte, Flow Cytometry, Humans, Interleukin-2, Phenotype, Skin, T-Lymphocytes, CD4-Positive T-Lymphocytes, Keratinocytes, Antigens, CD, Mice, SCID, Mice, Inbred NOD, CD8-Positive T-Lymphocytes, Lectins, C-Type, Integrin alpha Chains, Mice, Antibodies, Monoclonal, Humanized
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