Cited by 570T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisDermatology and Skin Diseases

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Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells

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Watanabe, Rei, Gehad, Ahmed, Yang, Chao, Scott, Laura L., Teague, Jessica E., Schlapbach, Christoph, Elco, Christopher P., Huang, Victor, Matos, Tiago R., Kupper, Thomas S., Clark, Rachael A.·2015·Science Translational Medicine

DOI 10.1126/scitranslmed.3010302PMC PMC4425193

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Four different T cell populations with different functions and migration patterns protect human skin.

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Gaide O., Emerson R. O., Jiang X., Nizza S., Desmarais C., Robins H., Clark R. A., Kupper T. S., Naive T cells give rise equally to TCR-identical TRM and TCM after skin antigen exposure, which exist in separate anatomic compartments and have different roles in long term memory. Nat. Med., in press.

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Authors: Watanabe, R., Gehad, A., Yang, C., Scott, L. L., Teague, J. E., Schlapbach, C., Elco, C. P., Huang, V., Matos, T. R., Kupper, T. S., & Clark, R. A.
Affiliations: Brigham and Women's Hospital (US)
University of Bern (CH)
Corresponding author: Clark, Rachael A.
ORCID: Watanabe, Rei
Gehad, Ahmed
Yang, Chao
Teague, Jessica E.
Schlapbach, Christoph
Huang, Victor
Matos, Tiago R.
Kupper, Thomas S.
Clark, Rachael A.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2015-03-18
Volume: 7
Issue: 279
Pages: 279ra39-279ra39
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3010302
PMC: PMC4425193
OpenAlex: W2166321278
Cited by: 569
References: 34
Citations by year: 2026: 23 · 2025: 44 · 2024: 40 · 2023: 43 · 2022: 58 · 2021: 84 · 2020: 58 · 2019: 56 · 2018: 52 · 2017: 54 · 2016: 37 · 2015: 18
FWCI: 26.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 366 d)
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
BORIS (University Library Bern) (submittedVersion, other-oa)
Pure Amsterdam UMC (submittedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
Open Access CRIS of the University of Bern
Funders: National Institute of Allergy and Infectious Diseases (R01 AI097128)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (R01 AR063962)
NIAMS (R01 AR056720)
Damon Runyon Clinical Investigator Award
Leukemia and Lymphoma Society
Swiss National Science Foundation
NIH/National Cancer Institute (P50 CA9368305)
Fondation Rene Touraine
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords: skin-resident memory T cells, central memory T cells, alemtuzumab, CD103, CD69, CCR7, L-selectin, cutaneous T-cell lymphoma, T cell migration, T cell effector function, human skin
MeSH terms: Alemtuzumab, CD69 Antigens, Animals, Antigens, Differentiation, T-Lymphocyte, Flow Cytometry, Humans, Interleukin-2, Phenotype, Skin, T-Lymphocytes, CD4-Positive T-Lymphocytes, Keratinocytes, Antigens, CD, Mice, SCID, Mice, Inbred NOD, CD8-Positive T-Lymphocytes, Lectins, C-Type, Integrin alpha Chains, Mice, Antibodies, Monoclonal, Humanized

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Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells

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