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Limitations of Jaw Movement in Fibrodysplasia Ossificans Progressiva: A Review

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Cellular Plasticity in Musculoskeletal Development, Regeneration, and Disease

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Genetic Disorders of Heterotopic Ossification

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Characterization of Fibrodysplasia Ossificans Progessiva relevant Acvr1/Acvr2 Activin receptors in medaka (Oryzias latipes)

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Novel insights from human induced pluripotent stem cells on origins and roles of fibro/adipogenic progenitors as heterotopic ossification precursors

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Molecular Developmental Biology of Fibrodysplasia Ossificans Progressiva: Measuring the Giant by Its Toe

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Current and emerging treatment modalities for fibrodysplasia ossificans progressiva

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Pharmacokinetics of Zilurgisertib With and Without Food from Single and Multiple Ascending Dose Phase 1 Studies in Healthy Adults

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Garetosmab in Fibrodysplasia Ossificans Progressiva: Clinical Pharmacology Results from the Phase 2 LUMINA‐1 Trial

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Human Mutations Affecting Reprogramming into Induced Pluripotent Stem Cells

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Methods in lineage tracing

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Transcriptomic Differences Underlying the Activin-A Induced Large Osteoclast Formation in Both Healthy Control and Fibrodysplasia Ossificans Progressiva Osteoclasts

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Muscle and Bone: Combating the Evil Side of the Connection

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Actionable disease insights from bedside-to-bench investigation in fibrodysplasia ossificans progressiva

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PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossificationPreprint

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Discovery and Characterization of Zilurgisertib, a Potent and Selective Inhibitor of Activin Receptor-like Kinase-2 (ALK2) for the Treatment of Fibrodysplasia Ossificans Progressiva

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SpA in animal models: Unraveling the duality of inflammation and bone formation

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Role of endocrinal dysregulations in traumatic heterotopic ossification pathogenesis

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Releasing the FKBP12 brake on hepcidin

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Sex as a Critical Variable in Basic and Pre-Clinical Studies of Fibrodysplasia Ossificans Progressiva

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Case Report: Unable to Jump Like a Kangaroo Due to Myositis Ossificans Circumscripta

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Signal Transduction: Gain of Activin Turns Muscle into Bone

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Molecular mechanisms for activation of mutant activin receptor-like kinase 2 in fibrodysplasia ossificans progressiva

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The TGFβ superfamily in Lisbon: navigating through development and disease

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Fibrodysplasia Ossificans Progressiva – FOP

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A Case Report of Heterotopic Ossification Caused by High-Voltage Electric Injury

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Combined rapamycin and mesenchymal stem/stromal cells derived from induced pluripotent stem cells-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva

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Physiological and Pathological Consequences of Vascular BMP Signaling

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Hints on transcriptional control of essential players in heterotopic ossification of Fibrodysplasia Ossificans Progressiva

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Association of Rs12997 Variant in the Acvr1 Gene: A Member of Bone Morphogenic Protein Signaling Pathway with Primary Open-Angle Glaucoma in a Saudi Cohort

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Heterotopic Ossification

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Editorial: Innovative Models in Bone Biology: What can be Learned From Rare Bone Diseases?

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Lineage Determination of Osteoblasts and Chondrocytes

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Microarchitecture of Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva: An HR-pQCT Case Series

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Advancements in mechanisms and drug treatments for fibrodysplasia ossificans progressiva

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Identifying global trends from case reports of fibrodysplasia ossificans progressiva: a scoping review

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Fibrodysplasia ossificans progressiva: from clinical complexity to therapeutic opportunity

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Advances in genetic and pharmacological therapeutic strategies for fibrodysplasia ossificans progressiva

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Content Validation of the Flares Diary: A Qualitative Analysis of the Flares Experience Within the Fibrodysplasia Ossificans Progressiva (FOP) Population

Baldasaro, J., Sanchez, R. J., Hartford, C., Dahir, K. M., Keen, R. W., Funck‐Brentano, T., Pignolo, R. J., Davis, M., & Altman, D. E. (2026) · Advances in Therapy · doi:10.1007/s12325-026-03506-6 · Cited by 1

Single-base 2′OMe-modified LNA and MOE gapmers selectively silence ACVR1R206H in fibrodysplasia ossificans progressiva

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Macrophage-driven pathological ossification of the posterior longitudinal ligament: mechanistic insights and therapeutic opportunities

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Heterotopic Ossification

Agrawal, K., Bhure, U., Chow, G., Armstrong, T., & Strobel, K. (2023) · Springer eBooks · doi:10.1007/978-3-031-26449-8_233 · Cited by 1

Comparison of PET/CT versus CT only in the assessment of new heterotopic ossification bone lesions in patients with fibrodysplasia ossificans progressiva

Trotter, D. E. G., McGinniss, J., Mohammadi, K. A., Musser, B. J., Herman, G. A., Mellis, S. J., & Economides, A. N. (2024) · Bone · doi:10.1016/j.bone.2024.117280 · Cited by 1

Molecular Control of Cartilage Differentiation

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Penicillic Acid Congener, a New Inhibitor of BMP-Induced Alkaline Phosphatase Activity in Myoblasts, Produced by the Fungus Penicillium sp. BF-0343

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Molecular Genetics of Fibrodysplasia Ossificans Progressiva

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Heterotopic Ossification and Calcification

Chen, K., Ding, N., & Kan, L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.66152-4 · Cited by 1

Molecular Genetics of Fibrodysplasia Ossificans Progressiva

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PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossificationPreprint

Valer, J. A., Deber, A., Wits, M., Pimenta-Lopes, C., Goumans, M., Rosa, J. L., Sánchez‐Duffhues, G., & Ventura, F. (2023) · eLife · doi:10.7554/elife.91779.1 · Cited by 1

Coordinate regulation of Activin and Bone Morphogenetic Protein signaling by a lysosomal trafficking switchPreprint

Hom, W. W., Aykul, S., Panagis, L., Patel, K., Brydges, S. D., Goebel, E. J., Lydon, K. N., Lees‐Shepard, J. B., Hatsell, S. J., Idone, V. J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.29.577837 · Cited by 1

Anti-activin treatment increases T cell infiltration in breast and pancreatic tumours and promotes survival in a SMAD4-null mouse pancreatic cancer modelPreprint

McCluney, S. J., Park, D., Miller, D. S. J., Mehić, M., Bloxham, R., de Vries, E., Wang, X., Boeing, S., D’Antonio, L., Wieteska, Ł., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.13.659133 · Cited by 1

Towards targeting overactive BMP signaling in Fibrodysplasia Ossificans Progressiva

van Staalduinen, J., Sánchez‐Duffhues, G., & ten Dijke, P. (2015) · Repository hosted by TU Delft Library (TU Delft)

Novel Oncogenic Drivers in Pediatric Gliomagenesis

Diaz, A. (2016) · doi:10.21007/etd.cghs.2016.0396

Novel In Vitro Assay Models to Study Osteogenesis and Chondrogenesis for Human Skeletal Disorders

Katagiri, T. (2017) · Springer eBooks · doi:10.1007/978-3-319-47507-3_5

BMP Signaling in Fibrodysplasia Ossificans Progressiva, a Rare Genetic Disorder of Heterotopic Ossification

Shore, E. M., & Kaplan, F. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-47507-3_14

The TGF‐β Superfamily in Bone Formation and Maintenance

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Fibrodysplasie ossifiante progressive et hétéroplasie ossifiante progressive

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Multifunctional Alleles: A novel method for the generation of “All-In-One” null and conditional alleles

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Genetic Skeletal Disorders in Humans

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Generation of an induced pluripotent stem cell line (TRNDi012-B) from Fibrodysplasia Ossificans Progressiva (FOP) patient carrying a heterozygous mutation c. 617G > A in the ACVR1 gene

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Reviewer #1 (Public Review): PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification

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eLife Assessment: PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification

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Reviewer #1 (Public Review): PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification

Valer, J. A., Deber, A., Wits, M., et al. (2024) · eLife · doi:10.7554/elife.91779.2.sa1

Reviewer #2 (Public Review): PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification

Valer, J. A., Deber, A., Wits, M., et al. (2024) · eLife · doi:10.7554/elife.91779.2.sa0

Author response: PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification

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PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossificationPreprint

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Targeting to BMP9 to restrain flare-up of fibrodysplasia ossificans progressiva

Li, Q., & Yuan, Q. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00180-5

FOP: From Biomolecules to Hope

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PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossificationPreprint

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Progressive Soft Tissue Swelling in a Pediatric Patient Leading to the Diagnosis of Fibrodysplasia Ossificans Progressiva: A Case Report

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Morpholino-Mediated Exon Skipping Targeting Human ACVR1/ALK2 for Fibrodysplasia Ossificans Progressiva

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