Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice
Abstract
Muscle-directed Smad7 gene delivery prevents the loss of skeletal muscle mass and strength in mouse models of cachexia, an important contributor to poor prognosis in patients with advanced cancer.
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Smad6 and 7 prevent receptor-mediated activation of Smad1/5/8 and Smad2/3.
“For instance, the inhibitor proteins Smad6 and 7 prevent receptor-mediated activation of Smad1/5/8 and Smad2/321.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [21]
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Self-citation
- Authors
- Winbanks, C. E., Murphy, K. T., Bernardo, B. C., Qian, H., Liu, Y., Sepulveda, P. V., Beyer, C., Hagg, A., Thomson, R. E., Chen, J. L., Walton, K. L., Loveland, K. L., McMullen, J. R., Rodgers, B. D., Harrison, C. A., Lynch, G. S., & Gregorevic, P.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- The University of Melbourne (AU)
- Hudson Institute of Medical Research (AU)
- Monash University (AU)
- Washington State University (US)
- Corresponding author
- Gregorevic, Paul
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2016-07-20
- Volume
- 8
- Issue
- 348
- Pages
- 348ra98-348ra98
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2490258630
- Cited by
- 95
- References
- 51
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 14 · 2023: 12 · 2022: 11 · 2021: 7 · 2020: 10 · 2019: 7 · 2018: 12 · 2017: 7
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council (1023178, 1013533, 1046782)
- National Science Foundation (IOS1147275)
- Muscular Dystrophy Association
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- cancer cachexia, muscle atrophy, Smad7, adeno-associated virus vectors, gene delivery, Smad2/3 signaling, skeletal muscle atrophy, myocardium, MuRF1, atrogin-1, ubiquitin ligase
- MeSH terms
- Tripartite Motif Proteins, Animals, Muscle Proteins, Muscular Atrophy, Myocardium, Neoplasms, Phosphorylation, Blotting, Western, Signal Transduction, Muscle, Skeletal, Activin Receptors, Type II, Ubiquitin-Protein Ligases, SKP Cullin F-Box Protein Ligases, Mice, Smad2 Protein, Smad3 Protein, Smad7 Protein
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