Cited by 97Muscle Physiology and DisordersNutrition and Health in AgingTGF-β signaling in diseases

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

Winbanks, Catherine E., Murphy, Kate T., Bernardo, Bianca C., Qian, Hongwei, Liu, Yingying, Sepulveda, Patricio V., Beyer, Claudia, Hagg, Adam +9 more·2016·Science Translational Medicine

Abstract

Muscle-directed Smad7 gene delivery prevents the loss of skeletal muscle mass and strength in mouse models of cachexia, an important contributor to poor prognosis in patients with advanced cancer.

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Crossref · 10.1126/scitranslmed.aac4976

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51 of 51 references verified0 citation errors · 0 not checkable

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Authors
Winbanks, C. E., Murphy, K. T., Bernardo, B. C., Qian, H., Liu, Y., Sepulveda, P. V., Beyer, C., Hagg, A., Thomson, R. E., Chen, J. L., Walton, K. L., Loveland, K. L., McMullen, J. R., Rodgers, B. D., Harrison, C. A., Lynch, G. S., & Gregorevic, P.
Affiliations
  • Baker Heart and Diabetes Institute (AU)
  • The University of Melbourne (AU)
  • Hudson Institute of Medical Research (AU)
  • Monash University (AU)
  • Washington State University (US)
Corresponding author
Gregorevic, Paul
Venue
Science Translational Medicine
Published
2016-07-20
Volume
8
Issue
348
Pages
348ra98-348ra98
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2490258630
Cited by
95
References
51
Citations by year
2026: 4 · 2025: 11 · 2024: 14 · 2023: 12 · 2022: 11 · 2021: 7 · 2020: 10 · 2019: 7 · 2018: 12 · 2017: 7
FWCI
4.50
Type
journal article
Language
en
Open access
closed
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Health and Medical Research Council (1023178, 1013533, 1046782)
  • National Science Foundation (IOS1147275)
  • Muscular Dystrophy Association
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords
cancer cachexia, muscle atrophy, Smad7, adeno-associated virus vectors, gene delivery, Smad2/3 signaling, skeletal muscle atrophy, myocardium, MuRF1, atrogin-1, ubiquitin ligase
MeSH terms
Tripartite Motif Proteins, Animals, Muscle Proteins, Muscular Atrophy, Myocardium, Neoplasms, Phosphorylation, Blotting, Western, Signal Transduction, Muscle, Skeletal, Activin Receptors, Type II, Ubiquitin-Protein Ligases, SKP Cullin F-Box Protein Ligases, Mice, Smad2 Protein, Smad3 Protein, Smad7 Protein

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