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Virtual typing by people with tetraplegia using a self-calibrating intracortical brain-computer interface
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Individuals with tetraplegia are able to type self-paced for hours across multiple days using a self-calibrating point-and-click intracortical brain-computer interface.
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“Prior BCI studies have shown that the motor intention for gross motor skills, such as reaching, grasping or moving a computer cursor, remains neurally encoded in motor cortex after paralysis1–7.”
From High-performance brain-to-text communication via handwriting (2021) · cites this paper as [6]
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“any differences in average firing rates observed between two behaviors collected in separate blocks could be due to spurious drifts in firing rates known to occur across time63,64.”
From Inner speech in motor cortex and implications for speech neuroprostheses (2025) · cites this paper as [63]
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“While the ‘isolated ’verbal behavior experiments (section 3) allowed us to explore a large number of behaviors, it did not allow us to assess differences in neural representation between behaviors, because any differences between blocks could also be caused by spurious neural nonstationarity known to be occur in microelectrode array recordings63,64.”
From Inner speech in motor cortex and implications for speech neuroprostheses (2025) · cites this paper as [63]
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Metadata
- Authors
- Jarosiewicz, B., Sarma, A. A., Bacher, D., Masse, N. Y., Simeral, J. D., Sorice, B., Oakley, E. M., Blabe, C., Pandarinath, C., Gilja, V., Cash, S. S., Eskandar, E. N., Friehs, G., Henderson, J. M., Shenoy, K. V., Donoghue, J. P., & Hochberg, L. R.
- Affiliations
- Brown University (US)
- Massachusetts General Hospital (US)
- Stanford Medicine (US)
- Harvard University (US)
- Rhode Island Hospital (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Jarosiewicz, Beata
- Friehs, Gerhard
- Donoghue, John P.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2015-11-11
- Volume
- 7
- Issue
- 313
- Pages
- 313ra179-313ra179
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4765319
- OpenAlex
- W2243428647
- Cited by
- 340
- References
- 50
- Citations by year
- 2026: 26 · 2025: 31 · 2024: 34 · 2023: 35 · 2022: 25 · 2021: 29 · 2020: 44 · 2019: 23 · 2018: 32 · 2017: 39 · 2016: 21 · 2015: 1
- FWCI
- 18.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- NIH: National Institute on Deafness and Other Communication Disorders (R01DC009899, R01DC014034)
- National Institute of Neurological Disorders and Stroke (RO1NS066311-S1)
- NICHD (RC1HD063931)
- Doris Duke Charitable Foundation
- Craig H. Neilsen Foundation
- Massachusetts General Hospital (MGH)
- Office of Research and Development, Rehabilitation R&D Service, Department of Veterans Affairs (B6310W, B6453R, B6459L, A6779I)
- National Institute of Child Health and Human_National Center for Medical Rehabilitation Research (NICHD-NCMRR) (N01HD53403)
- Joseph Martin Prize for Basic Research
- Katie Samson Foundation
- Stanford Institute for Neuro-Innovation and Translational Neuroscience
- Stanford BioX-NeuroVentures
- Garlick Family
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Computer Science › Human-Computer Interaction › Gaze Tracking and Assistive Technology
- Keywords
- intracortical brain-computer interfaces, tetraplegia, self-calibration, neural decoding, augmentative and alternative communication, paralysis
- MeSH terms
- Amyotrophic Lateral Sclerosis, Calibration, Female, Humans, Male, Motor Cortex, Quadriplegia, Self-Help Devices, Stroke, Brain-Computer Interfaces
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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