Cortical control of a prosthetic arm for self-feeding

Velliste, Meel; Perel, Sagi; Spalding, M. Chance; Whitford, Andrew S.; Schwartz, Andrew B.

doi:10.1038/nature06996

Cited by 1,591EEG and Brain-Computer InterfacesNeuroscience and Neural EngineeringMotor Control and Adaptation

Cortical control of a prosthetic arm for self-feeding

Velliste, Meel, Perel, Sagi, Spalding, M. Chance, Whitford, Andrew S., Schwartz, Andrew B.·2008·Nature

DOI 10.1038/nature06996

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Abstract

Arm movement is well represented in populations of neurons recorded from the motor cortex. Cortical activity patterns have been used in the new field of brain-machine interfaces to show how cursors on computer displays can be moved in two- and three-dimensional space. Although the ability to move a cursor can be useful in its own right, this technology could be applied to restore arm and hand function for amputees and paralysed persons. However, the use of cortical signals to control a multi-jointed prosthetic device for direct real-time interaction with the physical environment ('embodiment') has not been demonstrated. Here we describe a system that permits embodied prosthetic control; we show how monkeys (Macaca mulatta) use their motor cortical activity to control a mechanized arm replica in a self-feeding task. In addition to the three dimensions of movement, the subjects' cortical signals also proportionally controlled a gripper on the end of the arm. Owing to the physical interaction between the monkey, the robotic arm and objects in the workspace, this new task presented a higher level of difficulty than previous virtual (cursor-control) experiments. Apart from an example of simple one-dimensional control, previous experiments have lacked physical interaction even in cases where a robotic arm or hand was included in the control loop, because the subjects did not use it to interact with physical objects-an interaction that cannot be fully simulated. This demonstration of multi-degree-of-freedom embodied prosthetic control paves the way towards the development of dexterous prosthetic devices that could ultimately achieve arm and hand function at a near-natural level.

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The use of implantable intrafascicular PNS interfaces is of great potential, as confirmed in previous experiments in humans.
“Among the different approaches for restoring the link between the external world and the nervous system, the use of implantable intrafascicular PNS interfaces is of great potential, as confirmed in previous experiments in humans [6,7].”
From Decoding of grasping information from neural signals recorded using peripheral intrafascicular interfaces (2011) · cites this paper as [6]
LIFEs have been recently used to control artificial devices showing good results during short-term trials with human amputees.
“In fact, after appropriate control in experimental models to test their biocompatibility and efficacy [18], LIFEs have been recently used to control artificial devices [6,7,22-25] showing good results during short-term trials with human amputees.”
From Decoding of grasping information from neural signals recorded using peripheral intrafascicular interfaces (2011) · cites this paper as [6]

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Authors: Velliste, M., Perel, S., Spalding, M. C., Whitford, A. S., & Schwartz, A. B.
Affiliations: University of Pittsburgh (US)
Corresponding author: Schwartz, Andrew B.
ORCID: Spalding, M. Chance
Schwartz, Andrew B.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2008-05-28
Volume: 453
Issue: 7198
Pages: 1098-1101
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature06996
OpenAlex: W2117151438
Cited by: 1,591
References: 31
Citations by year: 2026: 23 · 2025: 37 · 2024: 40 · 2023: 58 · 2022: 45 · 2021: 66 · 2020: 61 · 2019: 74 · 2018: 86 · 2017: 89 · 2016: 95 · 2015: 107 · 2014: 156 · 2013: 151 · 2012: 119
FWCI: 66.19
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health (5r01ns050256-05)
U.S. Public Health Service (N01-2-2346)
National Institute of Neurological Disorders and Stroke (NS-050256)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Keywords: brain-computer interface, motor cortex, prosthetic arm, embodiment, robotic arm control, real-time neural decoding, macaque, neuroprosthetics, upper limb paralysis, multi-degree-of-freedom control
MeSH terms: Algorithms, Animals, Arm, Biomechanical Phenomena, Eating, Feeding Behavior, Food, Macaca mulatta, Man-Machine Systems, Motion, Motor Cortex, Robotics

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Cortical control of a prosthetic arm for self-feeding

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