The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target
Abstract
Squalene epoxidase is a therapeutic target in hepatocellular carcinoma arising from nonalcoholic fatty liver disease.
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Hepatocyte-specific SQLE transgenic mice have increased SQLE protein abundance, develop hepatosteatosis, and have a similar increase in the NADP+/NADPH ratio.
“Intriguingly, hepatocyte-specific SQLE transgenic mice which, similar to MARCHF6LKO mice, have increased SQLE protein abundance developed hepatosteatosis and had a similar increase in the NADP+/NADPH ratio [60].”
From Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis (2026) · cites this paper as [60]
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Cites
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A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
Goldstein, J. L., & Brown, M. S. (2015) · Cell · doi:10.1016/j.cell.2015.01.036 · Cited by 1,233
Younossi, Z. M., Otgonsuren, M., Henry, L., Venkatesan, C., Mishra, A., Erario, M., & Hunt, S. (2015) · Hepatology · doi:10.1002/hep.28123 · Cited by 802
White, D. L., Kanwal, F., & El–Serag, H. B. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.10.001 · Cited by 766
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Cited by
Sorted by citations
Mechanisms and disease consequences of nonalcoholic fatty liver disease
Loomba, R., Friedman, S. L., & Shulman, G. I. (2021) · Cell · doi:10.1016/j.cell.2021.04.015 · Cited by 2,002
Zhang, X., Coker, O. O., Chu, E. S., Fu, K., Lau, H. C. H., Wang, Y.-X., Chan, A. W. H., Wei, H., Yang, X., Sung, J. J. Y., et al. (2021) · Gut · doi:10.1136/gutjnl-2019-319664 · Cited by 841
Self-citationSachdev, V., van Loon, N. M., Kingma, J., Ottenhoff, R., Tan, J. M. E., van den Berg, M., Duijst, S., Jongejan, A., Levels, J. H. M., Rensen, P. C. N., et al. (2026) · Molecular Metabolism · doi:10.1016/j.molmet.2026.102379 · Cited by 1
Metadata
- Authors
- Liu, D., Wong, C. C., Fu, L., Chen, H., Zhao, L., Li, C., Zhou, Y., Zhang, Y., Xu, W., Yang, Y., Wu, B., Cheng, G., Lai, P. B.-S., Wong, N., Sung, J. J. Y., & Yu, J.
- Affiliations
- Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, 999077, Hong Kong.
- Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
- Department of Surgery, The Chinese University of Hong Kong, 999077, Hong Kong.
- Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, 999077, Hong Kong.
- Venue
- Science Translational Medicine
- Published
- 2018-04-18
- Volume
- 10
- Issue
- 437
- ISSN
- 1946-6234
- 1946-6242
- Cited by
- 257
- References
- 4
- Language
- en
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