Oxidative stress, DNA methylation and carcinogenesis

Franco, Rodrigo; Schoneveld, Onard; Georgakilas, Alexandros G.; Panayiotidis, Mihalis I.

doi:10.1016/j.canlet.2008.02.026

Cited by 603Epigenetics and DNA MethylationCancer and biochemical researchRedox biology and oxidative stress

Oxidative stress, DNA methylation and carcinogenesis

Franco, Rodrigo, Schoneveld, Onard, Georgakilas, Alexandros G., Panayiotidis, Mihalis I.·2008·Cancer Letters

DOI 10.1016/j.canlet.2008.02.026

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Abstract

Transformation of a normal cell to a malignant one requires phenotypic changes often associated with each of the initiation, promotion and progression phases of the carcinogenic process. Genes in each of these phases acquire alterations in their transcriptional activity that are associated either with hypermethylation-induced transcriptional repression (in the case of tumor suppressor genes) or hypomethylation-induced activation (in the case of oncogenes). Growing evidence supports a role of ROS-induced generation of oxidative stress in these epigenetic processes and as such we can hypothesize of potential mode(s) of action by which oxidative stress modulates epigenetic regulation of gene expression. This is of outmost importance given that various components of the epigenetic pathway and primarily aberrant DNA methylation patterns are used as potential biomarkers for cancer diagnosis and prognosis.

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Oxidative stress may lead to epigenetic alterations and aberrant DNA methylation which predispose susceptible cell populations to malignant transformation.
“Oxidative stress may lead to epigenetic alterations and aberrant DNA methylation which predispose susceptible cell populations to malignant transformation [15].”
From Clear cell carcinoma arising from abdominal wall endometriosis—A report on two cases and literature review (2022) · cites this paper as [15]

Nuclear factor-κB in cancer development and progression
Karin, M. (2006) · Nature · doi:10.1038/nature04870 · Cited by 3,519 · see citing works
Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia
Baylln, S. B., Herman, J. G., Graff, J. R., Vertino, P. M., & Issa, J. J. (1997) · Advances in cancer research · doi:10.1016/s0065-230x(08)60702-2 · Cited by 1,913 · see citing works
Oxyradicals and DNA damage
Marnett, L. J. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.361 · Cited by 1,887 · see citing works
The Role of Oxidative Stress in Carcinogenesis
Klaunig, J. E., & Kamendulis, L. M. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121851 · Cited by 1,537 · see citing works
Oxidative DNA damage and disease: induction, repair and significance
Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372 · see citing works
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362 · see citing works
Triggering and modulation of apoptosis by oxidative stress
Chandra, J., Samali, A., & Orrenius, S. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00302-6 · Cited by 1,335 · see citing works
Oxidative stress and cancer: Have we moved forward?
Halliwell, B. (2007) · Biochemical Journal · doi:10.1042/bj20061131 · Cited by 1,302 · see citing works
DNA methylation and gene silencing in cancer
Baylin, S. B. (2005) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0354 · Cited by 1,156 · see citing works
Reactive oxygen species in tumor progression
Peter, S. F. (2005) · Frontiers in bioscience · doi:10.2741/1667 · Cited by 957 · see citing works
The essentials of DNA methylation
Bird, A. (1992) · Cell · doi:10.1016/0092-8674(92)90526-i · Cited by 948 · see citing works
Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues
Kuchino, Y., Mori, F., Kasai, H., Inoue, H., Iwai, S., Miura, K., Ohtsuka, E., & Nishimura, S. (1987) · Nature · doi:10.1038/327077a0 · Cited by 770 · see citing works
Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2)
Valinluck, V. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh739 · Cited by 756 · see citing works
DNA methylation and histone modifications: teaming up to silence genes
Fuks, F. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.08.002 · Cited by 643 · see citing works
5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes
Rideout, W. M., Coetzee, G. A., Olumi, A. F., & Jones, P. A. (1990) · Science · doi:10.1126/science.1697983 · Cited by 640 · see citing works
Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells: 8-oxoguanine in DNA induces targeted G.C-->T.A transversions in simian kidney cells.
Moriya, M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.1122 · Cited by 418 · see citing works
DNA methylation errors and cancer.
Jones, P. A. (1996) · PubMed · Cited by 399 · see citing works
Reactive Oxygen Species Produced by NAD(P)H Oxidase Inhibit Apoptosis in Pancreatic Cancer Cells
Vaquero, E. C., Edderkaoui, M., Pandol, S. J., Gukovsky, I., & Gukovskaya, A. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400078200 · Cited by 366 · see citing works
Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia.
Esteller, M., Corn, P. G., Ureña, J. M., Gabrielson, E. W., Baylin, S. B., & Herman, J. G. (1998) · PubMed · Cited by 356 · see citing works
Chromatin modifier enzymes, the histone code and cancer
Santos-Rosa, H., & Caldas, C. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.08.010 · Cited by 336 · see citing works
High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.
El‐Deiry, W. S., Nelkin, B. D., Celano, P., Yen, R. W. C., Falco, J., Hamilton, S. R., & Baylin, S. B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3470 · Cited by 311 · see citing works
Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma.
Hagen, T. M., Huang, S., Curnutte, J. T., Fowler, P., Martinez, V., Wehr, C. M., Ames, B. N., & Chisari, F. V. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12808 · Cited by 310 · see citing works
Free radical adducts induce alterations in DNAcytosine methylation.
Weitzman, S. A., Turk, P. W., Milkowski, D. H., & Kozlowski, K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1261 · Cited by 299 · see citing works
Effect of diet on cancer development: is oxidative DNA damage a biomarker?1,2 1This article is part of a series of reviews on “Oxidative DNA Damage and Repair.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Miral Dizdaroglu
Halliwell, B. B. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00808-0 · Cited by 258 · see citing works
Inhibition of DNA methylation by chemical carcinogens in vitro
Wilson, V. L., & Jones, P. A. (1983) · Cell · doi:10.1016/0092-8674(83)90514-7 · Cited by 254 · see citing works
An epigenetic perspective on the free radical theory of development
Hitchler, M. J., & Domann, F. E. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.06.027 · Cited by 237 · see citing works
Detailed methylation analysis of the glutathione S-transferase π (GSTP1) gene in prostate cancer
Millar, D., Ow, K. T., Paul, C. L., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1202415 · Cited by 228 · see citing works
DNA adduct 8-hydroxyl-2′-deoxyguanosine (8-hydroxyguanine) affects function of human DNA methyltransferase
Turk, P. W., Laayoun, A., Smith, S. S., & Weitzman, S. A. (1995) · Carcinogenesis · doi:10.1093/carcin/16.5.1253 · Cited by 226 · see citing works
Invasive Potential Induced under Long-Term Oxidative Stress in Mammary Epithelial Cells
Mori, K., Shibanuma, M., & Nose, K. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1725 · Cited by 197 · see citing works
DNA methylation and cancer therapy: new developments and expectations
Esteller, M. (2004) · Current Opinion in Oncology · doi:10.1097/01.cco.0000147383.04709.10 · Cited by 184 · see citing works
In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.
Xiao, W., & Samson, L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2117 · Cited by 181 · see citing works
Silencing of GSTP1 gene by CpG island DNA hypermethylation in HBV-associated hepatocellular carcinomas.
Zhong, S., Tang, M., Yeo, W., et al. (2002) · PubMed · Cited by 175 · see citing works
DNA methylation and the association between genetic and epigenetic changes: relation to carcinogenesis
Wachsman, J. T. (1997) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(97)00003-1 · Cited by 143 · see citing works
AIF suppresses chemical stress‐induced apoptosis and maintains the transformed state of tumor cells
Urbano, A., Lakshmanan, U., Choo, P. H., Kwan, J., Ng, P. Y., Guo, K., Dhakshinamoorthy, S., & Porter, A. G. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600746 · Cited by 140 · see citing works
Epigenetic mechanisms of chemical carcinogenesis
Klaunig, J. E., Kamendulis, L. M., & Xu, Y. (2000) · Human & Experimental Toxicology · doi:10.1191/096032700701546442 · Cited by 115 · see citing works
Savior and slayer: the two faces of p53
Bensaad, K., & Vousden, K. H. (2005) · Nature Medicine · doi:10.1038/nm1205-1278 · Cited by 113 · see citing works
The Effect of γ Radiation on DNA Methylation
Kalinich, J. F., Catravas, G. N., & Snyder, S. L. (1989) · Radiation Research · doi:10.2307/3577319 · Cited by 108 · see citing works
Epigenetic Regulation of Manganese Superoxide Dismutase Expression in Human Breast Cancer Cells
Hitchler, M. J., Wikainapakul, K., Yu, L., Powers, K. M., Attatippaholkun, W., & Domann, F. E. (2006) · Epigenetics · doi:10.4161/epi.1.4.3401 · Cited by 97 · see citing works
5-Methyl-2'-deoxycytidine in single-stranded DNA can act in cis to signal de novo DNA methylation.
Christman, J. K., Sheikhnejad, G., Marasco, C. J., & Sufrin, J. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7347 · Cited by 91 · see citing works
Suppression of Metallothionein Gene Expression in a Rat Hepatoma Because of Promoter-specific DNA Methylation
Ghoshal, K., Majumder, S., Li, Z., Dong, X. C., & Jacob, S. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.539 · Cited by 89 · see citing works
Blocking tumor cell eicosanoid synthesis by GPx4 impedes tumor growth and malignancy
Heirman, I., Ginneberge, D., Brigelius‐Flohé, R., Hendrickx, N., Agostinis, P., Brouckaert, P., Rottiers, P., & Grooten, J. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.033 · Cited by 87 · see citing works
DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer
Ruth E Board, Knight, L., Greystoke, A., Blackhall, F. H., Hughes, A. M., Dive, C., & Ranson, M. (2007) · Biomarker Insights · doi:10.1177/117727190700200003 · Cited by 79 · see citing works
Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines
Hurt, E. M., Thomas, S. B., Peng, B. H., & Farrar, W. L. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6604000 · Cited by 76 · see citing works
The study using wild-type and Ogg1 knockout mice exposed to potassium bromate shows no tumor induction despite an extensive accumulation of 8-hydroxyguanine in kidney DNA
Arai, T., Kelly, V. P., Minowa, O., Noda, T., & Nishimura, S. (2006) · Toxicology · doi:10.1016/j.tox.2006.01.004 · Cited by 73 · see citing works
DNA methylation in circulating tumour DNA as a biomarker for cancer.
Ruth E Board, Knight, L., Greystoke, A., Blackhall, F. H., Hughes, A. M., Dive, C., & Ranson, M. (2008) · PubMed Central · Cited by 72 · see citing works
Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes
Nishikawa, M., Hyoudou, K., Kobayashi, Y., Umeyama, Y., Takakura, Y., & Hashida, M. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.09.017 · Cited by 67 · see citing works
Mutation Hotspots and DNA Methylation
Pfeifer, G. P., Tang, M.-S., & Denissenko, M. F. (2000) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-59696-4_1 · Cited by 67 · see citing works
Enzymatic methylation of cytosine in DNA is prevented by adjacent O6-methylguanine residues
Hepburn, P., Margison, G. P., & Tisdale, M. J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92928-5 · Cited by 61 · see citing works
Hypermethylation of NAD(P)H: quinone oxidoreductase 1 (NQO1) gene in human hepatocellular carcinoma
Tada, M., Yokosuka, O., Fukai, K., et al. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.11.024 · Cited by 57 · see citing works
The Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Derived Reactive Oxygen Species in the Acquisition of Metastatic Ability of Tumor Cells
Okada, F., Kobayashi, M., Tanaka, H., Kobayashi, T., Tazawa, H., Iuchi, Y., Onuma, K., Hosokawa, M., Dinauer, M. C., & Hunt, N. H. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060073 · Cited by 50 · see citing works
Silencing of metallothionein-I gene in mouse lymphosarcoma cells by methylation
Majumder, S., Ghoshal, K., Li, Z., Yuan, B., & Jacob, S. T. (1999) · Oncogene · doi:10.1038/sj.onc.1203004 · Cited by 44 · see citing works
Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase
Okada, F., Shionoya, H., Kobayashi, M., Kobayashi, T., Tazawa, H., Onuma, K., Iuchi, Y., Matsubara, N., Ijichi, T., Dugas, B., et al. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603016 · Cited by 38 · see citing works
Interaction of oligonucleotides containing 6-O-methylguanine with human DNA (cytosine-5-)-methyltransferase
Tan, N. W., & Li, B. F. L. (1990) · Biochemistry · doi:10.1021/bi00491a018 · Cited by 36 · see citing works
Free Radical Dna Adduct 8-Oh-Deoxyguanosine Affects Activity of Hp a II and Msp I Restriction Endonucleases
Turk, P. W., & Weitzman, S. A. (1995) · Free Radical Research · doi:10.3109/10715769509064038 · Cited by 26 · see citing works
Sulfur-Containing Compounds in Protecting Against Oxidant-Mediated Lung Diseases
Pappa, A., Franco, R., Schoneveld, O., Galanis, Α., Sandaltzopoulos, R., & Panayiotidis, M. I. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707782023262 · Cited by 24 · see citing works
Self-citation
Perturbation of maintenance and de novo DNA methylation in vitro by UVB (280-340 nm)-induced pyrimidine photodimers.
Becker, F. F., Holton, P., Ruchirawat, M., & Lapeyre, J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.18.6055 · Cited by 21 · see citing works

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Authors: Franco, R., Schoneveld, O., Georgakilas, A. G., & Panayiotidis, M. I.
Affiliations: National Institutes of Health (US)
East Carolina University (US)
University of Nevada, Reno (US)
Corresponding author: Panayiotidis, Mihalis I.
ORCID: Franco, Rodrigo
Georgakilas, Alexandros G.
Panayiotidis, Mihalis I.
Venue: Cancer Letters
Publisher: Elsevier BV
Published: 2008-07
Volume: 266
Issue: 1
Pages: 6-11
ISSN: 0304-3835 (ISSN-L)
DOI: 10.1016/j.canlet.2008.02.026
OpenAlex: W2025141680
Cited by: 603
References: 56
Citations by year: 2026: 11 · 2025: 26 · 2024: 13 · 2023: 26 · 2022: 26 · 2021: 31 · 2020: 30 · 2019: 37 · 2018: 30 · 2017: 36 · 2016: 42 · 2015: 35 · 2014: 38 · 2013: 40 · 2012: 49
FWCI: 3.40
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cancer Letters (publishedVersion)
PubMed (publishedVersion)
Funders: East Carolina University
University of Nevada, Reno
National Institutes of Health
National Institute of Environmental Health Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: oxidative stress, DNA methylation, carcinogenesis, reactive oxygen species, epigenetic regulation, tumor suppressor, oncogenes, hypermethylation, hypomethylation, gene expression regulation, tumor markers, cancer diagnosis and prognosis
MeSH terms: Cell Transformation, Neoplastic, DNA Damage, Neoplasms, Phenotype, Gene Expression Regulation, Neoplastic, Reactive Oxygen Species, Oxidative Stress, Disease Progression, DNA Methylation, Epigenesis, Genetic

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Oxidative stress, DNA methylation and carcinogenesis

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