Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

Ng, Benjamin, Dong, Jinrui, D’Agostino, Giuseppe, Viswanathan, Sivakumar, Widjaja, Anissa A., Lim, Wei-Wen, Ko, Nicole S. J., Tan, Jessie +14 more·2019·Science Translational Medicine

Cited by (311)

Items 201–300 of 311

  1. Structural optimization of Moracin M as novel selective phosphodiesterase 4 inhibitors for the treatment of idiopathic pulmonary fibrosis
    Sen Wang, Guofeng Yang, Kai Zhang, Zhexin Chen, Meiying Qiu, Siyu Hou, Tiansheng Zheng, Zongmin Wu, Qinjiang Ma, Furong Zhang et al. · 2024 · Bioorganic Chemistry
  2. Fibroblast-derived interleukin-11 as a potential biomarker for intestinal fibrostenosis in Crohn’s disease
    Jinyu Tan, Xiaomin Wu, Weidong Huang, Jinshen He, Jing Nie, Longyuan Zhou, Zishan Liu, Yu Wang, Caiguang Liu, Jie Li et al. · 2025 · Therapeutic Advances in Gastroenterology
  3. Interleukin 11–Induced MicroRNAs as Functional Mediators and Circulating Biomarkers of Cardiac Fibrosis
    Roman Tikhomirov, Veronika Boichenko, Benedict Reilly-O’Donnell, Carla Lucarelli, Prashant Kumar Srivastava, Maryam Anwar, Chi Him Kendrick Yiu, Julia Dielesen, Victoria Maria Noakes, Santiago Nicolas Piella et al. · 2026 · Circulation Research
  4. Bone Allograft Acid Lysates Change the Genetic Signature of Gingival Fibroblasts
    Layla Panahipour, Azarakhsh Oladzad Abbasabadi, Anja Wagner, Klaus Kratochwill, Monika Pichler, Reinhard Gruber · 2023 · International Journal of Molecular Sciences
  5. Blocking GP130 binding in interleukin-11 through site-specific PEGylation attenuates bleomycin-induced pulmonary fibrosis in mice
    Sa Wang, Pengyu Wang, Minhui Zhang, Xiaotong Song, Long Wei, Xinyuan Ma, Xin Yao, Shuwen Zhang, Zijie Chen, Yongxiang Zheng et al. · 2024 · International Journal of Pharmaceutics
  6. Anti-fibrotic strategies and pulmonary fibrosis
    Avanka Gunatilaka, Stephanie Zhang, W.S. Daniel Tan, Alastair G. Stewart · 2023 · Advances in pharmacology
  7. Jianghu decoction and its active component polydatin inhibit inflammation and fibrotic lesions in the lungs of ILD mice via the AMPK signaling pathway
    Zhengju Zhang, Xinqi Deng, Wen Gu, Yang Jiao, Canyu Su, Hui Liu, Wei‐Guo Ma, Honghong Zhang, Ruiyang Xiang, Dali Wang et al. · 2023 · Journal of Ethnopharmacology
  8. Targeting IL‐11 to reduce fibrocyte circulation and lung accumulation in animal models of pulmonary hypertension‐associated lung fibrosis
    Javier Milara, Inés Roger, Paula Montero, Enrique Artigues, Juan Escrivá, Raquel Del Río, Julio Cortijo · 2024 · British Journal of Pharmacology
  9. An engineered interleukin‐11 decoy cytokine inhibits receptor signaling and proliferation in lung adenocarcinoma
    Brianna J. McIntosh, Griffin G. Hartmann, Sean A. Yamada‐Hunter, Phillip Liu, Camille F. Williams, Julien Sage, Jennifer R. Cochran · 2023 · Bioengineering & Translational Medicine
  10. De novo discovery of cyclic peptide inhibitors of IL-11 signaling
    Sam Lear, Rosalba Tafi, Valentina Di Biasio, Petro Halkowycz, Ruhi Kamran, Joanne Miura, Tony Gibson, Jing Li, Bertram Bleck, Claudia Dall’Armi et al. · 2024 · Bioorganic & Medicinal Chemistry
  11. The carboxyl-terminal TSP1-homology domain is the biologically active effector peptide of matricellular protein CCN5 that counteracts profibrotic CCN2
    Sima Zolfaghari, Ole Jørgen Kaasbøll, Vivi Talstad Monsen, Bojana Sredic, Else Marie Valbjørn Hagelin, Håvard Attramadal · 2022 · Journal of Biological Chemistry
  12. Identification of PSMD11 as a novel cuproptosis‐ and immune‐related prognostic biomarker promoting lung adenocarcinoma progression
    Qiumin Huang, Ran Tian, Jinxi Yu, Wei Du · 2024 · Cancer Medicine
  13. Targeting IL-11 in idiopathic pulmonary fibrosis
    2019 · Nature Reviews Drug Discovery
  14. IL-11 Expression in Systemic Sclerosis Is Dependent on Caspase-1 Activity but Does Not Increase Collagen Deposition
    Caya M. McFalls, Lianne M. Connolly, Alfred G. Fustakgi, Carol M. Artlett · 2024 · Rheumato
  15. PDK2-enhanced glycolysis aggravates fibrosis via IL11 signaling pathway in Graves’ orbitopathy
    Zhiyu Peng, Rui Huang, Lu Gan, Jinghan Wang, Xiaofeng Li, Jie Ding, Yinan Han, Jihong Wu, Kang Xue, Jie Fang Guo et al. · 2025 · Frontiers in Immunology
  16. Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis
    Jessica Pei, Nathalia Luisa Oliveira, Sherilyn Junelle Recinto, Alexandra Kazanova, Celso Martins Queiroz‐Junior, Ziyi Li, Katalina Couto, Susan Westfall, Ahmed M. Fahmy, Camila Tiefensee Ribeiro et al. · 2025 · npj Parkinson s Disease
  17. Genome editing of Spp1 by inhalable CRISPR/Cas9 formulation for treating pulmonary fibrosis
    Weiwei Bao, Peng Ji, Wensong Xi, Chimed Ganzorig, Zhijia Liu, Yuan Ping · 2025 · Journal of Controlled Release
  18. Advances in our understanding of distal progenitors in idiopathic pulmonary fibrosis: implications for novel therapeutics
    Hans‐Willem Snoeck · 2025 · European Respiratory Journal
  19. An inherent T cell-activating mRNA delivery carrier for in vivo CAR T generation
    Qiannan Cao, Yufei Yao, Wenming Zheng, Hongqian Liu, Mingxia Jiang, Dayang Xie, Siting Zhang, Pijun Su, Huilin Yuan, Xiaoyuan Shawn Chen et al. · 2026 · Nature Materials
  20. Extracellular stimulation of lung fibroblasts with arachidonic acid increases interleukin 11 expression through p38 and ERK signaling
    Kanako Sasaki, Shotaro Komamura, Kazuyuki Matsuda · 2022 · Biological Chemistry
  21. Interleukin-11 receptor subunit α-1 is required for maximal airway responsiveness to methacholine after acute exposure to ozone
    Richard A. Johnston, Constance Lynn Atkins, Saad R. Siddiqui, William T. Jackson, Nicholas C. Mitchell, Chantal Y. Spencer, Albert W. Pilkington, Michael L. Kashon, Ikram U. Haque · 2022 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  22. Paclitaxel Aggravating Radiation-Induced Pulmonary Fibrosis Is Associated with the Down-Regulation of the Negative Regulatory Function of Spry2
    Jianxing Zheng, Jiandong Wu, Lingfeng Xie, Yihao Huang, Jinsheng Hong, Chun Chen · 2023 · Journal of Pharmacology and Experimental Therapeutics
  23. Amentoflavone as a dual-target inhibitor of IL11 signaling alleviates intervertebral disc fibrosis
    Rongsheng Chen, Zhibin Chen, Yiping Chen, Boxuan Xu, Min Su, Weihong Xu · 2025 · International Immunopharmacology
  24. Ameliorating post-infarction myocardial fibrosis and cardiac function via ROS-responsive hydrogel-mediated IL-11 antibody delivery
    Ting You, Yong Zhang, Haotao Su, Na Wang, Xinkui Zhang, Sainiwaier Anwaier, Xiang Lian Long, Linjiang Han, Yeting Wu, Jialiang Liang et al. · 2026 · Bioactive Materials
  25. Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung
    Xihua Liu, Saiya Li, Guodong Wu, Shuangjian Li, Long Huang, Xiaoyang Li, Yiguo Zhao, Wei Jie Lu, Cuixia Sun, Qin Cao et al. · 2026 · Advanced Science
  26. Potential therapeutic targets of fibrosis in inflammatory rheumatic diseases
    Su Jiang, Julianna Desmarais, Cong‐Qiu Chu, Jing Zhu · 2024 · Best Practice & Research Clinical Rheumatology
  27. Interleukin‐11 expressed in the polyp‐enriched fibroblast subset is a potential therapeutic target in Peutz‐Jeghers syndrome
    Eva Domènech‐Moreno, Wei‐Wen Lim, Melissa G Montrose, Myriam Sévigny, Anders Brandt, Toni T Lemmetyinen, Emma W Viitala, Tomi P. Mäkelä, Stuart A. Cook, Saara Ollila · 2025 · The Journal of Pathology
  28. Interleukin‐11 promotes lung adenocarcinoma tumourigenesis and immune evasion
    Cristina Cirauqui, Laura Ojeda, Itziar Otano, Irene Pazos, Alba Santos, Eva Maria Garrido-Martin, Patricia Yagüe, Javier Ramos‐Paradas, Sonia Molina‐Pinelo, Giovanna Roncador et al. · 2025 · Clinical and Translational Medicine
  29. TGF-β1 Induces Interlukin-11 Expression and Pro-Fibrotic Effect by DNA Demethylation in Subconjunctival Fibroblasts
    Shuhao Fu, Zhaozeng Lu, Wen Ye · 2022 · Evidence-based Complementary and Alternative Medicine · Retracted
  30. IL-11 Drives Dermal Fibroblast Activation in Mechanical Stretch-Mediated Skin Expansion
    Yunhan Liu, Yimin Khoong, Wenzheng Xia, Ruoqing Xu, Anissa Anindya Widjaja, Hsin Liang, Shenying Luo, En Yang, Xin Huang, Tao Zan · 2025 · Journal of Investigative Dermatology
  31. Emerging Concepts in Therapeutic Interventions for Idiopathic Pulmonary Fibrosis
    Cody A. Schott, Michael P. Mohning, Joseph C. Cooley · 2025 · Seminars in Respiratory and Critical Care Medicine
  32. Age-related diseases as a testbed for anti-aging therapeutics: the case of idiopathic pulmonary fibrosis
    Alex A. Zhavoronkov, Dominika Wilczok, Feng Ren, Fedor Galkin · 2025 · Aging
  33. The role of epigenetic regulation in idiopathic pulmonary fibrosis
    Roger M. Li, Maike Stentenbach, Dino B. A. Tan, Herbert P. Ludewick, Eugene Haydn Walters, Britt Clynick, Yuben P. Moodley · 2025 · American Journal of Physiology-Lung Cellular and Molecular Physiology
  34. Therapeutic effect of IL-11 inhibition on the pathogenesis of thyroid eye disease
    Hee Joo Yoon, Hyun Young Park, J. Kim, Soo Hyun Choi, Don O. Kikkawa, James S. Swaney, David J. King, Yasmin M. Vasquez, Jin Sook Yoon · 2025 · Journal of Molecular Endocrinology
  35. An enhanced mucus-penetrating miRNA delivery system for effective inhibition of bleomycin-induced pulmonary fibrosis in mice
    Beiduo Wang, Min Liang, Qiaoxuan Wang, Jieting Chang, Wenxing Liu, Changyou Gao · 2025 · Cell Biomaterials
  36. The Molecular Mechanisms and Therapeutic Potentials of Engrailed-1 in Fibrotic Scar Formation Post Glaucoma Filtration Surgery
    Yi Heng Lin, Wangdu Luo, Xiaomin Zhu, Julong Yu, Xiaofeng Li, Lin Xie · 2026 · Investigative Ophthalmology & Visual Science
  37. The role of IL-11 in chronic diseases
    Jingxuan Zhang, Yan Leng, Wenyuan Li, Bihan Wang, Baichuan Yang, Wei Li · 2026 · Frontiers in Immunology
  38. Silibinin alleviates lung fibrosis by targeting Annexin A6 to suppress endoplasmic reticulum stress and oxidative stress
    Ruijuan Guan, Yingli Zhang, Zhengyang Wang, Danxia Huang, Yakun Bai, Meifang Deng, Kailin Li, Xiao Hu, Fei Huang, Ying Dai et al. · 2026 · Phytomedicine
  39. Serum Level of Interleukin-11 Is Associated with the Severity of Hepatic Fibrosis in Adults with Metabolic Dysfunction-Associated Steatotic Liver Disease
    Yingying Xue, Hsiuying Fu, Hongyan Wu, Ziwei Wang, Li Shen, Jingyu Zhu, Ziwei Zhu, Yue Zhou Cao, Y Xiang, Xiaoyan Yu et al. · 2026 · Journal of Interferon & Cytokine Research
  40. IL-11 receptor is a novel target for drug development with pharmacological activity in fibro-inflammatory disease
    David J. King, James S. Swaney, Cadmus Collins Rich, H Toni Jun, Yasmin M. Vasquez, Shira Geller, Christine M Chidester, Merrick Chai, Eric K Elliott, Deborah A. Witherden et al. · 2026 · Scientific Reports
  41. Design and discovery of a novel interleukin-11 derived peptide with antagonistic activity for the treatment of renal fibrosis
    Ningning Pang, J J Li, Xing Cheng, Peiying Li, Xu Yang, Na Zhao, Yujie Wu, Zhenxin Ma, Ranran Zheng, Yunfan Ji et al. · 2026 · Bioorganic Chemistry
  42. Circulating Interleukin-11 Across Allergic and Non-Allergic Airway Disease Phenotypes: A Single-Center Exploratory Study
    Corina Porr, Anca Vidrighin, Emi Marinela Preda, Gabriela Mariana Iancu, Dana M. Harris, Valentin-Cristian Iovin, Alina Camelia Cătană, Cosmina Diaconu · 2026 · Life
  43. Immunotherapeutic implications on targeting the cytokines produced in rhinovirus-induced immunoreactions
    Le Sang, Xia Gong, Yunlei Huang, Linling Zhang, Jian Liang Sun · 2024 · Frontiers in Allergy
  44. Pathogenesis of pulmonary fibrosis
    Rybakova Mg, A. E. Myurzep · 2024 · Russian Journal of Archive of Pathology
  45. Downregulation of interleukin 11 regulates the transforming growth factor-β/ERK1/2 signaling pathway to inhibit articular capsule fibrosis and alleviate post-traumatic articular capsule contracture
    Heng Zheng, Zhenjia Zhong, Yichong Wang, Yang-Bai Sun, Fengfeng Li · 2024 · Journal of Shoulder and Elbow Surgery
  46. Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina
    Paula Liang, Jan N. Ness, Julian Rapp, Stefaniya Boneva, Melanie E. Schwämmle, Malte Jung, Günther Schlunck, Hansjürgen T. Agostini, Felicitas Bucher · 2024 · Journal of Neuroinflammation
  47. TGF-β1/IL-11 positive loop between renal tubular epithelial cell and fibroblast promotes the ectopic calcification of renal interstitial fibroblasts in rats
    Jinghua Zhong, Xiaolu Duan, Houmeng Yang, Zezhen Liu, Wen Zhong, Zhixiong Zhang, Yueqi Huang, Haodong Zeng, Hongyang Zhao, Yang Liu et al. · 2025 · Biochemical Pharmacology
  48. Gingival Fibroblasts Are Sensitive to Oral Cell Lysates Indicated by Their IL11 Expression
    Layla Panahipour, Azarakhsh Oladzad Abbasabadi, Reinhard Gruber · 2023 · Bioengineering
  49. Inhaled LTI-03 for idiopathic pulmonary fibrosis: a randomized dose escalation study
    Molyneaux, Philip L., Hirani, Nikhil A., Chia, Collin C. K., Kulkarni, Tejaswini, Zaman, Tanzira, Kaner, Robert J., Coelho, Ana Lucia, Jannini-Sa, Yago Amigo Pinho, Windsor, Brian, Kruger, Sydney et al. · 2026 · Nature Communications
  50. Evaluation of Cardiac IL-11 and IL-11Rα Expression During T. cruzi Infection
    Yarlla Loyane Lira Braga, José Rodrigues do Carmo Neto, Pablo Igor Ribeiro Franco, Jordana Fernandes de Oliveira, Rafael Obata Trevisan, Fernanda Bernadelli De Vito, Flávia Aparecida de Oliveira, Mara Rúbia Nunes Celes, Marcos Vinícius da Silva, Juliana Reis Machado · 2025 · Inflammation
  51. Ultrafine garlic powder alleviates non-alcoholic steatohepatitis by inhibiting hepatocyte ferroptosis and modulating ERK-dependent oxidative stress
    Junhui Yu, Ningning Shao, Jianming Yang, Long Yang, Kaiwen Hong, Yuzhu Chen, Xiaoming Zhao, Hongzhi Yu, Tao Zhang, Jinrui Dong · 2025 · Frontiers in Pharmacology
  52. Inhaled polystyrene nanoparticles may cause fibrotic lesions via immune dysregulation and energy metabolism disturbance
    Wonkyun Jung, Man S. Kim, Beom-Geon Kim, Sung-Min Hong, Sanghyeon Yu, Kanghyun Kwon, Mi-Jin Yang, Min Beom Heo, Ik Hwan Kwon, Seong-Jin Choi et al. · 2025 · Toxicology and Applied Pharmacology
  53. IL-11 acts as an alarmin-like pro-inflammatory mediator regulating mucosal responses during helminth infection
    Pedro Henrique Gazzinelli-Guimarães, Pablo Bara-Garcia, Jonah Kupritz, Fabrício Marcus Silva Oliveira, Camila Pereira Queiroz, Byunghyun Kang, Michelle A. Makiya, Thomas B. Nutman · 2026 · Mucosal Immunology
  54. Parathyroid hormone–related protein is a therapeutic target in idiopathic pulmonary fibrosis
    Xue-Quan Fang, Suha Lim, Yoon-Mi Lee, Chang-Hoon Lim, Han-Byeol Kim, Jeong Ho Joo, Sang-Woo Han, Seohyun Kim, Ji Hyung Kim, Kwon Joong Na et al. · 2026 · Signal Transduction and Targeted Therapy
  55. IL-11 neutralizing antibodies alleviate pulmonary fibrosis in aging mice by inhibiting TGF-β/NOX4/IL-11 signaling pathway
    Yang Miao, Y Q Hu, Li Xu, Li Xu, Lingxin Meng, Yue Yang, Zhigang Liu, Zhongyi Yang, Yu-ming Liu, Yuming Liu et al. · 2026 · Biochemical Pharmacology
  56. Molecular Systems Architecture of Fibrotic Lung Microenvironment in Idiopathic Pulmonary Fibrosis
    V. A. Shiva Ayyadurai, Yamuna Manoharan, Prabhakar Deonikar · 2026 · Cells
  57. Integrated analysis of endometrial stromal cell long noncoding RNA and mRNA expression profiles associated with TGF-β1-induced fibrosis
    Jianhong Wu, Linyuan Fan, Lin Li, Yudi Zhang, Yucui Tian, Ziwen Jiang, Zhaohui Liu, Dan Lu, Yinmei Dai · 2024 · Acta Biochimica et Biophysica Sinica
  58. Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury
    Eun‐Ah Sung, Mikhail G. Dozmorov, Su-Jeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae · 2025 · FEBS Letters
  59. Dapagliflozin Interrupts Pro‐Fibroinflammatory Interleukin 11‐Tenascin C Mutual Reinforcement in Fibroblasts by Antagonizing Interleukin‐11 Receptor Subunit Alpha
    Yen‐Chen Lin, Wei-Jan Chen, Yu‐Juei Hsu, Ying‐Ju Lai, Cheng‐Chin Kuo, Yung‐Hsin Yeh · 2025 · Journal of Cellular Physiology
  60. Molecular Dissection of Inflammatory Signals in Acute Lung Injury
    Marcus Jun Rui Lee, Li Heng Wong, Chen Xie, Fathima F Kuthubudeen, Benjamin Ng · 2023 · Springer eBooks
  61. Transforming Growth Factor β Signaling Pathway as a Potential Drug Target in Treating Aortic Diseases
    Zijie Liu, Tianyu Song, Liping Xie · 2024 · International Journal of Drug Discovery and Pharmacology
  62. Inflammation cellular platform (INCEPLAT) for testing anti-inflammatory compounds for SARS-CoV-2
    Blanca D. López‐Ayllón, Laura Mendoza‐García, Ana de Lucas‐Rius, Tránsito García‐García, Raúl Fernández‐Rodríguez, Antonio Romero-Guillen, Judit Serrat, Sonia Zúñiga, Natalia Redondo, Mar Siles‐Lucas et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  63. Elevated phosphorylated α-synuclein and phosphorylated tau in Lrrk2 p.G2019S-mutant mice following influenza A pneumonitis
    Michaela O. Lunn, Karan Thakur, Nathalie A. Lengacher, Quinton Hake-Volling, aSCENT-PD Investigators, Julianna J. Tomlinson, Subash Sad, Earl G. Brown, Michael G. Schlossmacher · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  64. Molecular Mechanisms of Danhong Injection in Treatment of Pulmonary Fibrosis Based on Network Pharmacology and Experimental Validation
    Di Han, Yong Xu, Wenpan Peng, Dan Wang, Tongxing Huang, Xianmei Zhou, Jinjun Shan · 2021 · Research Square
  65. Understanding and Therapeutically Targeting the Scleroderma Myofibroblast
    Anthony James Ocon, Sravani Lokineni, Benjamin D. Korman · 2022 · Current Treatment Options in Rheumatology
  66. Pulmonary Fibrosis: One Manifestation, Various Diseases
    Barbara Ruaro, Marco Matucci‐Cerinic, Elisa Baratella, Marco Confalonieri, Francesco Salton, Michael Hughes · 2022 · Frontiers research topics
  67. Data from Host IL11 Signaling Suppresses CD4+ T cell–Mediated Antitumor Responses to Colon Cancer in Mice
    Jennifer Huynh, David Baloyan, David Chisanga, Wei Shi, Megan O'Brien, Shoukat Afshar‐Sterle, Mariah Alorro, Lokman Pang, David S. Williams, Adam C. Parslow et al. · 2023
  68. The Role of Mechanosensitive Signaling Cascades in Repair and Fibrotic Remodeling of the Infarcted Heart
    Claudio D Humeres, Harikrishnan Venugopal, Nikolaos Georgios Frangogiannis · 2023 · Cardiac and vascular biology
  69. Neue Therapieverfahren für die idiopathische Lungenfibrose am Horizont
    Nataliia Artysh, Antje Prasse · 2023 · Zeitschrift für Pneumologie
  70. Identification of a targetable ST2-expressing fibroblast subset driving Peutz-Jeghers syndrome polyposis
    Eva Domènech‐Moreno, Wei‐Wen Lim, Anders Brandt, Toni T Lemmetyinen, Emma W Viitala, Tomi P. Mäkelä, Stuart A. Cook, Saara Ollila · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  71. The Gut Microbiome and Metabolomics Profiles of Dust-exposed Rats
    Xi Shen, Miaomiao Wang, Shasha Pei, Shuyu Xiao, Kun Xiao, Jinlong Li, Xiaoming Li, Qingan Xia, Heliang Liu, Fuhai Shen · 2025 · Combinatorial Chemistry & High Throughput Screening
  72. NLRP3 Inflammasome and IL-11 in Systemic Sclerosis Pulmonary Fibroblasts
    Caya M. McFalls, Carol M. Artlett · 2025 · Fibrosis
  73. Bmi-1 overexpression mitigates vitamin D deficiency-induced pulmonary fibrosis via TIME pathway
    Jinge Zhang, Mingxin Huang, Jiawen Zhou, Haiyun Chen, Ziyang Wang, Jianliang Jin, Lei Shu, Dengshun Miao · 2025 · Cellular Signalling
  74. A Long Stretch: IL-11 Drives Skin Regeneration
    Steven O’Reilly · 2025 · Journal of Investigative Dermatology
  75. Extracellular Remodeling, Tissue Fibrosis, and Clinical Translation
    Yves Fromes · 2025 · Fundamental and Clinical Pharmacology
  76. Additional file 4 of Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina
    Paula Liang, Jan N. Ness, Julian Rapp, Stefaniya Boneva, Melanie E. Schwämmle, Malte Jung, Günther Schlunck, Agostini, Hansjürgen, Felicitas Bucher · 2024 · Figshare
  77. Additional file 3 of Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina
    Paula Liang, Jan N. Ness, Julian Rapp, Stefaniya Boneva, Melanie E. Schwämmle, Malte Jung, Günther Schlunck, Agostini, Hansjürgen, Felicitas Bucher · 2024 · Figshare
  78. Additional file 1 of Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina
    Paula Liang, Jan N. Ness, Julian Rapp, Stefaniya Boneva, Melanie E. Schwämmle, Malte Jung, Günther Schlunck, Agostini, Hansjürgen, Felicitas Bucher · 2024 · Figshare
  79. Additional file 2 of Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina
    Paula Liang, Jan N. Ness, Julian Rapp, Stefaniya Boneva, Melanie E. Schwämmle, Malte Jung, Schlunck, Günther, Agostini, Hansjürgen, Felicitas Bucher · 2024 · Figshare
  80. Additional file 1 of Modeling of lung phenotype of Hermansky–Pudlak syndrome type I using patient-specific iPSCs
    Takahiro Suezawa, Shuhei Kanagaki, Korogi, Yohei, Kazuhisa Nakao, Hirai, Toyohiro, Murakami, Koji, Hagiwara, Masatoshi, Shimpei Gotoh · 2021 · Figshare
  81. Combined antagonism of Oncostatin M (OSM) and Interleukin 6 (IL-6) provides both anti-fibrotic and anti-inflammatory benefit in pulmonary fibrosis
    Rojo A. Ratsimandresy, Emma Doran, Hart S. Dengler, Sarah Emily Headland, Christopher J. Wedeles, Riccardo Guidi, Daqi Xu, Jiatong Liu, Yongchang Shi, Jianyong Wang et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  82. The “Reducing Inflammation for Greater Health Trial ( RIGHT )” Study—Concept, Rationale, and Design
    Sebastian Eduardo Sattui, Marnie H. Bertolet, Daniel E. Forman, Michelle E. Danielson, Shanshan Yao, Oscar L. López, Nancy W. Glynn, Neelesh K. Nadkarni, Akira M Sekikawa, Tullia Carmela Bruno et al. · 2026 · Journal of the American Geriatrics Society
  83. PHB2 acts as a braker of progressive pulmonary fibrosis via intervention of DDR2-elicited signaling
    Penghui Yang, Jinjun Jiang, Jiani Liu, Bing Su, Xiaohua Wang, Zhenli Fu, Ying He, Jing Han, Chunrong Ju, Yinuo Wang et al. · 2026 · Acta Biochimica et Biophysica Sinica
  84. Therapeutic targets for fibro-inflammation in Graves’ orbitopathy
    Young Jae Kang, Jin Sook Yoon · 2025 · Taiwan Journal of Ophthalmology
  85. Generation and characterization of the Il11-Cre knock-in mouse
    X. Edward Zhou, Zhongliang Xie, Wenjia Liu, Qingye Wang, Huisang Lin, Rongyu Li, Yiming Lang, Jun Chen, Xiao Yi Yang, Yan Teng et al. · 2026 · Transgenic Research
  86. Systematic Comparison of the TGF-β Isoforms in Normal Dermal and Lung Fibroblasts Identifies TGF-β2 and TGF-β3 as Priority Targets in Tissue Fibrosis
    Raveen Badyal, Brandon Kohlen, Kevin J. Keen, James V. Dunne, Tillie‐Louise Hackett · 2026 · Cells
  87. Gαi1 and Gαi3 mediate IL-11-induced signal transduction and are potential therapeutic targets for LUAD
    Gaomeng Luo, Wenxuan Hu, Jian Yang, Zheng Lu, Yuan Cui, Weibiao Zeng, Hao Ding, Qifan Li, Zhike Chen, Xin Tong et al. · 2026 · Cell Death and Disease
  88. Advances in pharmacotherapy for fibrotic interstitial lung disease
    Xiaoguo Feng, Mingming Deng, Jinrui Miao, Ziwen Zheng, Gang Hou · 2026 · Medical Review
  89. Immunomodulatory effects of Jingfang Granule polysaccharides in pulmonary fibrosis
    Yaoai Wang, Shan Jiang, Yifan Ren, Jingze Gao, Wenjing Fan, Xueke Bai, Sijv Lou, Jiaxin Ding, Ning Zhang, Guangli Yan et al. · 2026 · European Cytokine Network
  90. Unleashing innovative cross-organ fibrosis therapies by harnessing the omics revolution
    Cynthia Lebeaupin, Katelyn L. Donahue, Ken Dower, Thomas A. Wynn, Kevin M. Hart, Thomas Fabre · 2026 · JCI Insight
  91. ac4C modification of PDK4 by NAT10 promotes pulmonary fibrosis by reprogramming mitochondrial dynamics in fibroblasts
    Dongyu Liu, Yanqun Li, Tianyang Liu, Yuhan Du, Jinzhong Zhuo, Jiangzhou Du, Qi Yu, Liping Huang, Liping Huang, Yixin Chen et al. · 2026 · Free Radical Biology and Medicine
  92. Cytokines with pro- and antiinflammatory activities
    Zlatko Dembić · 2026 · Elsevier eBooks
  93. Host transcriptional programs underlying lesion development in contagious bovine pleuropneumonia
    Arlind B. Mara, Angela Makumi, Rosemary Grace Ozyck, Massimo Scacchia, Hezron Wesonga, Mark R. Ackermann, Noah O. Okumu, Winnie Chebore, Morgan L. Hunte, Jeremy M. Miller et al. · 2026 · Frontiers in Immunology
  94. From bench to clinical: Advances and prospects of siRNA inhalation therapy for idiopathic pulmonary fibrosis
    Ting Zhou, Li Yang, Shuguang Hou, Sanjun Shi · 2026 · Journal of Drug Delivery Science and Technology
  95. Cardiac effects of prolonged recombinant human interleukin-11 treatment in severe thrombocytopenia: a retrospective cohort study
    Xian-fa Li, Yue Sun, Wenrong Wang, Zi-Yang Bao, Yong-zhong Zhong, Hongyu Chen, Dongrong Yu, Caifeng Zhu, Jun Ni, Bin Zhu · 2026 · BMC Pharmacology and Toxicology
  96. Beyond fibrosis: Emerging role of IL-11 in regulating innate and adaptive immune cell plasticity
    Yu Zhang, Jing Chen, L H Gong · 2026 · Molecular Biology Reports
  97. Single-cell viral capture identifies injury-remodeling programs and host-response candidates in RSV-infected airway organoids
    R G Liu, Ziyu Liu, Pengbo Wang, Yi Zhang, Shiyuan Hou, Chenyu Zhang, Weina Guan, Shuhan Wang, Xing Sun, Chenxi Zhao et al. · 2026 · Research Square
  98. Reprogramming the fibrotic niche with an inhalable “weeding and root removal” RNA platform for idiopathic pulmonary fibrosis therapy
    Chang Liu, Ziwei Zhang, Hezhi Wang, Xin Zhang, Jian Guan, Shirui Mao · 2026 · Chemical Engineering Journal
  99. Mannose-modified tobacco mosaic virus-mediated macrophage regulation inhibits pulmonary fibrosis progression
    Jiaodan Jin, Ren Xu, Huaixiu Fu, Wei Qian, Yu Liu, Jinzhao Ou, Meng Zhu, Yunzhi Zhou, Ye Tian, Zhongwei Niu · 2026 · Journal of Materials Chemistry B
  100. Metabolic reprogramming in cardiac fibrosis: mechanisms, crosstalk, and therapeutic interventions
    X Y Wang, X Y Wang, Fei Guo, Qian Ding, Honghua Jin · 2026 · Frontiers in Physiology