Cited by 139TGF-β signaling in diseasesBlood Coagulation and Thrombosis MechanismsPlatelet Disorders and Treatments

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Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

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Metelli, Alessandra, Wu, Bill X., Riesenberg, Brian, Guglietta, Silvia, Huck, John D., Mills, Catherine, Li, Anqi, Rachidi, Saleh, Krieg, Carsten, Rubinstein, Mark P., Gewirth, Daniel T., Sun, Shaoli, Lilly, Michael B., Wahlquist, Amy H., Carbone, David P., Yang, Yiping, Liu, Bei, Li, Zihai·2020·Science Translational Medicine

DOI 10.1126/scitranslmed.aay4860PMC PMC7814995

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Abstract

Proteolysis of platelet-bound GARP by thrombin liberates active TGF-β and contributes to cancer immune evasion in the tumor microenvironment.

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Authors: Metelli, A., Wu, B. X., Riesenberg, B., Guglietta, S., Huck, J. D., Mills, C., Li, A., Rachidi, S., Krieg, C., Rubinstein, M. P., Gewirth, D. T., Sun, S., Lilly, M. B., Wahlquist, A. H., Carbone, D. P., Yang, Y., Liu, B., & Li, Z.
Affiliations: Medical University of South Carolina (US)
Pelotonia (US)
Hauptman-Woodward Medical Research Institute (US)
Corresponding author: Li, Zihai
ORCID: Metelli, Alessandra
Wu, Bill X.
Riesenberg, Brian
Guglietta, Silvia
Huck, John D.
Mills, Catherine
Li, Anqi
Rachidi, Saleh
Krieg, Carsten
Rubinstein, Mark P.
Gewirth, Daniel T.
Lilly, Michael B.
Carbone, David P.
Yang, Yiping
Liu, Bei
Li, Zihai
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2020-01-08
Volume: 12
Issue: 525
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.aay4860
PMC: PMC7814995
OpenAlex: W3000560268
Cited by: 139
References: 68
Citations by year: 2026: 21 · 2025: 22 · 2024: 20 · 2023: 26 · 2022: 24 · 2021: 19 · 2020: 7
FWCI: 6.16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P01CA186866)
National Institute of Allergy and Infectious Diseases (R01AI077283)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
Keywords: thrombin, tumor immune evasion, GARP, latent TGF-beta1, platelets, proteolysis, tumor microenvironment, antitumor immunity, PD-1 immune checkpoint blockade, circulating biomarkers, thrombin inhibition
MeSH terms: Immune Checkpoint Inhibitors, Animals, Blood Platelets, Cell Membrane, Humans, Membrane Proteins, Mice, Inbred BALB C, Mice, Inbred C57BL, Neoplasms, Protein Binding, Thrombin, Disease Progression, Latent TGF-beta Binding Proteins, Immune Evasion, Tumor Microenvironment, Proteolysis, Carcinogenesis

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Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

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