The DOI matches its Crossref record; 67 of the 68 references it cites were found in a registry or an index.
Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β
Open accessAbstract
Proteolysis of platelet-bound GARP by thrombin liberates active TGF-β and contributes to cancer immune evasion in the tumor microenvironment.
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“Since GARP is also expressed by endothelial cells, fibroblasts, megakaryocytes and platelets73,74”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [73]
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Global cancer statistics, 2012
Torre, L. A., Bray, F., Siegel, R. L., Ferlay, J., Lortet‐Tieulent, J., & Jemal, A. (2015) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21262 · Cited by 27,235
SWISS-MODEL: homology modelling of protein structures and complexes
Waterhouse, A. M., Bertoni, M., Bienert, S., Studer, G., Tauriello, G., Gumienny, R., Heer, F. T., de Beer, T., Rempfer, C., Bordoli, L., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky427 · Cited by 13,248
FlowSOM: Using self‐organizing maps for visualization and interpretation of cytometry data
Gassen, S. V., Callebaut, B., van Helden, M. J. G., Lambrecht, B. N., Demeester, P. M. A., Dhaene, T., & Saeys, Y. (2015) · Cytometry Part A · doi:10.1002/cyto.a.22625 · Cited by 1,930
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
Tauriello, D. V. F., Palomo-Ponce, S., Stork, D., Berenguer-Llergo, A., Badia-Ramentol, J., Iglesias, M., Sevillano, M., Ibiza, S., Cañellas, A., Hernando-Momblona, X., et al. (2018) · Nature · doi:10.1038/nature25492 · Cited by 1,851
Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression
Shevach, E. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.010 · Cited by 1,787
TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
Thomas, D. A., & Massagué, J. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.012 · Cited by 1,355
Bhowmick, N., Ghiassi, M., Bakin, A. V., Aakre, M., Lundquist, C., Engel, M., Arteaga, C., & Moses, H. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.1.27 · Cited by 1,087
Latent TGF-β structure and activation
Shi, M., Zhu, J., Wang, R., Chen, X., Mi, L., Walz, T., & Springer, T. A. (2011) · Nature · doi:10.1038/nature10152 · Cited by 1,013
The roles of TGFβ in the tumour microenvironment
Pickup, M. W., Novitskiy, S. V., & Moses, H. L. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3603 · Cited by 936
Overview of the coagulation system
Palta, S., Saroa, R., & Palta, A. (2014) · Indian Journal of Anaesthesia · doi:10.4103/0019-5049.144643 · Cited by 903
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- 10.12688/f1000research.11622.1 · DOI
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TGFβ biology in cancer progression and immunotherapy
Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944
Combination strategies to maximize the benefits of cancer immunotherapy
Zhu, S., Zhang, T., Zheng, L., Liu, H., Song, W., Liu, D., Li, Z., & Pan, C.-X. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01164-5 · Cited by 654
Self-citationOvercoming TGFβ-mediated immune evasion in cancer
Tauriello, D. V. F., Sancho, E., & Batlle, E. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-021-00413-6 · Cited by 377
TGF ‐β as a driver of fibrosis: physiological roles and therapeutic opportunities
Budi, E. H., Schaub, J. R., Decaris, M. L., Turner, S., & Derynck, R. (2021) · The Journal of Pathology · doi:10.1002/path.5680 · Cited by 310
Chen, W. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101921-045939 · Cited by 299
Metadata
- Authors
- Metelli, A., Wu, B. X., Riesenberg, B., Guglietta, S., Huck, J. D., Mills, C., Li, A., Rachidi, S., Krieg, C., Rubinstein, M. P., Gewirth, D. T., Sun, S., Lilly, M. B., Wahlquist, A. H., Carbone, D. P., Yang, Y., Liu, B., & Li, Z.
- Affiliations
- Medical University of South Carolina (US)
- Pelotonia (US)
- Hauptman-Woodward Medical Research Institute (US)
- Corresponding author
- Li, Zihai
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2020-01-08
- Volume
- 12
- Issue
- 525
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7814995
- OpenAlex
- W3000560268
- Cited by
- 139
- References
- 68
- Citations by year
- 2026: 21 · 2025: 22 · 2024: 20 · 2023: 26 · 2022: 24 · 2021: 19 · 2020: 7
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P01CA186866)
- National Institute of Allergy and Infectious Diseases (R01AI077283)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Keywords
- thrombin, tumor immune evasion, GARP, latent TGF-beta1, platelets, proteolysis, tumor microenvironment, antitumor immunity, PD-1 immune checkpoint blockade, circulating biomarkers, thrombin inhibition
- MeSH terms
- Immune Checkpoint Inhibitors, Animals, Blood Platelets, Cell Membrane, Humans, Membrane Proteins, Mice, Inbred BALB C, Mice, Inbred C57BL, Neoplasms, Protein Binding, Thrombin, Disease Progression, Latent TGF-beta Binding Proteins, Immune Evasion, Tumor Microenvironment, Proteolysis, Carcinogenesis
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