Overcoming TGFβ-mediated immune evasion in cancer

The Immune Landscape of Cancer

Thorsson, V., Gibbs, D. L., Brown, S. D., Wolf, D., Bortone, D. S., Ou Yang, T.-H., Porta-Pardo, E., Gao, G. F., Plaisier, C. L., Eddy, J. A., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.023 · Cited by 5,870 · see citing works

Neutrophil recruitment and function in health and inflammation

Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472 · see citing works

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Mariathasan, S., Turley, S. J., Nickles, D., Castiglioni, A., Yuen, K., Wang, Y., Kadel III, E. E., Koeppen, H., Astarita, J. L., Cubas, R., et al. (2018) · Nature · doi:10.1038/nature25501 · Cited by 5,400 · see citing works

Elements of cancer immunity and the cancer–immune set point

Chen, D. S., & Mellman, I. (2017) · Nature · doi:10.1038/nature21349 · Cited by 5,352 · see citing works

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

Chen, W., Jin, W., Hardegen, N. J., Lei, K.-J., Li, L., Marinos, N. J., McGrady, G., & Wahl, S. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030152 · Cited by 4,678 · see citing works

Tumors: Wounds That Do Not Heal

Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · see citing works

The biology and function of fibroblasts in cancer

Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366 · see citing works

Myofibroblasts and mechano-regulation of connective tissue remodelling

Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290 · see citing works

Innate and adaptive immune cells in the tumor microenvironment

Gajewski, T. F., Schreiber, H., & Fu, Y.-X. (2013) · Nature Immunology · doi:10.1038/ni.2703 · Cited by 4,148 · see citing works

Tumor-Associated Macrophages: From Mechanisms to Therapy

Noy, R., & Pollard, J. W. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.010 · Cited by 4,089 · see citing works

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

Dongre, A., & Weinberg, R. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0080-4 · Cited by 3,876 · see citing works

A framework for advancing our understanding of cancer-associated fibroblasts

Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0238-1 · Cited by 3,863 · see citing works

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

Fridlender, Z. G., Sun, J., Kim, S., Kapoor, V., Cheng, G., Ling, L. E., Worthen, G. S., & Albelda, S. Μ. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.017 · Cited by 3,382 · see citing works

M-1/M-2 Macrophages and the Th1/Th2 Paradigm

Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287 · see citing works

The Transforming Growth Factor-Beta Family

Massagué, J. (1990) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.06.110190.003121 · Cited by 3,041 · see citing works

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985 · see citing works

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U., Liotta, L. A., Falanga, V., & Kehrl, J. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4167 · Cited by 2,867 · see citing works

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162024 · Cited by 2,590 · see citing works

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

Twyman-Saint Victor, C., Rech, A. J., Maity, A., Rengan, R., Pauken, K. E., Stelekati, E., Benci, J. L., Xu, B., Dada, H., Odorizzi, P. M., et al. (2015) · Nature · doi:10.1038/nature14292 · Cited by 2,434 · see citing works

Transforming Growth Factor-β Signaling in Immunity and Cancer

Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366 · see citing works

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

Desmoulière, A., Geinoz, A., Gabbiani, F., & Gabbiani, G. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.1.103 · Cited by 2,226 · see citing works

Innate Lymphoid Cells: 10 Years On

Vivier, É., Artis, D., Colonna, M., Diefenbach, A., Santo, J. P. D., Eberl, G., Koyasu, S., Locksley, R. M., McKenzie, A. N. J., Mebius, R. E., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.017 · Cited by 2,136 · see citing works

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

Zhou, L., Ivanov, I. I., Spolski, R. J., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., & Littman, D. R. (2007) · Nature Immunology · doi:10.1038/ni1488 · Cited by 2,134 · see citing works

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

Feig, C., Jones, J. O., Kraman, M., Wells, R. J. B., Deonarine, A., Chan, D. S., Connell, C. M., Roberts, E. W., Zhao, Q., Caballero, O. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320318110 · Cited by 2,100 · see citing works

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

Becker, A., Thakur, B. K., Weiss, J. M., Kim, H. S., Peinado, H., & Lyden, D. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.009 · Cited by 2,003 · see citing works

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967 · see citing works

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

Yu, Q., & Stamenkovic, I. (2000) · PubMed · Cited by 1,952 · see citing works

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

Zhou, L., Lopes, J. E., Chong, M. M. W., Ivanov, I. I., Min, R., Victora, G. D., Shen, Y., Du, J., Rubtsov, Y. P., Rudensky, A. Y., et al. (2008) · Nature · doi:10.1038/nature06878 · Cited by 1,859 · see citing works

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

Tauriello, D. V. F., Palomo-Ponce, S., Stork, D., Berenguer-Llergo, A., Badia-Ramentol, J., Iglesias, M., Sevillano, M., Ibiza, S., Cañellas, A., Hernando-Momblona, X., et al. (2018) · Nature · doi:10.1038/nature25492 · Cited by 1,851 · see citing works

Neutrophils in cancer: Neutral no more

Coffelt, S. B., Wellenstein, M. D., & de Visser, K. E. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.52 · Cited by 1,830 · see citing works

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

Yu, Q., & Stamenkovic, I. (2000) · Genes & Development · doi:10.1101/gad.14.2.163 · Cited by 1,754 · see citing works

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

Kehrl, J. H., Wakefield, L. M., Roberts, A. B., Jakowlew, S. B., Álvarez‐Mon, M., Derynck, R., Sporn, M. B., & Fauci, A. S. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.163.5.1037 · Cited by 1,581 · see citing works

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

Sanford, L. P., Ormsby, I., Groot, A. C. G.-D., Sariola, H., Friedman, R., Boivin, G. P., Cardell, E. L., & Doetschman, T. (1997) · Development · doi:10.1242/dev.124.13.2659 · Cited by 1,447 · see citing works

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

Bhowmick, N. A., Chytil, A., Plieth, D., Gorska, A. E., Dumont, N., Shappell, S., Washington, M. K., Neilson, E. G., & Moses, H. L. (2004) · Science · doi:10.1126/science.1090922 · Cited by 1,401 · see citing works

IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma

Biffi, G., Oni, T. E., Spielman, B., Hao, Y., Elyada, E., Park, Y., Preall, J., & Tuveson, D. A. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0710 · Cited by 1,360 · see citing works

TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

Thomas, D. A., & Massagué, J. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.012 · Cited by 1,355 · see citing works

Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

Wipff, P.-J., Rifkin, D. B., Meister, J.-J., & Hinz, B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704042 · Cited by 1,346 · see citing works

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

Long, E. O., Kim, H. S., Liu, D., Peterson, M., & Rajagopalan, S. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075005 · Cited by 1,209 · see citing works

Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population

Imai, K., Matsuyama, S., Miyaké, S., Suga, K., & Nakachi, K. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03231-1 · Cited by 1,189 · see citing works

Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin

Cepek, K. L., Shaw, S. K., Parker, C. M., Russell, G. J., Morrow, J. S., Rimm, D. L., & Brenner, M. B. (1994) · Nature · doi:10.1038/372190a0 · Cited by 1,178 · see citing works

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

Salmon, H., Franciszkiewicz, K., Damotte, D., Dieu-Nosjean, M.-C., Validire, P., Trautmann, A., Mami-Chouaib, F., & Donnadieu, E. (2012) · Journal of Clinical Investigation · doi:10.1172/jci45817 · Cited by 1,138 · see citing works

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

Fantini, M. C., Becker, C., Monteleone, G., Pallone, F., Galle, P. R., & Neurath, M. F. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5149 · Cited by 1,137 · see citing works

Radiotherapy and immunotherapy: a beneficial liaison?

Weichselbaum, R. R., Liang, H. L., Deng, L., & Fu, Y. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.211 · Cited by 1,073 · see citing works

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

Calon, A., Lonardo, E., Berenguer-Llergo, A., Espinet, E., Hernando-Momblona, X., Iglesias, M., Sevillano, M., Palomo-Ponce, S., Tauriello, D. V. F., Byrom, D., et al. (2015) · Nature Genetics · doi:10.1038/ng.3225 · Cited by 1,070 · see citing works

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

Calon, A., Espinet, E., Palomo-Ponce, S., Tauriello, D. V. F., Iglesias, M., Céspedes, M. V., Sevillano, M., Nadal, C., Jung, P., Zhang, X. H.-F., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.08.013 · Cited by 1,060 · see citing works

Tumour-associated neutrophils in patients with cancer

Shaul, M. E., & Fridlender, Z. G. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0222-4 · Cited by 1,044 · see citing works

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

Kaartinen, V., Voncken, J. W., Shuler, C. F., Warburton, D., Bu, D., Heisterkamp, N., & Groffen, J. (1995) · Nature Genetics · doi:10.1038/ng1295-415 · Cited by 1,031 · see citing works

Control of Effector CD8 ⁺ T Cell Function by the Transcription Factor <i>Eomesodermin</i>

Pearce, E. L., Mullen, A. C., Martins, G. A., Krawczyk, C. M., Hutchins, A. S., Zediak, V. P., Banica, M., DiCioccio, C. B., Gross, D. A., Mao, C.-A., et al. (2003) · Science · doi:10.1126/science.1090148 · Cited by 1,014 · see citing works

Latent TGF-β structure and activation

Shi, M., Zhu, J., Wang, R., Chen, X., Mi, L., Walz, T., & Springer, T. A. (2011) · Nature · doi:10.1038/nature10152 · Cited by 1,013 · see citing works

Tissue-resident memory T cells: local specialists in immune defence

Mueller, S. N., & Mackay, L. K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.3 · Cited by 1,006 · see citing works

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

Gorelik, L., & Flavell, R. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80170-3 · Cited by 959 · see citing works

CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner

Ghiringhelli, F., Menard, C., Terme, M., Flament, C., Taı̈eb, J., Chaput, N., Puig, P. E., Novault, S., Escudier, B. J., Vivier, É., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051511 · Cited by 948 · see citing works

TGFβ biology in cancer progression and immunotherapy

Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944 · see citing works

Transforming growth factor–β3 is required for secondary palate fusion

Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., Ding, J., Ferguson, M. W. J., & Doetschman, T. (1995) · Nature Genetics · doi:10.1038/ng1295-409 · Cited by 908 · see citing works

Dendritic Cells and Cancer Immunity

Gardner, A., & Ruffell, B. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.09.006 · Cited by 896 · see citing works

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

Henderson, N. C., Arnold, T. D., Katamura, Y., Giacomini, M. M., Rodriguez, J. D., McCarty, J. H., Pellicoro, A., Raschperger, E., Betsholtz, C., Ruminski, P. G., et al. (2013) · Nature Medicine · doi:10.1038/nm.3282 · Cited by 866 · see citing works

Single-cell RNA sequencing reveals stromal evolution into LRRC15(+) myofibroblasts as a determinant of patient response to cancer immunotherapy

Dominguez, C. X., Müller, S., Keerthivasan, S., Koeppen, H., Hung, J., Gierke, S., Breart, B., Foreman, O., Bainbridge, T. W., Castiglioni, A., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0644 · Cited by 857 · see citing works

TGF-β Activation and Function in Immunity

Travis, M. A., & Sheppard, D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120257 · Cited by 856 · see citing works

Contextual determinants of TGFβ action in development, immunity and cancer

David, C. J., & Massagué, J. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0007-0 · Cited by 851 · see citing works

Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer

Sagiv, J. Y., Michaeli, J., Assi, S., Mishalian, I., Kisos, H., Levy, L., Damti, P., Lumbroso, D., Polyansky, L., Sionov, R. V., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.039 · Cited by 818 · see citing works

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

Tone, Y., Furuuchi, K., Kojima, Y., Tykocinski, M. L., Greene, M. I., & Tone, M. (2008) · Nature Immunology · doi:10.1038/ni1549 · Cited by 807 · see citing works

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

Gagliani, N., Vesely, M. C. A., Iseppon, A., Brockmann, L., Xu, H. Y., Palm, N. W., de Zoete, M. R., Licona-Limón, P., Paiva, R., Ching, T. H., et al. (2015) · Nature · doi:10.1038/nature14452 · Cited by 797 · see citing works

Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

Li, M. O., Sanjabi, S., & Flavell, R. A. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.011 · Cited by 794 · see citing works

Specificity, versatility, and control of TGF-β family signaling

Derynck, R., & Budi, E. H. (2019) · Science Signaling · doi:10.1126/scisignal.aav5183 · Cited by 785 · see citing works

Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF-β1

Li, H., Han, Y., Guo, Q., Zhang, M., & Cao, X. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.240 · Cited by 777 · see citing works

Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4 + CD25 + regulatory T cell proliferation

Ghiringhelli, F., Puig, P. E., Roux, S., Parcellier, A., Schmitt, E., Solary, É., Kroemer, G., Martin, F., Chauffert, B., & Zitvogel, L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050463 · Cited by 776 · see citing works

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

Gorelik, L., & Flavell, R. A. (2001) · Nature Medicine · doi:10.1038/nm1001-1118 · Cited by 770 · see citing works

Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.

Kehrl, J. H., Roberts, A. B., Wakefield, L. M., Jakowlew, S. B., Sporn, M. B., & Fauci, A. S. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.12.3855 · Cited by 759 · see citing works

Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells

Castriconi, R., Cantoni, C., Chiesa, M. D., Vitale, M., Marcenaro, E., Conte, R., Biassoni, R., Bottino, C., Moretta, L., & Moretta, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730640100 · Cited by 727 · see citing works

TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

Becker, C., Fantini, M. C., Schramm, C., Lehr, H. A., Wirtz, S., Nikolaev, A., Burg, J., Strand, S., Kiesslich, R., Huber, S., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.020 · Cited by 726 · see citing works

Signaling Receptors for TGF-β Family Members

Heldin, C.-H., & Moustakas, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022053 · Cited by 711 · see citing works

Cancer-related inflammation: Common themes and therapeutic opportunities

Balkwill, F. R., & Mantovani, A. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.12.005 · Cited by 685 · see citing works

NK cells and cancer immunosurveillance

Waldhauer, I., & Steinle, A. (2008) · Oncogene · doi:10.1038/onc.2008.267 · Cited by 682 · see citing works

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity

Mamessier, É., Sylvain, A., Thibult, M., Houvenaeghel, G. F., Jacquemier, J. D., Castellano, R., Gonçalvès, A., André, P., Romagné, F., Thibault, G., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45816 · Cited by 682 · see citing works

Plasmacytoid Dendritic Cells: Development, Regulation, and Function

Reizis, B. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.027 · Cited by 679 · see citing works

TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

Chakravarthy, A., Khan, L., Bensler, N. P., Bose, P., & De Carvalho, D. D. (2018) · Nature Communications · doi:10.1038/s41467-018-06654-8 · Cited by 656 · see citing works

Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells

Gao, Y., Souza-Fonseca-Guimarães, F., Bald, T., Ng, S. S., Young, A., Ngiow, S. F., Rautela, J., Straube, J., Waddell, N., Blake, S. J., et al. (2017) · Nature Immunology · doi:10.1038/ni.3800 · Cited by 654 · see citing works

Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta.

Yoram Vodovotz, B., Bogdan, C., Paik, J., Xie, Q. W., & Nathan, C. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.2.605 · Cited by 649 · see citing works

Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication

Kloss, C. C., Lee, J., Zhang, A., Chen, F., Melenhorst, J. J., Lacey, S. F., Maus, M. V., Fraietta, J. A., Zhao, Y., & June, C. H. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.05.003 · Cited by 648 · see citing works

Engineering CAR-T Cells for Next-Generation Cancer Therapy

Hong, M., Clubb, J. D., & Chen, Y. Y. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.07.005 · Cited by 644 · see citing works

Transforming growth factor beta (TGF‐β) isoforms in wound healing and fibrosis

Lichtman, M. K., Otero-Viñas, M., & Falanga, V. (2015) · Wound Repair and Regeneration · doi:10.1111/wrr.12398 · Cited by 635 · see citing works

Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and InfectionPreprint

Sanjabi, S., Oh, S. A., & Li, M. O. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022236 · Cited by 626 · see citing works

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

Mackay, L. K., Wynne-Jones, E., Freestone, D., Pellicci, D. G., Mielke, L. A., Newman, D. M., Braun, A., Masson, F., Kallies, A., Belz, G. T., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.11.008 · Cited by 597 · see citing works

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

Ohnmacht, C., Pullner, A., King, S. B. S., Drexler, I., Meier, S., Brocker, T., & Voehringer, D. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082394 · Cited by 578 · see citing works

Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression

Clayton, A., Mitchell, J. P., Court, J., Linnane, S. J., Mason, M. D., & Tabi, Z. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7249 · Cited by 574 · see citing works

Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.

Rook, A. H., Kehrl, J. H., Wakefield, L. M., Roberts, A. B., Sporn, M. B., Burlington, D. B., Lane, H. C., & Fauci, A. S. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.10.3916 · Cited by 570 · see citing works

Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway

Lahn, M. M. F., Herbertz, S., Sawyer, J. S., Stauber, A. J., Gueorguieva, I., Driscoll, K. E., Estrem, S. T., Cleverly, A., Desaiah, D., Guba, S. C., et al. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s86621 · Cited by 558 · see citing works

Elevated TGF-β1 Secretion and Down-Modulation of NKG2D Underlies Impaired NK Cytotoxicity in Cancer Patients

Lee, J.-C., Lee, K., Kim, D., & Heo, D. S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.12.7335 · Cited by 549 · see citing works

When worlds collide: Th17 and Treg cells in cancer and autoimmunity

Knochelmann, H. M., Dwyer, C. J., Bailey, S. R., Amaya, S. M., Elston, D. M., Mazza-McCrann, J. M., & Paulos, C. M. (2018) · Cellular &amp; Molecular Immunology · doi:10.1038/s41423-018-0004-4 · Cited by 535 · see citing works

Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer

Ganesan, A.-P., Clarke, J., Wood, O., Garrido-Martin, E. M., Chee, S. J., Mellows, T., Samaniego-Castruita, D., Singh, D., Seumois, G., Alzetani, A., et al. (2017) · Nature Immunology · doi:10.1038/ni.3775 · Cited by 528 · see citing works

Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation

Gorelik, L., Constant, S. L., & Flavell, R. A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20012076 · Cited by 521 · see citing works

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

Cruz‐Guilloty, F., Pipkin, M. E., Djuretic, I. M., Levanon, D., Lotem, J., Lichtenheld, M. G., Groner, Y., & Rao, A. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081242 · Cited by 518 · see citing works

TGFβ is a master regulator of radiation therapy-induced antitumor immunity

Vanpouille-Box, C., Diamond, J. M., Pilones, K. A., Zavadil, J., Babb, J. S., Formenti, S. C., Barcellos-Hoff, M. H., & Demaria, S. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3511 · Cited by 514 · see citing works

Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice

Travis, M. A., Reizis, B., Melton, A. C., Masteller, E., Tang, Q., Proctor, J. M., Wang, Y., Bernstein, X., Huang, X., Reichardt, L. F., et al. (2007) · Nature · doi:10.1038/nature06110 · Cited by 503 · see citing works

TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling

Bragado, P., Estrada, Y., Parikh, F., Krause, S., Capobianco, C., Farina, H. G., Schewe, D. M., & Aguirre-Ghiso, J. A. (2013) · Nature Cell Biology · doi:10.1038/ncb2861 · Cited by 503 · see citing works

Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1

Annes, J. P., Chen, Y., Munger, J. S., & Rifkin, D. B. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312172 · Cited by 500 · see citing works

Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β

Lan, Y., Zhang, D., Xu, C., Hance, K. W., Marelli, B., Qi, J., Yu, H., Qin, G., Sircar, A., Hernández, V. M., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan5488 · Cited by 494 · see citing works

Phase I study of GC1008 (fresolimumab): a human anti‐transforming growth factor‐beta (TGFβ) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma

Morris, J. C., Tan, A. R., Olencki, T. E., Shapiro, G. I., Dezube, B. J., Reiss, M., Hsu, F. J., Berzofsky, J. A., & Lawrence, D. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090353 · Cited by 487 · see citing works

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

Muraoka, R. S., Dumont, N., Ritter, C. A., Dugger, T. C., Brantley, D. M., Chen, J., Easterly, E., Roebuck, L. R., Ryan, S. T., Gotwals, P. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15234 · Cited by 485 · see citing works

Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm

Lindsay, M. E., Schepers, D., Bolar, N. A., Doyle, J. J., Gallo, E. M., Fert‐Bober, J., Kempers, M. J. E., Fishman, E. K., Chen, Y., Myers, L. A., et al. (2012) · Nature Genetics · doi:10.1038/ng.2349 · Cited by 482 · see citing works

Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

Marie, J. C., Liggitt, D., & Rudensky, A. Y. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.012 · Cited by 480 · see citing works

GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3 + regulatory T cells

Tran, D. Q., Andersson, J., Wang, R., Ramsey, H. E., Unutmaz, D., & Shevach, E. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901944106 · Cited by 473 · see citing works

TGF-β1 – A truly transforming growth factor in fibrosis and immunity

Lodyga, M., & Hinz, B. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.12.010 · Cited by 462 · see citing works

Novel therapies emerging in oncology to target the TGF‐β pathway

Kim, B.-G., Malek, E., Choi, S. H., Ignatz-Hoover, J. J., & Driscoll, J. J. (2021) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-021-01053-x · Cited by 453 · see citing works

Transforming growth factor-β controls T helper type 1 cell development through regulation of natural killer cell interferon-γ

Laouar, Y., Sutterwala, F. S., Gorelik, L., & Flavell, R. A. (2005) · Nature Immunology · doi:10.1038/ni1197 · Cited by 452 · see citing works

Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses

Garg, A. D., & Agostinis, P. (2017) · Immunological Reviews · doi:10.1111/imr.12574 · Cited by 448 · see citing works

Polypeptide Transforming Growth Factors Isolated from Bovine Sources and Used for Wound Healing in Vivo

Sporn, M. B., Roberts, A. B., Shull, J. H., Smith, J. M., Ward, J. M., & Sodek, J. (1983) · Science · doi:10.1126/science.6572416 · Cited by 442 · see citing works

Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases

Wolf, K., Müller, R., Borgmann, S., Bröcker, E., & Friedl, P. (2003) · Blood · doi:10.1182/blood-2002-12-3791 · Cited by 442 · see citing works

Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes

Webber, J. P., Spary, L. K., Sanders, A. J., Chowdhury, R., Jiang, W. G., Steadman, R., Wymant, J. M., Jones, A. T., Kynaston, H., Mason, M. D., et al. (2014) · Oncogene · doi:10.1038/onc.2013.560 · Cited by 438 · see citing works

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

Jackstadt, R., van Hooff, S. R., Leach, J. D. G., Cortés-Lavaud, X., Lohuis, J. O., Ridgway, R. A., Wouters, V. M., Roper, J., Kendall, T. J., Roxburgh, C. S. D., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.08.003 · Cited by 427 · see citing works

Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor- 1

Szczepański, M. J., Szajnik, M. E., Welsh, A., Whiteside, T. L., & Boyiadzis, M. M. (2011) · Haematologica · doi:10.3324/haematol.2010.039743 · Cited by 421 · see citing works

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

Kaur, A., Ecker, B. L., Douglass, S. M., Kugel, C. H., Webster, M. R., Almeida, F. V., Somasundaram, R., Hayden, J. E., Ban, E., Ahmadzadeh, H., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0193 · Cited by 421 · see citing works

TGF-β inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors

Tang, N., Cheng, C. Y., Zhang, X., Qiao, M., Li, N., Mu, W., Wei, X., Han, W., & Wang, H. (2020) · JCI Insight · doi:10.1172/jci.insight.133977 · Cited by 418 · see citing works

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

Muraoka, R. S., Dumont, N., Ritter, C. A., Dugger, T. C., Brantley, D. M., Chen, J., Easterly, E., Roebuck, L. R., Ryan, S. T., Gotwals, P. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215234 · Cited by 415 · see citing works

Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors

Strauss, J., Heery, C. R., Schlom, J., Madan, R. A., Cao, L., Kang, Z., Lamping, E., Marté, J. L., Donahue, R. N., Grenga, I., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2653 · Cited by 406 · see citing works

Transforming growth factor-β signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention

Zhang, N., & Bevan, M. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.019 · Cited by 403 · see citing works

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins

Robertson, I. B., & Rifkin, D. B. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021907 · Cited by 403 · see citing works

The Optimal Efficiency and the Economic Degrees of Coupling of Oxidative Phosphorylation

Stucki, J. W. (1980) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1980.tb04792.x · Cited by 401 · see citing works

Differences in tumor microenvironment dictate T helper lineage polarization and response to immune checkpoint therapy

Jiao, S., Subudhi, S. K., Aparicio, A., Ge, Z., Guan, B., Miura, Y., & Sharma, P. (2019) · Cell · doi:10.1016/j.cell.2019.10.029 · Cited by 386 · see citing works

Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma

Bates, R. C., Bellovin, D. I., Brown, C. L., Maynard, E., Wu, B., Kawakatsu, H., Sheppard, D., Oettgen, P., & Mercurio, A. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23183 · Cited by 380 · see citing works

Phase II Study of Belagenpumatucel-L, a Transforming Growth Factor Beta-2 Antisense Gene-Modified Allogeneic Tumor Cell Vaccine in Non–Small-Cell Lung Cancer

Nemunaitis, J. J., Dillman, R. O., Schwarzenberger, P. O., Senzer, N. N., Cunningham, C. C., Cutler, J., Tong, A., Kumar, P., Pappen, B. O., Hamilton, C., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.05.5335 · Cited by 365 · see citing works

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.

Arteaga, C. L., Hurd, S. D., Winnier, A. R., Johnson, M. D., Fendly, B. M., & Forbes, J. T. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116871 · Cited by 359 · see citing works

Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression

Mishalian, I., Bayuh, R., Levy, L., Zolotarov, L., Michaeli, J., & Fridlender, Z. G. (2013) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-013-1476-9 · Cited by 356 · see citing works

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade

Holmgaard, R. B., Schaer, D. A., Li, Y., Castaneda, S. P., Murphy, M. Y., Xu, X., Inigo, I., Dobkin, J., Manro, J. R., Iversen, P. W., et al. (2018) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-018-0356-4 · Cited by 356 · see citing works

Immunoregulation by members of the TGFβ superfamily

Chen, W., & ten Dijke, P. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.112 · Cited by 347 · see citing works

Smad2 and Smad3 Are Redundantly Essential for the TGF-β–Mediated Regulation of Regulatory T Plasticity and Th1 Development

Takimoto, T., Wakabayashi, Y., Sekiya, T., Inoue, N., Morita, R., Ichiyama, K., Takahashi, R., Asakawa, M., Muto, G., Mori, T., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904100 · Cited by 339 · see citing works

Platelets subvert T cell immunity against cancer via GARP-TGFβ axis

Rachidi, S., Metelli, A., Riesenberg, B., Wu, B. X., Nelson, M. H., Wallace, C., Paulos, C. M., Rubinstein, M. P., Garrett-Mayer, E. S., Hennig, M., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aai7911 · Cited by 338 · see citing works

SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling

Cortez, V. S., Ulland, T. K., Cervantes‐Barragán, L., Bando, J. K., Robinette, M. L., Wang, Q., White, A. J., Gilfillan, S., Cella, M., & Colonna, M. (2017) · Nature Immunology · doi:10.1038/ni.3809 · Cited by 335 · see citing works

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

Ravi, R., Noonan, K. A., Pham, V., Bedi, R., Zhavoronkov, A., Ozerov, I. V., Makarev, E., V. Artemov, A., Wysocki, P. T., Mehra, R., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02696-6 · Cited by 325 · see citing works

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer

Kim, B., Li, C., Qiao, W., Mamura, M., Kasperczak, B., Anver, M. R., Wolfraim, L. A., Hong, S., Mushinski, E. B., Potter, M., et al. (2006) · Nature · doi:10.1038/nature04846 · Cited by 320 · see citing works

Adapting a transforming growth factor β–related tumor protection strategy to enhance antitumor immunity

Bollard, C. M., Rössig, C., Calonge, M. J., Huls, M. H., Wagner, H.-J., Massagué, J., Brenner, M. K., Heslop, H. E., & Rooney, C. M. (2002) · Blood · doi:10.1182/blood.v99.9.3179 · Cited by 316 · see citing works

Induction of resident memory T cells enhances the efficacy of cancer vaccine

Nizard, M., Roussel, H., Diniz, M. O., Karaki, S., Tran, T., Voron, T., Dransart, E., Sandoval, F., Riquet, M., Rance, B., et al. (2017) · Nature Communications · doi:10.1038/ncomms15221 · Cited by 308 · see citing works

Human CD96 Correlates to Natural Killer Cell Exhaustion and Predicts the Prognosis of Human Hepatocellular Carcinoma

Sun, H., Huang, Q., Huang, M., Wen, H., Lin, R., Zheng, M., Qu, K., Li, K., Wei, H., Xiao, W., et al. (2018) · Hepatology · doi:10.1002/hep.30347 · Cited by 302 · see citing works

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis

Li, W., Li, Q., Jiao, Y., Qin, L., Ali, R., Zhou, J., Ferruzzi, J., Kim, R. W., Geirsson, A., Dietz, H. C., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci69942 · Cited by 284 · see citing works

Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors

Anderton, M. J., Mellor, H. R., Bell, A., Sadler, C., Pass, M., Powell, S., Steele, S. J., Roberts, R. R. A., & Heier, A. (2011) · Toxicologic Pathology · doi:10.1177/0192623311416259 · Cited by 284 · see citing works

High levels of transforming growth factor beta 1 in patients with colorectal cancer: Association with disease progression

Tsushima, H., Kawata, S., Tamura, S., Ito, N., Shirai, Y., Kiso, S., Imai, Y., Shimomukai, H., Nomura, Y., Matsuda, Y., et al. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8566583 · Cited by 282 · see citing works

A phase III study of belagenpumatucel-L, an allogeneic tumour cell vaccine, as maintenance therapy for non-small cell lung cancer

Giaccone, G., Bazhenova, L. A., Nemunaitis, J., Tan, M., Juhász, E., Ramlau, R., van den Heuvel, M. M., Lal, R., Kloecker, G. H., Eaton, K. D., et al. (2015) · European Journal of Cancer · doi:10.1016/j.ejca.2015.07.035 · Cited by 279 · see citing works

Pro- and Antiinflammatory Cytokine Signaling: Reciprocal Antagonism Regulates Interferon-gamma Production by Human Natural Killer Cells

Yu, J., Wei, M., Becknell, B., Trotta, R., Liu, S., Boyd, Z. S., Jaung, M., Blaser, B. W., Sun, J. P., Benson, D. M., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.03.016 · Cited by 279 · see citing works

Resident memory T cells in the skin mediate durable immunity to melanoma

Malik, B. T., Byrne, K. T., Vella, J. L., Zhang, P., Shabaneh, T. B., Steinberg, S. M., Molodtsov, A. K., Bowers, J. S., Angeles, C. V., Paulos, C. M., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aam6346 · Cited by 278 · see citing works

Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype.

Sad, S., & Mosmann, T. R. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.8.3514 · Cited by 277 · see citing works

TGF-β contributes to the shift toward Th2-type responses through direct and IL-10-mediated pathways in tumor-bearing mice

Maeda, H., & Shiraishi, A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.1.73 · Cited by 277 · see citing works

TGF-β Utilizes SMAD3 to Inhibit CD16-Mediated IFN-γ Production and Antibody-Dependent Cellular Cytotoxicity in Human NK Cells

Trotta, R., Col, J. D., Yu, J., Ciarlariello, D., Thomas, B., Zhang, X., Allard, J., Wei, M., Mao, H. C., Byrd, J. C., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.3784 · Cited by 276 · see citing works

MicroRNA-494 Is Required for the Accumulation and Functions of Tumor-Expanded Myeloid-Derived Suppressor Cells via Targeting of PTEN

Liu, Y., Lai, L., Chen, Q., Song, Y., Xu, S., Ma, F., Wang, X., Wang, J., Yu, H. C., Cao, X., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103505 · Cited by 272 · see citing works

TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease

El-Asady, R. S., Yuan, R., Liu, K., Wang, D., Gress, R. E., Lucas, P. J., Drachenberg, C. B., & Hadley, G. A. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041044 · Cited by 271 · see citing works

Clinical development of therapies targeting TGFβ: current knowledge and future perspectives

Ciardiello, D., Élez, E., Tabernero, J. M., & Seoane, J. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.07.009 · Cited by 271 · see citing works

A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation

Arwert, E. N., Harney, A. S., Entenberg, D. R., Wang, Y., Sahai, E. A., Pollard, J. W., & Condeelis, J. S. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.007 · Cited by 264 · see citing works

LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy

Pascual-García, M., Bonfill-Teixidor, E., Planas-Rigol, E., Rubio-Perez, C., Iurlaro, R., Arias, A., Cuartas, I., Sala-Hojman, A., Escudero, L., Martínez-Ricarte, F., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10369-9 · Cited by 262 · see citing works

Rewiring T-cell responses to soluble factors with chimeric antigen receptors

Chang, Z. L., Lorenzini, M. H., Chen, X., Tran, U., Bangayan, N. J., & Chen, Y. Y. (2018) · Nature Chemical Biology · doi:10.1038/nchembio.2565 · Cited by 259 · see citing works

Focal Irradiation and Systemic TGFβ Blockade in Metastatic Breast Cancer

Formenti, S. C., Lee, P. P., Adams, S., Goldberg, J. D., Li, X., Xie, M. W., Ratikan, J. A., Felix, C., Hwang, L. H., Faull, K. F., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-3322 · Cited by 258 · see citing works

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade

Bonavita, E., Bromley, C. P., Jonsson, G., Pelly, V. S., Sahoo, S., Walwyn-Brown, K., Mensurado, S., Moeini, A., Flanagan, E., Bell, C. R., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.10.020 · Cited by 252 · see citing works

Transforming growth factor beta inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines.

Kobie, J. J., Wu, R. S., Kurt, R. A., Lou, S., Adelman, M. K., Whitesell, L. J., Ramanathapuram, L. V., Arteaga, C. L., & Akporiaye, E. T. (2003) · PubMed · Cited by 247 · see citing works

Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances

Lind, H., Gameiro, S. R., Jochems, C., Donahue, R. N., Strauss, J., Gulley, J. L., Palena, C., & Schlom, J. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000433 · Cited by 247 · see citing works

Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation

Gutcher, I., Donkor, M. K., Ma, Q., Rudensky, A. Y., Flavell, R. A., & Li, M. O. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.005 · Cited by 244 · see citing works

Cancer immunotherapy via targeted TGF-β signalling blockade in TH cells

Li, S., Liu, M., Do, M. H., Chou, C., Stamatiades, E. G., Nixon, B. G., Shi, W., Zhang, X., Li, P., Gao, S., et al. (2020) · Nature · doi:10.1038/s41586-020-2850-3 · Cited by 242 · see citing works

Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3 + regulatory T cells

Wei, J., Duramad, O., Perng, O. A., Reiner, S. L., Liu, Y., & Qin, F. X.-F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703642104 · Cited by 241 · see citing works

First-in-Human Dose Study of the Novel Transforming Growth Factor-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Patients with Advanced Cancer and Glioma

Rodon, J. A., Carducci, M. A., Sepúlveda-Sánchez, J. M., Azaro, A., Calvo, E., Seoane, J., Braña, I., Sicart, E., Gueorguieva, I., Cleverly, A., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1380 · Cited by 235 · see citing works

TGF-β1 Attenuates the Acquisition and Expression of Effector Function by Tumor Antigen-Specific Human Memory CD8 T Cells

Ahmadzadeh, M., & Rosenberg, S. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5215 · Cited by 224 · see citing works

Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape

Martin, C. J., Datta, A., Littlefield, C., Kalra, A., Chapron, C., Wawersik, S., Dagbay, K. B., Brueckner, C. T., Nikiforov, A., Danehy, F. T., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay8456 · Cited by 224 · see citing works

TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking

Gunderson, A. J., Yamazaki, T., McCarty, K., Fox, N., Phillips, M., Alice, A. F., Blair, T. C., Whiteford, M. H., O’Brien, D. P., Ahmad, R., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15404-8 · Cited by 223 · see citing works

TGF- and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells

Eisele, G. (2006) · Brain · doi:10.1093/brain/awl205 · Cited by 220 · see citing works

Safety and activity of the TGFβ receptor I kinase inhibitor galunisertib plus the anti-PD-L1 antibody durvalumab in metastatic pancreatic cancer

Melisi, D., Oh, D., Hollebecque, A., Calvo, E., Varghese, A. M., Borazanci, E. H., Macarulla, T. M., Merz, V., Zecchetto, C., Zhao, Y., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002068 · Cited by 214 · see citing works

TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts

Grauel, A. L., Nguyen, B., Ruddy, D., Laszewski, T., Schwartz, S., Chang, J., Chen, J., Piquet, M., Pelletier, M., Yan, Z., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19920-5 · Cited by 211 · see citing works

LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer

Albrengues, J., Bourget, I., Pons, C., Butet, V., Hofman, P. M., Tartare‐Deckert, S., Féral, C. C., Meneguzzi, G., & Gaggioli, C. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.036 · Cited by 209 · see citing works

Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer

Desbois, M., Udyavar, A. R., Ryner, L. C., Kozlowski, C., Guan, Y., Dürrbaum, M., Lu, S., Fortin, J., Koeppen, H., Ziai, J. M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19408-2 · Cited by 209 · see citing works

Transforming growth factor beta enhances integrin expression and type IV collagenase secretion in human monocytes.

Wahl, S. M., Allen, J. B., Weeks, B. S., Wong, H. L., & Klotman, P. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4577 · Cited by 206 · see citing works

Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Second-Line Treatment of Patients With NSCLC: Results From an Expansion Cohort of a Phase 1 Trial

Paz-Ares, L. G., Kim, T. M., Vicente, D., Felip, E., Lee, D. H., Lee, K. H., Lin, C., Flor, M. J., Nicola, M. D., Alvarez, R. M., et al. (2020) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2020.03.003 · Cited by 205 · see citing works

Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation

Worthington, J. J., Kelly, A., Smedley, C., Bauché, D., Campbell, S. S., Marie, J. C., & Travis, M. A. (2015) · Immunity · doi:10.1016/j.immuni.2015.04.012 · Cited by 199 · see citing works

c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies

Bernink, J. H., Ohne, Y., Teunissen, M. B. M., Wang, J., Wu, J., Krabbendam, L., Guntermann, C., Volckmann, R., Köster, J., van Tol, S., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0423-0 · Cited by 199 · see citing works

Phase I Trial of “bi-shRNAifurin/GMCSF DNA/Autologous Tumor Cell” Vaccine (FANG) in Advanced Cancer

Senzer, N. N., Barve, M. A., Kuhn, J. A., Melnyk, A., Beitsch, P. D., Lazar, M. L., Lifshitz, S. G., Magee, M. J., Oh, J., Mill, S. W., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.269 · Cited by 198 · see citing works

CD103 or LFA-1 Engagement at the Immune Synapse between Cytotoxic T Cells and Tumor Cells Promotes Maturation and Regulates T-cell Effector Functions

Franciszkiewicz, K., Floc’h, A. L., Boutet, M., Vergnon, I., Schmitt, A., & Mami‐Chouaib, F. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2569 · Cited by 189 · see citing works

The Discovery and Early Days of TGF-β: A Historical PerspectivePreprint

Moses, H. L., Roberts, A. B., & Derynck, R. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021865 · Cited by 189 · see citing works

TGF-β suppresses type 2 immunity to cancer

Liu, M., Kuo, F., Capistrano, K. J., Kang, D., Nixon, B. G., Shi, W., Chou, C., Do, M. H., Stamatiades, E. G., Gao, S., et al. (2020) · Nature · doi:10.1038/s41586-020-2836-1 · Cited by 189 · see citing works

Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family

Katsuno, Y., & Derynck, R. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.028 · Cited by 187 · see citing works

Transforming growth factor-β stimulates arginase activity in macrophages. Implications for the regulation of macrophage cytotoxicity

Boutard, V., Havouis, R., Fouqueray, B. L., Philippe, C., Moulinoux, J.-P., & Baud, L. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.4.2077 · Cited by 186 · see citing works

Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies

Roth, T. L., Li, P. J., Blaeschke, F., Nies, J. F., Apathy, R., Mowery, C., Yu, R., Nguyen, M. L. T., Lee, Y., Truong, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.039 · Cited by 186 · see citing works

Tumor-Specific T-Cells Engineered to Overcome Tumor Immune Evasion Induce Clinical Responses in Patients With Relapsed Hodgkin Lymphoma

Bollard, C. M., Tripic, T., Cruz, C. R., Dotti, G., Gottschalk, S., Torrano, V., Dakhova, O., Carrum, G., Ramos, C. A., Liu, H., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.74.3179 · Cited by 181 · see citing works

GARP regulates the bioavailability and activation of TGFβ

Wang, R., Zhu, J., Dong, X., Shi, M., Lu, C., & Springer, T. A. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-12-1018 · Cited by 180 · see citing works

A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System

Qin, Y., Garrison, B. S., Ma, W., Wang, R., Jiang, A., Li, J., Mistry, M., Bronson, R. T., Santoro, D., Franco, C., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.027 · Cited by 180 · see citing works

Dendritic Cells As Inducers of Peripheral Tolerance

Iberg, C. A., Jones, A., & Hawiger, D. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.07.007 · Cited by 178 · see citing works

Transforming Growth Factor β1 Inhibits Fas Ligand Expression and Subsequent Activation-induced Cell Death in T Cells via Downregulation of c-Myc

Genestier, L., Kasibhatla, S., Brunner, T., & Green, D. R. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.2.231 · Cited by 177 · see citing works

Canonical TGF-β Signaling Pathway Represses Human NK Cell Metabolism

Zaiatz-Bittencourt, V., Finlay, D. K., & Gardiner, C. M. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701461 · Cited by 177 · see citing works

α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

Dodagatta-Marri, E., Meyer, D. S., Reeves, M. Q., Paniagua, R., To, M. D., Binnewies, M., Broz, M. L., Mori, H., Wu, D., Adoumie, M., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-018-0493-9 · Cited by 177 · see citing works

Human CD1c+ Dendritic Cells Drive the Differentiation of CD103+ CD8+ Mucosal Effector T Cells via the Cytokine TGF-β

Yu, C. I., Becker, C., Wang, Y., Marches, F., Helft, J., Leboeuf, M., Anguiano, E., Pourpe, S., Göller, K., Pascual, V., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.03.004 · Cited by 176 · see citing works

Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β

Campbell, M. G., Cormier, A., Ito, S., Seed, R., Bondesson, A. J., Lou, J., Marks, J. D., Baron, J. L., Cheng, Y., & Nishimura, S. L. (2020) · Cell · doi:10.1016/j.cell.2019.12.030 · Cited by 176 · see citing works

TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation

Zhang, N., & Bevan, M. J. (2012) · Nature Immunology · doi:10.1038/ni.2319 · Cited by 175 · see citing works

The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation

Kuwahara, M., Yamashita, M., Shinoda, K., Tofukuji, S., Onodera, A., Shinnakasu, R., Motohashi, S., Hosokawa, H., Tumes, D. J., Iwamura, C., et al. (2012) · Nature Immunology · doi:10.1038/ni.2362 · Cited by 175 · see citing works

The integrin αVβ6 binds and activates latent TGFβ3

Annes, J. P., Rifkin, D. B., & Munger, J. S. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03280-x · Cited by 173 · see citing works

Intestinal Dendritic Cells Specialize to Activate Transforming Growth Factor-β and Induce Foxp3+ Regulatory T Cells via Integrin αvβ8

Worthington, J. J., Czajkowska, B. I., Melton, A. C., & Travis, M. A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.057 · Cited by 172 · see citing works

Human Dendritic Cells Produce TGF-β1 under the Influence of Lung Carcinoma Cells and Prime the Differentiation of CD4+CD25+Foxp3+ Regulatory T Cells

Dumitriu, I. E., Dunbar, D. R., Howie, S., Sethi, T., & Gregory, C. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0712671 · Cited by 171 · see citing works

Epilysin (MMP-28) induces TGF-β mediated epithelial to mesenchymal transition in lung carcinoma cells

Illman, S. A., Lehti, K., Keski‐Oja, J., & Lohi, J. (2006) · Journal of Cell Science · doi:10.1242/jcs.03157 · Cited by 168 · see citing works

Transforming Growth Factor β Blocks Tec Kinase Phosphorylation, Ca2+ Influx, and NFATc Translocation Causing Inhibition of T Cell Differentiation

Chen, C.-H., Seguin‐Devaux, C., Burke, N. A., Oriss, T. B., Watkins, S. C., Clipstone, N. A., & Ray, A. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021170 · Cited by 166 · see citing works

Association of Pre- and Postoperative Plasma Levels of Transforming Growth Factor β1 and Interleukin 6 and Its Soluble Receptor with Prostate Cancer Progression

Shariat, S. F., Kattan, M. W., Traxel, E. J., Andrews, B., Zhu, K., Wheeler, T. M., & Slawin, K. M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0768-03 · Cited by 166 · see citing works

Tumor-derived TGF-β Mediates Conversion of CD4+Foxp3+ Regulatory T Cells in a Murine Model of Pancreas Cancer

Moo‐Young, T. A., Larson, J. W., Belt, B. A., Tan, M. C. B., Hawkins, W. G., Eberlein, T. J., Goedegebuure, P. S., & Linehan, D. C. (2008) · Journal of Immunotherapy · doi:10.1097/cji.0b013e318189f13c · Cited by 165 · see citing works

Reduced expression of tissue factor pathway inhibitor-2 contributes to apoptosis and angiogenesis in cervical cancer

Zhang, Q., Zhang, Y., Wang, S. Z., Wang, N., Jiang, W. G., Ji, Y. H., & Zhang, S. L. (2012) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-31-1 · Cited by 164 · see citing works

TGF-β1 Uses Distinct Mechanisms to Inhibit IFN-γ Expression in CD4+ T Cells at Priming and at Recall: Differential Involvement of Stat4 and T-bet

Lin, J. T., Martin, S. L., Xia, L., & Gorham, J. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.5950 · Cited by 163 · see citing works

Marfan Syndrome and Related Disorders: 25 Years of Gene Discovery

Verstraeten, A., Alaerts, M., Laer, L. V., & Loeys, B. (2016) · Human Mutation · doi:10.1002/humu.22977 · Cited by 160 · see citing works

Phase 2 study of pembrolizumab and circulating biomarkers to predict anticancer response in advanced, unresectable hepatocellular carcinoma

Feun, L. G., Li, Y., Wu, C., Wangpaichitr, M., Jones, P. D., Richman, S. P., Madrazo, B. L., Kwon, D., Garcia-Buitrago, M. T., Martin, P. B., et al. (2019) · Cancer · doi:10.1002/cncr.32339 · Cited by 160 · see citing works

Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo

Cuende, J., Liénart, S., Dedobbeleer, O., van der Woning, B., De Boeck, G., Stockis, J., Huygens, C., Colau, D., Somja, J., Delvenne, P., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa1983 · Cited by 155 · see citing works

TGF-β Signaling in Myeloid Cells Is Required for Tumor Metastasis

Pang, Y., Gara, S. K., Achyut, B. R., Li, Z., Yan, H. H., Day, C., Weiss, J. M., Trinchieri, G., Morris, J. C., & Li, Y. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0527 · Cited by 155 · see citing works

Mitochondrial dynamics in health and disease: mechanisms and potential targets

Chen, W., Zhao, H., & Li, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01547-9 · Cited by 1,306 · see citing works

The cancer-immunity cycle: Indication, genotype, and immunotype

Mellman, I., Chen, D. S., Powles, T. B., & Turley, S. J. (2023) · Immunity · doi:10.1016/j.immuni.2023.09.011 · Cited by 985 · see citing works

TGF-β signaling in health and disease

Massagué, J., & Sheppard, D. (2023) · Cell · doi:10.1016/j.cell.2023.07.036 · Cited by 890 · see citing works

The hallmarks of cancer immune evasion

Galassi, C., Chan, T. A.-T., Vitale, I., & Galluzzi, L. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.09.010 · Cited by 595 · see citing works

Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches

Tufail, M., Jiang, C., & Li, N. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02280-1 · Cited by 424 · see citing works

Cancer-Associated Fibroblasts in Inflammation and Antitumor Immunity

Kennel, K. B., Bozlar, M., Valk, A. F. D., & Greten, F. R. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-1031 · Cited by 283 · see citing works

Mechanisms driving the immunoregulatory function of cancer cells

van Weverwijk, A., & de Visser, K. E. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-022-00544-4 · Cited by 279 · see citing works

Roles of cancer-associated fibroblasts (CAFs) in anti- PD-1/PD-L1 immunotherapy for solid cancers

Pei, L., Liu, Y., Liu, L., Gao, S., Gao, X., Feng, Y., Sun, Z., Zhang, Y., & Wang, C. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01731-z · Cited by 265 · see citing works

Mechanisms of metastatic colorectal cancer

Cañellas-Socias, A., Sancho, E., & Batlle, E. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00934-z · Cited by 270 · see citing works

Advances in molecular pathology and therapy of non-small cell lung cancer

Huang, Q., Li, Y., Huang, Y., Wu, J., Bao, W., Xue, C., Li, X., Dong, S., Dong, Z., & Hu, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02243-6 · Cited by 197 · see citing works

NK cells and solid tumors: therapeutic potential and persisting obstacles

Tong, L., Jiménez‐Cortegana, C., Tay, A. H. M., Wickström, S. L., Galluzzi, L., & Lundqvist, A. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01672-z · Cited by 193 · see citing works

WNT signaling and cancer stemness

Katoh, M., & Katoh, M. (2022) · Essays in Biochemistry · doi:10.1042/ebc20220016 · Cited by 181 · see citing works

TGF-beta signal transduction: biology, function and therapy for diseases

Tie, Y., Tang, F., Peng, D., Zhang, Y., & Shi, H. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00109-9 · Cited by 178 · see citing works

TGF-β, EMT, and resistance to anti-cancer treatment

Wang, X., Eichhorn, P. J. A., & Thiery, J. P. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.10.004 · Cited by 180 · see citing works

ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain

Yegutkin, G. G., & Boison, D. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000528 · Cited by 171 · see citing works

Tumor battlefield within inflamed, excluded or desert immune phenotypes: the mechanisms and strategies

Zheng, S., Wang, W., Shen, L., Yao, Y., Xia, W.-J., & Ni, C. (2024) · Experimental Hematology & Oncology · doi:10.1186/s40164-024-00543-1 · Cited by 180 · see citing works

Localization, tissue biology and T cell state — implications for cancer immunotherapy

Schenkel, J. M., & Pauken, K. E. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00884-8 · Cited by 139 · see citing works

Extracellular matrix dynamics in tumor immunoregulation: from tumor microenvironment to immunotherapy

Hu, Q., Zhu, Y., Mei, J., Liu, Y. L., & Zhou, G. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01717-y · Cited by 151 · see citing works

Toll-like receptor 9 agonists and combination therapies: strategies to modulate the tumour immune microenvironment for systemic anti-tumour immunity

Dongye, Z., Li, J., & Wu, Y. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01876-6 · Cited by 135 · see citing works

The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis

Yoshimura, T., Li, C., Wang, Y., & Matsukawa, A. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01013-0 · Cited by 128 · see citing works

Macrophage polarization in cancer and beyond: from inflammatory signaling pathways to potential therapeutic strategies.

Bai, X., Guo, Y.-R., Zhao, Z.-M., Li, X.-Y., Dai, D.-Q., Zhang, J.-K., Li, Y.-S., & Zhang, C.-D. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217772 · Cited by 130 · see citing works

Application of radiomics-based multiomics combinations in the tumor microenvironment and cancer prognosis

Kang, W., Qiu, X., Luo, Y., Luo, J., Liu, Y., Xi, J., Li, X., & Yang, Z. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04437-4 · Cited by 125 · see citing works

Targeting inflammation as cancer therapy

Wang, M., Chen, S., He, X., Yuan, Y., & Wei, X. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01528-7 · Cited by 122 · see citing works

Neutrophil Extracellular Traps, Angiogenesis and Cancer

Poto, R., Cristinziano, L., Modestino, L., de Paulis, A., Marone, G., Loffredo, S., Galdiero, M. R., & Varricchi, G. (2022) · Biomedicines · doi:10.3390/biomedicines10020431 · Cited by 115 · see citing works

Hepatocellular carcinoma: signaling pathways, targeted therapy, and immunotherapy

Luo, X., He, X., Zhang, X., Zhao, X., Zhang, Y., Shi, Y., & Hua, S. (2024) · MedComm · doi:10.1002/mco2.474 · Cited by 111 · see citing works

Recent Developments in Layer‐by‐Layer Assembly for Drug Delivery and Tissue Engineering Applications

Borges, J., Zeng, J., Liu, X. Q., Chang, H., Monge, C., Garot, C., Ren, K., Machillot, P., Vrana, N. E., Lavall�e, P., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202302713 · Cited by 105 · see citing works

Convergent inducers and effectors of T cell paralysis in the tumour microenvironment

Hanahan, D., Michielin, O. A., & Pittet, M. J. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00761-z · Cited by 102 · see citing works

TGF-β: A novel predictor and target for anti-PD-1/PD-L1 therapy

Yi, M., Li, T., Niu, M., Wu, Y., Zhao, Z., & Wu, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1061394 · Cited by 94 · see citing works

TME-Related Biomimetic Strategies Against Cancer

Peng, C., Xu, Y., Wu, J., Wu, D., Zhou, L., & Xia, X. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s441135 · Cited by 90 · see citing works

Myeloid-Derived Suppressor Cells and Radiotherapy

Jiménez‐Cortegana, C., Galassi, C., Klapp, V., Gabrilovich, D. I., & Galluzzi, L. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-1105 · Cited by 88 · see citing works

The difficulty in translating the preclinical success of combined TGFβ and immune checkpoint inhibition to clinical trial

Metropulos, A. E., Munshi, H. G., & Principe, D. R. (2022) · eBioMedicine · doi:10.1016/j.ebiom.2022.104380 · Cited by 81 · see citing works

Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-β/SMAD3 pathway

Zhang, T., Xia, W., Song, X., Mao, Q., Huang, X., Chen, B., Liang, Y., Wang, H., Chen, Y., Yu, X., et al. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01331-2 · Cited by 85 · see citing works

Interventional hydrogel microsphere vaccine as an immune amplifier for activated antitumour immunity after ablation therapy

Liu, X., Zhuang, Y., Huang, W., Wu, Z., Chen, Y., Shan, Q., Zhang, Y., Wu, Z., Ding, X., Qiu, Z., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39759-w · Cited by 91 · see citing works

Oxidative Stress and Inflammation: Drivers of Tumorigenesis and Therapeutic Opportunities

Wang, M., Xiao, Y.-P., Miao, J., Zhang, X., Liu, M., Zhu, L., Liu, H., Shen, X., Wang, J.-H., Xie, B., et al. (2025) · Antioxidants · doi:10.3390/antiox14060735 · Cited by 102 · see citing works

Smart Lipid Nanoparticle that Remodels Tumor Microenvironment for Activatable H 2 S Gas and Photodynamic Immunotherapy

Wu, L., Liu, Y., Zeng, W., Ishigaki, Y., Zhou, S., Wang, X., Sun, Y., Zhang, Y., Jiang, X., Suzuki, T., et al. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c11328 · Cited by 84 · see citing works

TGF-β Signaling in Metastatic Colorectal Cancer (mCRC): From Underlying Mechanism to Potential Applications in Clinical Development

Li, X.-S., Wu, Y., & Tian, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214436 · Cited by 82 · see citing works

Nanoparticle-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation

Li, T., Jiang, S., Zhang, Y., Luo, J., Li, M., Ke, H., Deng, Y., Yang, T., Sun, X., & Chen, H. (2023) · Nature Communications · doi:10.1038/s41467-023-38128-x · Cited by 80 · see citing works

The strategies to cure cancer patients by eradicating cancer stem-like cells

Mai, Y., Su, J., Yang, C., Xia, C., & Fu, L. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01867-y · Cited by 78 · see citing works

Mapping Phenotypic Plasticity upon the Cancer Cell State Landscape Using Manifold Learning

Burkhardt, D. B., Juan, B. P. S., Lock, J. G., Krishnaswamy, S., & Chaffer, C. L. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0282 · Cited by 74 · see citing works

The Cytokine Network in Colorectal Cancer: Implications for New Treatment Strategies

Braumüller, H., Mauerer, B., Andris, J., Berlin, C., Wieder, T., & Kesselring, R. (2022) · Cells · doi:10.3390/cells12010138 · Cited by 74 · see citing works

UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment

Li, Y., Jiang, M., Aye, L., Luo, L., Zhang, Y., Xu, F., Wei, Y., Peng, D., He, X., Gu, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45340-w · Cited by 71 · see citing works

Interleukin-6 (IL-6)-associated tumor microenvironment remodelling and cancer immunotherapy

Wu, S., Cao, Z., Lu, R., Zhang, Z., Sethi, G., & You, Y. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.01.001 · Cited by 70 · see citing works

Immune checkpoint blockade resistance in lung cancer: emerging mechanisms and therapeutic opportunities

Konen, J. M., Wu, H., & Gibbons, D. L. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2024.04.006 · Cited by 72 · see citing works

Cancer stem cell in prostate cancer progression, metastasis and therapy resistance

Verma, P., Shukla, N., Kumari, S., Ansari, M. S., Gautam, N. K., & Patel, G. K. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188887 · Cited by 65 · see citing works

Small-molecule agents for cancer immunotherapy

Wang, F., Fu, K., Wang, Y., Pan, C., Wang, X., Liu, Z., Yang, C., Zheng, Y. Y., Li, X., Lu, Y., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.12.010 · Cited by 71 · see citing works

Development of pharmacological immunoregulatory anti-cancer therapeutics: current mechanistic studies and clinical opportunities

Yin, N., Li, X., Zhang, X., Xue, S., Cao, Y., Niedermann, G., Lu, Y., & Xue, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01826-z · Cited by 66 · see citing works

Nanodrug Inducing Autophagy Inhibition and Mitochondria Dysfunction for Potentiating Tumor Photo‐Immunotherapy

Xiao, H. P., Li, X., Li, B., Yang, S., Qin, J., Han, S., Ren, J., & Shuai, X. (2023) · Small · doi:10.1002/smll.202300280 · Cited by 63 · see citing works

The enhanced antitumor activity of bispecific antibody targeting PD-1/PD-L1 signaling

Li, T., Niu, M., Zhou, J., Wu, K., & Yi, M. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01562-5 · Cited by 63 · see citing works

Context-dependent TGFβ family signalling in cell fate regulation

Richardson, L., Wilcockson, S. G., Guglielmi, L., & Hill, C. S. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00638-3 · Cited by 59 · see citing works

TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages

Henriques, A. R., Salvany, M., Nieto, P., Palomo‐Ponce, S., Sevillano, M., Hernando‐Momblona, X., Guerra, E. M., Llanses, M., Haak, E., Nieto, J. C., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02380-2 · Cited by 60 · see citing works

The Landscape of Immunotherapy Resistance in NSCLC

Frisone, D., Friedlaender, A., Addeo, A., & Tsantoulis, P. K. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.817548 · Cited by 58 · see citing works

TGF-β signaling pathway: Therapeutic targeting and potential for anti-cancer immunity

Ali, S., Rehman, M. U., Yatoo, A. M., Arafah, A. M., Khan, A., Rashid, S., Majid, S., Ali, A., & Ali, M. N. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175678 · Cited by 57 · see citing works

TGF-β Modulated Pathways in Colorectal Cancer: New Potential Therapeutic Opportunities

Fasano, M., Pirozzi, M., Miceli, C. C., Cocule, M., Caraglia, M., Boccellino, M., Vitale, P., Falco, V. D., Farese, S., Zotta, A., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137400 · Cited by 57 · see citing works

Recent Advances in Immune-Based Therapies for Acute Myeloid Leukemia

Restelli, C., Ruella, M., Paruzzo, L., Tarella, C., Pelicci, P. G., & Colombo, E. (2024) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-23-0202 · Cited by 56 · see citing works

Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression

Rea, A., Santana-Hernández, S., Villanueva, J., Sanvicente-García, M., Cabo, M., Suárez-Olmos, J., Quimis, F. G., Qin, M., Llorens, E., Blasco-Benito, S., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02103-z · Cited by 55 · see citing works

Integrated Machine Learning and Single-Sample Gene Set Enrichment Analysis Identifies a TGF-Beta Signaling Pathway Derived Score in Headneck Squamous Cell Carcinoma

Wu, S., Lv, X., Li, Y., Gao, X., Ma, Z., Fu, X., & Li, Y. (2022) · Journal of Oncology · doi:10.1155/2022/3140263 · Cited by 52 · see citing works

Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy

Saadey, A. A., Yousif, A., Osborne, N., Shahinfar, R., Chen, Y., Laster, B., Rajeev, M., Bauman, P., Webb, A., & Ghoneim, H. E. (2022) · Nature Immunology · doi:10.1038/s41590-022-01384-y · Cited by 47 · see citing works

The Love-Hate Relationship Between TGF-β Signaling and the Immune System During Development and Tumorigenesis

Chen, B., Mu, C., Zhang, Z., He, X., & Liu, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.891268 · Cited by 46 · see citing works

Bispecific antibody targeting TGF-β and PD-L1 for synergistic cancer immunotherapy

Li, T., Wang, X., Niu, M., Wang, M., Zhou, J., Wu, K., & Yi, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1196970 · Cited by 50 · see citing works

Blocking tumor-platelet crosstalk to prevent tumor metastasis via reprograming glycolysis using biomimetic membrane-hybridized liposomes

Zhu, J., Wang, R., Yang, C., Shao, X., Zhang, Y., Hou, J., Gao, Y., Ou, A., Chen, M., & Huang, Y. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.12.052 · Cited by 45 · see citing works

Efficacy and safety of bispecific antibodies vs. immune checkpoint blockade combination therapy in cancer: a real-world comparison

Cheng, L., Chen, L., Shi, Y., Gu, W., Ding, W., Zheng, X. W., Liu, Y., Jiang, J., & Zheng, Z. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01956-6 · Cited by 45 · see citing works

Clinical Challenges of Consensus Molecular Subtype CMS4 Colon Cancer in the Era of Precision Medicine

Mouillet-Richard, S., Cazelles, A., Sroussi, M., Gallois, C., Taieb, J., & Laurent-Puig, P. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-3964 · Cited by 43 · see citing works

Flash Radiotherapy: Innovative Cancer Treatment

Chow, J. C. L., & Ruda, H. E. (2023) · Encyclopedia · doi:10.3390/encyclopedia3030058 · Cited by 43 · see citing works

Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis

Garbarino, O., Lambroia, L., Basso, G., Marrella, V., Franceschini, B., Soldani, C., Pasqualini, F., Giuliano, D., Costa, G., Peano, C., et al. (2023) · Aging Cell · doi:10.1111/acel.13853 · Cited by 43 · see citing works

Advances in Targeted and Chemotherapeutic Strategies for Colorectal Cancer: Current Insights and Future Directions

Shaham, S. H., Vij, P., & Tripathi, M. K. (2025) · Biomedicines · doi:10.3390/biomedicines13030642 · Cited by 44 · see citing works

The immunosuppressive landscape in tumor microenvironment

Liu, W., Zhou, H., Lai, W., Hu, C., Xu, R., Gu, P., Luo, M., Zhang, R., & Li, G. (2024) · Immunologic Research · doi:10.1007/s12026-024-09483-8 · Cited by 41 · see citing works

Mutant RAS and the tumor microenvironment as dual therapeutic targets for advanced colorectal cancer

Janssen, J. B. E., Medema, J. P., Gootjes, E. C., Tauriello, D. V. F., & Verheul, H. M. W. (2022) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2022.102433 · Cited by 41 · see citing works

Anti-TGF-β/PD-L1 bispecific antibody synergizes with radiotherapy to enhance antitumor immunity and mitigate radiation-induced pulmonary fibrosis

Wu, Y., Yan, Y., Guo, Y., Niu, M., Zhou, B., Zhang, J., Zhou, P., Chu, Q., Mei, Q., Yi, M., et al. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01678-2 · Cited by 40 · see citing works

Multi-armored allogeneic MUC1 CAR T cells enhance efficacy and safety in triple-negative breast cancer

Erler, P., Kurćon, T., Cho, H., Skinner, J. N., Dixon, C., Grudman, S., Rozlan, S., Dessez, E., Mumford, B., Jo, S., et al. (2024) · Science Advances · doi:10.1126/sciadv.adn9857 · Cited by 40 · see citing works

Single-cell and spatial transcriptomics integration: new frontiers in tumor microenvironment and cellular communication

Shi, W., Zhang, Z., Xu, X., Tian, Y., Feng, L., Huang, X., Du, Y., & Li, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1649468 · Cited by 42 · see citing works

Perfluorotributylamine-Loaded Albumin Nanoparticles Downregulate Platelet-Derived TGFβ to Inhibit Tumor Metastasis

Luo, L., Zhang, B., Tao, F., Chen, Z., Ye, Q., Zhao, X., & Wu, J. (2023) · ACS Nano · doi:10.1021/acsnano.3c00295 · Cited by 38 · see citing works

Growth factors in the treatment of Achilles tendon injury

Lin, M., Li, W., Ni, X., Yu, S., Li, H., Chen, X., Lu, Y., Jiang, M., & Wang, C. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1250533 · Cited by 37 · see citing works

Radiation-induced lung injury: from mechanism to prognosis and drug therapy

Wang, S., Xu, D., Xiao, L., Liu, B., & Yuan, X. (2025) · Radiation Oncology · doi:10.1186/s13014-025-02617-8 · Cited by 37 · see citing works

Mutual regulation of TGFβ-induced oncogenic EMT, cell cycle progression and the DDR

Schuhwerk, H., & Brabletz, T. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.11.009 · Cited by 35 · see citing works

Preclinical and clinical studies of bintrafusp alfa, a novel bifunctional anti-PD-L1/TGFβRII agent: Current status

Gameiro, S. R., Strauss, J., Gulley, J. L., & Schlom, J. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702221089910 · Cited by 35 · see citing works

SOX12 Facilitates Hepatocellular Carcinoma Progression and Metastasis through Promoting Regulatory T‐Cells Infiltration and Immunosuppression

Luo, X., Huang, W., Li, S., Sun, M., Hu, D. X., Jiang, J., Zhang, Z., Wang, Y., Wang, Y., Zhang, J., et al. (2024) · Advanced Science · doi:10.1002/advs.202310304 · Cited by 33 · see citing works

Pharmacological suppression of the OTUD4/CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers

Zhu, Y., Banerjee, A., Xie, P., Ivanov, A. A., Uddin, A., Jiao, Q., Chi, J. J., Zeng, L., Lee, J. Y., Xue, Y., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci176390 · Cited by 33 · see citing works

MDSC: a new potential breakthrough in CAR-T therapy for solid tumors

Abdalsalam, N. M. F., Ibrahim, A., Saliu, M. A., Liu, T., Wan, X., & Yan, D. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01995-y · Cited by 33 · see citing works

The radiobiology of TGFβ

Barcellos‐Hoff, M. H. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.02.001 · Cited by 32 · see citing works

Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity

Zhang, T., Yu, W., Cheng, X., Yeung, J. T., Ahumada, V., Norris, P. C., Pearson, M. J., Yang, X., van Deursen, W. H., Halcovich, C., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adh2334 · Cited by 32 · see citing works

Radiotherapy enhances the anti-tumor effect of CAR-NK cells for hepatocellular carcinoma

Lin, X., Liu, Z., Dong, X., Wang, K., Sun, Y., Zhang, H., Wang, F., Chen, Y., Jing, L., Guo, Y., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05724-4 · Cited by 32 · see citing works

Claudin 1, 4, 6 and 18 isoform 2 as targets for the treatment of cancer (Review)

Katoh, M., & Katoh, M. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5424 · Cited by 31 · see citing works

Immunological control of ovarian carcinoma by chemotherapy and targeted anticancer agents

Fucikova, J. P., Palová-Jelínková, L., Klapp, V., Holíček, P., Láníčková, T., Kašíková, L., Drozenová, J., Cibula, D., Álvarez-Abril, B., García-Martínez, E., et al. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.01.010 · Cited by 31 · see citing works

Hypoxic tumor microenvironment: Destroyer of natural killer cell function

Zhang, Y., Guo, F., & Wang, Y. (2024) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2024.02.04 · Cited by 32 · see citing works

Cancer-Homing CAR-T Cells and Endogenous Immune Population Dynamics

Guerra, E., Pietro, R. D., Basile, M., Trerotola, M., & Alberti, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010405 · Cited by 30 · see citing works

TIM-3 Expression and M2 Polarization of Macrophages in the TGFβ-Activated Tumor Microenvironment in Colorectal Cancer

Katagata, M., Okayama, H., Nakajima, S., Saito, K., Sato, T., Sakuma, M., Fukai, S., Endo, E., Sakamoto, W., Saito, M., et al. (2023) · Cancers · doi:10.3390/cancers15204943 · Cited by 30 · see citing works

ZEB1-mediated fibroblast polarization controls inflammation and sensitivity to immunotherapy in colorectal cancer

Menche, C., Schuhwerk, H., Armstark, I., Gupta, P., Fuchs, K., van Roey, R., Mosa, M. H., Hartebrodt, A., Hajjaj, Y., Ezquerra, A. C., et al. (2024) · EMBO Reports · doi:10.1038/s44319-024-00186-7 · Cited by 31 · see citing works

Coengineering specificity, safety, and function into T cells for cancer immunotherapy

Attianese, G. M. P. G., Ash, S., & Irving, M. B. (2023) · Immunological Reviews · doi:10.1111/imr.13252 · Cited by 29 · see citing works

Nanomaterial-assisted CRISPR gene-engineering – A hallmark for triple-negative breast cancer therapeutics advancement

Farheen, J., Hosmane, N. S., Zhao, R., Zhao, Q. D., Iqbal, M. Z., & Kong, X. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100450 · Cited by 28 · see citing works

γδ T Cell‐mediated Tumor Immunity is Tightly Regulated by STING and TGF‐β Signaling Pathways

Luo, J., Wang, S., Yang, Q., Fu, Q., Zhu, C., Li, T., Yang, S., Zhao, Y., Guo, R., Ben, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202404432 · Cited by 26 · see citing works

A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options

Yuan, F., Hu, Y., Xu, F., & Feng, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1374236 · Cited by 22 · see citing works

Convergent evolution of a parasite-encoded complement control protein-scaffold to mimic binding of mammalian TGF-β to its receptors, TβRI and TβRII

Mukundan, A., Byeon, C., Hinck, C. S., Cunningham, K. T., Campion, T., Smyth, D. J., Maizels, R. M., & Hinck, A. P. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101994 · Cited by 21 · see citing works

SMAD4, activated by the TCR-triggered MEK/ERK signaling pathway, critically regulates CD8 + T cell cytotoxic function

Liu, X., Hao, J., Wei, P., Zhao, X., Lan, Q., Ni, L., Chen, Y., Bai, X., Ni, L., & Dong, C. (2022) · Science Advances · doi:10.1126/sciadv.abo4577 · Cited by 25 · see citing works

Charting the Course: Sequencing Immunotherapy for Multiple Myeloma

Mohan, M., Oekelen, O. V., Akhtar, O. S., Cohen, A. D., & Parekh, S. S. (2024) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_432204 · Cited by 27 · see citing works

Targeting IL-33 reprograms the tumor microenvironment and potentiates antitumor response to anti-PD-L1 immunotherapy

Nan, Y., Bai, Y., Hu, X., Zhou, K., Wu, T., Zhu, A., Li, M., Dou, Z., Cao, Z., Zhang, X., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009236 · Cited by 24 · see citing works

Increased peritoneal TGF-β1 is associated with ascites-induced NK-cell dysfunction and reduced survival in high-grade epithelial ovarian cancer

Maas, R. J. A., Evert, J. S. H., Hagemans, I. M., Brummelman, J., van Ens, D., de Jonge, P. K. J. D., Hooijmaijers, L., Mahajan, S., van der Waart, A. B., Hermans, C. K. J. C., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1448041 · Cited by 24 · see citing works

Natural photothermal-responsive MXene-based antimicrobial nanomaterials Ti3C2/Au NPs for the treatment of deep Staphylococcus aureus-Infected wound

Chen, X., Wang, J., Endo, Y., Liu, G., Wang, N., & Shao, Z. (2023) · Materials & Design · doi:10.1016/j.matdes.2023.112138 · Cited by 24 · see citing works

Understanding and Overcoming Immunosuppression Shaped by Cancer Stem Cells

Li, L., & Jensen, R. A. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-0230 · Cited by 24 · see citing works

Potentiating anti-tumor immunity by re-engaging immune synapse molecules

Zhou, X., Xu, T., Li, C., He, Y., Hu, Y., Gong, H., Li, J., Jiang, H., Wen, L., Fu, Y., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.101975 · Cited by 23 · see citing works

Triple targeting of STING, TGF-β, and PD-L1 boosts CXCL16–CXCR6 signaling for potent antitumor response

Yi, M., Li, T., Gu, Y., Niu, M., Xue, D., Hu, S., Wu, Y., Zhao, B., Zhang, D., Ma, Y., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69456-3 · Cited by 23 · see citing works

Overcoming TGF beta-mediated immune evasion in cancer

Tauriello, D. V. F., Sancho, E., & Batlle, E. (2022) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) · Cited by 1 · see citing works

TGFβ biology in cancer progression and immunotherapy

Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944 · see citing works

Transforming Growth Factor-β Signaling in Immunity and Cancer

Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366 · see citing works

TGF-β Signaling in Cancer Immunity: Immune Suppression, Stromal Remodeling, and Therapeutic Targeting

Jiang, M., Zhang, K., Zheng, X., Bo, Z., & Wei, R. (2026) · Cancer Biome and Targeted Therapy · doi:10.66505/cbtt.v1i2.17

Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression

van den Bulk, J., de Miranda, N. F. C. C., & ten Dijke, P. (2021) · Clinical Science · doi:10.1042/cs20201236 · Cited by 75 · see citing works