The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair
Abstract
Senescent renal epithelia promote fibrosis and functional loss after injury, whereas depletion improves regeneration in aged or irradiated kidneys.
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In aged murine models, navitoclax treatment restored hematopoietic stem cell function and reversed radiation-induced tissue damage.
“In aged murine models, treatment restored hematopoietic stem cell function29 and reversed radiation-induced tissue damage30,31.”
From Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming (2026) · cites this paper as [31]
The available passages identify a paper about senolytic treatment and renal repair in mice, but provide no finding about radiation-induced damage. Searches for radiation, navitoclax, and hematopoietic stem cell function found no passage addressing the attributed claim. (LLM, conf=0.72)
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Cites
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“Because TGF-1 is a recognized driver of renal fibrosis after IRI (23–25) and is produced by SC (26, 27), this protein was measured in the kidney.”
BackgroundCellular senescence mediates fibrotic pulmonary disease
Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., et al. (2017) · Nature Communications · doi:10.1038/ncomms14532 · Cited by 1,613 · cited 1×
“These findings mirror those recently reported in other organ systems including the lung and liver (37, 38).”
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Cellular Senescence in the Kidney
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Self-citationWnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells
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Cited by
Sorted by citations
Cellular senescence: the good, the bad and the unknown
Huang, W., Hickson, L. J., Eirin, A., Kirkland, J. L., & Lerman, L. O. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00601-z · Cited by 1,150
Cellular senescence and senolytics: the path to the clinic
Chaib, S., Tchkonia, T., & Kirkland, J. L. (2022) · Nature Medicine · doi:10.1038/s41591-022-01923-y · Cited by 1,134
The costs and benefits of senotherapeutics for human health
Raffaele, M., & Vinciguerra, M. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(21)00300-7 · Cited by 140
Englund, D. A., Zhang, X., Aversa, Z., & LeBrasseur, N. K. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111595 · Cited by 94
The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress
Anerillas, C., Mazan-Mamczarz, K., Herman, A. B., Munk, R., Lam, K.-W. G., Calvo-Rubio, M., Garrido, A., Tsitsipatis, D., Martindale, J. L., Altés, G., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00480-4 · Cited by 76
Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis
O’Sullivan, E. D., Mylonas, K. J., Bell, R., Carvalho, C., Baird, D. P., Cairns, C., Gallagher, K. M., Campbell, R., Docherty, M., Laird, A., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.154124 · Cited by 43
Self-citationContext‐dependent roles of cellular senescence in normal, aged, and disease states
Moiseeva, V., Cisneros, A., Cobos, A. C., Tarrega, A. B., Oñate, C. S., Perdiguero, E., Serrano, A. L., & Muñoz‐Cánoves, P. (2023) · The FEBS Journal · doi:10.1111/febs.16573 · Cited by 34
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Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming
Zhang, W., Song, S., Zhang, Y., Pan, Y., Hu, D., & Wang, Y. (2026) · npj Aging · doi:10.1038/s41514-026-00355-z · Cited by 6
Metadata
- Authors
- Mylonas, K. J., O’Sullivan, E. D., Humphries, D., Baird, D. P., Docherty, M.-H., Neely, S. A., Krimpenfort, P. J., Melk, A., Schmitt, R., Ferreira-Gonzalez, S., Forbes, S. J., Hughes, J., & Ferenbach, D. A.
- Venue
- Science Translational Medicine
- Published
- 2021-05-19
- Volume
- 13
- Issue
- 594
- ISSN
- 1946-6234
- 1946-6242
- Cited by
- 219
- References
- 13
- Language
- en
- Update notices
- correction (2026-01-07)
- Funders
- Wellcome (100171/Z/12/Z, 108906/Z/15/Z)
- Kidney Research UK (RP_036_20160304)
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