The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
Combining rejuvenation interventions in rodents: a milestone in biomedical gerontology whose time has come
Open accessAbstract
INTRODUCTION: Longevity research has matured to the point where significantly postponing age-related decline in physical and mental function is now achievable in the laboratory and foreseeable in the clinic. The most promising strategies involve rejuvenation, i.e. reducing biological age, not merely slowing its progression. AREAS COVERED: We discuss therapeutic strategies for rejuvenation and results achieved thus far, with a focus on in vivo studies. We discuss the implications of interventions which act on mean or maximum lifespan and those showing effects in accelerated disease models. While the focus is on work conducted in mice, we also highlight notable insights in the field from studies in other model organisms. EXPERT OPINION: Rejuvenation was originally proposed as easier than slowing aging because it targets initially inert changes to tissue structure and composition, rather than trying to disentangle processes that both create aging damage and maintain life. While recent studies support this hypothesis, a true test requires a panel of rejuvenation interventions targeting multiple damage categories simultaneously. Considerations of cost, profitability, and academic significance have dampened enthusiasm for such work, but it is vital. Now is the time for the field to take this key step toward the medical control of aging.
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Cited works that were retracted
Works this paper cites that were later retracted, from the retraction notices publishers deposit. Major when the notice came out before this paper was published.
Cites a retracted work: 10.1073/pnas.2121499119
InfoThe cited work was retracted on 2025-08-11 (notice 10.1073/pnas.2519570122), not before this paper was published (2024-03-18).
Cited work 10.1073/pnas.2121499119 · retracted 2025-08-11 · notice 10.1073/pnas.2519570122 · this paper published 2024-03-18
“10.1073/pnas.2121499119”
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Yamada, H. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14103604 · Cited by 22
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Metadata
- Authors
- Lewis, C. J., & de Grey, A. D.
- Affiliations
- Longevity Escape Velocity Foundation, San Francisco, CA, USA
- Corresponding author
- de Grey, Aubrey D.
- Venue
- Expert Opinion on Therapeutic Targets
- Publisher
- Informa UK Limited
- Published
- 2024-03-18
- Volume
- 28
- Issue
- 6
- Pages
- 501-511
- ISSN
- 1472-8222 (ISSN-L)
- 1744-7631
- OpenAlex
- W4392749258
- Semantic Scholar
- 7037a384342019ff5448d717e80514743f05331c
- Cited by
- 10
- References
- 94
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Expert Opinion on Therapeutic Targets (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Longevity Escape Velocity (LEV) Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- rejuvenation, aging, longevity, biological age, age-related decline, lifespan extension, anti-aging interventions, mice, model organisms
- MeSH terms
- Aging, Animals, Disease Models, Animal, Geriatrics, Humans, Longevity, Rejuvenation, Rodentia, Mice
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