The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography
Open accessAbstract
An automated method to quantify TAU PET detected initial cortical tauopathy in Alzheimer’s disease and tracked subsequent amyloid-related TAU spread.
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The middle temporal gyrus is a transition zone between aging-related or preclinical AD-related medial temporal lobe pTau and more advanced stages of AD, where neocortical pTau extends across the brain and is strongly correlated with dementia.
“Many studies, from the histopathology of Braak and Braak4 to longitudinal studies of Tau positron emission tomography imaging27,28, demonstrate that MTG is a transition zone between aging-related or preclinical AD-related medial temporal lobe pTau and more advanced stages of AD, where neocortical pTau extends across the brain and is strongly correlated with dementia4,29–31.”
From Integrated multimodal cell atlas of Alzheimer’s disease (2024) · cites this paper as [30]
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Experimental — accuracy not yet measuredAmyloid-beta pathology drives tau pathology in Alzheimer disease.
“we propose that Aβ pathology drives tau pathology”
From The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics (2022) · cites this paper as [27]
In participants with varied ages, cognitive status, and amyloid loads, tau pathology first appeared in the transentorhinal cortex and spread into the neocortex at amyloid burdens above 40 centiloids.
“They demonstrated that the initial site of tau pathology was in the transentorhinal cortex and that further spreading into neocortex occurred at amyloid burdens of >40 CL.”
From The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics (2022) · cites this paper as [27]
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References 71 · Cited by 200
- Authors
- Sanchez, J. S., Becker, J. A., Jacobs, H. I. L., Hanseeuw, B. J., Jiang, S., Schultz, A. P., Properzi, M. J., Katz, S. R., Beiser, A., Satizabal, C. L., O’Donnell, A., DeCarli, C., Killiany, R., El Fakhri, G., Normandin, M. D., Gómez-Isla, T., Quiroz, Y. T., Rentz, D. M., Sperling, R. A., Seshadri, S., Augustinack, J., Price, J. C., & Johnson, K. A.
- Affiliations
- Harvard University (US)
- Boston University (US)
- Boston University School of Medicine, Boston, MA 02118, USA.
- University of California, Davis (US)
- Massachusetts General Hospital, Boston, MA 02114, USA.
- Brigham and Women's Hospital (US)
- Corresponding author
- Sanchez, Justin S.
- Johnson, Keith A.
- ORCID
- Sanchez, Justin S.
- Becker, J. Alex
- Jacobs, Heidi I. L.
- Hanseeuw, Bernard J.
- Jiang, Shu
- Schultz, Aaron P.
- Properzi, Michael J.
- Katz, Samantha R.
- Beiser, Alexa
- Satizabal, Claudia L.
- O’Donnell, Adrienne
- DeCarli, Charles
- Killiany, Ron
- Normandin, Marc D.
- Quiroz, Yakeel T.
- Rentz, Dorene M.
- Sperling, Reisa A.
- Seshadri, Sudha
- Augustinack, Jean
- Price, Julie C.
- Johnson, Keith A.
- Venue
- Science Translational Medicine
- Published
- 2021-01-20
- Volume
- 13
- Issue
- 577
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7978042
- OpenAlex
- W3122375100
- Cited by
- 200
- References
- 71
- Citations by year
- 2026: 18 · 2025: 37 · 2024: 47 · 2023: 32 · 2022: 39 · 2021: 26 · 2020: 1
- FWCI
- 22.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Libraries (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Funders
- U.S. Department of Health and Human Services (HHSN268201500001I)
- National Institute on Aging (R01 AG046396, AG049607, P01 AG036694, P30 AG 010129, R01 AG061206, R01 AG054671, R01 AG050436, R01 AG052414, R01 AG062559, R01 AG057672)
- NIH Office of the Director (DP5OD019833)
- National Institute of Biomedical Imaging and Bioengineering (P41 EB022544)
- National Heart, Lung, and Blood Institute (75N92019D00031)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, tauopathy, tau spread, amyloid-beta, medial temporal lobe, positron emission tomography, amyloid imaging, disease progression, natural history (disease), clinicopathological correlation
- MeSH terms
- Adult, Alzheimer Disease, Humans, Amyloid beta-Peptides, tau Proteins, Tauopathies, Positron-Emission Tomography
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