The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.
The Many Forks in FOXO's Road
Abstract
The FOXO family of transcription factors constitute an evolutionarily conserved subgroup within the larger family known as winged helix or Forkhead transcriptional regulators. Building upon work in the nematode, researchers have uncovered a role for these proteins in a diverse set of cellular responses that include glucose metabolism, stress response, cell cycle regulation, and apoptosis. At the organismal level, FOXO transcription factors are believed to function in various pathological processes ranging from cancer and diabetes to organismal aging. A number of studies have also shed light on the signaling pathways that regulate FOXO activity in response to external stimuli and have identified multiple FOXO target genes that mediate this varied set of biological responses.
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Metadata
- Authors
- Tran, H., Brunet, A., Griffith, E. C., & Greenberg, M. E.
- Venue
- Science's STKE
- Published
- 2003-03-04
- Volume
- 2003
- Issue
- 172
- Pages
- RE5-RE5
- ISSN
- 1525-8882 (ISSN-L)
- OpenAlex
- W2064738912
- Cited by
- 434
- References
- 115
- FWCI
- 11.15
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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