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Cited by 42Bacterial biofilms and quorum sensingMicrobial Natural Products and BiosynthesisBacterial Genetics and Biotechnology

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Thiostrepton Hijacks Pyoverdine Receptors To Inhibit Growth of Pseudomonas aeruginosa

Open access
Ranieri, Michael R. M., Chan, Derek C. K., Yaeger, Luke N., Rudolph, Madeleine, Karabelas-Pittman, Sawyer, Abdo, Hamdi, Chee, Jessica, Harvey, Hanjeong, Nguyen, Uyen, Burrows, Lori L.·2019·Antimicrobial Agents and Chemotherapy
DOI 10.1128/aac.00472-19PMC PMC6709454

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Abstract

Pseudomonas aeruginosa is a biofilm-forming opportunistic pathogen and is intrinsically resistant to many antibiotics. In a high-throughput screen for molecules that modulate biofilm formation, we discovered that the thiopeptide antibiotic thiostrepton (TS), which is considered to be inactive against Gram-negative bacteria, stimulated P. aeruginosa biofilm formation in a dose-dependent manner.

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Citations

Cites

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Metadata

Authors
Ranieri, M. R. M., Chan, D. C. K., Yaeger, L. N., Rudolph, M., Karabelas-Pittman, S., Abdo, H., Chee, J., Harvey, H., Nguyen, U., & Burrows, L. L.
Affiliations
Michael G. DeGroote Institute for Infectious Disease Research (CA)
Corresponding author
Burrows, Lori L.
ORCID
Venue
Antimicrobial Agents and Chemotherapy
Publisher
American Society for Microbiology
Published
2019-09
Volume
63
Issue
9
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
DOI
10.1128/aac.00472-19
PMC
PMC6709454
OpenAlex
W2954455527
Cited by
42
References
3
Citations by year
2026: 3 · 2025: 1 · 2024: 7 · 2023: 12 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 2
FWCI
1.57
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Antimicrobial Agents and Chemotherapy (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ontario Graduate Scholarship
  • Natural Sciences and Engineering Research Council of Canada (USRA)
  • Glyconet (Summer studentship)
  • Cystic Fibrosis Canada (Summer studentship)
  • Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (RGPIN-2016-06521)
  • Ontario Research Foundation (RE07-048)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
thiostrepton, Pseudomonas aeruginosa, outer membrane transport, biofilm formation, multidrug resistance, iron limitation, Gram-negative pathogens, antibiotic resistance
MeSH terms
Anti-Bacterial Agents, Bacterial Outer Membrane Proteins, Bacterial Proteins, Dose-Response Relationship, Drug, Iron Chelating Agents, Membrane Proteins, Microbial Sensitivity Tests, Mutation, Pseudomonas aeruginosa, Thiostrepton, Biofilms, Drug Resistance, Multiple, Bacterial, Acinetobacter baumannii

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