Crystal structures of full-length lanosterol 14α-demethylases of prominent fungal pathogens Candida albicans and Candida glabrata provide tools for antifungal discovery

Features and development of Coot

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Scaling and assessment of data quality

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Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism

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Amino Acid Substitutions in the Cytochrome P-450 Lanosterol 14α-Demethylase (CYP51A1) from Azole-Resistant Candida albicans Clinical Isolates Contribute to Resistance to Azole Antifungal Agents

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Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

Hargrove, T. Y., Friggeri, L., Wawrzak, Z., Qi, A., Hoekstra, W. J., Schotzinger, R. J., York, J. D., Guengerich, F. P., & Lepesheva, G. I. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.778308 · Cited by 444 · see citing works

Possible Environmental Origin of Resistance of <i>Aspergillus fumigatus</i> to Medical Triazoles

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Contribution of Clinically Derived Mutations in <i>ERG11</i> to Azole Resistance in Candida albicans

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Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

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Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature

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Azole Resistance in Aspergillus fumigatus: A Consequence of Antifungal Use in Agriculture?

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Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens

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The genetic basis of fluconazole resistance development in Candida albicans

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Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase

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Resistance to antifungals that target CYP51

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<i>Erg11</i> mutations associated with azole resistance in clinical isolates of <i>Candida albicans</i>

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Design and optimization of highly-selective fungal CYP51 inhibitors

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Characterization of Three Classes of Membrane Proteins Involved in Fungal Azole Resistance by Functional Hyperexpression inSaccharomyces cerevisiae

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Application of Real-Time Quantitative PCR to Molecular Analysis of Candida albicans Strains Exhibiting Reduced Susceptibility to Azoles

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Diethylcarbamazine-related antimicrobial activity in Mycobacterium tuberculosis-infected blood

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The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme

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Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs

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Structural basis for conservation in the CYP51 family

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Evaluation of fluconazole resistance mechanisms in candida albicans clinical isolates from HIV-infected patients in Brazil

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Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase

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CYP51: A Major Drug Target in the Cytochrome P450 Superfamily

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Expression, Purification, and Characterization of <i>Aspergillus fumigatus</i> Sterol 14-α Demethylase (CYP51) Isoenzymes A and B

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Intrinsic short-tailed azole resistance in mucormycetes is due to an evolutionary conserved aminoacid substitution of the lanosterol 14α-demethylase

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The investigational drug VT-1129 is a highly potent inhibitor of cryptococcus species CYP51 but only weakly inhibits the human enzyme

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Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity

Hargrove, T. Y., Garvey, E. P., Hoekstra, W. J., Yates, C. M., Wawrzak, Z., Rachakonda, G., Villalta, F., & Lepesheva, G. I. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00570-17 · Cited by 75 · see citing works

Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals

Tyndall, J. D. A., Sabherwal, M., Sagatova, A. A., Keniya, M. V., Negroni, J., Wilson, R. K., Woods, M. A., Tietjen, K., & Monk, B. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167485 · Cited by 67 · see citing works

Clinical Candidate VT-1161's Antiparasitic EffectIn Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi

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Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase

Sagatova, A. A., Keniya, M. V., Tyndall, J. D. A., & Monk, B. C. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02242-17 · Cited by 31 · see citing works

Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design

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Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery

Keniya, M. V., Ruma, Y. N., Tyndall, J. D. A., & Monk, B. C. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01131-18 · Cited by 14 · see citing works

History of the development of antifungal azoles: A review on structures, SAR, and mechanism of action

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Molecular and genetic basis of azole antifungal resistance in the opportunistic pathogenic fungus<i>Candida albicans</i>

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Inhibition of ergosterol synthesis in Candida albicans by novel eugenol tosylate congeners targeting sterol 14α-demethylase (CYP51) enzyme

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In vitro study on the potential fungicidal effects of atorvastatin in combination with some azole drugs against multidrug resistant Candida albicans

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The role of azole antifungal agents for systemic antifungal therapy

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Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates

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Effects of three azole derivatives on the lipids of different strains of Cryptococcus neoformans

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Effects of three azole derivatives on the lipids of different strains ofSporothrix schenckii

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Amino Acid Substitutions in the Cytochrome P-450 Lanosterol 14α-Demethylase (CYP51A1) from Azole-Resistant Candida albicans Clinical Isolates Contribute to Resistance to Azole Antifungal Agents

Sanglard, D., Ischer, F., Koymans, L. M. H., & Billé, J. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.2.241 · Cited by 465 · see citing works