Candida auris Invasive Infections during a COVID-19 Case Surge
Open accessAbstract
Clinical cases of C. auris noted during a COVID-19 surge led to an epidemiological, clinical, and genomic investigation. Evaluation identified a close genetic relationship but inconclusive epidemiologic link between all cases. Prolonged hospitalization due to critical illness from COVID-19 and use of antimicrobials may have contributed to clinical infections.
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Multi-drug resistant Candida infections are on the rise due to a variety of mechanisms, particularly C. auris, with widespread azole resistance and the potential for development of resistance to all classes of antifungals during therapy.
“Multi-drug resistant Candida infections are on the rise due to a variety of mechanisms (Table 2), particularly C. auris, with widespread azole resistance and the potential for development of resistance to all classes of antifungals during therapy, highlighting the need for new agents to keep up with changes in epidemiology.133,145–153”
From Epidemiology of Invasive Candidiasis (2024) · cites this paper as [148]
The Introduction (page not available) describes C. auris as resistant to multiple antifungals and reports growing clinical case numbers in Florida. It does not establish widespread azole resistance, explain a variety of resistance mechanisms, or say that resistance to all antifungal classes can develop during therapy. (LLM, conf=0.85)
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Cites
Van der Auwera, G. A., Carneiro, M. O., Hartl, C., Poplin, R., del Angel, G., Levy‐Moonshine, A., Jordan, T., Shakir, K., Roazen, D., Thibault, J., et al. (2013) · Current Protocols in Bioinformatics · doi:10.1002/0471250953.bi1110s43 · Cited by 6,687 · see citing works
Candida auris: a Review of the Literature
Jeffery-Smith, A., Taori, S. K., Schelenz, S., Jeffery, K. J., Johnson, E. M., Borman, A. M., Candida auris Incident Management Team, Manuel, R. J., & Brown, C. S. (2017) · Clinical Microbiology Reviews · doi:10.1128/cmr.00029-17 · Cited by 610 · see citing works
van Duin, D., Arias, C. A., Komarow, L., et al. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(19)30755-8 · Cited by 336 · see citing works
Self-citationFalcone, M., Tiseo, G., Giordano, C., Leonildi, A., Menichini, M., Vecchione, A., Pistello, M., Guarracino, F., Ghiadoni, L., Forfori, F., et al. (2020) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkaa530 · Cited by 151 · see citing works
Rossow, J., Ostrowsky, B., Adams, E., Greenko, J., McDonald, R., Vallabhaneni, S., Forsberg, K., Perez, S., Lucas, T., Alroy, K. A., et al. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1462 · Cited by 125 · see citing works
Shropshire, W. C., Aitken, S. L., Pifer, R., et al. (2020) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkaa447 · Cited by 58 · see citing works
Chatterjee, P., Choi, H., Ochoa, B., Garmon, G., Coppin, J. D., Allton, Y., Lukey, J., Williams, M. D., Navarathna, D. H. M. L. P., & Jinadatha, C. (2020) · Infection Control and Hospital Epidemiology · doi:10.1017/ice.2020.410 · Cited by 29 · see citing works
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Epidemiology of Invasive Candidiasis
Bays, D., Jenkins, E., Lyman, M., Chiller, T., Strong, N., Ostrosky-Zeichner, L., Hoenigl, M., Pappas, P., & Thompson, G. (2024) · Clinical Epidemiology · doi:10.2147/clep.s459600 · Cited by 109 · see citing works
Vazquez, J. A., Pappas, P. G., Boffard, K., Paruk, F., Bien, P. A., Tawadrous, M., Ople, E., Wedel, P., Oborska, I., & Hodges, M. R. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01419-22 · Cited by 92 · see citing works
- Authors
- Hanson, B. M., Dinh, A. Q., Tran, T. T., Arenas, S., Pronty, D., Gershengorn, H. B., Ferreira, T., Arias, C. A., & Shukla, B. S.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Center for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, Houston, Texas, USA
- University of Miami Health System (US)
- Albert Einstein College of Medicine (US)
- University of Miami (US)
- Center for Infectious Diseases, University of Texas Health Science Center, School of Public Health, Houston, Texas, USA
- Corresponding author
- Hanson, Blake M.
- Shukla, Bhavarth S.
- ORCID
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2021-09-17
- Volume
- 65
- Issue
- 10
- Pages
- e0114621-e0114621
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC8448104
- OpenAlex
- W3187612454
- Cited by
- 81
- References
- 7
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 9 · 2023: 22 · 2022: 38 · 2021: 5
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute of Allergy and Infectious Diseases (K01AI148593, P01AI152999, K24AI121296, R01AI134637, R01AI48342)
- University of Texas Health Science Center at Houston (STARS Award)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida auris, invasive candidiasis, COVID-19 surge, SARS-CoV-2, hospital-acquired fungal infection, antimicrobial use, prolonged hospital stay, genetic relatedness, epidemiological link, critical illness
- MeSH terms
- COVID-19, SARS-CoV-2, Antifungal Agents, Candida, Humans, Candidiasis, Invasive
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