The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Computer-Aided Identification of Recognized Drugs as Pseudomonas aeruginosa Quorum-Sensing Inhibitors
Open accessAbstract
Attenuation of Pseudomonas aeruginosa virulence by the use of small-molecule quorum-sensing inhibitors (referred to as the antipathogenic drug principle) is likely to play a role in future treatment strategies for chronic infections. In this study, structure-based virtual screening was used in a search for putative quorum-sensing inhibitors from a database comprising approved drugs and natural compounds. The database was built from compounds which showed structural similarities to previously reported quorum-sensing inhibitors, the ligand of the P. aeruginosa quorum-sensing receptor LasR, and a quorum-sensing receptor agonist. Six top-ranking compounds, all recognized drugs, were identified and tested for quorum-sensing-inhibitory activity. Three compounds, salicylic acid, nifuroxazide, and chlorzoxazone, showed significant inhibition of quorum-sensing-regulated gene expression and related phenotypes in a dose-dependent manner. These results suggest that the identified compounds have the potential to be used as antipathogenic drugs. Furthermore, the results indicate that structure-based virtual screening is an efficient tool in the search for novel compounds to combat bacterial infections.
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Cites
Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396
Cited by
The role of bacterial biofilms in chronic infections
Bjarnsholt, T. (2013) · APMIS · doi:10.1111/apm.12099 · Cited by 1,080
Self-citationGalloway, W. R. J. D., Hodgkinson, J. T., Bowden, S. D., Welch, M., & Spring, D. R. (2011) · Chemical Reviews · doi:10.1021/cr100109t · Cited by 665
Brackman, G., Cos, P., Maes, L., Nelis, H. J., & Coenye, T. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00045-11 · Cited by 561
Ajoene, a Sulfur-Rich Molecule from Garlic, Inhibits Genes Controlled by Quorum Sensing
Jakobsen, T. H., van Gennip, M., Phipps, R. K., Shanmugham, M. S., Christensen, L. D., Alhede, M., Skindersoe, M. E., Rasmussen, T. B., Friedrich, K., Uthe, F., et al. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05919-11 · Cited by 458
Self-citationPseudomonas aeruginosa Biofilms: Host Response and Clinical Implications in Lung Infections
Maurice, N. M., Bedi, B., & Sadikot, R. T. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0321tr · Cited by 373
Metadata
- Authors
- Yang, L., Rybtke, M. T., Jakobsen, T. H., Hentzer, M., Bjarnsholt, T., Givskov, M., & Tolker-Nielsen, T.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2009-06
- Volume
- 53
- Issue
- 6
- Pages
- 2432-2443
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2154447238
- Cited by
- 219
- References
- 2
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Yang, L., Rybtke, M. T., Jakobsen, T. H., Hentzer, M., Bjarnsholt, T., Givskov, M., & Tolker-Nielsen, T. (2009). Computer-Aided Identification of Recognized Drugs as Pseudomonas aeruginosa Quorum-Sensing Inhibitors. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.01283-08
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