Regulation of Efflux Pump Expression and Drug Resistance by the Transcription Factors Mrr1, Upc2, and Cap1 in Candida albicans

Schubert, Sabrina; Barker, Katherine S.; Znaidi, Sadri; Schneider, Sabrina; Dierolf, Franziska; Dunkel, Nico; Aïd, Malika; Boucher, Geneviève; Rogers, P. David; Raymond, Martine; Morschhäuser, Joachim

doi:10.1128/aac.01343-10

Regulation of Efflux Pump Expression and Drug Resistance by the Transcription Factors Mrr1, Upc2, and Cap1 in Candida albicans

Constitutive overexpression of the Mdr1 efflux pump is an important mechanism of acquired drug resistance in the yeast Candida albicans . The zinc cluster transcription factor Mrr1 is a central regulator of MDR1 expression, but other transcription factors have also been implicated in MDR1 regulat…