Cited by 57Antimicrobial Resistance in StaphylococcusBacterial Genetics and BiotechnologyAntibiotic Resistance in Bacteria

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Novel Mobile Variants of Staphylococcal Cassette Chromosome mec in Staphylococcus aureus

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Jansen, W. T. M., Beitsma, M. M., Koeman, C. J., van Wamel, W. J. B., Verhoef, J., Fluit, A. C.·2006·Antimicrobial Agents and Chemotherapy

DOI 10.1128/aac.01539-05

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Abstract

Staphylococcus aureus staphylococcal cassette chromosome mec type IV (SSC mec IV) is associated with virulent community-acquired methicillin-resistant Staphylococcus aureus (MRSA) and frequent horizontal transfer among staphylococci. To gain insight into the mechanism of transfer, we studied the ccrA/B type 2 recombinase-mediated excision of SCC mec IV ( n = 5 strains) and SCC mec II ( n = 2). In SCC mec IV- but not SCC mec II-containing strains, spontaneous excision of the cassette was observed. Introduction of ccrA/B type 2 recombinase genes under control of an S. aureus bacterial phage promoter in the different strains yielded excision of SCC mec II and multiple excision variants of SCC mec IV. Sequencing of the alternatively excised products in SCC mec IV strains identified a 100-bp shortened SCC mec ′ variant and a 5,877-bp, conserved SCC-like element that lacks mecA and ccrA/B recombinases. Excision of the SCC-like element in wild-type S. aureus was dependent on the presence of SCC mec . The element could be excised separately or as part of a novel composite cassette together with SCC mec . The relative abundance of and variety in SCC mec IV excisions may contribute to the frequency of horizontal transfer and genetic plasticity in SCC mec IV MRSA strains.

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Authors: Jansen, W. T. M., Beitsma, M. M., Koeman, C. J., van Wamel, W. J. B., Verhoef, J., & Fluit, A. C.
Affiliations: University Medical Center Utrecht (NL)
Corresponding author: Jansen, W. T. M.
ORCID: Jansen, W. T. M.
van Wamel, W. J. B.
Fluit, A. C.
Venue: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
Published: 2006-06
Volume: 50
Issue: 6
Pages: 2072-2078
ISSN: 0066-4804 (ISSN-L)
1098-6596
DOI: 10.1128/aac.01539-05
OpenAlex: W2106492667
Cited by: 57
References: 17
Citations by year: 2026: 3 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 4 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 2
FWCI: 2.27
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Antimicrobial Agents and Chemotherapy (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Keywords: staphylococcal cassette chromosome mec, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, horizontal gene transfer, mecA gene, mobile genetic elements, genome plasticity, community-acquired MRSA
MeSH terms: Anti-Bacterial Agents, Chromosomes, Bacterial, Genes, Bacterial, Methicillin, Models, Genetic, Staphylococcal Infections, Staphylococcus aureus, Genetic Variation, Methicillin Resistance, Gene Transfer, Horizontal, Recombinases

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Novel Mobile Variants of Staphylococcal Cassette Chromosome mec in Staphylococcus aureus

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