The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Novel Mobile Variants of Staphylococcal Cassette Chromosome mec in Staphylococcus aureus
Open accessAbstract
Staphylococcus aureus staphylococcal cassette chromosome mec type IV (SSC mec IV) is associated with virulent community-acquired methicillin-resistant Staphylococcus aureus (MRSA) and frequent horizontal transfer among staphylococci. To gain insight into the mechanism of transfer, we studied the ccrA/B type 2 recombinase-mediated excision of SCC mec IV ( n = 5 strains) and SCC mec II ( n = 2). In SCC mec IV- but not SCC mec II-containing strains, spontaneous excision of the cassette was observed. Introduction of ccrA/B type 2 recombinase genes under control of an S. aureus bacterial phage promoter in the different strains yielded excision of SCC mec II and multiple excision variants of SCC mec IV. Sequencing of the alternatively excised products in SCC mec IV strains identified a 100-bp shortened SCC mec ′ variant and a 5,877-bp, conserved SCC-like element that lacks mecA and ccrA/B recombinases. Excision of the SCC-like element in wild-type S. aureus was dependent on the presence of SCC mec . The element could be excised separately or as part of a novel composite cassette together with SCC mec . The relative abundance of and variety in SCC mec IV excisions may contribute to the frequency of horizontal transfer and genetic plasticity in SCC mec IV MRSA strains.
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“This molecular aberration was likely due to the loss of the SCCmec cassette or a portion thereof and is consistent with the relatively high rate of excision and integration of SCCmec IV (6, 8, 9, 13).”
From Methicillin-Resistant Staphylococcus aureus Nasal Carriage among Injection Drug Users: Six Years Later (2008) · cites this paper as [13]
In the citing paper
“This molecular aberration was likely due to the loss of the SCCmec cassette or a portion thereof and is consistent with the relatively high rate of excision and integration of SCCmec IV (6, 8, 9, 13).”
From Methicillin-Resistant Staphylococcus aureus Nasal Carriage among Injection Drug Users: Six Years Later (2008) · cites this paper as [13]
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Cites
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Evidence for in-vivo transfer of mecA DNA between strains of Staphylococcus aureus
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Self-citation馬, 笑. (2004) · Medical Entomology and Zoology · Cited by 152
Integrons: an Antibiotic Resistance Gene Capture and Expression System
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van Belkum, A., Tassios, P. T., Dijkshoorn, L., Haeggman, S., Cookson, B., Fry, N. K., Fussing, V., Green, J., Feil, E. J., Gerner‐Smidt, P., et al. (2007) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2007.01786.x · Cited by 890
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Conjugative and mobilizable genomic islands in bacteria: evolution and diversity
Bellanger, X., Payot, S., Leblond-Bourget, N., & Guédon, G. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12058 · Cited by 375
Staphylococcus aureus Bacteremia: Epidemiology, Pathophysiology, and Management Strategies
Naber, C. K. (2009) · Clinical Infectious Diseases · doi:10.1086/598189 · Cited by 313
Schijffelen, M. J., Boel, C. E., van Strijp, J. A. G., & Fluit, A. C. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-376 · Cited by 207
Self-citation
Metadata
- Authors
- Jansen, W. T. M., Beitsma, M. M., Koeman, C. J., van Wamel, W. J. B., Verhoef, J., & Fluit, A. C.
- Affiliations
- University Medical Center Utrecht (NL)
- Corresponding author
- Jansen, W. T. M.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2006-06
- Volume
- 50
- Issue
- 6
- Pages
- 2072-2078
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2106492667
- Cited by
- 57
- References
- 17
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 4 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- journals.asm.org/non-commercial-tdm-license (tdm)
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Keywords
- staphylococcal cassette chromosome mec, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, horizontal gene transfer, mecA gene, mobile genetic elements, genome plasticity, community-acquired MRSA
- MeSH terms
- Anti-Bacterial Agents, Chromosomes, Bacterial, Genes, Bacterial, Methicillin, Models, Genetic, Staphylococcal Infections, Staphylococcus aureus, Genetic Variation, Methicillin Resistance, Gene Transfer, Horizontal, Recombinases
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
