The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Emergence of Imipenem-Resistant Gram-Negative Bacilli in Intestinal Flora of Intensive Care Patients
Open accessAbstract
Intestinal flora contains a reservoir of Gram-negative bacilli (GNB) resistant to cephalosporins, which are potentially pathogenic for intensive care unit (ICU) patients; this has led to increasing use of carbapenems. The emergence of carbapenem resistance is a major concern for ICUs. Therefore, in this study, we aimed to assess the intestinal carriage of imipenem-resistant GNB (IR-GNB) in intensive care patients. For 6 months, 523 consecutive ICU patients were screened for rectal IR-GNB colonization upon admission and weekly thereafter. The phenotypes and genotypes of all isolates were determined, and a case control study was performed to identify risk factors for colonization. The IR-GNB colonization rate increased regularly from 5.6% after 1 week to 58.6% after 6 weeks in the ICU. In all, 56 IR-GNB strains were collected from 50 patients: 36 Pseudomonas aeruginosa strains, 12 Stenotrophomonas maltophilia strains, 6 Enterobacteriaceae strains, and 2 Acinetobacter baumannii strains. In P. aeruginosa , imipenem resistance was due to chromosomally encoded resistance (32 strains) or carbapenemase production (4 strains). In the Enterobacteriaceae strains, resistance was due to AmpC cephalosporinase and/or extended-spectrum β-lactamase production with porin loss. Genomic comparison showed that the strains were highly diverse, with 8 exceptions (4 VIM-2 carbapenemase-producing P. aeruginosa strains, 2 Klebsiella pneumoniae strains, and 2 S. maltophilia strains). The main risk factor for IR-GNB colonization was prior imipenem exposure. The odds ratio for colonization was already as high as 5.9 (95% confidence interval [95% CI], 1.5 to 25.7) after 1 to 3 days of exposure and increased to 7.8 (95% CI, 2.4 to 29.8) thereafter. In conclusion, even brief exposure to imipenem is a major risk factor for IR-GNB carriage.
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Self-citationEmergence of Oxacillinase-Mediated Resistance to Imipenem in Klebsiella pneumoniae
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Cited by
Kalil, A. C., Metersky, M. L., Klompas, M., Muscedere, J., Sweeney, D. A., Palmer, L. B., Napolitano, L. M., O'Grady, N. P., Bartlett, J. G., Carratalà, J., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw353 · Cited by 3,892
Carbapenem Resistance: A Review
Codjoe, F., & Donkor, E. (2017) · Medical Sciences · doi:10.3390/medsci6010001 · Cited by 746
Mechanisms of antimicrobial resistance in Gram-negative bacilli
Ruppé, É., Woerther, P.-L., & Barbier, F. (2015) · Annals of Intensive Care · doi:10.1186/s13613-015-0061-0 · Cited by 490
Self-citationBloodstream infections in critically ill patients: an expert statement
Timsit, J.-F., Ruppé, E., Barbier, F., Tabah, A., & Bassetti, M. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05950-6 · Cited by 448
Self-citationTabah, A., Cotta, M. O., Garnacho-Montero, J., Schouten, J., Roberts, J. A., Lipman, J., Tacey, M., Timsit, J.-F., Leone, M., Zahar, J. R., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/civ1199 · Cited by 220
Metadata
- Authors
- Armand-Lefèvre, L., Angebault, C., Barbier, F., Hamelet, E., Defrance, G., Ruppé, E., Bronchard, R., Lepeule, R., Lucet, J.-C., El Mniai, A., Wolff, M., Montravers, P., Plésiat, P., & Andremont, A.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2013-03
- Volume
- 57
- Issue
- 3
- Pages
- 1488-1495
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2162031520
- Cited by
- 300
- References
- 34
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Armand-Lefèvre, L., Angebault, C., Barbier, F., Hamelet, E., Defrance, G., Ruppé, E., Bronchard, R., Lepeule, R., Lucet, J.-C., El Mniai, A., Wolff, M., Montravers, P., Plésiat, P., & Andremont, A. (2013). Emergence of Imipenem-Resistant Gram-Negative Bacilli in Intestinal Flora of Intensive Care Patients. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.01823-12
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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