Cited by 3,892Nosocomial Infections in ICUPneumonia and Respiratory InfectionsInfection Control in Healthcare

Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society.

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Kalil, Andre C., Metersky, Mark L., Klompas, Michael, Muscedere, John, Sweeney, Daniel A., Palmer, Lucy B., Napolitano, Lena M., O'Grady, Naomi P. +12 more·2016·Clinical Infectious Diseases

Abstract

It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances. These guidelines are intended for use by healthcare professionals who care for patients at risk for hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), including specialists in infectious diseases, pulmonary diseases, critical care, and surgeons, anesthesiologists, hospitalists, and any clinicians and healthcare providers caring for hospitalized patients with nosocomial pneumonia. The panel's recommendations for the diagnosis and treatment of HAP and VAP are based upon evidence derived from topic-specific systematic literature reviews.

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  1. [25]25. Gastmeier P, Sohr D, Geffers C, Ruden H, Vonberg RP, Welte T. Early- and lateonset pneumonia: is this still a useful classi fi cation? Antimicrob Agents Chemother 2009 ; 53:2714 -8.
  2. [65]65. Kirtland SH, Corley DE, Winterbauer RH, et al. The diagnosis of ventilatorassociated pneumonia: a comparison of histologic, microbiologic, and clinical criteria. Chest 1997 ; 112:445 -57.
  3. [166]166. Thomas PD, Daly S, Misan G, Steele T. Comparison of the ef fi cacy and adverse effect pro fi le of cefotaxime, 3 g/day, and ceftriaxone, 2 g/day, in the treatment of nosocomial lower respiratory tract infections in ICU patients. Eur Respir Rev 1994 ; 4:321 -8.
  4. [175]175. Beaucaire G, Nicolas MH, Martin C, et al. Phare study. Comparative study of combined cefepime-amikacin versus ceftazidime combined with amikacin in the treatment of nosocomial pneumonias in ventilated patients. Multicenter group study [in French]. Ann Fr Anesth Reanim 1999 ; 18:186 -95.
  5. [181]181. Brown RB, Lemeshow S, Teres D. Moxalactam vs carbenicillin plus tobramycin: treatment of nosocomial gram-negative bacillary pneumonias in non-neutropenic patients. Curr Ther Res 1984 ; 36:557 -64.
  6. [211]211. Jacob J, Klein E, Laxminarayan R, et al. Carbapenem resistant enterobactereciae. MMWR Morb Mortal Wkly Rep 2013 ; 62:165 -70.
  7. [215]215. Alsuraikh M, Hamdy G. Incidence, risk factors, and causative agents of hospital acquired pneumonia (nosocomial pneumonia) in adult hospitalized patients in medical wards of a general hospital in Kuwait. Kuwait Med J 2008 ; 40:297 -300.
  8. [224]224. Barreiro-Lopez B, Tricas JM, Mauri E, Quintana S, Garau J. Risk factors and prognostic factors in nosocomial pneumonia outside the intensive care units setting [in Spanish]. Enferm Infecc Microbiol Clin 2005 ; 23:519 -24.
  9. [238]238. Pea F, Di Qual E, Cusenza A, Brollo L, Baldassarre M, Furlanut M. Pharmacokinetics and pharmacodynamics of intravenous levo fl oxacin in patients with earlyonset ventilator-associated pneumonia. Clin Pharmacokinet 2003 ; 42:589 -98.
  10. [263]263. Mendelman PM, Smith AL, Levy J, Weber A, Ramsey B, Davis RL. Aminoglycoside penetration, inactivation, and ef fi cacy in cystic fi brosis sputum. Am Rev Respir Dis 1985 ; 132:761 -5.
  11. [346]346. Fekih Hassen M, Ayed S, Ben Sik Ali H, Gharbi R, Marghli S, Elatrous S. Duration of antibiotic therapy for ventilator-associated pneumonia: comparison of 7 and 10 days. A pilot study [in French]. Ann Fr Anesth Reanim 2009 ; 28:16 -23.
  12. [347]347. Medina J, Perez Protto S, Paciel D, Pontet J, Saldun P, Berro M. Antibiotic treatment for the ventilator-associated pneumonia: 8 vs. 12 days randomized trial preliminary data. In: Proceedings of the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy, 2007 :361.
  13. [355]355. Hoffken G, Niederman MS. Nosocomial pneumonia: the importance of a deescalating strategy for antibiotic treatment of pneumonia in the ICU. Chest 2002 ; 122:2183 -96.
  14. [363]363. Pontet J, Paciel D, Olivera W, Bentancourt S, Cancela M, Gervas J. Procalcitonin (PCT) guided antibiotic treatment in ventilator associated pneumonia (VAP). Multi-centre, clinical prospective, randomized-controlled study. Am J Respir Crit Care Med 2007 ; 175:A212.

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Authors
Kalil, A. C., Metersky, M. L., Klompas, M., Muscedere, J., Sweeney, D. A., Palmer, L. B., Napolitano, L. M., O'Grady, N. P., Bartlett, J. G., Carratalà, J., El Solh, A. A., Ewig, S., Fey, P. D., File, T. M., Restrepo, M. I., Roberts, J. A., Waterer, G. W., Cruse, P., Knight, S. L., & Brozek, J. L.
Affiliations
  • Department  of Internal Medicine, Division of Infectious Diseases, University of Nebraska Medical Center, Omaha
  • University of Connecticut (US)
  • Brigham and Women's Hospital (US)
  • Queen's University (CA)
  • University of California San Diego (US)
  • State University of New York (US)
  • University of Michigan (US)
  • Department of Critical Care Medicine, National Institutes of Health, Bethesda
  • Johns Hopkins University (US)
  • Bellvitge University Hospital (ES)
  • Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University at Buffalo, Veterans Affairs Western New York Healthcare System, New York
  • Augusta-Kranken-Anstalt (DE)
  • Nebraska Medical Center (US)
  • Summa Health System (US)
  • The University of Texas at San Antonio Health Science Center (US)
  • The University of Queensland (AU)
  • The University of Western Australia (AU)
  • National Jewish Health (US)
  • Department of Clinical Epidemiology and Biostatistics and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Venue
Clinical Infectious Diseases
Published
2016-07-14
Volume
63
Issue
5
Pages
e61-e111
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
OpenAlex
W2473016454
Cited by
3,892
References
363
Citations by year
2026: 333 · 2025: 355 · 2024: 367 · 2023: 477 · 2022: 493 · 2021: 448 · 2020: 415 · 2019: 351 · 2018: 328 · 2017: 263 · 2016: 50 · 2015: 1 · 2014: 2
FWCI
300.13
Type
journal article
Language
en
Open access
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by)
  • HighWire Press Open Archive (submittedVersion)
  • RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by)
Funders
  • National Heart, Lung, and Blood Institute
  • NIH
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
  • Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
  • Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
Keywords
nosocomial pneumonia, ventilator-associated pneumonia, pneumonia diagnosis, pneumonia treatment, critically ill patients, hospitalized adults
MeSH terms
Adult, Anti-Bacterial Agents, Bacteriological Techniques, Cross Infection, Humans, United States, Pneumonia, Bacterial, Drug Resistance, Multiple, Bacterial, Pneumonia, Ventilator-Associated

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