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Cited by 27Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Plant Pathogen Control

MSH2 Gene Point Mutations Are Not Antifungal Resistance Markers in Candida glabrata

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Bordallo-Cardona, María Ángeles, Agnelli, Caroline, Gómez-Nuñez, Ana, Sánchez-Carrillo, Carlos, Bouza, Emilio, Muñoz, Patricia, Escribano, Pilar, Guinea, Jesús·2019·Antimicrobial Agents and Chemotherapy
DOI 10.1128/aac.01876-18PMC PMC6325230
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Abstract

The high rates of antifungal resistance in Candida glabrata may be facilitated by the presence of alterations in the MSH2 gene. We aimed to study the sequence of the MSH2 gene in 124 invasive C. glabrata isolates causing incident episodes of candidemia ( n = 81), subsequent candidemia episodes ( n = 9), endocarditis ( n = 2), and in vitro -generated echinocandin-resistant isolates ( n = 32) and assessed its relationship with genotypes, acquisition of antifungal resistance in vivo and in vitro , and patient prognosis.

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  • More recent work found no correlation between MSH2 mutations and antifungal resistance in vitro or in vivo.

    “however, more recent work did not find a correlation between MSH2 mutations and antifungal resistance in vitro or in vivo69,70.”

    From Drug resistance and tolerance in fungi. (2020) · cites this paper as [69]

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References 31 · Cited by 27

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Authors
Bordallo-Cardona, M. Á., Agnelli, C., Gómez-Nuñez, A., Sánchez-Carrillo, C., Bouza, E., Muñoz, P., Escribano, P., & Guinea, J.
Affiliations
  • Hospital General Universitario Gregorio Marañón (ES)
  • Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain
  • Universidad Complutense de Madrid (ES)
ORCID
Venue
Antimicrobial Agents and Chemotherapy
Publisher
American Society for Microbiology
Published
2019-01
Volume
63
Issue
1
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
DOI
10.1128/aac.01876-18
PMC
PMC6325230
OpenAlex
W2906341356
Cited by
27
References
31
Citations by year
2025: 1 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 8 · 2020: 2 · 2019: 3 · 2018: 1
FWCI
2.65
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Antimicrobial Agents and Chemotherapy (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Depósito Digital e-UCJC (submittedVersion, cc-by-nc-nd)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders
  • Fondo de Investigación Sanitaria (MSI15/00115, PI16/01012, PI14/00740)
  • FEDER
  • Instituto de Investigación Sanitaria Gregorio Marañón (II-Predoc-2016-IISGM)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Keywords
point mutations, Candida glabrata, antifungal resistance, echinocandin resistance, candidemia, invasive candidiasis, endocarditis, resistance markers
MeSH terms
Micafungin, Anidulafungin, Adolescent, Adult, Aged, Aged, 80 and over, Antifungal Agents, Child, Child, Preschool, Endocarditis, Female, Fungal Proteins, Genotype, Humans, Infant, Infant, Newborn, Male, Middle Aged, Mutation, Phenotype, Fluconazole, Gene Expression, Candida glabrata, MutS Homolog 2 Protein, Echinocandins, Candidemia

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